Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Propagation of LacR regulog to Streptococcus pyogenes MGAS5005

Reference regulog properties
Source regulog: LacR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: DeoR
Regulation mode: repressor
Biological process: Lactose utilization; Galactose utilization
Effector: D-galactose-6-phosphate
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pyogenes MGAS5005
Orthologous TF(s) M5005_Spy_1639, M5005_Spy_1402
Regulated genes 3
Built upon 37 sites [see more]
Predicted regulatory interactions in Streptococcus pyogenes MGAS5005
Locus tag Position Score Sequence
Position: -171
Score: 7.6
Sequence: AATAAAACA-(1)-AATAAACAA
Position: -170
Score: 6.5
Sequence: ATAAAACAA-(1)-ATAAACAAA
Position: -166
Score: 7.2
Sequence: AACAAAATA-(1)-ACAAAACAA
Position: -161
Score: 7
Sequence: AATAAACAA-(1)-ACAAAAACA
Position: -156
Score: 8.2
Sequence: ACAAAACAA-(1)-AACAAACAT
Locus tag: M5005_Spy_1401
M5005_Spy_1401 -171 7.6 AATAAAACA-(1)-AATAAACAA
-170 6.5 ATAAAACAA-(1)-ATAAACAAA
-166 7.2 AACAAAATA-(1)-ACAAAACAA
-161 7 AATAAACAA-(1)-ACAAAAACA
-156 8.2 ACAAAACAA-(1)-AACAAACAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gatA
Ortholog function: Galactose-specific PTS, EIIA component (EC 2.7.1.69)
Streptococcus agalactiae 2603V/R SAG1935 -137 9.1 AATAAACAA-(1)-AATAAACAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1766 -155 8.6 ATAAAACAA-(1)-AATAAACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_1522 -117 6.5 GAAAAAAAC-(1)-AACAAATAA
Streptococcus pyogenes M1 GAS SPy1711 -166 7.2 AACAAAATA-(1)-ACAAAACAA
-156 8.2 ACAAAACAA-(1)-AACAAACAT
Streptococcus uberis 0140J SUB1460 -155 8.8 AAATAACAA-(1)-AACAAACAA
-145 8.8 AACAAACAA-(1)-AAATAACAA
Position: -41
Score: 6.3
Sequence: GATAAACAT-(1)-AGTAAATAA
Locus tag: M5005_Spy_1402
M5005_Spy_1402 -41 6.3 GATAAACAT-(1)-AGTAAATAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: lacR
Ortholog function: Lactose utilization transcriptional regulator LacR, DeoR family
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1767 -97 -1.4 TTGTTTATT-(1)-TTGTTTTAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0452 -174 -1.9 TTGTTCGAT-(1)-TTGTTTGTT
Streptococcus pyogenes M1 GAS SPy1712 -99 -2 ATGTTTGTT-(1)-TTGTTTTGT
Streptococcus uberis 0140J SUB1461 -89 -1.7 TTGTTATTT-(1)-TTGTTTGTT
-79 -1.7 TTGTTTGTT-(1)-TTGTTATTT
Position: -287
Score: 6.1
Sequence: ATAAAAAAT-(1)-AACAAAATA
Locus tag: M5005_Spy_1639
M5005_Spy_1639 -287 6.1 ATAAAAAAT-(1)-AACAAAATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: lacR
Ortholog function: Lactose utilization transcriptional regulator LacR, DeoR family
Lactococcus lactis subsp. cremoris SK11 LACR_D07 -105 -1.4 TTGTTTGAA-(1)-TTGTTTGTT
Streptococcus agalactiae 2603V/R SAG1936 -91 -2.3 TTGTTTATT-(1)-TTGTTTATT
Streptococcus gallolyticus UCN34 GALLO_0176 -201 -1.1 TTTTTTAAT-(1)-TTGTTTGTT
-191 -1.6 TTGTTTGTT-(1)-TTTTATGTT
Streptococcus mitis B6 smi_1041 -76 -2.3 TTGTTTTCT-(1)-TTGTTTTTT
Streptococcus pneumoniae TIGR4 SP_1182 -88 -0.6 ATTTTTGTT-(1)-TTGTTTTAT
-78 -1.4 TTGTTTTAT-(1)-TTGTTGTTT
Streptococcus pyogenes M1 GAS SPy1924 -113 -1.4 TTGTTAATT-(1)-TTGTTTTTT
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