Regulog CadR-PbrR - Comamonadaceae

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator
Biological process:	Lead resistance; Cadmium resistance
Effector:	Lead ion, (Pb2+); Cadmium, ion (Cd2+)
Phylum:	Proteobacteria/Beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 21 sites [see more]

Member of regulog collections

By taxonomy - Comamonadaceae
By trascription factor - CadR-PbrR
By TF family - MerR
By effector - Lead ion, (Pb2+)
By effector - Cadmium, ion (Cd2+)
By pathway - Lead resistance
By pathway - Cadmium resistance

Statistics of regulated genes
Genome	Genes	Operons
Acidovorax avenae subsp. citrulli AAC00-1	1	1
Acidovorax sp. JS42	9	5
Comamonas testosteroni KF-1	7	5
Delftia acidovorans SPH-1	3	2
Polaromonas naphthalenivorans CJ2	1	1
Polaromonas sp. JS666	1	1
Rhodoferax ferrireducens DSM 15236	1	1
Variovorax paradoxus S110	1	1
Verminephrobacter eiseniae EF01-2	2	2
Methylibium petroleiphilum PM1	6	2
Leptothrix cholodnii SP-6

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
cadA	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	* Rhodoferax ferrireducens DSM 15236 Site: position = -54 score = 5.73069 sequence = ACTCTATACCTACTATAGGGT Gene: Rfer_0854: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)

CRON 2.
cadA	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	* Comamonas testosteroni KF-1 Site: position = -150 score = 4.73255 sequence = ACTCTCAATCTGCTTTAGGGT Gene: CtesDRAFT_1793: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Delftia acidovorans SPH-1 Site: position = -274 score = 5.73634 sequence = ACCTTGGAGCTACTCCAAGGT Gene: Daci_0479: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)
lspA	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1 Gene: CtesDRAFT_1792: Lipoprotein signal peptidase (EC 3.4.23.36)	Delftia acidovorans SPH-1 Gene: Daci_0480: Lipoprotein signal peptidase (EC 3.4.23.36)	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lipoprotein signal peptidase (EC 3.4.23.36)

CRON 3.
cadA	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -61 score = 6.29717 sequence = ACTCTATAGTAACTATAGAGT Gene: Ajs_1242: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Comamonas testosteroni KF-1 Site: position = -61 score = 6.30565 sequence = ACTCTATAGTAGCTATAGGGT Gene: CtesDRAFT_2650: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)
lspA	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42 Gene: Ajs_1243: Lipoprotein signal peptidase (EC 3.4.23.36)	Comamonas testosteroni KF-1 Gene: CtesDRAFT_2649: Lipoprotein signal peptidase (EC 3.4.23.36)	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lipoprotein signal peptidase (EC 3.4.23.36)

CRON 4.
pbrT	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42 Gene: Ajs_1240: Pb(II) uptake protein, ILT family	2 Comamonas testosteroni KF-1 Gene: CtesDRAFT_1706: Pb(II) uptake protein, ILT family Gene: CtesDRAFT_1790: Pb(II) uptake protein, ILT family	Delftia acidovorans SPH-1 Gene: Daci_0482: Pb(II) uptake protein, ILT family	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	* Methylibium petroleiphilum PM1 Site: position = -78 score = 5.38839 sequence = ACCCTGTAGTGGCTACGGACT Gene: Mpe_A2353: Pb(II) uptake protein, ILT family	Leptothrix cholodnii SP-6	Pb(II) uptake protein, ILT family
PF04116	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1 Gene: Mpe_A2354: Sterol desaturase	Leptothrix cholodnii SP-6	Sterol desaturase
czcD	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1 Gene: Mpe_A2355: Co/Zn/Cd efflux protein	Leptothrix cholodnii SP-6	Co/Zn/Cd efflux protein
czcC	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1 Gene: Mpe_A2356: Heavy metal efflux RND outer membrane protein	Leptothrix cholodnii SP-6	Heavy metal efflux RND outer membrane protein
pbrR	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -54 score = 6.29717 sequence = ACTCTATAGTTACTATAGAGT Gene: Ajs_1241: Lead resistance transcriptional regulator, MerR family	* Comamonas testosteroni KF-1 Site: position = -44 score = 6.30565 sequence = ACCCTATAGCTACTATAGAGT Gene: CtesDRAFT_2651: Lead resistance transcriptional regulator, MerR family	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead resistance transcriptional regulator, MerR family

CRON 5.
cadA	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -34 score = 5.49138 sequence = ACTCTATACCCACTTCAGGGT Gene: Ajs_1335: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Comamonas testosteroni KF-1 Site: position = -55 score = 5.79306 sequence = ACTCTATACCAACTACAGGGT Gene: CtesDRAFT_1695: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Delftia acidovorans SPH-1	* Polaromonas naphthalenivorans CJ2 Site: position = -50 score = 4.92512 sequence = ACCTTCAAGTGGGTTCAGGGT Gene: Pnap_4001: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	* Variovorax paradoxus S110 Site: position = -26 score = 4.82998 sequence = ACTCTACACCTGCTTCAGGGT Gene: Vapar_3562: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)
PF01841	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42 Gene: Ajs_1334: Transglutaminase-like protein	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Transglutaminase-like protein

CRON 6.
cadA	* Acidovorax avenae subsp. citrulli AAC00-1 Site: position = -328 score = 5.21158 sequence = ACCTTGAAGCGGCTTGAAGGT Gene: Aave_1815: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Acidovorax sp. JS42 Site: position = -34 score = 5.7138 sequence = ACCTTGGAGTGGCTTCAAGGT Gene: Ajs_2594: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Comamonas testosteroni KF-1 Site: position = -34 score = 5.02186 sequence = ACCTTGAAGTGACTTTATTGT Gene: CtesDRAFT_0050: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	* Delftia acidovorans SPH-1 Site: position = -34 score = 4.94754 sequence = ACCTTGAAGTGACTTCACCGT Gene: Daci_2915: Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3)

CRON 7.
czcD	Acidovorax avenae subsp. citrulli AAC00-1	* Acidovorax sp. JS42 Site: position = -61 score = 5.24334 sequence = ACATTATAGCTACTATATAGT Gene: Ajs_3474: Co/Zn/Cd efflux protein	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	* Polaromonas sp. JS666 Site: position = -60 score = 5.28308 sequence = ACCTTGAAGTGGGTCCAGGGT Gene: Bpro_3481: Co/Zn/Cd efflux protein	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	2 Verminephrobacter eiseniae EF01-2* Site: position = -57 score = 6.24161 sequence = ACCCTAGAGTTGCTACAGGGT Gene: Veis_2983: Co/Zn/Cd efflux protein Site: position = -68 score = 4.68292 sequence = ACCATCGATCGACTCCAGGGT Gene: Veis_1666: Co/Zn/Cd efflux protein	* Methylibium petroleiphilum PM1 Site: position = -55 score = 6.00699 sequence = ACTCTGGAGCAGCTACAGGGT Gene: Mpe_A1655: Co/Zn/Cd efflux protein	Leptothrix cholodnii SP-6	Co/Zn/Cd efflux protein
lspA	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42 Gene: Ajs_3473: Lipoprotein signal peptidase (EC 3.4.23.36)	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1	Leptothrix cholodnii SP-6	Lipoprotein signal peptidase (EC 3.4.23.36)
PF01841	Acidovorax avenae subsp. citrulli AAC00-1	Acidovorax sp. JS42	Comamonas testosteroni KF-1	Delftia acidovorans SPH-1	Polaromonas naphthalenivorans CJ2	Polaromonas sp. JS666	Rhodoferax ferrireducens DSM 15236	Variovorax paradoxus S110	Verminephrobacter eiseniae EF01-2	Methylibium petroleiphilum PM1 Gene: Mpe_A1654: Transglutaminase-like protein	Leptothrix cholodnii SP-6	Transglutaminase-like protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog CadR-PbrR - Comamonadaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --