Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of PurR regulog to Streptococcus pyogenes MGAS5005

Reference regulog properties
Source regulog: PurR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: PurR
Regulation mode: repressor
Biological process: Purine metabolism
Effector: 5-phosphoribosyl 1-pyrophosphate
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pyogenes MGAS5005
Orthologous TF(s) M5005_Spy_0228
Regulated genes 6
Built upon 100 sites [see more]
Predicted regulatory interactions in Streptococcus pyogenes MGAS5005
Locus tag Position Score Sequence
Position: -78
Score: 4.7
Sequence: AAAAACGAACCTT
Position: 14
Score: 4
Sequence: AAAGGCGAATAAT
Locus tag: M5005_Spy_0022
M5005_Spy_0022 -78 4.7 AAAAACGAACCTT
14 4 AAAGGCGAATAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purC
Ortholog function: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Lactococcus lactis subsp. cremoris SK11 LACR_1622 -132 4.8 ATTTCCGAACATT
-115 5.1 AAAACCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L177350 -132 4.8 ATTTCCGAACATT
-115 5.1 AAAACCGAACAAT
Streptococcus agalactiae 2603V/R SAG0024 -108 4.9 AAATACGAACGTT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0043 -106 5.2 AAAAACGAACATT
-13 4.2 AAAGACGAATATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0023 -110 5.2 AAAAACGAACATT
-16 4.3 AAAGGCGAACAAA
Streptococcus gallolyticus UCN34 GALLO_0025 -109 4.3 AATTTCGAACGTT
-16 4.3 AAAGGCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0034 -16 4.8 AAAGGCGAACATT
Streptococcus mitis B6 smi_0066 155 4.3 AAAGGCGAACTTT
Streptococcus mutans UA159 SMU.29 -109 4.8 AAATGCGAACGAT
-16 4.7 AAAGGCGAACAAT
Streptococcus pneumoniae TIGR4 SP_0044 -16 4.3 AAAGGCGAACTTT
Streptococcus pyogenes M1 GAS SPy0024 -78 4.7 AAAAACGAACCTT
Streptococcus sanguinis SK36 SSA_0028 -16 4.1 AAAGGCGAATATT
Streptococcus suis 05ZYH33 SSU05_0026 -16 4.8 AAAGGCGAACATT
Streptococcus thermophilus CNRZ1066 str0030 -109 4.9 AAATCCGAACGTT
-16 4.6 AAAGGCGAACGAT
Streptococcus uberis 0140J SUB0025 -108 5.2 AAAAACGAACATT
-15 4.7 AAAGGCGAACAAT
Position: 35
Score: 4.9
Sequence: AAAAGCGAACGTT
Locus tag: M5005_Spy_0029
M5005_Spy_0029 35 4.9 AAAAGCGAACGTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: purD
Ortholog function: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Lactococcus lactis subsp. cremoris SK11 LACR_1601 -266 4.9 AATTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L153005 -224 5 AATACCGAACAAT
Streptococcus agalactiae 2603V/R SAG0043 -88 4.5 AAAAGCGAACAAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0051 -108 4.9 ATTAACGAACATT
-57 4.5 ATAAACGAACAAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0030 -14 5 ATAAACGAACAAT
Streptococcus gallolyticus UCN34 GALLO_0032 -116 4.3 ATTTCCGAACAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_2092 -121 4.5 TAAAACGAACGAT
Streptococcus mitis B6 smi_0073 -56 4.6 TAAAACGAACGTT
Streptococcus mutans UA159 SMU.48 -122 3.5 ACTCCCGAACAAA
Streptococcus pneumoniae TIGR4 SP_0051 -56 4.2 TAAAACGAACTTT
Streptococcus pyogenes M1 GAS SPy0032 -55 4.9 AAAAGCGAACGTT
Streptococcus sanguinis SK36 SSA_0037 -121 4.5 TAAAACGAACGAT
Streptococcus suis 05ZYH33 SSU05_0033 -88 4.5 ATTCCCGAACATT
Streptococcus thermophilus CNRZ1066 str0040 -121 3.8 ATCTCCGAACAAA
Streptococcus uberis 0140J SUB0053 -57 4 ATTCACGAACAAA
Position: -205
Score: 4.7
Sequence: AAAACCGAACTTT
Locus tag: M5005_Spy_0857
M5005_Spy_0857 -205 4.7 AAAACCGAACTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: guaC
Ortholog function: GMP reductase (EC 1.7.1.7)
Lactococcus lactis subsp. cremoris SK11 LACR_1256 -232 4.7 ATTTCCGAACGTT
Lactococcus lactis subsp. lactis Il1403 L158186 -227 3.9 ATTTCCGAATGAT
Streptococcus agalactiae 2603V/R SAG1087 -149 5.2 AAAAACGAACATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0894 -205 5.2 AAAACCGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1036 -209 5 AAAAACGAACGTT
Streptococcus gallolyticus UCN34 GALLO_1025 -260 5.2 AAAAACGAACATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1159 -146 4.7 ATTTCCGAACGTT
Streptococcus mitis B6 smi_1212 -141 4.9 AAATCCGAACGAT
Streptococcus pneumoniae TIGR4 SP_1249 -141 4.6 AAACCCGAACGAT
Streptococcus pyogenes M1 GAS SPy1135 -205 4.7 AAAACCGAACTTT
Streptococcus suis 05ZYH33 SSU05_0815 -87 4.3 AATTCTGAACATT
Streptococcus uberis 0140J SUB0865 -187 4.6 AAATCCGAACAAA
Position: -93
Score: 5.1
Sequence: AAAAACGAACAAT
Locus tag: M5005_Spy_0927
M5005_Spy_0927 -93 5.1 AAAAACGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: fhs
Ortholog function: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Lactococcus lactis subsp. cremoris SK11 LACR_1007 -134 4.8 ATTTCCGAACAAT
Lactococcus lactis subsp. lactis Il1403 L159505 -131 4.8 ATTTCCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1033 -93 5.2 AAAAACGAACATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0945 -94 4.9 AAAAGCGAACGTT
Streptococcus gallolyticus UCN34 GALLO_1115 -100 4.8 AAACACGAACATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1210 -95 4.8 AAACACGAACAAT
Streptococcus mitis B6 smi_1192 -90 4.2 TTTTACGAACGTT
Streptococcus mutans UA159 SMU.1073 -90 5.1 AAATCCGAACATT
Streptococcus pneumoniae TIGR4 SP_1229 -172 4.6 AAAAACGAAGATT
-89 4.7 ATTTACGAACGTT
Streptococcus pyogenes M1 GAS SPy1213 -93 5.1 AAAAACGAACAAT
Streptococcus sanguinis SK36 SSA_1200 -93 4.1 TTTCCCGAACATT
Streptococcus suis 05ZYH33 SSU05_0690 -97 4.1 AATTCCGTACGTT
Streptococcus thermophilus CNRZ1066 str0791 -94 5.2 AAAACCGAACATT
Position: -102
Score: 4.6
Sequence: TAATACGAACAAT
Locus tag: M5005_Spy_1477
M5005_Spy_1477 -102 4.6 TAATACGAACAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: pbuO
Ortholog function: Guanine/hypoxanthine permease
Lactococcus lactis subsp. cremoris SK11 LACR_1894 -184 4.7 ATTACCGAACGAT
Lactococcus lactis subsp. lactis Il1403 L171588 -184 4.9 ATTACCGAACAAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1804 -143 4.3 AAATAAGAACAAT
-100 5 AAATACGAACAAT
Streptococcus gallolyticus UCN34 GALLO_0354 -96 4.3 AAAAGTGAACAAT
Streptococcus pyogenes M1 GAS SPy1736 -102 5 AATACCGAACAAT
Streptococcus uberis 0140J SUB1480 -166 4.9 AAAAGCGAACGTT