Regulog LldR - Various betaproteobacteria

Properties
Regulator type:	Transcription factor
Regulator family:	GntR/Others
Regulation mode:	repressor
Biological process:	Lactate utilization
Effector:	L-lactate
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 15 sites [see more]

Member of regulog collections

By taxonomy - Various betaproteobacteria
By trascription factor - LldR
By TF family - GntR/Others
By effector - L-lactate
By pathway - Lactate utilization

Statistics of regulated genes
Genome	Genes	Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T	4	1
Dechloromonas aromatica RCB	5	2
Nitrosomonas europaea ATCC 19718
Nitrosospira multiformis ATCC 25196
Thiobacillus denitrificans
Chromobacterium violaceum ATCC 12472	6	2
Neisseria meningitidis MC58	3	3
Laribacter hongkongensis HLHK9	6	2
Methylobacillus flagellatus KT
Methylotenera mobilis JLW8
Methylophilales bacterium HTCC2181

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
lldP2	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	* Neisseria meningitidis MC58 Site: position = -110 score = 6.34746 sequence = AATTGGTCTTACCAATT Gene: NMB0543: L-lactate permease	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate permease

CRON 2.
lldE	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_1715: L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE	* Dechloromonas aromatica RCB Site: position = -47 score = 5.99053 sequence = TATTGGTCTTACCAATT Site: position = -160 score = 4.04757 sequence = GATTGGTAAGACCAGCA Site: position = -178 score = 4.24161 sequence = CATTGGTAAGACCACAT Gene: Daro_1766: L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -30 score = 6.34746 sequence = AATTGGTCTTACCAATT Gene: CV3030: L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE	Neisseria meningitidis MC58 Gene: NMB1436: L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE	* Laribacter hongkongensis HLHK9 Site: position = -36 score = 6.19238 sequence = AATTGGCCTGACCAATT Gene: LHK_02843: L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate dehydrogenase, Fe-S oxidoreductase subunit LldE
lldG	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_1717: L-lactate dehydrogenase, subunit LldG	Dechloromonas aromatica RCB Gene: Daro_1765: L-lactate dehydrogenase, subunit LldG	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3029: L-lactate dehydrogenase, subunit LldG	Neisseria meningitidis MC58 Gene: NMB1437: L-lactate dehydrogenase, subunit LldG	Laribacter hongkongensis HLHK9 Gene: LHK_02844: L-lactate dehydrogenase, subunit LldG	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate dehydrogenase, subunit LldG
lldF	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_1716: L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF	Dechloromonas aromatica RCB Gene: Daro_1764: L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3028: L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF	Neisseria meningitidis MC58 Gene: NMB1438: L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF	Laribacter hongkongensis HLHK9 Gene: LHK_02845: L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit LldF
dld	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_1763: D-lactate dehydrogenase	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3027: D-lactate dehydrogenase	Neisseria meningitidis MC58	2 Laribacter hongkongensis HLHK9 Gene: LHK_02847: D-lactate dehydrogenase Gene: LHK_02846: D-lactate dehydrogenase	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	D-lactate dehydrogenase
lldP	Azoarcus sp. EbN1	* Thauera sp. MZ1T Site: position = -147 score = 4.59854 sequence = AAGTGGTAAGACCACTT Gene: Tmz1t_1714: L-lactate permease	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV3026: L-lactate permease	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate permease

CRON 3.
lldR	Azoarcus sp. EbN1	Thauera sp. MZ1T Gene: Tmz1t_1705: Lactate-responsive regulator LldR, GntR family	* Dechloromonas aromatica RCB Site: position = -32 score = 4.7556 sequence = TGCTGGTCTTACCAATC Site: position = -145 score = 5.48746 sequence = AATTGGTAAGACCAATA Site: position = -14 score = 4.53973 sequence = ATGTGGTCTTACCAATG Gene: Daro_1767: Lactate-responsive regulator LldR, GntR family	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -27 score = 4.43209 sequence = ATCCGGTCAGACCAATT Gene: CV3037: Lactate-responsive regulator LldR, GntR family	* Neisseria meningitidis MC58 Site: position = -226 score = 5.29394 sequence = GATTGGTCAGTCCAATT Gene: NMB1711: Lactate-responsive regulator LldR, GntR family	* Laribacter hongkongensis HLHK9 Site: position = -229 score = 5.69295 sequence = AATTGGTCAGGCCAATT Gene: LHK_02842: Lactate-responsive regulator LldR, GntR family	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Lactate-responsive regulator LldR, GntR family

CRON 4.
lldP	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	* Neisseria meningitidis MC58 Site: position = 15 score = 5.14005 sequence = AATTGGTTTGACCACTA Site: position = -221 score = 5.83545 sequence = AATTGGACTGACCAATC Gene: NMB1712: L-lactate permease	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	L-lactate permease

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog LldR - Various betaproteobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --