Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog HexR - Various betaproteobacteria

Properties
Regulator type: Transcription factor
Regulator family: RpiR
Regulation mode: repressor (activator)
Biological process: Central carbohydrate metabolism
Effector: 2-keto-3-deoxy-6-phosphogluconate
Phylum: Proteobacteria/beta
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 13 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T
Dechloromonas aromatica RCB
Nitrosomonas europaea ATCC 19718
Nitrosospira multiformis ATCC 25196
Thiobacillus denitrificans
Chromobacterium violaceum ATCC 12472 9 3
Neisseria meningitidis MC58 10 4
Laribacter hongkongensis HLHK9
Methylobacillus flagellatus KT
Methylotenera mobilis JLW8
Methylophilales bacterium HTCC2181
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
tal
 
Azoarcus sp. EbN1

Gene: ebA4676: Transaldolase (EC 2.2.1.2)
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB

Gene: Daro_2062: Transaldolase (EC 2.2.1.2)
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV0564: Transaldolase (EC 2.2.1.2)
*
Neisseria meningitidis MC58

Site:
position = -81
score = 4.8461
sequence = CTGTAATAAAACTACCC

Gene: NMB0351: Transaldolase (EC 2.2.1.2)
 
Laribacter hongkongensis HLHK9

Gene: LHK_00167: Transaldolase (EC 2.2.1.2)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Transaldolase (EC 2.2.1.2)
 
CRON 2.
ptsHI
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
*
Chromobacterium violaceum ATCC 12472

Site:
position = -213
score = 5.63622
sequence = ATGTAGTTTAACTACAA

Gene: CV0980: PTS system, glucose-specific IIA component (EC 2.7.1.69) / Phosphocarrier protein of PTS system / Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
PTS system, glucose-specific IIA component (EC 2.7.1.69) / Phosphocarrier protein of PTS system / Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)
ptsG
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV0979: PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIC component (EC 2.7.1.69)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIC component (EC 2.7.1.69)
 
CRON 3.
gntU
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
*
Neisseria meningitidis MC58

Site:
position = -32
score = 4.94269
sequence = TTGTACTTTTATTACAG

Gene: NMB2027: Low-affinity gluconate/H+ symporter GntU
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Low-affinity gluconate/H+ symporter GntU
gntK
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB2028: Gluconokinase (EC 2.7.1.12)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Gluconokinase (EC 2.7.1.12)
 
CRON 4.
zwf
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
*
Chromobacterium violaceum ATCC 12472

Site:
position = -227
score = 5.85665
sequence = TAGTAGTTTTACTACAC

Site:
position = -47
score = 4.77473
sequence = TGGTAATATAACTACAT

Gene: CV0145: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Neisseria meningitidis MC58

Site:
position = -117
score = 5.98826
sequence = GTGTAGTATTACTACTC

Site:
position = -293
score = 4.60655
sequence = GTGTTATTATAGTACAA

Site:
position = -273
score = 4.53518
sequence = TTGTAATTTTGTTACAA

Gene: NMB1392: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
pgl
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB

Gene: Daro_2071: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Nitrosomonas europaea ATCC 19718

Gene: NE1691: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1628: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Thiobacillus denitrificans

Gene: Tbd_2121: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Chromobacterium violaceum ATCC 12472

Gene: CV0146: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Neisseria meningitidis MC58

Gene: NMB1391: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Laribacter hongkongensis HLHK9

Gene: LHK_01339: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 2
Methylobacillus flagellatus KT

Gene: Mfla_1063: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type

Gene: Mfla_0919: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Methylotenera mobilis JLW8

Gene: Mmol_1526: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Methylophilales bacterium HTCC2181

Gene: MB2181_03445: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
glk
 
Azoarcus sp. EbN1

Gene: ebA584: Glucokinase (EC 2.7.1.2)
 
Thauera sp. MZ1T

Gene: Tmz1t_2047: Glucokinase (EC 2.7.1.2)
 
Dechloromonas aromatica RCB

Gene: Daro_0592: Glucokinase (EC 2.7.1.2)
 
Nitrosomonas europaea ATCC 19718

Gene: NE1694: Glucokinase (EC 2.7.1.2)
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1872: Glucokinase (EC 2.7.1.2)
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV0147: Glucokinase (EC 2.7.1.2)
 
Neisseria meningitidis MC58

Gene: NMB1390: Glucokinase (EC 2.7.1.2)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Glucokinase (EC 2.7.1.2)
hexR
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV0148: Central carbohydrate metabolism transcription regulator HexR, RpiR family
 
Neisseria meningitidis MC58

Gene: NMB1389: Central carbohydrate metabolism transcription regulator HexR, RpiR family
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Central carbohydrate metabolism transcription regulator HexR, RpiR family
pgi
 
Azoarcus sp. EbN1

Gene: ebA5208: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Thauera sp. MZ1T

Gene: Tmz1t_2030: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Dechloromonas aromatica RCB

Gene: Daro_0581: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Nitrosomonas europaea ATCC 19718

Gene: NE2263: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A0469: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 2
Thiobacillus denitrificans

Gene: Tbd_0974: Glucose-6-phosphate isomerase (EC 5.3.1.9)

Gene: Tbd_2063: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 2
Chromobacterium violaceum ATCC 12472

Gene: CV0149: Glucose-6-phosphate isomerase (EC 5.3.1.9)

Gene: CV2369: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 2
Neisseria meningitidis MC58

Gene: NMB0334: Glucose-6-phosphate isomerase (EC 5.3.1.9)

Gene: NMB1388: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Laribacter hongkongensis HLHK9

Gene: LHK_02316: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Methylobacillus flagellatus KT

Gene: Mfla_1325: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Methylotenera mobilis JLW8

Gene: Mmol_0827: Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
Methylophilales bacterium HTCC2181

Gene: MB2181_04675: Glucose-6-phosphate isomerase (EC 5.3.1.9)
Glucose-6-phosphate isomerase (EC 5.3.1.9)
 
CRON 5.
edd
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
*
Chromobacterium violaceum ATCC 12472

Site:
position = -48
score = 5.85665
sequence = GTGTAGTAAAACTACTA

Site:
position = -228
score = 4.77473
sequence = ATGTAGTTATATTACCA

Gene: CV0144: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Neisseria meningitidis MC58

Site:
position = -291
score = 4.60655
sequence = TTGTACTATAATAACAC

Site:
position = -311
score = 4.53518
sequence = TTGTAACAAAATTACAA

Site:
position = -467
score = 5.98826
sequence = GAGTAGTAATACTACAC

Gene: NMB1393: Phosphogluconate dehydratase (EC 4.2.1.12)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT

Gene: Mfla_0759: Phosphogluconate dehydratase (EC 4.2.1.12)
 
Methylotenera mobilis JLW8

Gene: Mmol_1727: Phosphogluconate dehydratase (EC 4.2.1.12)
 
Methylophilales bacterium HTCC2181

Gene: MB2181_02745: Phosphogluconate dehydratase (EC 4.2.1.12)
Phosphogluconate dehydratase (EC 4.2.1.12)
eda
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV0143: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Neisseria meningitidis MC58

Gene: NMB1394: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Laribacter hongkongensis HLHK9

Gene: LHK_03117: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Methylobacillus flagellatus KT

Gene: Mfla_0760: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Methylotenera mobilis JLW8

Gene: Mmol_1726: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Methylophilales bacterium HTCC2181

Gene: MB2181_02750: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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