Regulog SAM - Staphylococcaceae

Properties
Regulator type:	RNA regulatory element
Name:	SAM
RFAM:	RF00162
Regulation mode:
Biological process:	Methionine biosynthesis
Effector:	S-adenosylmethionine
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Staphylococcaceae
By RNA motif - SAM
By effector - S-adenosylmethionine
By pathway - Methionine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	6	4
Staphylococcus capitis SK14	6	4
Staphylococcus epidermidis ATCC 12228	6	4
Staphylococcus carnosus subsp. carnosus TM300	14	8
Staphylococcus haemolyticus JCSC1435	8	6
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	9	6
Macrococcus caseolyticus JCSC5402	17	8

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
metK	* Staphylococcus aureus subsp. aureus N315 Site: position = -218 score = 79.24 sequence = TCTCTTATCCTGAGT... Gene: SA1608: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Staphylococcus capitis SK14 Site: position = -221 score = 80.83 sequence = TCTCTTATCCTGAGT... Gene: STACA0001_0676: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Staphylococcus epidermidis ATCC 12228 Site: position = -219 score = 82.51 sequence = TCTCTTATCCTGAGT... Gene: SE1458: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -225 score = 70.59 sequence = TCTCTTATCCTGAGT... Gene: Sca_1389: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Staphylococcus haemolyticus JCSC1435 Site: position = -225 score = 79.25 sequence = TCTTATCCTGAGTGG... Gene: SH1139: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -221 score = 80.18 sequence = TCTTATCCTGAGTGG... Gene: SSP0976: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Macrococcus caseolyticus JCSC5402 Site: position = -201 score = 72.14 sequence = TCTCTTATCCAGAGT... Gene: MCCL_1498: S-adenosylmethionine synthetase (EC 2.5.1.6)	S-adenosylmethionine synthetase (EC 2.5.1.6)

CRON 2.
metT	* Staphylococcus aureus subsp. aureus N315 Site: position = -107 score = 76.1 sequence = TCACTTATCTAGAGA... Gene: SA2117: Methionine transporter MetT	* Staphylococcus capitis SK14 Site: position = -291 score = 77.27 sequence = ACTTATCGAGAGAAG... Gene: STACA0001_1163: Methionine transporter MetT	* Staphylococcus epidermidis ATCC 12228 Site: position = -231 score = 78.75 sequence = TAACTTATCAAGAGA... Gene: SE1902: Methionine transporter MetT	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -82 score = 71.74 sequence = TTGCTTATCAAGAGA... Gene: Sca_1822: Methionine transporter MetT	Staphylococcus haemolyticus JCSC1435 Gene: SH0729: Methionine transporter MetT	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -179 score = 75.05 sequence = ACTTATCAAGAGAAG... Gene: SSP0578: Methionine transporter MetT	Macrococcus caseolyticus JCSC5402	Methionine transporter MetT

CRON 3.
metX	* Staphylococcus aureus subsp. aureus N315 Site: position = -136 score = 69.39 sequence = TCTTATTGTGAGAAG... Gene: SA0011: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Staphylococcus capitis SK14 Site: position = -167 score = 64.24 sequence = AATCTTATTTCGAGA... Gene: STACA0001_1363: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Staphylococcus epidermidis ATCC 12228 Site: position = -164 score = 68.61 sequence = CCTTATTTTGAGAAG... Gene: SE0011: Homoserine O-acetyltransferase (EC 2.3.1.31)	Staphylococcus carnosus subsp. carnosus TM300	* Staphylococcus haemolyticus JCSC1435 Site: position = -171 score = 71.51 sequence = ACTTATTAAGAGAAG... Gene: SH0011: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -159 score = 60.06 sequence = TCTTATTTCGAGAAG... Gene: SSP0012: Homoserine O-acetyltransferase (EC 2.3.1.31)	Macrococcus caseolyticus JCSC5402	Homoserine O-acetyltransferase (EC 2.3.1.31)

CRON 4.
metN	* Staphylococcus aureus subsp. aureus N315 Site: position = -191 score = 85.67 sequence = TCTTATCGAGAGTGG... Gene: SA0769: Methionine ABC transporter ATP-binding protein	* Staphylococcus capitis SK14 Site: position = -193 score = 89.61 sequence = ACTCTTATCGAGAGA... Gene: STACA0001_0218: Methionine ABC transporter ATP-binding protein	* Staphylococcus epidermidis ATCC 12228 Site: position = -195 score = 89.56 sequence = TCTTATCGAGAGAGG... Gene: SE0600: Methionine ABC transporter ATP-binding protein	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -203 score = 89.52 sequence = TCTTATCAAGAGAGG... Gene: Sca_0455: Methionine ABC transporter ATP-binding protein	* Staphylococcus haemolyticus JCSC1435 Site: position = -191 score = 92.73 sequence = ATTCTTATCAAGAGA... Gene: SH2047: Methionine ABC transporter ATP-binding protein	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -198 score = 84.24 sequence = ACTCTTATCACGAGA... Gene: SSP1866: Methionine ABC transporter ATP-binding protein	* Macrococcus caseolyticus JCSC5402 Site: position = -173 score = 89.62 sequence = TCTTATCAAGAGAGG... Gene: MCCL_0539: Methionine ABC transporter ATP-binding protein	Methionine ABC transporter ATP-binding protein
metP	Staphylococcus aureus subsp. aureus N315 Gene: SA0770: Methionine ABC transporter permease protein	Staphylococcus capitis SK14 Gene: STACA0001_0217: Methionine ABC transporter permease protein	Staphylococcus epidermidis ATCC 12228 Gene: SE0601: Methionine ABC transporter permease protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0456: Methionine ABC transporter permease protein	Staphylococcus haemolyticus JCSC1435 Gene: SH2046: Methionine ABC transporter permease protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1865: Methionine ABC transporter permease protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0540: Methionine ABC transporter permease protein	Methionine ABC transporter permease protein
metQ	Staphylococcus aureus subsp. aureus N315 Gene: SA0771: Methionine ABC transporter substrate-binding protein	Staphylococcus capitis SK14 Gene: STACA0001_0216: Methionine ABC transporter substrate-binding protein	Staphylococcus epidermidis ATCC 12228 Gene: SE0602: Methionine ABC transporter substrate-binding protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0457: Methionine ABC transporter substrate-binding protein	Staphylococcus haemolyticus JCSC1435 Gene: SH2045: Methionine ABC transporter substrate-binding protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1864: Methionine ABC transporter substrate-binding protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0541: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein

CRON 5.
SH0402	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	* Staphylococcus haemolyticus JCSC1435 Site: position = -173 score = 74.05 sequence = TCTTATTAAGAGTGA... Gene: SH0402: Hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	Hypothetical protein

CRON 6.
metQ2	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -209 score = 81.89 sequence = TCTTATCCAGAGCGG... Gene: Sca_0342: Methionine ABC transporter substrate-binding protein	* Staphylococcus haemolyticus JCSC1435 Site: position = -218 score = 88.89 sequence = TCTTATCAAGAGTGG... Gene: SH0458: Methionine ABC transporter substrate-binding protein	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -195 score = 87.78 sequence = TCTTATCAAGAGTGG... Gene: SSP0248: Methionine ABC transporter substrate-binding protein	* Macrococcus caseolyticus JCSC5402 Site: position = -188 score = 80.01 sequence = TCTTATCCAGAGAGG... Gene: MCCL_0254: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein
SSP0249	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0343: Putative dehydrogenase	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0249: Putative dehydrogenase	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0255: Putative dehydrogenase	Putative dehydrogenase

CRON 7.
mtnE	Staphylococcus aureus subsp. aureus N315 Gene: SA2347: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	Staphylococcus capitis SK14 Gene: STACA0001_0934: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	Staphylococcus epidermidis ATCC 12228 Gene: SE2122: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -208 score = 73.9 sequence = ACTTATCAAGAGAAG... Gene: Sca_0010: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	* Staphylococcus haemolyticus JCSC1435 Site: position = -186 score = 72.07 sequence = ACTTATCCAGAGAAG... Gene: SH0492: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -166 score = 76.5 sequence = ACTTATCCAGAGAAG... Gene: SSP0294: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	* Macrococcus caseolyticus JCSC5402 Site: position = -157 score = 81.74 sequence = TCTTATCCAGAGAAG... Gene: MCCL_0180: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)	N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)

CRON 8.
cysD	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -159 score = 83.14 sequence = ACTTATCCAGAATGG... Gene: Sca_1003: O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	* Macrococcus caseolyticus JCSC5402 Site: position = -160 score = 91.21 sequence = ATGCTTATCCAGAGT... Gene: MCCL_0060: O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)	O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)
metA	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1004: Homoserine O-succinyltransferase (EC 2.3.1.46)	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0059: Homoserine O-succinyltransferase (EC 2.3.1.46)	Homoserine O-succinyltransferase (EC 2.3.1.46)

CRON 9.
metN3	Staphylococcus aureus subsp. aureus N315 Gene: SA0420: Methionine ABC transporter ATP-binding protein	Staphylococcus capitis SK14 Gene: STACA0001_1483: Methionine ABC transporter ATP-binding protein	Staphylococcus epidermidis ATCC 12228 Gene: SE2322: Methionine ABC transporter ATP-binding protein	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -226 score = 73.09 sequence = ACTCTTATCCAGAGA... Gene: Sca_2191: Methionine ABC transporter ATP-binding protein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	* Macrococcus caseolyticus JCSC5402 Site: position = -172 score = 72.86 sequence = TTTTATCAAGAGAGA... Gene: MCCL_0417: Methionine ABC transporter ATP-binding protein	Methionine ABC transporter ATP-binding protein
metP3	Staphylococcus aureus subsp. aureus N315 Gene: SA0421: Methionine ABC transporter permease protein	Staphylococcus capitis SK14 Gene: STACA0001_1484: Methionine ABC transporter permease protein	Staphylococcus epidermidis ATCC 12228 Gene: SE2321: Methionine ABC transporter permease protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_2190: Methionine ABC transporter permease protein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0418: Methionine ABC transporter permease protein	Methionine ABC transporter permease protein
metQ3	Staphylococcus aureus subsp. aureus N315 Gene: SA0422: Methionine ABC transporter substrate-binding protein	Staphylococcus capitis SK14 Gene: STACA0001_1485: Methionine ABC transporter substrate-binding protein	Staphylococcus epidermidis ATCC 12228 Gene: SE2320: Methionine ABC transporter substrate-binding protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_2189: Methionine ABC transporter substrate-binding protein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0419: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein

CRON 10.
p20d2	Staphylococcus aureus subsp. aureus N315 Gene: SA1935: Predicted peptidase	Staphylococcus capitis SK14 Gene: STACA0001_0837: Predicted peptidase	Staphylococcus epidermidis ATCC 12228 Gene: SE1731: Predicted peptidase	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1636: Predicted peptidase	Staphylococcus haemolyticus JCSC1435 Gene: SH0902: Predicted peptidase	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0752: Predicted peptidase	* Macrococcus caseolyticus JCSC5402 Site: position = -166 score = 79.5 sequence = ACACTTATCGAGACG... Gene: MCCL_1787: Predicted peptidase	Predicted peptidase
SA1934	Staphylococcus aureus subsp. aureus N315 Gene: SA1934: Hypothetical protein	Staphylococcus capitis SK14 Gene: STACA0001_0836: Hypothetical protein	Staphylococcus epidermidis ATCC 12228 Gene: SE1730: Hypothetical protein	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435 Gene: SH0903: Hypothetical protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP0753: Hypothetical protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_1786: Hypothetical protein	Hypothetical protein

CRON 11.
mmuP	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2173: Probable S-methylmethionine permease	* Macrococcus caseolyticus JCSC5402 Site: position = -150 score = 77.92 sequence = ACTTATACAGAGAGA... Gene: MCCL_0329: Probable S-methylmethionine permease	Probable S-methylmethionine permease
metE	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP2172: Homocysteine S-methyltransferase (EC 2.1.1.10)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0330: Homocysteine S-methyltransferase (EC 2.1.1.10)	Homocysteine S-methyltransferase (EC 2.1.1.10)
MCCL_0331	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0331: Hypothetical protein	Hypothetical protein

CRON 12.
Sca_0068	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -488 score = 76.07 sequence = TCTTATTAAGAGTGA... Gene: Sca_0068: Putative lipoprotein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0531: Putative lipoprotein	Putative lipoprotein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog SAM - Staphylococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --