Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CmbR regulog to Streptococcus pneumoniae SP18-BS74

Reference regulog properties
Source regulog: CmbR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Cysteine metabolism
Effector: O-acetyl-L-serine
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pneumoniae SP18-BS74
Orthologous TF(s) CGSSp18BS74_03779, CGSSp18BS74_09510
Regulated genes 5
Built upon 104 sites [see more]
Predicted regulatory interactions in Streptococcus pneumoniae SP18-BS74
Locus tag Position Score Sequence
Position: -251
Score: 4.5
Sequence: GTTATAGTCTTTTCTAATAAC
Position: -218
Score: 4.9
Sequence: CTTATAAGAATTACTAATAAC
Locus tag: CGSSp18BS74_09030
CGSSp18BS74_09030 -251 4.5 GTTATAGTCTTTTCTAATAAC
-218 4.9 CTTATAAGAATTACTAATAAC
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Lactococcus lactis subsp. cremoris SK11 LACR_1368 -39 4.7 TTGATAAGATAGACCTATTAA
Lactococcus lactis subsp. lactis Il1403 L0100 -76 4.1 ATCATATTAAAAATGTATTAT
-39 4.7 TTGATAAGATAGACCTATTAA
Streptococcus agalactiae 2603V/R SAG2049 -109 4.1 GCTAAAAATATAAAATATTAA
Streptococcus gallolyticus UCN34 GALLO_1316 -221 4.2 ATAATAAATTTTATTAATCTA
-172 4.6 GTTATAGTTAAAAACTATAAT
Streptococcus gordonii str. Challis substr. CH1 SGO_0310 -182 4.2 GTTATAGTTTTTGATTATACC
Streptococcus mutans UA159 SMU.873 -188 4.6 GTTATAGATGAAAACTATAAC
Streptococcus pneumoniae TIGR4 SP_0585 -218 4.9 CTTATAAGAATTACTAATAAC
Streptococcus sanguinis SK36 SSA_0416 -182 4.3 GTCATAATTTCTACCTATAGC
Streptococcus suis 05ZYH33 SSU05_1774 -237 4.3 TTCATAGATAAAATCTATACC
Streptococcus thermophilus CNRZ1066 str0785 -119 4.2 GCTATACAAATATCTAATTAA
Position: -102
Score: 4.8
Sequence: ATGGTAAAAAATCCTTATAAC
Position: -80
Score: 4.4
Sequence: GCAATAAAAAATAGATATTAT
Locus tag: CGSSp18BS74_09640
CGSSp18BS74_09640 -102 4.8 ATGGTAAAAAATCCTTATAAC
-80 4.4 GCAATAAAAAATAGATATTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: str1582
Ortholog function: Predicted polar amino acid ABC transporter, permease protein 1
Streptococcus gallolyticus UCN34 GALLO_1237 -96 5.3 GCTATAAAAATTATTTATGGC
Streptococcus gordonii str. Challis substr. CH1 SGO_0985 -139 5.2 CTTATAAATTTTTTCTATCAG
-117 4.9 CCGATAAAATATACATATTAT
Streptococcus mitis B6 smi_1436 -102 5.5 ATGATAAAAAATCCTTATAAC
-80 4.4 GCAATAAAAAATAGATATTAT
Streptococcus pneumoniae TIGR4 SP_0711 -140 4.4 GCAATAAAAAATAGATATTAT
Streptococcus thermophilus CNRZ1066 str1582 -237 4.8 GTTATATCTTTTCTTTATCAC
-215 5.2 TTGATAAAAAATACATATTAT
Position: -103
Score: 5.2
Sequence: TCCATAAAAAATGTTTATCAC
Locus tag: CGSSp18BS74_12126
CGSSp18BS74_12126 -103 5.2 TCCATAAAAAATGTTTATCAC
Supported by regulated orthologs from reference regulons
Ortholog gene name: yvdE
Ortholog function: Predicted glutamine amidotransferase, class I
Streptococcus gallolyticus UCN34 GALLO_1848 -98 5.2 GTGATAAAAAAAATCTATTGG
-61 5 AGGATAGAATAATCTTATCAC
Streptococcus gordonii str. Challis substr. CH1 SGO_0167 -97 5.5 TTGATAAAAAATTTTTATAAG
Streptococcus pneumoniae TIGR4 SP_2072 -64 5.2 TCCATAAAAAATGTTTATCAC
Streptococcus sanguinis SK36 SSA_2164 -100 5.8 CTGATAAAAAATTTTTATAAC
Streptococcus suis 05ZYH33 SSU05_1773 -95 5.3 CTGATAGTTATTTTTTATCAA
Position: -142
Score: 5.2
Sequence: TTGATAGATAAAATATATAAC
Locus tag: CGSSp18BS74_00406
CGSSp18BS74_00406 -142 5.2 TTGATAGATAAAATATATAAC
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyB
Ortholog function: Cystine ABC transporter, permease protein
Lactococcus lactis subsp. cremoris SK11 LACR_1010 -77 5.1 GCTATAAGTTTTTTTTATGGC
Lactococcus lactis subsp. lactis Il1403 L163056 -77 5.1 GCTATAAGTTTTTTTTATGGC
Streptococcus agalactiae 2603V/R SAG0291 -96 5.5 TTGATATAAAATCTTTATCAC
-75 4.7 CTGATAAGGAAATACTATTAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1719 -99 5.3 GTGATAAGTTTTGCTTATTGC
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1580 -106 5 GCGATAGGCTTTTCTTATCGT
Streptococcus gallolyticus UCN34 GALLO_0415 -100 5.2 CTGATAGTTTTTTCTTATCAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0578 -170 4.7 GTCATAAAATTTGCTTATACC
-148 4.3 TTGATAAATAATTTATACTGT
Streptococcus mitis B6 smi_1382 -164 4.7 GAGATAGTTTTTACTTATCTC
-142 5 TTGATAGATAAAATATATAGC
Streptococcus mutans UA159 SMU.460 -102 5.8 GTGATAGAAAAATATTATCAC
-80 5 GTGATAGGAAAAAACTATTAT
Streptococcus pneumoniae TIGR4 SP_1461 -164 4.3 GAAATAGTTTTTATCTATCTC
-142 5.2 TTGATAGATAAAATATATAAC
Streptococcus sanguinis SK36 SSA_1868 -250 5.4 GTGATATACTTTTCTTATCGC
-228 5.3 GTGATAAGAAAAATATATTAG
Streptococcus thermophilus CNRZ1066 str1653 -217 5.8 GTGATATGATTTACTTATCAC
Streptococcus uberis 0140J SUB1415 -80 4.8 GTGATAGGCTTTAACTATTGC
Position: -98
Score: 4.6
Sequence: GATATATAGAAATCCTATCGC
Locus tag: CGSSp18BS74_00220
CGSSp18BS74_00220 -98 4.6 GATATATAGAAATCCTATCGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Lactococcus lactis subsp. lactis Il1403 L0089 -79 5.3 GCTATAAAAAAATCTTATAGC
Lactococcus lactis subsp. lactis Il1403 L0088 -87 4.5 ATCATAAATTTTTTTTAGAGC
Streptococcus mitis B6 smi_2060 -98 5.3 GATATAAAAAAATCCTATCAC
Streptococcus thermophilus CNRZ1066 str0366 -16 5.2 ATGATAAAATTTTTTTATGGA
Streptococcus uberis 0140J SUB1379 -104 5.1 ATGATAAGCCTTTCCTATCAC