Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of Rex regulog to Streptococcus mutans NN2025

Reference regulog properties
Source regulog: Rex - Streptococcaceae
Regulator type: Transcription factor
Regulator family: Rex
Regulation mode: repressor
Biological process: Energy metabolism
Effector: NADH
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus mutans NN2025
Orthologous TF(s) SmuNN2025_0982
Regulated genes 13
Built upon 161 sites [see more]
Predicted regulatory interactions in Streptococcus mutans NN2025
Locus tag Position Score Sequence
Position: -163
Score: 4.1
Sequence: TTTTGAAAAACTTCCAAA
Locus tag: SmuNN2025_0075
SmuNN2025_0075 -163 4.1 TTTTGAAAAACTTCCAAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: nirC
Ortholog function: Formate/nitrite family of transporters
Streptococcus agalactiae 2603V/R SAG1084 -32 4.5 AAGTTAATAAAATCACAT
Streptococcus gordonii str. Challis substr. CH1 SGO_1137 -40 3.8 ATGATATATTGGTCATAA
Streptococcus mitis B6 smi_1009 -41 4.3 TTGTGATATAATTATCAG
Streptococcus pneumoniae TIGR4 SP_1215 -41 5 TTGTGATATAATTATCAA
Streptococcus sanguinis SK36 SSA_1098 -44 4.5 TTGTGATATACTATACAT
Position: -61
Score: 4.6
Sequence: AAGTGATAAAATAAACAA
Locus tag: SmuNN2025_0092
SmuNN2025_0092 -61 4.6 AAGTGATAAAATAAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: fba
Ortholog function: Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
Streptococcus gallolyticus UCN34 GALLO_0255 -60 4.2 TTGTGATAAAATGTACGT
Streptococcus gordonii str. Challis substr. CH1 SGO_1745 -61 4.6 AAGTGATAAAATAAACAA
Streptococcus mutans UA159 SMU.99 -61 4.6 AAGTGATAAAATAAACAA
Streptococcus pneumoniae TIGR4 SP_0605 -62 4.5 AAGTGATAAAATGAACAA
Streptococcus sanguinis SK36 SSA_1992 -62 4.6 AAGTGATAAAATAAACAA
Position: -130
Score: 5.3
Sequence: TTGGGAAAAAATTCACAA
Position: -96
Score: 4.8
Sequence: TTGTGAAAAGGGTTACAA
Position: -74
Score: 4.8
Sequence: AAGTGAAGAAAATCACAA
Locus tag: SmuNN2025_0126
SmuNN2025_0126 -130 5.3 TTGGGAAAAAATTCACAA
-96 4.8 TTGTGAAAAGGGTTACAA
-74 4.8 AAGTGAAGAAAATCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: adhE
Ortholog function: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
Lactococcus lactis subsp. cremoris SK11 LACR_2457 -101 5 TTGTAAATTTCATCACAA
-58 4.7 TTGTTAAACTATTCACGT
-34 4.5 AAGTGAATGAAATCACAA
Lactococcus lactis subsp. lactis Il1403 L13145 -101 5 TTGTAAAAACTATCACAA
-58 4.7 TTGTTAAACTATTCACGT
-34 4.3 AAGTGAATGAAGTCACAA
Streptococcus gallolyticus UCN34 GALLO_0220 -260 4.2 TTGTAATAAAAATGAAAA
-216 4.3 TTGAAAAAAGTTTAATAT
-195 4.7 TGGTGAAGAATATCACAA
Streptococcus mutans UA159 SMU.148 -130 5.3 TTGGGAAAAAATTCACAA
-96 4.8 TTGTGAAAAGGGTTACAA
-74 4.8 AAGTGAAGAAAATCACAA
Position: -64
Score: 4.1
Sequence: ATGTGATGTTTTTCACTT
Locus tag: SmuNN2025_0691
SmuNN2025_0691 -64 4.1 ATGTGATGTTTTTCACTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: frdC
Ortholog function: Fumarate reductase
Streptococcus mutans UA159 SMU.1410 -57 4.1 ATGTGATGTTTTTCACTT
Position: -49
Score: 4.6
Sequence: TTGTGGTATGATTAACAT
Locus tag: SmuNN2025_0809
SmuNN2025_0809 -49 4.6 TTGTGGTATGATTAACAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: eno
Ortholog function: Enolase (EC 4.2.1.11)
Lactococcus lactis subsp. cremoris SK11 LACR_0668 -80 4.4 TTGAAAAATCTTTCAAAA
Lactococcus lactis subsp. lactis Il1403 L0007 -80 4.4 TTGAAAAATCTTTCAAAA
Streptococcus agalactiae 2603V/R SAG0628 -123 4.4 TAGTGATTTTTTTATCAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0704 -52 4.8 TTGTGGTATTATTAACAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0774 -52 4.8 TTGTGGTATTATTAACAT
Streptococcus gallolyticus UCN34 GALLO_1458 -38 4.4 GTGTAAAAATATTAAAAA
Streptococcus mutans UA159 SMU.1247 -49 4.6 TTGTGGTATGATTAACAT
Streptococcus pyogenes M1 GAS SPy0731 -52 4.3 TTGTGGTATTATGAACAT
Streptococcus sanguinis SK36 SSA_0886 -111 4.7 TTGTGCAAAATTTCTCAA
-35 4.2 TAGTAAATAATTTTAAAT
Streptococcus uberis 0140J SUB0655 -101 4.3 AAGTGAAATTTTTCATTA
-52 4.2 TTGTGATATTATGGACAT
Position: -154
Score: 3.8
Sequence: TTTTATATTATATCACAA
Position: -81
Score: 4.4
Sequence: TAGTGACTTTCTTAACAA
Locus tag: SmuNN2025_0926
SmuNN2025_0926 -154 3.8 TTTTATATTATATCACAA
-81 4.4 TAGTGACTTTCTTAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ldh
Ortholog function: L-lactate dehydrogenase (EC 1.1.1.27)
Lactococcus lactis subsp. cremoris SK11 LACR_1455 -63 4.1 TTGTTGAAAAGATTATAT
Lactococcus lactis subsp. lactis Il1403 L0017 -63 4.1 TTGTTGAAAAGATTATAT
Streptococcus agalactiae 2603V/R SAG0959 -102 4.4 TTGCAAATTTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0911 -77 4.2 ATGACAAACAATTCTCAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1022 -79 3.9 ATGACAAAGACATTACAA
Streptococcus gallolyticus UCN34 GALLO_1129 -106 4 TTTTCAAAGTTTTTACAA
Streptococcus gallolyticus UCN34 GALLO_2034 -85 3.8 TTATTATACAATTCCAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_1232 -118 3.8 TTCTAAAAACGTTTACAT
Streptococcus mitis B6 smi_1006 -62 4.2 AAGTGATAAAATTAAAAT
Streptococcus mutans UA159 SMU.1115 -81 4.4 TAGTGACTTTCTTAACAA
Streptococcus pyogenes M1 GAS SPy1151 -77 4.1 ATGACAAACAATTATCAA
Streptococcus sanguinis SK36 SSA_1221 -116 4.5 TTGTAAAAACGTTTACAT
Streptococcus uberis 0140J SUB0879 -77 4.3 GTGACAAACTATTCACAA
Position: -117
Score: 4.4
Sequence: TTGTTATAAAAAAAACTA
Position: -58
Score: 4.5
Sequence: ATGTTGCATTTTTCACAA
Locus tag: SmuNN2025_0982
SmuNN2025_0982 -117 4.4 TTGTTATAAAAAAAACTA
-58 4.5 ATGTTGCATTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: rex
Ortholog function: Redox-sensitive transcriptional regulator Rex, Rex family
Lactococcus lactis subsp. cremoris SK11 LACR_1156 -74 5.3 TTGATAAAATTATCACAA
Lactococcus lactis subsp. lactis Il1403 L71932 -75 5.3 TTGATAAAATTATCACAA
Streptococcus agalactiae 2603V/R SAG1100 -36 4.5 TAATAAAATTTTTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1050 -31 4.4 TAGTTGCATATTTCACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_1228 -54 4.7 TAGTTGATTTTTTCACAA
Streptococcus mitis B6 smi_1188 -57 5 TTGTTGATTTTTTCACAA
Streptococcus mutans UA159 SMU.1053 -117 4.4 TTGTTATAAAAAAAACTA
-58 4.5 ATGTTGCATTTTTCACAA
Streptococcus pneumoniae TIGR4 SP_1090 -57 5 TTGTTGATTTTTTCACAA
Streptococcus pyogenes M1 GAS SPy1120 -76 4.5 ATGTTGCATTTTTCACAA
Streptococcus sanguinis SK36 SSA_1216 -55 4.7 TAGTTGATTTTTTCACAA
Streptococcus suis 05ZYH33 SSU05_1069 -100 4.5 CTGTTGATTTTTTCACAA
Streptococcus thermophilus CNRZ1066 str1463 -39 4.6 TTGTTGCAATCTTCACAA
Streptococcus uberis 0140J SUB0845 -52 4.4 TTGTTACAATAGTAACAT
Position: -30
Score: 4.2
Sequence: TTGTAAATAAAAGAAGAA
Locus tag: SmuNN2025_1282
SmuNN2025_1282 -30 4.2 TTGTAAATAAAAGAAGAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: tpi
Ortholog function: Triosephosphate isomerase (EC 5.3.1.1)
Streptococcus agalactiae 2603V/R SAG0763 -72 4 TCGTGAAACTTTTAATTA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0629 -97 5.1 TTGTGAAAATATTCCTAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1321 -97 5 TTGTGAAAATATTACTAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0762 -89 4.5 TTGATAAAAACTTAGCAA
Streptococcus pyogenes M1 GAS SPy0613 -97 5.1 TTGTGAAAATATTCCTAA
Streptococcus thermophilus CNRZ1066 str0488 -46 4.7 TTGTGATAAAATAAACGA
Streptococcus uberis 0140J SUB0605 -98 5.2 TTGTGAAAATTATCCCAA
Position: -267
Score: 4.3
Sequence: GTGTTATAATAGTAACAA
Position: -258
Score: 3.8
Sequence: TAGTAACAATAAACATAA
Locus tag: SmuNN2025_1504
SmuNN2025_1504 -267 4.3 GTGTTATAATAGTAACAA
-258 3.8 TAGTAACAATAAACATAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: pncB
Ortholog function: Nicotinate phosphoribosyltransferase (EC 2.4.2.11)
Lactococcus lactis subsp. cremoris SK11 LACR_1202 -218 4 TTGTAGTATAAAAAACAT
Lactococcus lactis subsp. lactis Il1403 L107468 -181 3.9 TTGTAGTACAAAAAACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1714 -39 4.7 ATGTTATAATAGTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1574 -39 4.3 ATGGTATAATAATAACAA
Streptococcus mitis B6 smi_1492 -114 4.3 TTGTTACTCTTTTCTCAA
Streptococcus mutans UA159 SMU.464 -265 4.3 GTGTTATAATAGTAACAA
Streptococcus pneumoniae TIGR4 SP_1421 -114 4.3 TTGTTACTCTTTTCTCAA
Streptococcus pyogenes M1 GAS SPy1653 -39 4.7 ATGTTATAATAGTAACAA
Position: -46
Score: 4.7
Sequence: TTGTGATATAATTATCAT
Locus tag: SmuNN2025_1589
SmuNN2025_1589 -46 4.7 TTGTGATATAATTATCAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: pgk
Ortholog function: Phosphoglycerate kinase (EC 2.7.2.3)
Lactococcus lactis subsp. cremoris SK11 LACR_0248 -91 4.5 TTGTGATATAATTAACCT
Lactococcus lactis subsp. lactis Il1403 L0010 -91 4.5 TTGTGATATAATTAACCT
Streptococcus agalactiae 2603V/R SAG1766 -84 4.7 TTGTGAAAAAGTAATCAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0272 -96 4.3 TTGTGAAATAGTTAATTT
Streptococcus gallolyticus UCN34 GALLO_1995 -137 4.4 TTGTAAAATGATACAGAA
-47 4.5 TTGTGATATAATTAGCAT
Streptococcus gordonii str. Challis substr. CH1 SGO_0209 -46 4.7 TTGTGATATAATTATCAT
Streptococcus mutans UA159 SMU.361 -47 4.7 TTGTGATATAATTATCAT
Streptococcus sanguinis SK36 SSA_0302 -87 4.5 TTGTGAAAATTTTCTTTA
Streptococcus suis 05ZYH33 SSU05_0157 -87 4.4 TTGTGAAAAAAATATCTT
Streptococcus uberis 0140J SUB1629 -96 4.5 TTGTGAAAAAAATAATTT
Position: -134
Score: 4
Sequence: TTCTTAAAATAATTATAT
Position: -81
Score: 4.7
Sequence: AAGTTAATCTTTTCACAA
Locus tag: SmuNN2025_1590
SmuNN2025_1590 -134 4 TTCTTAAAATAATTATAT
-81 4.7 AAGTTAATCTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gap
Ortholog function: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
Streptococcus agalactiae 2603V/R SAG1768 -76 4.4 AAGTTAATCTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1936 -78 4.7 AAGTTAATCTTTTCACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0207 -158 4 ATTTGAAAGAATGAACAA
Streptococcus mutans UA159 SMU.360 -81 4.7 AAGTTAATCTTTTCACAA
Streptococcus pyogenes M1 GAS SPy0274 -79 4.7 AAGTTAATCTTTTCACAA
Streptococcus sanguinis SK36 SSA_2108 -157 4.8 TAGTGAAAGAATTCATAA
Streptococcus thermophilus CNRZ1066 str1788 -50 4.7 AAGTTAATCTTTTCACAA
Streptococcus uberis 0140J SUB1630 -78 4.7 AAGTTAATCTTTTCACAA