Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Propagation of CmbR regulog to Streptococcus gallolyticus UCN34

Reference regulog properties
Source regulog: CmbR - Streptococcaceae
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Cysteine metabolism
Effector: O-acetyl-L-serine
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus gallolyticus UCN34
Orthologous TF(s) GALLO_0943, GALLO_1340
Regulated genes 11
Built upon 104 sites [see more]
Predicted regulatory interactions in Streptococcus gallolyticus UCN34
Locus tag Position Score Sequence
Position: -100
Score: 5.2
Sequence: CTGATAGTTTTTTCTTATCAA
Locus tag: GALLO_0414
GALLO_0414 -100 5.2 CTGATAGTTTTTTCTTATCAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyA
Ortholog function: Cystine ABC transporter, substrate-binding protein
Lactococcus lactis subsp. cremoris SK11 LACR_1009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Lactococcus lactis subsp. lactis Il1403 L162009 -77 5.1 GCTATAAGTTTTTTTTATGGC
Streptococcus agalactiae 2603V/R SAG0290 -96 5.5 TTGATATAAAATCTTTATCAC
-75 4.7 CTGATAAGGAAATACTATTAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1582 -98 4.7 TTGATACTATTTTCTTATTGC
-76 4.2 TTGATAGAGAAATGATATTAT
Streptococcus gallolyticus UCN34 GALLO_0414 -100 5.2 CTGATAGTTTTTTCTTATCAA
Streptococcus mutans UA159 SMU.459 -102 5.8 GTGATAGAAAAATATTATCAC
-80 5 GTGATAGGAAAAAACTATTAT
Streptococcus uberis 0140J SUB1416 -98 4.5 GTCATATAAATAGCTAATTAC
-76 4.2 TTGATAGAAAAATGGTATTAT
Position: -85
Score: 4.4
Sequence: TTGATAAGAAATATGTATTTT
Locus tag: GALLO_0500
GALLO_0500 -85 4.4 TTGATAAGAAATATGTATTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Lactococcus lactis subsp. lactis Il1403 L0089 -79 5.3 GCTATAAAAAAATCTTATAGC
Lactococcus lactis subsp. lactis Il1403 L0088 -87 4.5 ATCATAAATTTTTTTTAGAGC
Streptococcus mitis B6 smi_2060 -98 5.3 GATATAAAAAAATCCTATCAC
Streptococcus thermophilus CNRZ1066 str0366 -16 5.2 ATGATAAAATTTTTTTATGGA
Streptococcus uberis 0140J SUB1379 -104 5.1 ATGATAAGCCTTTCCTATCAC
Position: -96
Score: 5.3
Sequence: GCTATAAAAATTATTTATGGC
Locus tag: GALLO_1237
GALLO_1237 -96 5.3 GCTATAAAAATTATTTATGGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: str1582
Ortholog function: Predicted polar amino acid ABC transporter, permease protein 1
Streptococcus gallolyticus UCN34 GALLO_1237 -96 5.3 GCTATAAAAATTATTTATGGC
Streptococcus gordonii str. Challis substr. CH1 SGO_0985 -139 5.2 CTTATAAATTTTTTCTATCAG
-117 4.9 CCGATAAAATATACATATTAT
Streptococcus mitis B6 smi_1436 -102 5.5 ATGATAAAAAATCCTTATAAC
-80 4.4 GCAATAAAAAATAGATATTAT
Streptococcus pneumoniae TIGR4 SP_0711 -140 4.4 GCAATAAAAAATAGATATTAT
Streptococcus thermophilus CNRZ1066 str1582 -237 4.8 GTTATATCTTTTCTTTATCAC
-215 5.2 TTGATAAAAAATACATATTAT
Position: -104
Score: 4.9
Sequence: GCTATAAGCAAATCTTATGGC
Locus tag: GALLO_1275
GALLO_1275 -104 4.9 GCTATAAGCAAATCTTATGGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: tcyD
Ortholog function: Predicted uroporphyrinogen-III decarboxylase
Streptococcus gallolyticus UCN34 GALLO_1275 -104 4.9 GCTATAAGCAAATCTTATGGC
Streptococcus mutans UA159 SMU.932 -168 5 GTGATAACTTTTTCTTATGGC
-103 5.3 GTCATAAATAAAATTTATAGC
Streptococcus sanguinis SK36 SSA_2105 -194 5.3 TTGATAAAAATTACCTATCTC
-59 5.1 TTGATAAATATTTTTAATCAG
Streptococcus sanguinis SK36 SSA_2102 -194 5.3 TTGATAAAAATTACCTATCTC
-59 5.1 TTGATAAATATTTTTAATCAG
Position: -113
Score: 5.9
Sequence: GTTATAAAAAAATCTTATCAC
Locus tag: GALLO_1277
GALLO_1277 -113 5.9 GTTATAAAAAAATCTTATCAC
Supported by regulated orthologs from reference regulons
Ortholog gene name: homR
Ortholog function: Homocysteine biosynthesis transcriptional regulato HomR, LysR family
Streptococcus gallolyticus UCN34 GALLO_1277 -175 4.4 ATAATCTAAATTTTTTATTAT
-113 5.9 GTTATAAAAAAATCTTATCAC
Streptococcus mutans UA159 SMU.930c -175 5.3 GCTATAAATTTTATTTATGAC
-110 5 GCCATAAGAAAAAGTTATCAC
Streptococcus thermophilus CNRZ1066 str0452 -108 5.3 TTTATAAAAATTTCATATCAG
Position: -172
Score: 4.6
Sequence: GTTATAGTTAAAAACTATAAT
Locus tag: GALLO_1316
GALLO_1316 -172 4.6 GTTATAGTTAAAAACTATAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Lactococcus lactis subsp. cremoris SK11 LACR_1368 -39 4.7 TTGATAAGATAGACCTATTAA
Lactococcus lactis subsp. lactis Il1403 L0100 -76 4.1 ATCATATTAAAAATGTATTAT
-39 4.7 TTGATAAGATAGACCTATTAA
Streptococcus agalactiae 2603V/R SAG2049 -109 4.1 GCTAAAAATATAAAATATTAA
Streptococcus gallolyticus UCN34 GALLO_1316 -221 4.2 ATAATAAATTTTATTAATCTA
-172 4.6 GTTATAGTTAAAAACTATAAT
Streptococcus gordonii str. Challis substr. CH1 SGO_0310 -182 4.2 GTTATAGTTTTTGATTATACC
Streptococcus mutans UA159 SMU.873 -188 4.6 GTTATAGATGAAAACTATAAC
Streptococcus pneumoniae TIGR4 SP_0585 -218 4.9 CTTATAAGAATTACTAATAAC
Streptococcus sanguinis SK36 SSA_0416 -182 4.3 GTCATAATTTCTACCTATAGC
Streptococcus suis 05ZYH33 SSU05_1774 -237 4.3 TTCATAGATAAAATCTATACC
Streptococcus thermophilus CNRZ1066 str0785 -119 4.2 GCTATACAAATATCTAATTAA
Position: -142
Score: 5
Sequence: GTTATAGTTTTTACTTATAGC
Locus tag: GALLO_1768
GALLO_1768 -142 5 GTTATAGTTTTTACTTATAGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: metB1
Ortholog function: Cystathionine gamma-synthase (EC 2.5.1.48)
Lactococcus lactis subsp. lactis Il1403 L0102 -132 4.3 GCCATAGGCAAGTTTTATTAT
Streptococcus gallolyticus UCN34 GALLO_1768 -142 5 GTTATAGTTTTTACTTATAGC
Streptococcus mutans UA159 SMU.1675 -110 4.3 CTTATAGTTTCTTTTTATAGC
Streptococcus suis 05ZYH33 SSU05_1562 -120 5.1 GTTATAAAGAAAAACTATAAC
Streptococcus thermophilus CNRZ1066 str0352 -132 4.5 GTTATAGTAATAAACTATATC
Position: -122
Score: 6
Sequence: GTGATAAGTTTTATTTATCAC
Locus tag: GALLO_1845
GALLO_1845 -122 6 GTGATAAGTTTTATTTATCAC
Supported by regulated orthologs from reference regulons
Ortholog gene name: gshT
Ortholog function: Predicted glutathione ABC transporter, substrate-binding protein
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0381 -75 5 TTGATAGGAATTAATTATTAG
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1680 -41 5 ATGATAAACTAATCTTATGAA
Streptococcus gallolyticus UCN34 GALLO_1845 -122 6 GTGATAAGTTTTATTTATCAC
Streptococcus mitis B6 smi_1945 -99 5.1 GCCATAAAGAAAACCTATCAC
Streptococcus mutans UA159 SMU.1942c -98 6 GTGATAGAATTTTCTTATCAC
-76 4.6 GTGATAGAAATTATATAATAG
Streptococcus pyogenes M1 GAS SPy0317 -75 4.5 TTGATAGGAATCAATTATTAG
Streptococcus thermophilus CNRZ1066 str0296 -98 5.7 GTGATAGTATTTTCTTATCAC
Streptococcus uberis 0140J SUB0365 -93 4.9 GTGATAGAGAACTATTATCAT
-71 4.2 GCGATAGTGAATCACTATTAG
Position: -98
Score: 5.2
Sequence: GTGATAAAAAAAATCTATTGG
Locus tag: GALLO_1848
GALLO_1848 -98 5.2 GTGATAAAAAAAATCTATTGG
Supported by regulated orthologs from reference regulons
Ortholog gene name: yvdE
Ortholog function: Predicted glutamine amidotransferase, class I
Streptococcus gallolyticus UCN34 GALLO_1848 -98 5.2 GTGATAAAAAAAATCTATTGG
-61 5 AGGATAGAATAATCTTATCAC
Streptococcus gordonii str. Challis substr. CH1 SGO_0167 -97 5.5 TTGATAAAAAATTTTTATAAG
Streptococcus pneumoniae TIGR4 SP_2072 -64 5.2 TCCATAAAAAATGTTTATCAC
Streptococcus sanguinis SK36 SSA_2164 -100 5.8 CTGATAAAAAATTTTTATAAC
Streptococcus suis 05ZYH33 SSU05_1773 -95 5.3 CTGATAGTTATTTTTTATCAA
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