Statistics of regulated genes

Genome	Genes	Operons
Chloroflexus aggregans DSM 9485	12	3
Chloroflexus sp. Y-400-fl	12	3
Roseiflexus castenholzii DSM 13941	3	2
Roseiflexus sp. RS-1	3	2
Herpetosiphon aurantiacus ATCC 23779	13	4

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes						Function
CRON 1.
cysH	Chloroflexus aggregans DSM 9485	Chloroflexus sp. Y-400-fl	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0330: Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)	Roseiflexus sp. RS-1 Gene: RoseRS_0739: Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)	* Herpetosiphon aurantiacus ATCC 23779 Site: position = -181 score = 73.4 sequence = GCACTCATCCAGAGG... Gene: Haur_1749: Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)	Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) / Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
sat-cysC	Chloroflexus aggregans DSM 9485 Gene: Cagg_1550: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25)	Chloroflexus sp. Y-400-fl Gene: Chy400_2278: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_4308: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25)	Roseiflexus sp. RS-1 Gene: RoseRS_3336: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25)	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_1748: Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4)	Sulfate adenylyltransferase, dissimilatory-type (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25)
cysC	Chloroflexus aggregans DSM 9485	Chloroflexus sp. Y-400-fl	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_1747: Adenylylsulfate kinase (EC 2.7.1.25)	Adenylylsulfate kinase (EC 2.7.1.25)
cysI	Chloroflexus aggregans DSM 9485	Chloroflexus sp. Y-400-fl	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_1746: Ferredoxin--sulfite reductase, bacillial type (EC 1.8.7.1)	Ferredoxin--sulfite reductase, bacillial type (EC 1.8.7.1)
CRON 2.
metI	* Chloroflexus aggregans DSM 9485 Site: position = -181 score = 69.53 sequence = GCACTCATCCAGAGC... Gene: Cagg_1948: Cystathionine gamma-synthase (EC 2.5.1.48)	* Chloroflexus sp. Y-400-fl Site: position = -182 score = 67.5 sequence = GCACTCATCCAGAGC... Gene: Chy400_1581: Cystathionine gamma-synthase (EC 2.5.1.48)	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779	Cystathionine gamma-synthase (EC 2.5.1.48)
metF	Chloroflexus aggregans DSM 9485 Gene: Cagg_1947: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Chloroflexus sp. Y-400-fl Gene: Chy400_1580: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_3006: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Roseiflexus sp. RS-1 Gene: RoseRS_2032: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Herpetosiphon aurantiacus ATCC 23779	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
map	Chloroflexus aggregans DSM 9485 Gene: Cagg_1946: Methionine aminopeptidase (EC 3.4.11.18)	Chloroflexus sp. Y-400-fl Gene: Chy400_1579: Methionine aminopeptidase (EC 3.4.11.18)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_1086: Methionine aminopeptidase (EC 3.4.11.18)	Roseiflexus sp. RS-1 Gene: RoseRS_3795: Methionine aminopeptidase (EC 3.4.11.18)	2 Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_1134: Methionine aminopeptidase (EC 3.4.11.18) Gene: Haur_1133: Methionine aminopeptidase (EC 3.4.11.18)	Methionine aminopeptidase (EC 3.4.11.18)
Cagg_1945	Chloroflexus aggregans DSM 9485 Gene: Cagg_1945: hypothetical protein	Chloroflexus sp. Y-400-fl Gene: Chy400_1578: hypothetical protein	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779	hypothetical protein
CRON 3.
metH	Chloroflexus aggregans DSM 9485 Gene: Cagg_0032: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	Chloroflexus sp. Y-400-fl Gene: Chy400_4231: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Roseiflexus castenholzii DSM 13941 Site: position = -237 score = 57.35 sequence = GCTCATCCAGAGGAG... Gene: Rcas_3878: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Roseiflexus sp. RS-1 Site: position = -151 score = 62.39 sequence = GCTCATCCAGAGGAG... Gene: RoseRS_0064: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	* Herpetosiphon aurantiacus ATCC 23779 Site: position = -203 score = 68.94 sequence = CCTCATCACGAGGAG... Gene: Haur_2544: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)	5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)
CRON 4.
mtnA	* Chloroflexus aggregans DSM 9485 Site: position = -135 score = 84.38 sequence = GCTCATCGAGATGGG... Gene: Cagg_3560: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)	* Chloroflexus sp. Y-400-fl Site: position = -166 score = 84.11 sequence = ATGCTCATCGAGATG... Gene: Chy400_3271: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0156: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)	Roseiflexus sp. RS-1 Gene: RoseRS_0485: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)	* Herpetosiphon aurantiacus ATCC 23779 Site: position = -137 score = 88.24 sequence = TCTCATCGAGATGGG... Gene: Haur_2349: Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)	Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)
Cagg_3561	Chloroflexus aggregans DSM 9485 Gene: Cagg_3561: hypothetical protein	Chloroflexus sp. Y-400-fl Gene: Chy400_3270: hypothetical protein	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0157: hypothetical protein	Roseiflexus sp. RS-1 Gene: RoseRS_0486: hypothetical protein	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_2350: hypothetical protein	hypothetical protein
adk	Chloroflexus aggregans DSM 9485 Gene: Cagg_3562: putative Adenosine kinase (EC 2.7.1.20)	Chloroflexus sp. Y-400-fl Gene: Chy400_3269: putative Adenosine kinase (EC 2.7.1.20)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0158: putative Adenosine kinase (EC 2.7.1.20)	Roseiflexus sp. RS-1 Gene: RoseRS_0487: putative Adenosine kinase (EC 2.7.1.20)	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_2351: putative Adenosine kinase (EC 2.7.1.20)	putative Adenosine kinase (EC 2.7.1.20)
Cagg_3563	Chloroflexus aggregans DSM 9485 Gene: Cagg_3563: oxidoreductase domain protein	Chloroflexus sp. Y-400-fl Gene: Chy400_3268: oxidoreductase domain protein	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779	oxidoreductase domain protein
ahcY	Chloroflexus aggregans DSM 9485 Gene: Cagg_3564: Adenosylhomocysteinase (EC 3.3.1.1)	Chloroflexus sp. Y-400-fl Gene: Chy400_3267: Adenosylhomocysteinase (EC 3.3.1.1)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0159: Adenosylhomocysteinase (EC 3.3.1.1)	Roseiflexus sp. RS-1 Gene: RoseRS_0488: Adenosylhomocysteinase (EC 3.3.1.1)	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_2352: Adenosylhomocysteinase (EC 3.3.1.1)	Adenosylhomocysteinase (EC 3.3.1.1)
metK	Chloroflexus aggregans DSM 9485 Gene: Cagg_3565: S-adenosylmethionine synthetase (EC 2.5.1.6)	Chloroflexus sp. Y-400-fl Gene: Chy400_3266: S-adenosylmethionine synthetase (EC 2.5.1.6)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_0160: S-adenosylmethionine synthetase (EC 2.5.1.6)	Roseiflexus sp. RS-1 Gene: RoseRS_0489: S-adenosylmethionine synthetase (EC 2.5.1.6)	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_2353: S-adenosylmethionine synthetase (EC 2.5.1.6)	S-adenosylmethionine synthetase (EC 2.5.1.6)
CRON 5.
metY	* Chloroflexus aggregans DSM 9485 Site: position = -215 score = 82.38 sequence = GCACTCATCCAGAGC... Gene: Cagg_0970: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	* Chloroflexus sp. Y-400-fl Site: position = -212 score = 80.03 sequence = ACTCATCCAGAGCGG... Gene: Chy400_3740: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	* Roseiflexus castenholzii DSM 13941 Site: position = -403 score = 46.66 sequence = ACTCTTATCCAGAGA... Gene: Rcas_2040: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	* Roseiflexus sp. RS-1 Site: position = -411 score = 42.47 sequence = TCTTATCCAGAGAGG... Gene: RoseRS_1758: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	* Herpetosiphon aurantiacus ATCC 23779 Site: position = -256 score = 73.98 sequence = ACTCATCCAGAGGGG... Gene: Haur_0927: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
Haur_0928	Chloroflexus aggregans DSM 9485	Chloroflexus sp. Y-400-fl	Roseiflexus castenholzii DSM 13941	Roseiflexus sp. RS-1	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_0928: hypothetical protein	hypothetical protein
metX	Chloroflexus aggregans DSM 9485 Gene: Cagg_0969: Homoserine O-acetyltransferase (EC 2.3.1.31)	Chloroflexus sp. Y-400-fl Gene: Chy400_3741: Homoserine O-acetyltransferase (EC 2.3.1.31)	Roseiflexus castenholzii DSM 13941 Gene: Rcas_2039: Homoserine O-acetyltransferase (EC 2.3.1.31)	Roseiflexus sp. RS-1 Gene: RoseRS_1759: Homoserine O-acetyltransferase (EC 2.3.1.31)	Herpetosiphon aurantiacus ATCC 23779 Gene: Haur_0929: Homoserine O-acetyltransferase (EC 2.3.1.31)	Homoserine O-acetyltransferase (EC 2.3.1.31)

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