Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of FruR in Escherichia coli str. K-12 substr. MG1655

Properties
Regulator type: Transcription factor
TF locus tag: b0080
Regulator family: LacI
Regulation mode: activator (repressor)
Biological process: Central carbohydrate metabolism
Effector: Fructose-1-phosphate; Fructose-1,6-diphosphate
Regulog: FruR - Enterobacteriales
Statistics of regulated genes:
- Genes 54
- Operons 24
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 213 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function
Position: -113
Score: 4.4
Sequence: ACTGAAACGTTTTTGC
Locus tag: b1851
Name: edd
Funciton: Phosphogluconate dehydratase (EC 4.2.1.12)
Locus tag: b1850
Name: eda
Funciton: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
b1851
edd
Phosphogluconate dehydratase (EC 4.2.1.12)
b1850
eda
2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
Position: -246
Score: 4.6
Sequence: GCTGAATCGCTTAACC
Locus tag: b1136
Name: icdA
Funciton: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
b1136
icdA
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
Position: -35
Score: 5.4
Sequence: GCTGAATCGTTTCAAT
Locus tag: b2169
Name: fruB
Funciton: Fructose-specific phosphocarrier protein HPr (EC 2.7.1.69) / PTS system, fructose-specific IIA component (EC 2.7.1.69)
Locus tag: b2168
Name: fruK
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: b2167
Name: fruA
Funciton: PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69)
b2169
fruB
Fructose-specific phosphocarrier protein HPr (EC 2.7.1.69) / PTS system, fructose-specific IIA component (EC 2.7.1.69)
b2168
fruK
1-phosphofructokinase (EC 2.7.1.56)
b2167
fruA
PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69)
Position: -121
Score: 5.1
Sequence: CCTGAATCAATTCAGC
Locus tag: b3916
Name: pfkA
Funciton: 6-phosphofructokinase (EC 2.7.1.11)
b3916
pfkA
6-phosphofructokinase (EC 2.7.1.11)
Position: -286
Score: 4.3
Sequence: GGTGAATCGATACTTT
Locus tag: b3403
Name: pckA
Funciton: Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49)
b3403
pckA
Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49)
Position: -221
Score: 4.9
Sequence: CTTGAATGGTTTCAGC
Locus tag: b1676
Name: pykF
Funciton: Pyruvate kinase (EC 2.7.1.40)
b1676
pykF
Pyruvate kinase (EC 2.7.1.40)
Position: -102
Score: 4.6
Sequence: GCTTGAACGATTCACC
Locus tag: b1702
Name: ppsA
Funciton: Phosphoenolpyruvate synthase (EC 2.7.9.2)
b1702
ppsA
Phosphoenolpyruvate synthase (EC 2.7.9.2)
Position: -134
Score: 4.9
Sequence: GCTGAAACGATAAAGT
Locus tag: b2388
Name: glk
Funciton: Glucokinase (EC 2.7.1.2)
b2388
glk
Glucokinase (EC 2.7.1.2)
Position: -47
Score: 4.6
Sequence: GCTGAATCGTTAAGGT
Locus tag: b3365
Name: nirB
Funciton: Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4)
Locus tag: b3366
Name: nirD
Funciton: Nitrite reductase [NAD(P)H] small subunit (EC 1.7.1.4)
Locus tag: b3367
Name: nirC
Funciton: FNT family, nitrite transport protein
Locus tag: b3368
Name: cysG
Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
b3365
nirB
Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4)
b3366
nirD
Nitrite reductase [NAD(P)H] small subunit (EC 1.7.1.4)
b3367
nirC
FNT family, nitrite transport protein
b3368
cysG
Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
Position: -82
Score: 4.5
Sequence: TCTGAATCGATTCGAT
Locus tag: b1817
Name: manX
Funciton: PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69)
Locus tag: b1818
Name: manY
Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69)
Locus tag: b1819
Name: manZ
Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
b1817
manX
PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69)
b1818
manY
PTS system, mannose-specific IIC component (EC 2.7.1.69)
b1819
manZ
PTS system, mannose-specific IID component (EC 2.7.1.69)
Position: -137
Score: 5.4
Sequence: GCTGAAGCGTTTCAGT
Locus tag: b2927
Name: epd
Funciton: D-erythrose-4-phosphate dehydrogenase (EC 1.2.1.72)
Locus tag: b2926
Name: pgk
Funciton: Phosphoglycerate kinase (EC 2.7.2.3)
b2927
epd
D-erythrose-4-phosphate dehydrogenase (EC 1.2.1.72)
b2926
pgk
Phosphoglycerate kinase (EC 2.7.2.3)
Position: -219
Score: 4.7
Sequence: GCTGAATCGATTTTAT
Locus tag: b2415
Name: ptsH
Funciton: PTS family, Hpr protein, phosphohistidinoprotein-hexose phosphotransferase
Locus tag: b2416
Name: ptsI
Funciton: Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
Locus tag: b2417
Name: crr
Funciton: PTS system, glucose-specific IIA component (EC 2.7.1.69)
b2415
ptsH
PTS family, Hpr protein, phosphohistidinoprotein-hexose phosphotransferase
b2416
ptsI
Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
b2417
crr
PTS system, glucose-specific IIA component (EC 2.7.1.69)
Position: -161
Score: 4.6
Sequence: GTTGAACCGATTAAGC
Locus tag: b3919
Name: tpiA
Funciton: Triosephosphate isomerase (EC 5.3.1.1)
b3919
tpiA
Triosephosphate isomerase (EC 5.3.1.1)
Position: -283
Score: 3.6
Sequence: ACGGACACGATTCAAC
Locus tag: b2288
Name: nuoA
Funciton: NADH dehydrogenase I chain A
Locus tag: b2287
Name: nuoB
Funciton: NADH dehydrogenase I chain B
Locus tag: b2286
Name: nuoD
Funciton: NADH dehydrogenase I chain C,D
Locus tag: b2285
Name: nuoE
Funciton: NADH dehydrogenase I chain E
Locus tag: b2284
Name: nuoF
Funciton: NADH dehydrogenase I chain F
Locus tag: b2283
Name: nuoG
Funciton: NADH dehydrogenase I chain G
Locus tag: b2282
Name: nuoH
Funciton: NADH dehydrogenase I chain H
Locus tag: b2281
Name: nuoI
Funciton: NADH dehydrogenase I chain I
Locus tag: b2280
Name: nuoJ
Funciton: NADH dehydrogenase I chain J
Locus tag: b2279
Name: nuoK
Funciton: NADH dehydrogenase I chain K
Locus tag: b2278
Name: nuoL
Funciton: NADH dehydrogenase I chain L
Locus tag: b2277
Name: nuoM
Funciton: NADH dehydrogenase I chain M
Locus tag: b2276
Name: nuoN
Funciton: NADH dehydrogenase I chain N
b2288
nuoA
NADH dehydrogenase I chain A
b2287
nuoB
NADH dehydrogenase I chain B
b2286
nuoD
NADH dehydrogenase I chain C,D
b2285
nuoE
NADH dehydrogenase I chain E
b2284
nuoF
NADH dehydrogenase I chain F
b2283
nuoG
NADH dehydrogenase I chain G
b2282
nuoH
NADH dehydrogenase I chain H
b2281
nuoI
NADH dehydrogenase I chain I
b2280
nuoJ
NADH dehydrogenase I chain J
b2279
nuoK
NADH dehydrogenase I chain K
b2278
nuoL
NADH dehydrogenase I chain L
b2277
nuoM
NADH dehydrogenase I chain M
b2276
nuoN
NADH dehydrogenase I chain N
Position: -123
Score: 4
Sequence: AGTTAACCGATTCAGT
Locus tag: b3599
Name: mtlA
Funciton: mannitol-specific PTS system, IIABC components
b3599
mtlA
mannitol-specific PTS system, IIABC components
Position: -220
Score: 4.3
Sequence: GCTGAAGCGAGACACC
Locus tag: b3357
Name: crp
Funciton: Catabolite gene activator (cAMP receptor protein), CRP family
b3357
crp
Catabolite gene activator (cAMP receptor protein), CRP family
Position: -305
Score: 4.2
Sequence: ATTGAACCGATTCACT
Locus tag: b0112
Name: aroP
Funciton: Aromatic amino acid transport protein AroP
b0112
aroP
Aromatic amino acid transport protein AroP
Position: -146
Score: 4.4
Sequence: GCTGAAGCGATTTCGC
Locus tag: b3956
Name: ppc
Funciton: Phosphoenolpyruvate carboxylase (EC 4.1.1.31)
b3956
ppc
Phosphoenolpyruvate carboxylase (EC 4.1.1.31)
Position: -250
Score: 4.6
Sequence: CGTTAAGCGATTCAGC
Locus tag: b4014
Name: aceB
Funciton: Malate synthase (EC 2.3.3.9)
Locus tag: b4015
Name: aceA
Funciton: Isocitrate lyase (EC 4.1.3.1)
Locus tag: b4016
Name: aceK
Funciton: Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)
b4014
aceB
Malate synthase (EC 2.3.3.9)
b4015
aceA
Isocitrate lyase (EC 4.1.3.1)
b4016
aceK
Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)
Position: -264
Score: 4.6
Sequence: GCTGAAAGGTGTCAGC
Locus tag: b1241
Name: adhE
Funciton: Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)
b1241
adhE
Alcohol dehydrogenase (EC 1.1.1.1); Acetaldehyde dehydrogenase (EC 1.2.1.10)
Position: -90
Score: 4.3
Sequence: GCTGGCGCGATTCACC
Locus tag: b4232
Name: fbp
Funciton: Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11)
b4232
fbp
Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11)
Position: -251
Score: 4.2
Sequence: AGTGAATCGGTTCAAT
Locus tag: b0113
Name: pdhR
Funciton: Transcriptional repressor for pyruvate dehydrogenase, GntR family
Locus tag: b0114
Name: aceE
Funciton: Pyruvate dehydrogenase E1 component (EC 1.2.4.1)
Locus tag: b0115
Name: aceF
Funciton: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)
b0113
pdhR
Transcriptional repressor for pyruvate dehydrogenase, GntR family
b0114
aceE
Pyruvate dehydrogenase E1 component (EC 1.2.4.1)
b0115
aceF
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)
Position: -87
Score: 3.7
Sequence: ATTGACACGATTCCGC
Locus tag: b1779
Name: gapA
Funciton: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
Locus tag: b1780
Name: yeaD
Funciton: Aldose 1-epimerase family protein YeaD
b1779
gapA
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
b1780
yeaD
Aldose 1-epimerase family protein YeaD
Position: -64
Score: 4.1
Sequence: ATTTTATCGATTCAGC
Locus tag: b3612
Name: gpmM
Funciton: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)
Locus tag: b3613
Name: yibP
Funciton: murein hydrolase
Locus tag: b3614
Name: yibQ
Funciton: protein of unknown function DUF610
b3612
gpmM
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)
b3613
yibP
murein hydrolase
b3614
yibQ
protein of unknown function DUF610
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