Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CmbR regulog to Streptococcus mutans NN2025

Reference regulog properties
Source regulog: CmbR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Cysteine metabolism
Effector: O-acetyl-L-serine
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus mutans NN2025
Orthologous TF(s) SmuNN2025_1163, SmuNN2025_0828
Regulated genes 10
Built upon 104 sites [see more]
Predicted regulatory interactions in Streptococcus mutans NN2025
Locus tag Position Score Sequence
Position: -98
Score: 5.5
Sequence: GTGATAGAATTCTTTTATCAC
Position: -76
Score: 4.5
Sequence: GTGATAGGAATTATATAATAG
Locus tag: SmuNN2025_0210
SmuNN2025_0210 -98 5.5 GTGATAGAATTCTTTTATCAC
-76 4.5 GTGATAGGAATTATATAATAG
Supported by regulated orthologs from reference regulons
Ortholog gene name: gshT
Ortholog function: Predicted glutathione ABC transporter, substrate-binding protein
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0381 -75 5 TTGATAGGAATTAATTATTAG
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1680 -41 5 ATGATAAACTAATCTTATGAA
Streptococcus gallolyticus UCN34 GALLO_1845 -122 6 GTGATAAGTTTTATTTATCAC
Streptococcus mitis B6 smi_1945 -99 5.1 GCCATAAAGAAAACCTATCAC
Streptococcus mutans UA159 SMU.1942c -98 6 GTGATAGAATTTTCTTATCAC
-76 4.6 GTGATAGAAATTATATAATAG
Streptococcus pyogenes M1 GAS SPy0317 -75 4.5 TTGATAGGAATCAATTATTAG
Streptococcus thermophilus CNRZ1066 str0296 -98 5.7 GTGATAGTATTTTCTTATCAC
Streptococcus uberis 0140J SUB0365 -93 4.9 GTGATAGAGAACTATTATCAT
-71 4.2 GCGATAGTGAATCACTATTAG
Position: -110
Score: 4.3
Sequence: CTTATAGTTTCTTTTTATAGC
Locus tag: SmuNN2025_0442
SmuNN2025_0442 -110 4.3 CTTATAGTTTCTTTTTATAGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: metB1
Ortholog function: Cystathionine gamma-synthase (EC 2.5.1.48)
Lactococcus lactis subsp. lactis Il1403 L0102 -132 4.3 GCCATAGGCAAGTTTTATTAT
Streptococcus gallolyticus UCN34 GALLO_1768 -142 5 GTTATAGTTTTTACTTATAGC
Streptococcus mutans UA159 SMU.1675 -110 4.3 CTTATAGTTTCTTTTTATAGC
Streptococcus suis 05ZYH33 SSU05_1562 -120 5.1 GTTATAAAGAAAAACTATAAC
Streptococcus thermophilus CNRZ1066 str0352 -132 4.5 GTTATAGTAATAAACTATATC
Position: -168
Score: 5
Sequence: GTGATAACTTTTTCTTATGGC
Position: -103
Score: 4.9
Sequence: GCCATAAATAAAATTTATAGT
Locus tag: SmuNN2025_1096
SmuNN2025_1096 -168 5 GTGATAACTTTTTCTTATGGC
-103 4.9 GCCATAAATAAAATTTATAGT
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyD
Ortholog function: Predicted uroporphyrinogen-III decarboxylase
Streptococcus gallolyticus UCN34 GALLO_1275 -104 4.9 GCTATAAGCAAATCTTATGGC
Streptococcus mutans UA159 SMU.932 -168 5 GTGATAACTTTTTCTTATGGC
-103 5.3 GTCATAAATAAAATTTATAGC
Streptococcus sanguinis SK36 SSA_2105 -194 5.3 TTGATAAAAATTACCTATCTC
-59 5.1 TTGATAAATATTTTTAATCAG
Streptococcus sanguinis SK36 SSA_2102 -194 5.3 TTGATAAAAATTACCTATCTC
-59 5.1 TTGATAAATATTTTTAATCAG
Position: -188
Score: 4.6
Sequence: GTTATAGATGAAAACTATAAC
Position: -100
Score: 4
Sequence: TTAATAAGGATTATCTAGTAT
Locus tag: SmuNN2025_1143
SmuNN2025_1143 -188 4.6 GTTATAGATGAAAACTATAAC
-100 4 TTAATAAGGATTATCTAGTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Lactococcus lactis subsp. cremoris SK11 LACR_1368 -39 4.7 TTGATAAGATAGACCTATTAA
Lactococcus lactis subsp. lactis Il1403 L0100 -76 4.1 ATCATATTAAAAATGTATTAT
-39 4.7 TTGATAAGATAGACCTATTAA
Streptococcus agalactiae 2603V/R SAG2049 -109 4.1 GCTAAAAATATAAAATATTAA
Streptococcus gallolyticus UCN34 GALLO_1316 -221 4.2 ATAATAAATTTTATTAATCTA
-172 4.6 GTTATAGTTAAAAACTATAAT
Streptococcus gordonii str. Challis substr. CH1 SGO_0310 -182 4.2 GTTATAGTTTTTGATTATACC
Streptococcus mutans UA159 SMU.873 -188 4.6 GTTATAGATGAAAACTATAAC
Streptococcus pneumoniae TIGR4 SP_0585 -218 4.9 CTTATAAGAATTACTAATAAC
Streptococcus sanguinis SK36 SSA_0416 -182 4.3 GTCATAATTTCTACCTATAGC
Streptococcus suis 05ZYH33 SSU05_1774 -237 4.3 TTCATAGATAAAATCTATACC
Streptococcus thermophilus CNRZ1066 str0785 -119 4.2 GCTATACAAATATCTAATTAA
Position: -77
Score: 5
Sequence: GTGATAAATAATTTATATTTT
Locus tag: SmuNN2025_1476
SmuNN2025_1476 -77 5 GTGATAAATAATTTATATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Lactococcus lactis subsp. lactis Il1403 L0089 -79 5.3 GCTATAAAAAAATCTTATAGC
Lactococcus lactis subsp. lactis Il1403 L0088 -87 4.5 ATCATAAATTTTTTTTAGAGC
Streptococcus mitis B6 smi_2060 -98 5.3 GATATAAAAAAATCCTATCAC
Streptococcus thermophilus CNRZ1066 str0366 -16 5.2 ATGATAAAATTTTTTTATGGA
Streptococcus uberis 0140J SUB1379 -104 5.1 ATGATAAGCCTTTCCTATCAC
Position: -102
Score: 5.8
Sequence: GTGATAGAAAAATATTATCAC
Position: -80
Score: 5
Sequence: GTGATAGGAAAAAACTATTAT
Locus tag: SmuNN2025_1509
SmuNN2025_1509 -102 5.8 GTGATAGAAAAATATTATCAC
-80 5 GTGATAGGAAAAAACTATTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyA
Ortholog function: Cystine ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_1009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Lactococcus lactis subsp. lactis Il1403 L162009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Streptococcus agalactiae 2603V/R SAG0290 -96 5.5 TTGATATAAAATCTTTATCAC
-75 4.7 CTGATAAGGAAATACTATTAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1582 -98 4.7 TTGATACTATTTTCTTATTGC
-76 4.2 TTGATAGAGAAATGATATTAT
Streptococcus gallolyticus UCN34 GALLO_0414 -100 5.2 CTGATAGTTTTTTCTTATCAA
Streptococcus mutans UA159 SMU.459 -102 5.8 GTGATAGAAAAATATTATCAC
-80 5 GTGATAGGAAAAAACTATTAT
Streptococcus uberis 0140J SUB1416 -98 4.5 GTCATATAAATAGCTAATTAC
-76 4.2 TTGATAGAAAAATGGTATTAT
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