Statistics of regulated genes

Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	5	1
Staphylococcus capitis SK14	5	1
Staphylococcus epidermidis ATCC 12228	5	1
Staphylococcus carnosus subsp. carnosus TM300	5	2
Staphylococcus haemolyticus JCSC1435	5	1
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	5	1
Macrococcus caseolyticus JCSC5402	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes								Function
CRON 1.
metE2	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -309 score = 105.89 sequence = AAAAGATAAAGATGA... Gene: Sca_0069: Methionine synthase II (cobalamin-independent)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	* Macrococcus caseolyticus JCSC5402 Site: position = -380 score = 92.52 sequence = ACAAAGCGATAAAAA... Gene: MCCL_0261: Methionine synthase II (cobalamin-independent)	Methionine synthase II (cobalamin-independent)
CRON 2.
metI	* Staphylococcus aureus subsp. aureus N315 Site: position = -229 score = 35.66 sequence = GTTAATAAGTATGGG... Site: position = -434 score = 74.83 sequence = CGTAAACACAATAAA... Gene: SA0347: Cystathionine gamma-synthase (EC 2.5.1.48)	* Staphylococcus capitis SK14 Site: position = -134 score = 38.27 sequence = TAGAGGTTACTTTAG... Gene: STACA0001_1416: Cystathionine gamma-synthase (EC 2.5.1.48)	* Staphylococcus epidermidis ATCC 12228 Site: position = -131 score = 36.51 sequence = AGGTTACTTTAGTAA... Gene: SE2379: Cystathionine gamma-synthase (EC 2.5.1.48)	Staphylococcus carnosus subsp. carnosus TM300	* Staphylococcus haemolyticus JCSC1435 Site: position = -135 score = 33.69 sequence = AGGTTACTTTAGCAA... Gene: SH2635: Cystathionine gamma-synthase (EC 2.5.1.48)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -431 score = 72.59 sequence = GAAACACAGTAACAA... Gene: SSP2413: Cystathionine gamma-synthase (EC 2.5.1.48)	Macrococcus caseolyticus JCSC5402	Cystathionine gamma-synthase (EC 2.5.1.48)
metC	Staphylococcus aureus subsp. aureus N315 Gene: SA0346: Cystathionine beta-lyase (EC 4.4.1.8)	Staphylococcus capitis SK14 Gene: STACA0001_1415: Cystathionine beta-lyase (EC 4.4.1.8)	Staphylococcus epidermidis ATCC 12228 Gene: SE2380: Cystathionine beta-lyase (EC 4.4.1.8)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -247 score = 39.81 sequence = GATTATTATAATAGC... Gene: Sca_0014: Cystathionine beta-lyase (EC 4.4.1.8)	Staphylococcus haemolyticus JCSC1435 Gene: SH2636: Cystathionine beta-lyase (EC 4.4.1.8)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2414: Cystathionine beta-lyase (EC 4.4.1.8)	Macrococcus caseolyticus JCSC5402	Cystathionine beta-lyase (EC 4.4.1.8)
metF	Staphylococcus aureus subsp. aureus N315 Gene: SA0345: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Staphylococcus capitis SK14 Gene: STACA0001_1414: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Staphylococcus epidermidis ATCC 12228 Gene: SE2381: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0013: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Staphylococcus haemolyticus JCSC1435 Gene: SH2637: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2415: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Macrococcus caseolyticus JCSC5402	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
metE	Staphylococcus aureus subsp. aureus N315 Gene: SA0344: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Staphylococcus capitis SK14 Gene: STACA0001_1413: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Staphylococcus epidermidis ATCC 12228 Gene: SE2382: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0012: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Staphylococcus haemolyticus JCSC1435 Gene: SH2638: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2416: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Macrococcus caseolyticus JCSC5402	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
mdh	Staphylococcus aureus subsp. aureus N315 Gene: SA0343: Metal-dependent hydrolase/cyclase	Staphylococcus capitis SK14 Gene: STACA0001_1412: Metal-dependent hydrolase/cyclase	Staphylococcus epidermidis ATCC 12228 Gene: SE2383: Metal-dependent hydrolase/cyclase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0011: Metal-dependent hydrolase/cyclase	Staphylococcus haemolyticus JCSC1435 Gene: SH2639: Metal-dependent hydrolase/cyclase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2417: Metal-dependent hydrolase/cyclase	Macrococcus caseolyticus JCSC5402	Metal-dependent hydrolase/cyclase

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