Regulog HexR - Various betaproteobacteria

Properties
Regulator type:	Transcription factor
Regulator family:	RpiR
Regulation mode:	repressor (activator)
Biological process:	Central carbohydrate metabolism
Effector:	2-keto-3-deoxy-6-phosphogluconate
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 13 sites [see more]

Member of regulog collections

By taxonomy - Various betaproteobacteria
By trascription factor - HexR
By TF family - RpiR
By effector - 2-keto-3-deoxy-6-phosphogluconate
By pathway - Central carbohydrate metabolism

Statistics of regulated genes
Genome	Genes	Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T
Dechloromonas aromatica RCB
Nitrosomonas europaea ATCC 19718
Nitrosospira multiformis ATCC 25196
Thiobacillus denitrificans
Chromobacterium violaceum ATCC 12472	9	3
Neisseria meningitidis MC58	10	4
Laribacter hongkongensis HLHK9
Methylobacillus flagellatus KT
Methylotenera mobilis JLW8
Methylophilales bacterium HTCC2181

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
tal	Azoarcus sp. EbN1 Gene: ebA4676: Transaldolase (EC 2.2.1.2)	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_2062: Transaldolase (EC 2.2.1.2)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0564: Transaldolase (EC 2.2.1.2)	* Neisseria meningitidis MC58 Site: position = -81 score = 4.8461 sequence = CTGTAATAAAACTACCC Gene: NMB0351: Transaldolase (EC 2.2.1.2)	Laribacter hongkongensis HLHK9 Gene: LHK_00167: Transaldolase (EC 2.2.1.2)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Transaldolase (EC 2.2.1.2)

CRON 2.
ptsHI	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -213 score = 5.63622 sequence = ATGTAGTTTAACTACAA Gene: CV0980: PTS system, glucose-specific IIA component (EC 2.7.1.69) / Phosphocarrier protein of PTS system / Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	PTS system, glucose-specific IIA component (EC 2.7.1.69) / Phosphocarrier protein of PTS system / Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
ptsG	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0979: PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIC component (EC 2.7.1.69)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIC component (EC 2.7.1.69)

CRON 3.
gntU	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	* Neisseria meningitidis MC58 Site: position = -32 score = 4.94269 sequence = TTGTACTTTTATTACAG Gene: NMB2027: Low-affinity gluconate/H+ symporter GntU	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Low-affinity gluconate/H+ symporter GntU
gntK	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB2028: Gluconokinase (EC 2.7.1.12)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Gluconokinase (EC 2.7.1.12)

CRON 4.
zwf	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -227 score = 5.85665 sequence = TAGTAGTTTTACTACAC Site: position = -47 score = 4.77473 sequence = TGGTAATATAACTACAT Gene: CV0145: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	* Neisseria meningitidis MC58 Site: position = -117 score = 5.98826 sequence = GTGTAGTATTACTACTC Site: position = -293 score = 4.60655 sequence = GTGTTATTATAGTACAA Site: position = -273 score = 4.53518 sequence = TTGTAATTTTGTTACAA Gene: NMB1392: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
pgl	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB Gene: Daro_2071: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Nitrosomonas europaea ATCC 19718 Gene: NE1691: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Nitrosospira multiformis ATCC 25196 Gene: Nmul_A1628: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Thiobacillus denitrificans Gene: Tbd_2121: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Chromobacterium violaceum ATCC 12472 Gene: CV0146: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Neisseria meningitidis MC58 Gene: NMB1391: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Laribacter hongkongensis HLHK9 Gene: LHK_01339: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	2 Methylobacillus flagellatus KT Gene: Mfla_1063: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type Gene: Mfla_0919: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Methylotenera mobilis JLW8 Gene: Mmol_1526: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	Methylophilales bacterium HTCC2181 Gene: MB2181_03445: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type	6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
glk	Azoarcus sp. EbN1 Gene: ebA584: Glucokinase (EC 2.7.1.2)	Thauera sp. MZ1T Gene: Tmz1t_2047: Glucokinase (EC 2.7.1.2)	Dechloromonas aromatica RCB Gene: Daro_0592: Glucokinase (EC 2.7.1.2)	Nitrosomonas europaea ATCC 19718 Gene: NE1694: Glucokinase (EC 2.7.1.2)	Nitrosospira multiformis ATCC 25196 Gene: Nmul_A1872: Glucokinase (EC 2.7.1.2)	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0147: Glucokinase (EC 2.7.1.2)	Neisseria meningitidis MC58 Gene: NMB1390: Glucokinase (EC 2.7.1.2)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Glucokinase (EC 2.7.1.2)
hexR	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0148: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Neisseria meningitidis MC58 Gene: NMB1389: Central carbohydrate metabolism transcription regulator HexR, RpiR family	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Central carbohydrate metabolism transcription regulator HexR, RpiR family
pgi	Azoarcus sp. EbN1 Gene: ebA5208: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Thauera sp. MZ1T Gene: Tmz1t_2030: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Dechloromonas aromatica RCB Gene: Daro_0581: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Nitrosomonas europaea ATCC 19718 Gene: NE2263: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Nitrosospira multiformis ATCC 25196 Gene: Nmul_A0469: Glucose-6-phosphate isomerase (EC 5.3.1.9)	2 Thiobacillus denitrificans Gene: Tbd_0974: Glucose-6-phosphate isomerase (EC 5.3.1.9) Gene: Tbd_2063: Glucose-6-phosphate isomerase (EC 5.3.1.9)	2 Chromobacterium violaceum ATCC 12472 Gene: CV0149: Glucose-6-phosphate isomerase (EC 5.3.1.9) Gene: CV2369: Glucose-6-phosphate isomerase (EC 5.3.1.9)	2 Neisseria meningitidis MC58 Gene: NMB0334: Glucose-6-phosphate isomerase (EC 5.3.1.9) Gene: NMB1388: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Laribacter hongkongensis HLHK9 Gene: LHK_02316: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Methylobacillus flagellatus KT Gene: Mfla_1325: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Methylotenera mobilis JLW8 Gene: Mmol_0827: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Methylophilales bacterium HTCC2181 Gene: MB2181_04675: Glucose-6-phosphate isomerase (EC 5.3.1.9)	Glucose-6-phosphate isomerase (EC 5.3.1.9)

CRON 5.
edd	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -48 score = 5.85665 sequence = GTGTAGTAAAACTACTA Site: position = -228 score = 4.77473 sequence = ATGTAGTTATATTACCA Gene: CV0144: Phosphogluconate dehydratase (EC 4.2.1.12)	* Neisseria meningitidis MC58 Site: position = -291 score = 4.60655 sequence = TTGTACTATAATAACAC Site: position = -311 score = 4.53518 sequence = TTGTAACAAAATTACAA Site: position = -467 score = 5.98826 sequence = GAGTAGTAATACTACAC Gene: NMB1393: Phosphogluconate dehydratase (EC 4.2.1.12)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT Gene: Mfla_0759: Phosphogluconate dehydratase (EC 4.2.1.12)	Methylotenera mobilis JLW8 Gene: Mmol_1727: Phosphogluconate dehydratase (EC 4.2.1.12)	Methylophilales bacterium HTCC2181 Gene: MB2181_02745: Phosphogluconate dehydratase (EC 4.2.1.12)	Phosphogluconate dehydratase (EC 4.2.1.12)
eda	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV0143: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Neisseria meningitidis MC58 Gene: NMB1394: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Laribacter hongkongensis HLHK9 Gene: LHK_03117: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Methylobacillus flagellatus KT Gene: Mfla_0760: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Methylotenera mobilis JLW8 Gene: Mmol_1726: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	Methylophilales bacterium HTCC2181 Gene: MB2181_02750: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)	2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HexR - Various betaproteobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --