Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CodY regulog to Streptococcus mutans UA159

Reference regulog properties
Source regulog: CodY - Streptococcaceae
Regulator type: Transcription factor
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus mutans UA159
Orthologous TF(s) SMU.1824c
Regulated genes 23
Built upon 273 sites [see more]
Predicted regulatory interactions in Streptococcus mutans UA159
Locus tag Position Score Sequence
Position: -139
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.63c
SMU.63c -139 5.3 AATTTTCTGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: SMU.63c
Ortholog function: Conserved hypothetical secreted protein
Streptococcus gallolyticus UCN34 GALLO_0890 -206 4.6 AATATTTTTAAAATT
Streptococcus mutans UA159 SMU.63c -139 5.3 AATTTTCTGAATTTT
Position: -59
Score: 5.2
Sequence: AATTGTCTGATAATT
Locus tag: SMU.70
SMU.70 -59 5.2 AATTGTCTGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: thrC
Ortholog function: Threonine synthase (EC 4.2.3.1)
Streptococcus agalactiae 2603V/R SAG0055 -100 5.2 AATTTTCTGAAAATC
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0063 -113 5.2 AATTTTCAGAAAACT
Streptococcus gallolyticus UCN34 GALLO_0042 -61 5.6 AATTTTCTGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0139 -57 5.2 AATTTTCTGATAAAT
Streptococcus mitis B6 smi_0193 -57 5.4 AATTTTCTGAAAAAT
Streptococcus mutans UA159 SMU.70 -59 5.2 AATTGTCTGATAATT
Streptococcus pneumoniae TIGR4 SP_2066 -57 5.4 AATTTTCTGAAAAAT
Streptococcus sanguinis SK36 SSA_0095 -57 5.2 AATTTTCTGATAAAT
Streptococcus suis 05ZYH33 SSU05_0281 -56 4.8 AATTTTCTGTCAATT
Streptococcus thermophilus CNRZ1066 str1878 -59 5.4 AATTTTCTGACAATT
Position: -42
Score: 5.5
Sequence: AATTTTTTGAAAATT
Locus tag: SMU.231
SMU.231 -42 5.5 AATTTTTTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvB
Ortholog function: Acetolactate synthase large subunit (EC 2.2.1.6)
Lactococcus lactis subsp. cremoris SK11 LACR_1311 -86 4.9 AATATTCTGACAAAT
Lactococcus lactis subsp. lactis Il1403 L0078 -86 4.9 AATATTCTGACAAAT
Streptococcus gallolyticus UCN34 GALLO_0305 -42 5.2 AATTTTTAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0526 -249 5.8 AATTTTCTGAAAATT
-27 5.1 AATTTTTTGACAATT
Streptococcus mitis B6 smi_1825 -93 5.3 AAAATTCAGAAAATT
Streptococcus mutans UA159 SMU.231 -42 5.5 AATTTTTTGAAAATT
Streptococcus pneumoniae TIGR4 SP_0445 -93 5.3 AAAATTCAGAAAATT
Streptococcus sanguinis SK36 SSA_1970 -37 5.5 AATTTTTAGAAAATT
Streptococcus suis 05ZYH33 SSU05_1888 -296 5.8 AATTTTCAGAAAATT
Streptococcus thermophilus CNRZ1066 str1873 -27 5.2 AATTTTTAGATAATT
Position: -36
Score: 5.3
Sequence: AATTTTCAGATTATT
Locus tag: SMU.255
SMU.255 -36 5.3 AATTTTCAGATTATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA1
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Streptococcus mutans UA159 SMU.255 -36 5.3 AATTTTCAGATTATT
Position: -39
Score: 5.1
Sequence: AATTTTCAGAATATA
Locus tag: SMU.363
SMU.363 -39 5.1 AATTTTCAGAATATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: glnR
Ortholog function: Nitrogen metabolism transcriptional regulator GlnR, MerR family
Streptococcus gallolyticus UCN34 GALLO_1993 -38 4.7 AATTTTCAGACTATA
Streptococcus mutans UA159 SMU.363 -39 5.1 AATTTTCAGAATATA
Streptococcus thermophilus CNRZ1066 str1777 -38 4.6 AAAATTCAGAATATA
Streptococcus uberis 0140J SUB1627 -103 5.1 AATATTCAGAAAATA
Position: -108
Score: 5.3
Sequence: AATTTTCAGAATTTT
Locus tag: SMU.365
SMU.365 -108 5.3 AATTTTCAGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gltB
Ortholog function: Glutamate synthase [NADPH] large chain (EC 1.4.1.13)
Lactococcus lactis subsp. cremoris SK11 LACR_1407 -80 4.9 AATTATCAGAATATA
Lactococcus lactis subsp. lactis Il1403 L0119 -80 4.7 AATTGTCAGAATATA
Streptococcus gallolyticus UCN34 GALLO_1991 -59 5 AATATTCTGAATAAT
Streptococcus mutans UA159 SMU.365 -108 5.3 AATTTTCAGAATTTT
Position: -89
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.676
SMU.676 -89 5.3 AATTTTCTGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gapN
Ortholog function: Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9)
Streptococcus agalactiae 2603V/R SAG0823 -72 4.6 ATATGTCAGATAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1419 -87 4.9 AATTTTCTGATACTT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0766 -87 4.6 AATTTTCAGACTCTT
Streptococcus gallolyticus UCN34 GALLO_0746 -87 5.3 AATTTTCTGAATTTT
Streptococcus mutans UA159 SMU.676 -89 5.3 AATTTTCTGAATTTT
Streptococcus pneumoniae TIGR4 SP_1119 -55 5.2 GATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy1371 -87 5.3 AATTTTCAGATATTT
Streptococcus sanguinis SK36 SSA_0774 -53 5.8 AATTTTCAGAAAATT
Streptococcus thermophilus CNRZ1066 str1263 -89 5 AATTTTCTGAATACT
Streptococcus uberis 0140J SUB1220 -87 5.4 AATTTTCAGACAATT
Position: -61
Score: 5.2
Sequence: AATTTTCTAAAATTT
Locus tag: SMU.784
SMU.784 -61 5.2 AATTTTCTAAAATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: aroA
Ortholog function: 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
Streptococcus gallolyticus UCN34 GALLO_1433 -56 4.6 AATTTTCAGTTATTT
Streptococcus mutans UA159 SMU.784 -61 5.2 AATTTTCTAAAATTT
Streptococcus suis 05ZYH33 SSU05_0596 -63 4.6 AAAAATCAGAAAATA
Streptococcus suis 05ZYH33 SSU05_0597 -63 4.6 AAAAATCAGAAAATA
Streptococcus suis 05ZYH33 SSU05_0598 -63 4.6 AAAAATCAGAAAATA
Streptococcus thermophilus CNRZ1066 str0645 -81 4.9 AATATTTTGACAATT
Position: -68
Score: 5.6
Sequence: AATATTCAGAAAATT
Locus tag: SMU.913
SMU.913 -68 5.6 AATATTCAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gdhA
Ortholog function: NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
Streptococcus agalactiae 2603V/R SAG1335 -55 4.9 AAAATTCTGACAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0823 -61 5.3 AAAATTCAGAAAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1090 -65 5.3 AAAATTCAGAAAATT
Streptococcus gallolyticus UCN34 GALLO_1293 -78 5.8 AATTTTCAGAAAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0276 -95 5.8 AATTTTCAGAAAATT
Streptococcus mitis B6 smi_0814 -95 5.5 AATTTTTAGAAAATT
Streptococcus mutans UA159 SMU.913 -68 5.6 AATATTCAGAAAATT
Streptococcus pneumoniae TIGR4 SP_1306 -94 5.5 AATTTTTAGAAAATT
Streptococcus sanguinis SK36 SSA_0371 -182 5.5 AATTTTTAGAAAATT
Streptococcus suis 05ZYH33 SSU05_0252 -45 5.1 AATTGTCAGACAATT
Streptococcus thermophilus CNRZ1066 str0430 -52 5 AAGATTCTGAAAATT
Streptococcus uberis 0140J SUB0762 -60 5.6 AATATTCTGAAAATT
Position: -105
Score: 5.3
Sequence: AATTTTCTGAAAATA
Locus tag: SMU.1109c
SMU.1109c -105 5.3 AATTTTCTGAAAATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: SMU.1109
Ortholog function: Predicted Mn2+/Fe2+ transporter, NRAMP family
Streptococcus gallolyticus UCN34 GALLO_1124 -45 5.3 AATTATCTGAATATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1506 -102 4.8 TATTTTCCGAAAATT
-42 5.6 AATTATCTGAAAATT
Streptococcus mutans UA159 SMU.1109c -105 5.3 AATTTTCTGAAAATA
Streptococcus pneumoniae TIGR4 SP_0159 -33 5.2 ATTATTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str0745 -106 5 ATTTTTCAGAAAATA
-33 5.2 ATTATTCTGAAAATT
Position: -291
Score: 4.7
Sequence: AATTTTCAGAAAAGA
Locus tag: SMU.1175
SMU.1175 -291 4.7 AATTTTCAGAAAAGA
Supported by regulated orthologs from reference regulons
Ortholog gene name: dagA
Ortholog function: Sodium/glycine symporter
Streptococcus mutans UA159 SMU.1175 -291 4.7 AATTTTCAGAAAAGA
Streptococcus sanguinis SK36 SSA_0363 -290 4.7 AATTTTCATAAAATA
Position: -83
Score: 5.3
Sequence: AATTTTCAGAATTTT
Locus tag: SMU.1203
SMU.1203 -83 5.3 AATTTTCAGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvE
Ortholog function: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Lactococcus lactis subsp. cremoris SK11 LACR_1409 -97 4.8 AATTGTTTGAAATTT
Streptococcus agalactiae 2603V/R SAG1152 -83 4.7 ATTTATCTGAATTTT
Streptococcus gallolyticus UCN34 GALLO_0979 -84 5.3 AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1 SGO_1238 -99 5.8 AATTTTCTGAAAATT
Streptococcus mitis B6 smi_0906 -88 5.8 AATTTTCTGAAAATT
Streptococcus mutans UA159 SMU.1203 -83 5.3 AATTTTCAGAATTTT
Streptococcus pneumoniae TIGR4 SP_0856 -88 5.8 AATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0911 -102 4.6 AATTTTATGATAAAT
Streptococcus sanguinis SK36 SSA_1225 -98 5.8 AATTTTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str0590 -90 4.9 AATTGTCAGAATTTT
Streptococcus uberis 0140J SUB1010 -88 4.8 AATATTCCGAATATT
Position: -310
Score: 5.1
Sequence: AATATTCAGAATTTT
Locus tag: SMU.1273
SMU.1273 -310 5.1 AATATTCAGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: hisC
Ortholog function: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
Lactococcus lactis subsp. cremoris SK11 LACR_1336 -309 4.7 ATAATTCAGATAATT
Lactococcus lactis subsp. lactis Il1403 L0065 -299 4.7 ATAATTCAGATAATT
Streptococcus mutans UA159 SMU.1273 -310 5.1 AATATTCAGAATTTT
Position: -65
Score: 5.1
Sequence: TATTTTCAGAATATT
Locus tag: SMU.1301c
SMU.1301c -65 5.1 TATTTTCAGAATATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ubiE
Ortholog function: SAM-dependent methyltransferase
Streptococcus gordonii str. Challis substr. CH1 SGO_0226 -60 5.2 AAATGTCAGAAAATT
Streptococcus mitis B6 smi_1568 -56 4.7 AATTGTCAGATAATA
Streptococcus mutans UA159 SMU.1301c -65 5.1 TATTTTCAGAATATT
Streptococcus pneumoniae TIGR4 SP_1578 -55 4.7 AATTGTCAGATAATA
Streptococcus sanguinis SK36 SSA_0321 -64 5 AATTGTCTGAAAATA
Position: -246
Score: 5.4
Sequence: ATTTTTCAGAAAATT
Locus tag: SMU.1384
SMU.1384 -246 5.4 ATTTTTCAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: leuA
Ortholog function: 2-isopropylmalate synthase (EC 2.3.3.13)
Streptococcus gallolyticus UCN34 GALLO_0758 -266 5 AGTATTCAGAAAATT
Streptococcus mitis B6 smi_1218 -259 5.3 AATTTTCAGAAAATA
Streptococcus mutans UA159 SMU.1384 -246 5.4 ATTTTTCAGAAAATT
Streptococcus sanguinis SK36 SSA_0975 -269 5.3 AATTTTCAGAAAATA
Position: -101
Score: 5.1
Sequence: AATTTTCTGATAATA
Locus tag: SMU.1519
SMU.1519 -101 5.1 AATTTTCTGATAATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gluQ
Ortholog function: Glutamate ABC transporter, ATP-binding protein
Streptococcus agalactiae 2603V/R SAG0718 -96 4.6 AATATTCTGAATTTA
Streptococcus gallolyticus UCN34 GALLO_1555 -114 5.1 AATTTTCTGAATATA
Streptococcus mutans UA159 SMU.1519 -101 5.1 AATTTTCTGATAATA
Position: -136
Score: 5.1
Sequence: AAAATTCTGAATATT
Locus tag: SMU.1595
SMU.1595 -136 5.1 AAAATTCTGAATATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: cah
Ortholog function: Carbonic anhydrase precursor (EC 4.2.1.1)
Streptococcus mutans UA159 SMU.1595 -136 5.1 AAAATTCTGAATATT
Position: -50
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: SMU.1656
SMU.1656 -50 5.3 AAAATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: serC
Ortholog function: Phosphoserine aminotransferase (EC 2.6.1.52)
Lactococcus lactis subsp. cremoris SK11 LACR_0619 -59 5.6 AATTATCAGAAAATT
Lactococcus lactis subsp. lactis Il1403 L0083 -59 5.6 AATTATCAGAAAATT
Streptococcus gallolyticus UCN34 GALLO_1746 -51 5.3 AAAATTCAGAAAATT
Streptococcus mutans UA159 SMU.1656 -50 5.3 AAAATTCTGAAAATT
Streptococcus suis 05ZYH33 SSU05_0665 -54 5.2 AATTGTCTGAATATT
Streptococcus uberis 0140J SUB0445 -53 5.3 AAAATTCTGAAAATT
Position: -85
Score: 5.5
Sequence: AATTTTTAGAAAATT
Locus tag: SMU.1658
SMU.1658 -85 5.5 AATTTTTAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: nrgA
Ortholog function: Ammonium transporter
Lactococcus lactis subsp. cremoris SK11 LACR_1699 -61 5.1 AATATTCAGAAAATA
Lactococcus lactis subsp. lactis Il1403 L0236 -62 5 AATTGTCAGAAAATA
Streptococcus gallolyticus UCN34 GALLO_1749 -148 5 AAAATTTAGAAAATT
Streptococcus mitis B6 smi_0683 -93 5.2 AATTATCAAAAAATT
Streptococcus mutans UA159 SMU.1658 -85 5.5 AATTTTTAGAAAATT
Streptococcus thermophilus CNRZ1066 str0494 -45 5.2 AATTATCAAAAAATT
Position: -66
Score: 5.3
Sequence: AATATTCAGATAATT
Locus tag: SMU.1669
SMU.1669 -66 5.3 AATATTCAGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: livK
Ortholog function: Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
Streptococcus agalactiae 2603V/R SAG1582 -56 5.3 AATATTCTGATAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0443 -98 4.9 ATTTTTCAAAATATT
-65 5.6 AATTTTCTGATAATT
Streptococcus gallolyticus UCN34 GALLO_1760 -66 5.6 AATTTTCTGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1630 -66 5.6 AATTTTCTGATAATT
Streptococcus mitis B6 smi_1415 -61 5.6 AATTTTCTGATAATT
Streptococcus mutans UA159 SMU.1669 -66 5.3 AATATTCAGATAATT
Streptococcus pneumoniae TIGR4 SP_0749 -60 5.6 AATTTTCTGATAATT
Streptococcus sanguinis SK36 SSA_1729 -65 5.2 AATTGTCAGATAATT
Streptococcus suis 05ZYH33 SSU05_1548 -64 5.6 AATTTTCAGATAATT
Streptococcus thermophilus CNRZ1066 str0359 -65 5.6 AATTTTCTGATAATT
Streptococcus uberis 0140J SUB0432 -66 5.6 AATTTTCTGATAATT
Position: -53
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.1748
SMU.1748 -53 5.3 AATTTTCTGAATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: thrA
Ortholog function: Aspartokinase (EC 2.7.2.4)
Lactococcus lactis subsp. cremoris SK11 LACR_0783 -71 5.6 AATTATCTGAAAATT
Lactococcus lactis subsp. lactis Il1403 L0097 -70 5.6 AATTATCTGAAAATT
Streptococcus agalactiae 2603V/R SAG0339 -52 4.9 AATTTTCTGACTTTT
Streptococcus gallolyticus UCN34 GALLO_0331 -52 5.3 AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1 SGO_1701 -38 4.5 AATTGTTTGAATAAT
Streptococcus mutans UA159 SMU.1748 -53 5.3 AATTTTCTGAATTTT
Streptococcus sanguinis SK36 SSA_1943 -47 5.3 AATTTTCAGAATTTT
Streptococcus suis 05ZYH33 SSU05_1811 -123 4.6 GTTTTTCTGAAATTT
Streptococcus thermophilus CNRZ1066 str0378 -56 5.1 AATTATCAGAATTTT
Streptococcus uberis 0140J SUB0316 -26 5 AATATTCATAAAATT
Position: -75
Score: 5.4
Sequence: AATTTTCTGACAATT
Locus tag: SMU.1824c
SMU.1824c -75 5.4 AATTTTCTGACAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: codY
Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family
Lactococcus lactis subsp. cremoris SK11 LACR_0168 -101 5.4 AATTTTCTGACAATT
Lactococcus lactis subsp. lactis Il1403 L0243 -101 5.4 AATTTTCTGACAATT
Streptococcus agalactiae 2603V/R SAG1675 -46 5 AATTTTGAGAATATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1848 -80 5.6 AATTTTCTGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0387 -78 5.6 AATTTTCTGATAATT
Streptococcus gallolyticus UCN34 GALLO_1876 -77 5.6 AATTTTCAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0431 -71 5.6 AATTTTCAGATAATT
Streptococcus mitis B6 smi_0687 -71 5.6 AATTTTCAGATAATT
Streptococcus mutans UA159 SMU.1824c -75 5.4 AATTTTCTGACAATT
Streptococcus pneumoniae TIGR4 SP_1584 -71 5.6 AATTTTCAGATAATT
Streptococcus pyogenes M1 GAS SPy1777 -80 5.6 AATTTTCTGATAATT
Streptococcus sanguinis SK36 SSA_0566 -71 5.6 AATTTTCAGATAATT
Streptococcus suis 05ZYH33 SSU05_0350 -74 5.3 AATATTCTGATAATT
Streptococcus thermophilus CNRZ1066 str1635 -132 5.4 AATTTTCAGACAATT
Streptococcus uberis 0140J SUB1528 -82 5.6 AATTTTCTGATAATT
Position: -84
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: SMU.1990
SMU.1990 -84 5.3 AAAATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: rpoB
Ortholog function: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Streptococcus agalactiae 2603V/R SAG0160 -128 5.2 AACTTTCTGAAAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0131 -91 4.6 AAGATTCTAAAAATT
Streptococcus gallolyticus UCN34 GALLO_0084 -165 4.6 AAGATTCTAAAAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1927 -222 5.4 ATTTTTCTGAAAATT
Streptococcus mitis B6 smi_1847 -113 5 AAGATTCTGAAAATT
Streptococcus mutans UA159 SMU.1990 -84 5.3 AAAATTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_1961 -112 5 AAGATTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0098 -91 5.2 AATATTCTAAAAATT
Streptococcus suis 05ZYH33 SSU05_0121 -276 4.6 AAGATTCTAAAAATT
Streptococcus thermophilus CNRZ1066 str1868 -171 4.6 AAAGTTCTAAAAATT
Streptococcus uberis 0140J SUB0115 -90 4.6 AAGATTCTAAAAATT
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