Statistics of regulated genes

Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168	9	3
Bacillus amyloliquefaciens FZB42	9	3
Bacillus pumilus SAFR-032	10	4
Bacillus licheniformis DSM 13	9	3
Anoxybacillus flavithermus WK1	8	2
Geobacillus kaustophilus HTA426	8	2
Bacillus cereus ATCC 14579	2	2
Bacillus halodurans C-125	8	2
Bacillus clausii KSM-K16	8	2
Oceanobacillus iheyensis HTE831	3	2
Paenibacillus sp. JDR-2	7	4

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes												Function
CRON 1.
ilvB	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -369 score = 111.75 sequence = ATGAAAAGCGCAGAT... Gene: BSU28310: Acetolactate synthase large subunit (EC 2.2.1.6)	* Bacillus amyloliquefaciens FZB42 Site: position = -303 score = 118.6 sequence = ATAAAAAGCGCAGAA... Gene: RBAM_025370: Acetolactate synthase large subunit (EC 2.2.1.6)	* Bacillus pumilus SAFR-032 Site: position = -370 score = 127.91 sequence = TCGATAAACGTTGAA... Gene: BPUM_2472: Acetolactate synthase large subunit (EC 2.2.1.6)	* Bacillus licheniformis DSM 13 Site: position = -421 score = 97.53 sequence = AAGATAAACGTTGAA... Gene: BLi02961: Acetolactate synthase large subunit (EC 2.2.1.6)	* Anoxybacillus flavithermus WK1 Site: position = -234 score = 97.71 sequence = AAAAAGCGTTGAAGA... Gene: Aflv_0591: Acetolactate synthase large subunit (EC 2.2.1.6)	* Geobacillus kaustophilus HTA426 Site: position = -287 score = 93.0 sequence = CGAAAAAGCGTTGAC... Gene: GK2661: Acetolactate synthase large subunit (EC 2.2.1.6)	Bacillus cereus ATCC 14579	* Bacillus halodurans C-125 Site: position = -362 score = 115.65 sequence = TTTTAACACGTTGAA... Gene: BH3061: Acetolactate synthase large subunit (EC 2.2.1.6)	* Bacillus clausii KSM-K16 Site: position = -332 score = 122.5 sequence = CGATAACACAATGAA... Gene: ABC2645: Acetolactate synthase large subunit (EC 2.2.1.6)	Oceanobacillus iheyensis HTE831 Gene: OB2623: Acetolactate synthase large subunit (EC 2.2.1.6)	*3 Paenibacillus sp. JDR-2 Site: position = -353 score = 84.62 sequence = TATCGGCAATGATGA... Gene: Pjdr2_1302: Acetolactate synthase large subunit (EC 2.2.1.6) Site: position = -332 score = 87.73 sequence = AAAAGAAGCGTGGAA... Gene: Pjdr2_4086: Acetolactate synthase large subunit (EC 2.2.1.6) Gene: Pjdr2_2907: Acetolactate synthase large subunit (EC 2.2.1.6)	Acetolactate synthase large subunit (EC 2.2.1.6)
ilvH	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28300: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025360: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus pumilus SAFR-032 Gene: BPUM_2471: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus licheniformis DSM 13 Gene: BLi02960: Acetolactate synthase small subunit (EC 2.2.1.6)	Anoxybacillus flavithermus WK1 Gene: Aflv_0592: Acetolactate synthase small subunit (EC 2.2.1.6)	Geobacillus kaustophilus HTA426 Gene: GK2660: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus cereus ATCC 14579 Gene: BC1398: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus halodurans C-125 Gene: BH3060: Acetolactate synthase small subunit (EC 2.2.1.6)	Bacillus clausii KSM-K16 Gene: ABC2644: Acetolactate synthase small subunit (EC 2.2.1.6)	Oceanobacillus iheyensis HTE831 Gene: OB2622: Acetolactate synthase small subunit (EC 2.2.1.6)	2 Paenibacillus sp. JDR-2 Gene: Pjdr2_1303: Acetolactate synthase small subunit (EC 2.2.1.6) Gene: Pjdr2_2908: Acetolactate synthase small subunit (EC 2.2.1.6)	Acetolactate synthase small subunit (EC 2.2.1.6)
ilvC	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28290: Ketol-acid reductoisomerase (EC 1.1.1.86)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025350: Ketol-acid reductoisomerase (EC 1.1.1.86)	Bacillus pumilus SAFR-032 Gene: BPUM_2470: Ketol-acid reductoisomerase (EC 1.1.1.86)	Bacillus licheniformis DSM 13 Gene: BLi02959: Ketol-acid reductoisomerase (EC 1.1.1.86)	Anoxybacillus flavithermus WK1 Gene: Aflv_0593: Ketol-acid reductoisomerase (EC 1.1.1.86)	Geobacillus kaustophilus HTA426 Gene: GK2659: Ketol-acid reductoisomerase (EC 1.1.1.86)	2 Bacillus cereus ATCC 14579 Gene: BC1779: Ketol-acid reductoisomerase (EC 1.1.1.86) Gene: BC1399: Ketol-acid reductoisomerase (EC 1.1.1.86)	Bacillus halodurans C-125 Gene: BH3059: Ketol-acid reductoisomerase (EC 1.1.1.86)	Bacillus clausii KSM-K16 Gene: ABC2643: Ketol-acid reductoisomerase (EC 1.1.1.86)	Oceanobacillus iheyensis HTE831 Gene: OB2621: Ketol-acid reductoisomerase (EC 1.1.1.86)	Paenibacillus sp. JDR-2 Gene: Pjdr2_1304: Ketol-acid reductoisomerase (EC 1.1.1.86)	Ketol-acid reductoisomerase (EC 1.1.1.86)
leuA	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28280: 2-isopropylmalate synthase (EC 2.3.3.13)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025340: 2-isopropylmalate synthase (EC 2.3.3.13)	*2 Bacillus pumilus SAFR-032 Gene: BPUM_2469: 2-isopropylmalate synthase (EC 2.3.3.13) Site: position = -322 score = 120.64 sequence = TGAGAATGCGATGAT... Gene: BPUM_0582: 2-isopropylmalate synthase (EC 2.3.3.13)	Bacillus licheniformis DSM 13 Gene: BLi02958: 2-isopropylmalate synthase (EC 2.3.3.13)	Anoxybacillus flavithermus WK1 Gene: Aflv_0594: 2-isopropylmalate synthase (EC 2.3.3.13)	Geobacillus kaustophilus HTA426 Gene: GK2658: 2-isopropylmalate synthase (EC 2.3.3.13)	Bacillus cereus ATCC 14579 Gene: BC1400: 2-isopropylmalate synthase (EC 2.3.3.13)	Bacillus halodurans C-125 Gene: BH3058: 2-isopropylmalate synthase (EC 2.3.3.13)	Bacillus clausii KSM-K16 Gene: ABC2642: 2-isopropylmalate synthase (EC 2.3.3.13)	Oceanobacillus iheyensis HTE831 Gene: OB2620: 2-isopropylmalate synthase (EC 2.3.3.13)	*2 Paenibacillus sp. JDR-2 Site: position = -364 score = 56.21 sequence = ATTGAACGAACAGGC... Gene: Pjdr2_1026: 2-isopropylmalate synthase (EC 2.3.3.13) Gene: Pjdr2_1305: 2-isopropylmalate synthase (EC 2.3.3.13)	2-isopropylmalate synthase (EC 2.3.3.13)
leuB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28270: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025330: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus pumilus SAFR-032 Gene: BPUM_2468: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus licheniformis DSM 13 Gene: BLi02957: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Anoxybacillus flavithermus WK1 Gene: Aflv_0595: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Geobacillus kaustophilus HTA426 Gene: GK2657: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus cereus ATCC 14579 Gene: BC1401: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus halodurans C-125 Gene: BH3057: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Bacillus clausii KSM-K16 Gene: ABC2641: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Oceanobacillus iheyensis HTE831 Gene: OB2619: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)	Paenibacillus sp. JDR-2	3-isopropylmalate dehydrogenase (EC 1.1.1.85)
leuC	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28260: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025320: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus pumilus SAFR-032 Gene: BPUM_2467: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus licheniformis DSM 13 Gene: BLi02956: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Anoxybacillus flavithermus WK1 Gene: Aflv_0596: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Geobacillus kaustophilus HTA426 Gene: GK2656: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus cereus ATCC 14579 Gene: BC1402: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus halodurans C-125 Gene: BH3056: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Bacillus clausii KSM-K16 Gene: ABC2640: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Oceanobacillus iheyensis HTE831 Gene: OB2618: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	Paenibacillus sp. JDR-2 Gene: Pjdr2_2473: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)	3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
leuD	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU28250: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_025310: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus pumilus SAFR-032 Gene: BPUM_2466: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus licheniformis DSM 13 Gene: BLi02955: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Anoxybacillus flavithermus WK1 Gene: Aflv_0597: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Geobacillus kaustophilus HTA426 Gene: GK2655: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus cereus ATCC 14579 Gene: BC1403: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus halodurans C-125 Gene: BH3055: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Bacillus clausii KSM-K16 Gene: ABC2639: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Oceanobacillus iheyensis HTE831 Gene: OB2617: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	Paenibacillus sp. JDR-2 Gene: Pjdr2_2474: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)	3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
CRON 2.
leuS	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -325 score = 142.98 sequence = GATAAGAACAATGAA... Gene: BSU30320: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus amyloliquefaciens FZB42 Site: position = -323 score = 132.69 sequence = GATAAGAACAGTGAA... Gene: RBAM_027250: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus pumilus SAFR-032 Site: position = -185 score = 123.18 sequence = GATAAGAACAGTGAA... Gene: BPUM_2669: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus licheniformis DSM 13 Site: position = -320 score = 138.26 sequence = GGCAAGAACAGTGAA... Gene: BLi03175: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Anoxybacillus flavithermus WK1 Site: position = -274 score = 147.3 sequence = AAATGACGGTGAAAA... Gene: Aflv_0425: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Geobacillus kaustophilus HTA426 Site: position = -298 score = 111.68 sequence = GCGAATAACGGTGAA... Gene: GK2842: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus cereus ATCC 14579 Site: position = -286 score = 147.43 sequence = TGTAATAACAGTGAG... Gene: BC4737: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus halodurans C-125 Site: position = -391 score = 116.55 sequence = TGAAAAAACAGTGAC... Gene: BH3281: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Bacillus clausii KSM-K16 Site: position = -269 score = 117.85 sequence = GGGAAATACAAGGAT... Gene: ABC2871: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Oceanobacillus iheyensis HTE831 Site: position = -303 score = 125.78 sequence = ATTAACGACTATGAT... Gene: OB2307: Leucyl-tRNA synthetase (EC 6.1.1.4)	* Paenibacillus sp. JDR-2 Site: position = -287 score = 119.78 sequence = TAATGGCGTTGAAGA... Gene: Pjdr2_2189: Leucyl-tRNA synthetase (EC 6.1.1.4)	Leucyl-tRNA synthetase (EC 6.1.1.4)
CRON 3.
yocR	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	* Bacillus cereus ATCC 14579 Site: position = -365 score = 107.7 sequence = ACAATGTGTTGAATA... Gene: BC2170: Sodium-dependent leucine transporter	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Sodium-dependent leucine transporter
CRON 4.
yuaI	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU31000: Acetyltransferase, GNAT family	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032 Gene: BPUM_2727: Acetyltransferase, GNAT family	Bacillus licheniformis DSM 13 Gene: BLi02771: Acetyltransferase, GNAT family	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK0964: Acetyltransferase, GNAT family	Bacillus cereus ATCC 14579 Gene: BC1977: Acetyltransferase, GNAT family	Bacillus halodurans C-125 Gene: BH2157: Acetyltransferase, GNAT family	Bacillus clausii KSM-K16 Gene: ABC3305: Acetyltransferase, GNAT family	* Oceanobacillus iheyensis HTE831 Site: position = -254 score = 125.13 sequence = TATAGGCAATGAAGA... Gene: OB1271: Acetyltransferase, GNAT family	Paenibacillus sp. JDR-2 Gene: Pjdr2_1269: Acetyltransferase, GNAT family	Acetyltransferase, GNAT family
BC4195	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC4195: Predicted acetyltransferase	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831 Gene: OB1272: Predicted acetyltransferase	Paenibacillus sp. JDR-2	Predicted acetyltransferase
CRON 5.
yvbW	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -305 score = 117.89 sequence = CTAAAACACATAGAT... Gene: BSU34010: Amino acid permease	* Bacillus amyloliquefaciens FZB42 Site: position = -302 score = 106.94 sequence = ATAAAACACTGTGAA... Gene: RBAM_031370: Amino acid permease	* Bacillus pumilus SAFR-032 Site: position = -302 score = 120.82 sequence = ATAAAACGCTTTGAC... Gene: BPUM_3159: Amino acid permease	* Bacillus licheniformis DSM 13 Site: position = -318 score = 100.17 sequence = AGAAAACACAATGAA... Gene: BLi03669: Amino acid permease	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Amino acid permease

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