Regulog TPP - Various betaproteobacteria

Properties
Regulator type:	RNA regulatory element
Name:	TPP
RFAM:	RF00059
Regulation mode:
Biological process:	Thiamine biosynthesis
Effector:	Thiamine pyrophosphate
Phylum:	Proteobacteria/Beta

Member of regulog collections

By taxonomy - Various betaproteobacteria
By RNA motif - TPP
By effector - Thiamine pyrophosphate
By pathway - Thiamine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Azoarcus sp. EbN1	2	1
Thauera sp. MZ1T	2	1
Dechloromonas aromatica RCB	1	1
Nitrosomonas europaea ATCC 19718	1	1
Nitrosospira multiformis ATCC 25196	1	1
Thiobacillus denitrificans	1	1
Chromobacterium violaceum ATCC 12472	5	2
Neisseria meningitidis MC58	4	2
Laribacter hongkongensis HLHK9	4	1
Methylobacillus flagellatus KT	3	3
Methylotenera mobilis JLW8	1	1
Methylophilales bacterium HTCC2181	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
omp_thi	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	* Methylobacillus flagellatus KT Site: position = -171 score = 58.13 sequence = CGCCACGCTAGGGGT... Gene: Mfla_1993: Predicted thiamin-specific outer membrane transporter, TonB-dependent	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Predicted thiamin-specific outer membrane transporter, TonB-dependent

CRON 2.
thiM	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -151 score = 50.69 sequence = CAACCGTGACTCGGG... Gene: LHK_02662: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02661: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
thiD	* Azoarcus sp. EbN1 Site: position = -146 score = 62.0 sequence = CAGCTCGTTGGGGGT... Gene: ebA1711: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	* Thauera sp. MZ1T Site: position = -88 score = 63.68 sequence = GCTCTCGTTGGGGGT... Gene: Tmz1t_3463: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02660: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Phosphomethylpyrimidine kinase (EC 2.7.4.7)
thiC	Azoarcus sp. EbN1 Gene: ebA1712: Thiamin biosynthesis protein ThiC	Thauera sp. MZ1T Gene: Tmz1t_3464: Thiamin biosynthesis protein ThiC	* Dechloromonas aromatica RCB Site: position = -151 score = 64.5 sequence = GCCCACTCGTTAGGG... Gene: Daro_3921: Thiamin biosynthesis protein ThiC	* Nitrosomonas europaea ATCC 19718 Site: position = -138 score = 51.74 sequence = GCTGTGGCTAGGGGT... Gene: NE0038: Thiamin biosynthesis protein ThiC	* Nitrosospira multiformis ATCC 25196 Site: position = -196 score = 33.07 sequence = GCAGCAGCTAGGGGT... Gene: Nmul_A2285: Thiamin biosynthesis protein ThiC	* Thiobacillus denitrificans Site: position = -185 score = 52.14 sequence = ACCCGCTCGCCAGGG... Gene: Tbd_2694: Thiamin biosynthesis protein ThiC	* Chromobacterium violaceum ATCC 12472 Site: position = -223 score = 50.43 sequence = GGCATCGCTAGGGGT... Gene: CV0235: Thiamin biosynthesis protein ThiC	* Neisseria meningitidis MC58 Site: position = -193 score = 63.98 sequence = AACATTGAAACAGGG... Gene: NMB2040: Thiamin biosynthesis protein ThiC	Laribacter hongkongensis HLHK9 Gene: LHK_02659: Thiamin biosynthesis protein ThiC	* Methylobacillus flagellatus KT Site: position = -181 score = 62.62 sequence = CTTCCATCGCTAGGG... Gene: Mfla_2530: Thiamin biosynthesis protein ThiC	* Methylotenera mobilis JLW8 Site: position = -181 score = 62.53 sequence = CGCTAATTGCTAGGG... Gene: Mmol_0035: Thiamin biosynthesis protein ThiC	* Methylophilales bacterium HTCC2181 Site: position = -132 score = 64.13 sequence = CCTACTGCTAGGGGT... Gene: MB2181_01330: Thiamin biosynthesis protein ThiC	Thiamin biosynthesis protein ThiC

CRON 3.
cytX	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	* Neisseria meningitidis MC58 Site: position = -169 score = 62.35 sequence = GCTCCTTGTCGGAGT... Gene: NMB2067: Predicted hydroxymethylpyrimidine transporter CytX	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Predicted hydroxymethylpyrimidine transporter CytX
thiO	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB2068: Glycine oxidase ThiO (EC 1.4.3.19)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Glycine oxidase ThiO (EC 1.4.3.19)
thiE	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB2069: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)

CRON 4.
Mfla_1786	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	* Methylobacillus flagellatus KT Site: position = -150 score = 62.89 sequence = ACCTAACCTAGGGGA... Gene: Mfla_1786: predicted thaimine salvage transporter, Na+/solute symporter PutP family	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	predicted thaimine salvage transporter, Na+/solute symporter PutP family

CRON 5.
thiB	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -146 score = 64.34 sequence = GCCCTGTCACCGGGG... Gene: CV3164: Thiamin ABC transporter, substrate-binding component	Neisseria meningitidis MC58 Gene: NMB0041: Thiamin ABC transporter, substrate-binding component	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Thiamin ABC transporter, substrate-binding component
CV3163	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3163: conserved hypothetical protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical acyltransferase
thiP	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3162: Thiamin ABC transporter, transmembrane component	Neisseria meningitidis MC58 Gene: NMB2026: Thiamin ABC transporter, transmembrane component	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Thiamin ABC transporter, transmembrane component
thiQ	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3161: Thiamin ABC transporter, ATPase component	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Thiamin ABC transporter, ATPase component

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog TPP - Various betaproteobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --