Regulog HisR - Bacillales

Properties
Regulator type:	Transcription factor
Regulator family:	TrpR
Regulation mode:	repressor
Biological process:	Histidine biosynthesis
Effector:	Histidine
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

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Member of regulog collections

By taxonomy - Bacillales
By trascription factor - HisR
By TF family - TrpR
By effector - Histidine
By pathway - Histidine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168	9	2
Bacillus amyloliquefaciens FZB42	9	2
Bacillus pumilus SAFR-032	9	2
Bacillus licheniformis DSM 13	9	2
Anoxybacillus flavithermus WK1	9	2
Geobacillus kaustophilus HTA426	2	1
Bacillus cereus ATCC 14579
Bacillus halodurans C-125	9	2
Bacillus clausii KSM-K16	9	2
Oceanobacillus iheyensis HTE831	10	2
Paenibacillus sp. JDR-2	8	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
hisZ	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -65 score = 5.30038 sequence = CATATTAGCGAACTAAAGGA Gene: BSU34930: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Bacillus amyloliquefaciens FZB42 Site: position = -61 score = 5.30038 sequence = CATATTAGCGAACTAAAGGA Gene: RBAM_032140: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Bacillus pumilus SAFR-032 Site: position = -62 score = 5.30038 sequence = CATATTAGCGAACTAAAGGA Gene: BPUM_3128: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Bacillus licheniformis DSM 13 Site: position = -62 score = 5.47964 sequence = CATATTAGCGAACTAAAGTA Gene: BLi03738: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Anoxybacillus flavithermus WK1 Site: position = -55 score = 4.87513 sequence = AACTTTACTTTGCTAATATA Site: position = -39 score = 5.61978 sequence = TATATTAGCGAACTAAAGTA Gene: Aflv_2537: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Geobacillus kaustophilus HTA426 Site: position = -42 score = 5.39188 sequence = CATATTAGCAAACTAAAGCA Gene: GK3077: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	Bacillus cereus ATCC 14579 Gene: BC1404: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Bacillus halodurans C-125 Site: position = -71 score = 4.34804 sequence = TCCTTTATCTTGTTAGTATA Site: position = -55 score = 5.61978 sequence = TATATTAGCGAACTAAAGTA Gene: BH3584: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Bacillus clausii KSM-K16 Site: position = -43 score = 5.58061 sequence = TGATTTAGCAAACTAAAGTA Gene: ABC3050: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Oceanobacillus iheyensis HTE831 Site: position = -66 score = 4.84255 sequence = AACTTTACTTAGATAAAGTG Gene: OB0553: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	* Paenibacillus sp. JDR-2 Site: position = -37 score = 5.58607 sequence = CACTTTAATATACTAAAGTA Gene: Pjdr2_0159: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)	ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)
hisG	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34920: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032130: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus pumilus SAFR-032 Gene: BPUM_3127: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus licheniformis DSM 13 Gene: BLi03737: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Anoxybacillus flavithermus WK1 Gene: Aflv_2536: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Geobacillus kaustophilus HTA426 Gene: GK3076: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus cereus ATCC 14579 Gene: BC1405: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus halodurans C-125 Gene: BH3583: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Bacillus clausii KSM-K16 Gene: ABC3049: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Oceanobacillus iheyensis HTE831 Gene: OB0552: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0160: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)	ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)
hisD	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34910: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032120: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus pumilus SAFR-032 Gene: BPUM_3126: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus licheniformis DSM 13 Gene: BLi03736: Histidinol dehydrogenase (EC 1.1.1.23)	Anoxybacillus flavithermus WK1 Gene: Aflv_2535: Histidinol dehydrogenase (EC 1.1.1.23)	Geobacillus kaustophilus HTA426 Gene: GK3075: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus cereus ATCC 14579 Gene: BC1406: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus halodurans C-125 Gene: BH3582: Histidinol dehydrogenase (EC 1.1.1.23)	Bacillus clausii KSM-K16 Gene: ABC3048: Histidinol dehydrogenase (EC 1.1.1.23)	Oceanobacillus iheyensis HTE831 Gene: OB0551: Histidinol dehydrogenase (EC 1.1.1.23)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0161: Histidinol dehydrogenase (EC 1.1.1.23)	Histidinol dehydrogenase (EC 1.1.1.23)
hisB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34900: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032110: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus pumilus SAFR-032 Gene: BPUM_3125: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus licheniformis DSM 13 Gene: BLi03735: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Anoxybacillus flavithermus WK1 Gene: Aflv_2534: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Geobacillus kaustophilus HTA426 Gene: GK3074: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus cereus ATCC 14579 Gene: BC1407: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus halodurans C-125 Gene: BH3581: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Bacillus clausii KSM-K16 Gene: ABC3047: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Oceanobacillus iheyensis HTE831 Gene: OB0550: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0162: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)	Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hisH	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34890: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032100: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus pumilus SAFR-032 Gene: BPUM_3124: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus licheniformis DSM 13 Gene: BLi03734: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Anoxybacillus flavithermus WK1 Gene: Aflv_2533: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Geobacillus kaustophilus HTA426 Gene: GK3073: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus cereus ATCC 14579 Gene: BC1408: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus halodurans C-125 Gene: BH3580: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Bacillus clausii KSM-K16 Gene: ABC3046: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Oceanobacillus iheyensis HTE831 Gene: OB0549: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0163: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)	Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34880: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032090: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus pumilus SAFR-032 Gene: BPUM_3123: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus licheniformis DSM 13 Gene: BLi03733: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Anoxybacillus flavithermus WK1 Gene: Aflv_2532: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Geobacillus kaustophilus HTA426 Gene: GK3072: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus cereus ATCC 14579 Gene: BC1409: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus halodurans C-125 Gene: BH3579: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Bacillus clausii KSM-K16 Gene: ABC3045: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Oceanobacillus iheyensis HTE831 Gene: OB0548: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)	Paenibacillus sp. JDR-2	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34870: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032080: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus pumilus SAFR-032 Gene: BPUM_3122: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus licheniformis DSM 13 Gene: BLi03732: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Anoxybacillus flavithermus WK1 Gene: Aflv_2531: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Geobacillus kaustophilus HTA426 Gene: GK3071: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus cereus ATCC 14579 Gene: BC1410: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus halodurans C-125 Gene: BH3578: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Bacillus clausii KSM-K16 Gene: ABC3044: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Oceanobacillus iheyensis HTE831 Gene: OB0547: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0164: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)	Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
hisIE	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU34860: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_032070: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus pumilus SAFR-032 Gene: BPUM_3121: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus licheniformis DSM 13 Gene: BLi03731: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Anoxybacillus flavithermus WK1 Gene: Aflv_2530: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Geobacillus kaustophilus HTA426 Gene: GK3070: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus cereus ATCC 14579 Gene: BC1411: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus halodurans C-125 Gene: BH3577: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Bacillus clausii KSM-K16 Gene: ABC3043: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Oceanobacillus iheyensis HTE831 Gene: OB0546: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Paenibacillus sp. JDR-2 Gene: Pjdr2_0165: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)	Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
hisC	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831 Gene: OB0545: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Paenibacillus sp. JDR-2 Gene: Pjdr2_5865: Histidinol-phosphate aminotransferase (EC 2.6.1.9)	Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisJ	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC1413: Histidinol-phosphatase (EC 3.1.3.15)	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_0166: Histidinol-phosphatase (EC 3.1.3.15)	Histidinol-phosphatase (EC 3.1.3.15)

CRON 2.
yuiF	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -39 score = 5.7462 sequence = TACATTAGCAAACTAAAGGA Gene: BSU32040: Histidine permease	* Bacillus amyloliquefaciens FZB42 Site: position = -39 score = 5.7462 sequence = TACATTAGCAAACTAAAGGA Gene: RBAM_029090: Histidine permease	* Bacillus pumilus SAFR-032 Site: position = -36 score = 5.78059 sequence = TACATTAGTAAACTAAAGGA Gene: BPUM_2865: Histidine permease	* Bacillus licheniformis DSM 13 Site: position = -40 score = 5.78531 sequence = TACATTAGCAAACTAAAGTG Gene: BLi03386: Histidine permease	* Anoxybacillus flavithermus WK1 Site: position = -34 score = 5.24991 sequence = CAATTTATCAAACTAAAGTG Gene: Aflv_1385: Histidine permease	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC4103: Histidine permease	2 Bacillus halodurans C-125* Site: position = -47 score = 5.09523 sequence = TGATTTAATAAACTAAAGCA Gene: BH3359: Histidine permease Gene: BH1986: Histidine permease	* Bacillus clausii KSM-K16 Site: position = -30 score = 4.83117 sequence = TGATTTAATAAGATAAAGGA Gene: ABC2918: Histidine permease	* Oceanobacillus iheyensis HTE831 Site: position = -50 score = 4.79583 sequence = TGCTTTATCATGATGAAGTA Gene: OB0879: Histidine permease	Paenibacillus sp. JDR-2	Histidine permease

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HisR - Bacillales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --