Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog TPP - Various betaproteobacteria

Properties
Regulator type: RNA regulatory element
Name: TPP
RFAM: RF00059
Regulation mode:
Biological process: Thiamine biosynthesis
Effector: Thiamine pyrophosphate
Phylum: Proteobacteria/Beta
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azoarcus sp. EbN1 2 1
Thauera sp. MZ1T 2 1
Dechloromonas aromatica RCB 1 1
Nitrosomonas europaea ATCC 19718 1 1
Nitrosospira multiformis ATCC 25196 1 1
Thiobacillus denitrificans 1 1
Chromobacterium violaceum ATCC 12472 5 2
Neisseria meningitidis MC58 4 2
Laribacter hongkongensis HLHK9 4 1
Methylobacillus flagellatus KT 3 3
Methylotenera mobilis JLW8 1 1
Methylophilales bacterium HTCC2181 1 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
omp_thi
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
*
Methylobacillus flagellatus KT

Site:
position = -171
score = 58.13
sequence = CGCCACGCTAGGGGT...

Gene: Mfla_1993: Predicted thiamin-specific outer membrane transporter, TonB-dependent
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Predicted thiamin-specific outer membrane transporter, TonB-dependent
 
CRON 2.
thiM
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
*
Laribacter hongkongensis HLHK9

Site:
position = -151
score = 50.69
sequence = CAACCGTGACTCGGG...

Gene: LHK_02662: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_02661: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
thiD
*
Azoarcus sp. EbN1

Site:
position = -146
score = 62.0
sequence = CAGCTCGTTGGGGGT...

Gene: ebA1711: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
*
Thauera sp. MZ1T

Site:
position = -88
score = 63.68
sequence = GCTCTCGTTGGGGGT...

Gene: Tmz1t_3463: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_02660: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Phosphomethylpyrimidine kinase (EC 2.7.4.7)
thiC
 
Azoarcus sp. EbN1

Gene: ebA1712: Thiamin biosynthesis protein ThiC
 
Thauera sp. MZ1T

Gene: Tmz1t_3464: Thiamin biosynthesis protein ThiC
*
Dechloromonas aromatica RCB

Site:
position = -151
score = 64.5
sequence = GCCCACTCGTTAGGG...

Gene: Daro_3921: Thiamin biosynthesis protein ThiC
*
Nitrosomonas europaea ATCC 19718

Site:
position = -138
score = 51.74
sequence = GCTGTGGCTAGGGGT...

Gene: NE0038: Thiamin biosynthesis protein ThiC
*
Nitrosospira multiformis ATCC 25196

Site:
position = -196
score = 33.07
sequence = GCAGCAGCTAGGGGT...

Gene: Nmul_A2285: Thiamin biosynthesis protein ThiC
*
Thiobacillus denitrificans

Site:
position = -185
score = 52.14
sequence = ACCCGCTCGCCAGGG...

Gene: Tbd_2694: Thiamin biosynthesis protein ThiC
*
Chromobacterium violaceum ATCC 12472

Site:
position = -223
score = 50.43
sequence = GGCATCGCTAGGGGT...

Gene: CV0235: Thiamin biosynthesis protein ThiC
*
Neisseria meningitidis MC58

Site:
position = -193
score = 63.98
sequence = AACATTGAAACAGGG...

Gene: NMB2040: Thiamin biosynthesis protein ThiC
 
Laribacter hongkongensis HLHK9

Gene: LHK_02659: Thiamin biosynthesis protein ThiC
*
Methylobacillus flagellatus KT

Site:
position = -181
score = 62.62
sequence = CTTCCATCGCTAGGG...

Gene: Mfla_2530: Thiamin biosynthesis protein ThiC
*
Methylotenera mobilis JLW8

Site:
position = -181
score = 62.53
sequence = CGCTAATTGCTAGGG...

Gene: Mmol_0035: Thiamin biosynthesis protein ThiC
*
Methylophilales bacterium HTCC2181

Site:
position = -132
score = 64.13
sequence = CCTACTGCTAGGGGT...

Gene: MB2181_01330: Thiamin biosynthesis protein ThiC
Thiamin biosynthesis protein ThiC
 
CRON 3.
cytX
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
*
Neisseria meningitidis MC58

Site:
position = -169
score = 62.35
sequence = GCTCCTTGTCGGAGT...

Gene: NMB2067: Predicted hydroxymethylpyrimidine transporter CytX
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Predicted hydroxymethylpyrimidine transporter CytX
thiO
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB2068: Glycine oxidase ThiO (EC 1.4.3.19)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Glycine oxidase ThiO (EC 1.4.3.19)
thiE
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB2069: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
CRON 4.
Mfla_1786
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
*
Methylobacillus flagellatus KT

Site:
position = -150
score = 62.89
sequence = ACCTAACCTAGGGGA...

Gene: Mfla_1786: predicted thaimine salvage transporter, Na+/solute symporter PutP family
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
predicted thaimine salvage transporter, Na+/solute symporter PutP family
 
CRON 5.
thiB
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
*
Chromobacterium violaceum ATCC 12472

Site:
position = -146
score = 64.34
sequence = GCCCTGTCACCGGGG...

Gene: CV3164: Thiamin ABC transporter, substrate-binding component
 
Neisseria meningitidis MC58

Gene: NMB0041: Thiamin ABC transporter, substrate-binding component
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Thiamin ABC transporter, substrate-binding component
CV3163
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV3163: conserved hypothetical protein
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
hypothetical acyltransferase
thiP
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV3162: Thiamin ABC transporter, transmembrane component
 
Neisseria meningitidis MC58

Gene: NMB2026: Thiamin ABC transporter, transmembrane component
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Thiamin ABC transporter, transmembrane component
thiQ
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV3161: Thiamin ABC transporter, ATPase component
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Thiamin ABC transporter, ATPase component
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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