Propagation of PurR regulog to Streptococcus pyogenes MGAS5005

Reference regulog properties
Source regulog:	PurR - Streptococcaceae
Regulator type:	Transcription factor
Regulator family:	PurR
Regulation mode:	repressor
Biological process:	Purine metabolism
Effector:	5-phosphoribosyl 1-pyrophosphate
Phylum:	Firmicutes
Propagated regulon:
Target genome	Streptococcus pyogenes MGAS5005
Orthologous TF(s)	M5005_Spy_0228
Regulated genes	6

Built upon 100 sites [see more]

Predicted regulatory interactions in *Streptococcus pyogenes MGAS5005*
	Locus tag	Position	Score	Sequence
Position: -78 Score: 4.7 Sequence: AAAAACGAACCTT Position: 14 Score: 4 Sequence: AAAGGCGAATAAT Locus tag: M5005_Spy_0022
	M5005_Spy_0022	-78	4.7	AAAAACGAACCTT
		14	4	AAAGGCGAATAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purC
Ortholog function: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Lactococcus lactis subsp. cremoris SK11	LACR_1622	-132	4.8	ATTTCCGAACATT
		-115	5.1	AAAACCGAACAAT
Lactococcus lactis subsp. lactis Il1403	L177350	-132	4.8	ATTTCCGAACATT
		-115	5.1	AAAACCGAACAAT
Streptococcus agalactiae 2603V/R	SAG0024	-108	4.9	AAATACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0043	-106	5.2	AAAAACGAACATT
		-13	4.2	AAAGACGAATATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0023	-110	5.2	AAAAACGAACATT
		-16	4.3	AAAGGCGAACAAA
Streptococcus gallolyticus UCN34	GALLO_0025	-109	4.3	AATTTCGAACGTT
		-16	4.3	AAAGGCGAACAAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0034	-16	4.8	AAAGGCGAACATT
Streptococcus mitis B6	smi_0066	155	4.3	AAAGGCGAACTTT
Streptococcus mutans UA159	SMU.29	-109	4.8	AAATGCGAACGAT
		-16	4.7	AAAGGCGAACAAT
Streptococcus pneumoniae TIGR4	SP_0044	-16	4.3	AAAGGCGAACTTT
Streptococcus pyogenes M1 GAS	SPy0024	-78	4.7	AAAAACGAACCTT
Streptococcus sanguinis SK36	SSA_0028	-16	4.1	AAAGGCGAATATT
Streptococcus suis 05ZYH33	SSU05_0026	-16	4.8	AAAGGCGAACATT
Streptococcus thermophilus CNRZ1066	str0030	-109	4.9	AAATCCGAACGTT
		-16	4.6	AAAGGCGAACGAT
Streptococcus uberis 0140J	SUB0025	-108	5.2	AAAAACGAACATT
		-15	4.7	AAAGGCGAACAAT

Position: 35 Score: 4.9 Sequence: AAAAGCGAACGTT Locus tag: M5005_Spy_0029
	M5005_Spy_0029	35	4.9	AAAAGCGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purD
Ortholog function: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Lactococcus lactis subsp. cremoris SK11	LACR_1601	-266	4.9	AATTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403	L153005	-224	5	AATACCGAACAAT
Streptococcus agalactiae 2603V/R	SAG0043	-88	4.5	AAAAGCGAACAAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0051	-108	4.9	ATTAACGAACATT
		-57	4.5	ATAAACGAACAAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0030	-14	5	ATAAACGAACAAT
Streptococcus gallolyticus UCN34	GALLO_0032	-116	4.3	ATTTCCGAACAAA
Streptococcus gordonii str. Challis substr. CH1	SGO_2092	-121	4.5	TAAAACGAACGAT
Streptococcus mitis B6	smi_0073	-56	4.6	TAAAACGAACGTT
Streptococcus mutans UA159	SMU.48	-122	3.5	ACTCCCGAACAAA
Streptococcus pneumoniae TIGR4	SP_0051	-56	4.2	TAAAACGAACTTT
Streptococcus pyogenes M1 GAS	SPy0032	-55	4.9	AAAAGCGAACGTT
Streptococcus sanguinis SK36	SSA_0037	-121	4.5	TAAAACGAACGAT
Streptococcus suis 05ZYH33	SSU05_0033	-88	4.5	ATTCCCGAACATT
Streptococcus thermophilus CNRZ1066	str0040	-121	3.8	ATCTCCGAACAAA
Streptococcus uberis 0140J	SUB0053	-57	4	ATTCACGAACAAA

Position: -205 Score: 4.7 Sequence: AAAACCGAACTTT Locus tag: M5005_Spy_0857
	M5005_Spy_0857	-205	4.7	AAAACCGAACTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: guaC
Ortholog function: GMP reductase (EC 1.7.1.7)
Lactococcus lactis subsp. cremoris SK11	LACR_1256	-232	4.7	ATTTCCGAACGTT
Lactococcus lactis subsp. lactis Il1403	L158186	-227	3.9	ATTTCCGAATGAT
Streptococcus agalactiae 2603V/R	SAG1087	-149	5.2	AAAAACGAACATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0894	-205	5.2	AAAACCGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1036	-209	5	AAAAACGAACGTT
Streptococcus gallolyticus UCN34	GALLO_1025	-260	5.2	AAAAACGAACATT
Streptococcus gordonii str. Challis substr. CH1	SGO_1159	-146	4.7	ATTTCCGAACGTT
Streptococcus mitis B6	smi_1212	-141	4.9	AAATCCGAACGAT
Streptococcus pneumoniae TIGR4	SP_1249	-141	4.6	AAACCCGAACGAT
Streptococcus pyogenes M1 GAS	SPy1135	-205	4.7	AAAACCGAACTTT
Streptococcus suis 05ZYH33	SSU05_0815	-87	4.3	AATTCTGAACATT
Streptococcus uberis 0140J	SUB0865	-187	4.6	AAATCCGAACAAA

Position: -93 Score: 5.1 Sequence: AAAAACGAACAAT Locus tag: M5005_Spy_0927
	M5005_Spy_0927	-93	5.1	AAAAACGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: fhs
Ortholog function: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Lactococcus lactis subsp. cremoris SK11	LACR_1007	-134	4.8	ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403	L159505	-131	4.8	ATTTCCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1033	-93	5.2	AAAAACGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0945	-94	4.9	AAAAGCGAACGTT
Streptococcus gallolyticus UCN34	GALLO_1115	-100	4.8	AAACACGAACATT
Streptococcus gordonii str. Challis substr. CH1	SGO_1210	-95	4.8	AAACACGAACAAT
Streptococcus mitis B6	smi_1192	-90	4.2	TTTTACGAACGTT
Streptococcus mutans UA159	SMU.1073	-90	5.1	AAATCCGAACATT
Streptococcus pneumoniae TIGR4	SP_1229	-172	4.6	AAAAACGAAGATT
		-89	4.7	ATTTACGAACGTT
Streptococcus pyogenes M1 GAS	SPy1213	-93	5.1	AAAAACGAACAAT
Streptococcus sanguinis SK36	SSA_1200	-93	4.1	TTTCCCGAACATT
Streptococcus suis 05ZYH33	SSU05_0690	-97	4.1	AATTCCGTACGTT
Streptococcus thermophilus CNRZ1066	str0791	-94	5.2	AAAACCGAACATT

Position: -102 Score: 4.6 Sequence: TAATACGAACAAT Locus tag: M5005_Spy_1477
	M5005_Spy_1477	-102	4.6	TAATACGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: pbuO
Ortholog function: Guanine/hypoxanthine permease
Lactococcus lactis subsp. cremoris SK11	LACR_1894	-184	4.7	ATTACCGAACGAT
Lactococcus lactis subsp. lactis Il1403	L171588	-184	4.9	ATTACCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1804	-143	4.3	AAATAAGAACAAT
		-100	5	AAATACGAACAAT
Streptococcus gallolyticus UCN34	GALLO_0354	-96	4.3	AAAAGTGAACAAT
Streptococcus pyogenes M1 GAS	SPy1736	-102	5	AATACCGAACAAT
Streptococcus uberis 0140J	SUB1480	-166	4.9	AAAAGCGAACGTT

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Propagation of PurR regulog to Streptococcus pyogenes MGAS5005

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --