Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CmbR regulog to Lactococcus lactis subsp. lactis Il1403

Reference regulog properties
Source regulog: CmbR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Cysteine metabolism
Effector: O-acetyl-L-serine
Phylum: Firmicutes
Propagated regulon:
Target genome Lactococcus lactis subsp. lactis Il1403
Orthologous TF(s) L0219
Regulated genes 10
Built upon 104 sites [see more]
Predicted regulatory interactions in Lactococcus lactis subsp. lactis Il1403
Locus tag Position Score Sequence
Position: -172
Score: 4.2
Sequence: TCCATTAAAAAATCATATCGA
Locus tag: L75975
L75975 -172 4.2 TCCATTAAAAAATCATATCGA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysD
Ortholog function: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
Lactococcus lactis subsp. cremoris SK11 LACR_0068 -171 4.4 ACTATTTAAAAATTCTATAAC
Lactococcus lactis subsp. lactis Il1403 L75975 -172 4.2 TCCATTAAAAAATCATATCGA
Position: -16
Score: 4.5
Sequence: ATGAAAGGATTTATTTATGAA
Locus tag: L120334
L120334 -16 4.5 ATGAAAGGATTTATTTATGAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: plp
Ortholog function: Methionine ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_0360 -476 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. cremoris SK11 LACR_0361 -476 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. cremoris SK11 LACR_0362 -476 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. cremoris SK11 LACR_0364 -476 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. lactis Il1403 L117444 -514 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. lactis Il1403 L118475 -514 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. lactis Il1403 L119452 -514 4.4 TTTATAAATTAAACTTAAAAA
Lactococcus lactis subsp. lactis Il1403 L120334 -514 4.4 TTTATAAATTAAACTTAAAAA
Position: -87
Score: 4.5
Sequence: ATCATAAATTTTTTTTAGAGC
Locus tag: L0088
L0088 -87 4.5 ATCATAAATTTTTTTTAGAGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Lactococcus lactis subsp. lactis Il1403 L0089 -79 5.3 GCTATAAAAAAATCTTATAGC
Lactococcus lactis subsp. lactis Il1403 L0088 -87 4.5 ATCATAAATTTTTTTTAGAGC
Streptococcus mitis B6 smi_2060 -98 5.3 GATATAAAAAAATCCTATCAC
Streptococcus thermophilus CNRZ1066 str0366 -16 5.2 ATGATAAAATTTTTTTATGGA
Streptococcus uberis 0140J SUB1379 -104 5.1 ATGATAAGCCTTTCCTATCAC
Position: -59
Score: 4.8
Sequence: TTGAAAAAATATTTTTATTAG
Locus tag: L167675
L167675 -59 4.8 TTGAAAAAATATTTTTATTAG
Supported by regulated orthologs from reference regulons
Ortholog gene name: dfpB
Ortholog function: Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)
Lactococcus lactis subsp. lactis Il1403 L167675 -59 4.8 TTGAAAAAATATTTTTATTAG
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0944 -177 4.7 TTGATAGTATCATTATATCAC
-10 4.3 CTGATAAAATATGGCTATGAA
Streptococcus thermophilus CNRZ1066 str0790 -83 4.3 GTTATAACTTTATTTTATATG
Position: -79
Score: 5.3
Sequence: GCTATAAAAAAATCTTATAGC
Locus tag: L0181
L0181 -79 5.3 GCTATAAAAAAATCTTATAGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: metB2
Ortholog function: Cystathionine gamma-lyase (EC 4.4.1.1)
Lactococcus lactis subsp. lactis Il1403 L0181 -79 5.3 GCTATAAAAAAATCTTATAGC
Position: -77
Score: 5.1
Sequence: GCTATAAGTTTTTTTTATGGC
Locus tag: L162009
L162009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyA
Ortholog function: Cystine ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_1009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Lactococcus lactis subsp. lactis Il1403 L162009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Streptococcus agalactiae 2603V/R SAG0290 -96 5.5 TTGATATAAAATCTTTATCAC
-75 4.7 CTGATAAGGAAATACTATTAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1582 -98 4.7 TTGATACTATTTTCTTATTGC
-76 4.2 TTGATAGAGAAATGATATTAT
Streptococcus gallolyticus UCN34 GALLO_0414 -100 5.2 CTGATAGTTTTTTCTTATCAA
Streptococcus mutans UA159 SMU.459 -102 5.8 GTGATAGAAAAATATTATCAC
-80 5 GTGATAGGAAAAAACTATTAT
Streptococcus uberis 0140J SUB1416 -98 4.5 GTCATATAAATAGCTAATTAC
-76 4.2 TTGATAGAAAAATGGTATTAT
Position: -76
Score: 4.1
Sequence: ATCATATTAAAAATGTATTAT
Position: -39
Score: 4.7
Sequence: TTGATAAGATAGACCTATTAA
Locus tag: L0100
L0100 -76 4.1 ATCATATTAAAAATGTATTAT
-39 4.7 TTGATAAGATAGACCTATTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Lactococcus lactis subsp. cremoris SK11 LACR_1368 -39 4.7 TTGATAAGATAGACCTATTAA
Lactococcus lactis subsp. lactis Il1403 L0100 -76 4.1 ATCATATTAAAAATGTATTAT
-39 4.7 TTGATAAGATAGACCTATTAA
Streptococcus agalactiae 2603V/R SAG2049 -109 4.1 GCTAAAAATATAAAATATTAA
Streptococcus gallolyticus UCN34 GALLO_1316 -221 4.2 ATAATAAATTTTATTAATCTA
-172 4.6 GTTATAGTTAAAAACTATAAT
Streptococcus gordonii str. Challis substr. CH1 SGO_0310 -182 4.2 GTTATAGTTTTTGATTATACC
Streptococcus mutans UA159 SMU.873 -188 4.6 GTTATAGATGAAAACTATAAC
Streptococcus pneumoniae TIGR4 SP_0585 -218 4.9 CTTATAAGAATTACTAATAAC
Streptococcus sanguinis SK36 SSA_0416 -182 4.3 GTCATAATTTCTACCTATAGC
Streptococcus suis 05ZYH33 SSU05_1774 -237 4.3 TTCATAGATAAAATCTATACC
Streptococcus thermophilus CNRZ1066 str0785 -119 4.2 GCTATACAAATATCTAATTAA
Position: -132
Score: 4.3
Sequence: GCCATAGGCAAGTTTTATTAT
Locus tag: L0101
L0101 -132 4.3 GCCATAGGCAAGTTTTATTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: metA
Ortholog function: Homoserine O-succinyltransferase (EC 2.3.1.46)
Lactococcus lactis subsp. lactis Il1403 L0101 -132 4.3 GCCATAGGCAAGTTTTATTAT
Streptococcus gallolyticus UCN34 GALLO_0824 -107 4.3 ATTATAGCTAAAAACTATAAC
Streptococcus pneumoniae TIGR4 SP_1576 -145 4.6 GATATAAAAATAGACTATAAC
Streptococcus suis 05ZYH33 SSU05_1306 -46 4.7 GTTATAGCCAAAACTTATAAC
Position: -136
Score: 4.7
Sequence: GTCATAAATCTTTTTTATGGT
Locus tag: L121253
L121253 -136 4.7 GTCATAAATCTTTTTTATGGT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gshT
Ortholog function: Predicted glutathione ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_2344 -136 4.5 ATCATAAATCTTTTTTATGGT
Lactococcus lactis subsp. lactis Il1403 L121253 -136 4.7 GTCATAAATCTTTTTTATGGT
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