Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of Rex regulog to Streptococcus pyogenes MGAS10394

Reference regulog properties
Source regulog: Rex - Streptococcaceae
Regulator type: Transcription factor
Regulator family: Rex
Regulation mode: repressor
Biological process: Energy metabolism
Effector: NADH
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pyogenes MGAS10394
Orthologous TF(s) M6_Spy0840
Regulated genes 13
Built upon 161 sites [see more]
Predicted regulatory interactions in Streptococcus pyogenes MGAS10394
Locus tag Position Score Sequence
Position: -112
Score: 5.2
Sequence: TTGAAAAAAACTTCACAA
Position: -89
Score: 4.7
Sequence: TCGTGAAATGATTTACAA
Position: -34
Score: 5.5
Sequence: TTGTGAAACTTTTAACAA
Locus tag: M6_Spy0088
M6_Spy0088 -112 5.2 TTGAAAAAAACTTCACAA
-89 4.7 TCGTGAAATGATTTACAA
-34 5.5 TTGTGAAACTTTTAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: adhE
Ortholog function: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
Streptococcus agalactiae 2603V/R SAG0053 -113 5.2 TTGAAAAAAAGTTCACAA
-90 5.5 TTGTGAAACTATTTACAA
-35 5.6 TTGTGAAACATTTAACAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0061 -112 5.2 TTGAAAAAAACTTCACAA
-89 5.4 TTGTGAAATGATTTACAA
-34 5.5 TTGTGAAACTTTTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0043 -112 5 TTGAAAAAAACATCACAA
-89 5.4 TTGTGAAATGATTTACAA
-34 5.5 TTGTGAAACTTTTAACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0113 -140 5.1 TTGAAATATATTTCACAA
-51 5.8 TTGTGAAAAAATTAACAA
Streptococcus mitis B6 smi_0231 -209 4.5 TTGTGAAATAAAAAATAT
-191 5.1 TTGAAATAATTTTCACAA
-141 5.4 ATGAGAAAAATTTCACAA
-97 4.6 TTATGAAACTGTTTACAA
-53 5.8 TTGTGAAAAAATTAACAA
Streptococcus pneumoniae TIGR4 SP_2026 -208 4.5 TTGTGAAATAAAAAATAT
-190 5.1 TTGAAATAAATTTCACAA
-140 5.1 ATGAGAAAAGTTTCACAA
-96 4.6 TTATGAAACTGTTTACAA
-52 5.8 TTGTGAAAAAATTAACAA
Streptococcus sanguinis SK36 SSA_0068 -226 4.3 ATGTGAAATCTTTAAAAT
-156 5 TTGTTATGTATTTCACAA
-67 5.7 TTGTGAAATATTTAACAA
Streptococcus suis 05ZYH33 SSU05_0280 -129 4.5 TTGGGGAAAAGTTAACAA
Streptococcus uberis 0140J SUB0063 -116 5.2 TTGAAAAAAAGTTCACAA
-93 5.5 TTGTGAAACTATTTACAA
-38 5.5 TTGTGAAACTTTTAACAA
Position: -67
Score: 5
Sequence: TTGTGAAAAGATGTACAA
Locus tag: M6_Spy0090
M6_Spy0090 -67 5 TTGTGAAAAGATGTACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: adhB1
Ortholog function: Alcohol dehydrogenase (EC 1.1.1.1), Zn-dependent
Streptococcus agalactiae 2603V/R SAG0054 -118 4.4 TTAAGAATATTTTCAAAA
-73 4.8 TTGTGAAGAATAATACAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0062 -76 5.1 TTGTGAAAAGATATACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0046 -80 5.1 TTGTGAAAAAGTATACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0565 -52 5.2 TTGTGATATAATTAACAT
Streptococcus mitis B6 smi_0275 -114 5.1 TTGTGATATACTTCACAT
Streptococcus pneumoniae TIGR4 SP_0285 -114 5.1 TTGTGATATACTTCACAT
Streptococcus pyogenes M1 GAS SPy0044 -67 5 TTGTGAAAAGATGTACAA
Streptococcus sanguinis SK36 SSA_1917 -51 5.2 TTGTGATATAATTAACAT
Streptococcus suis 05ZYH33 SSU05_0279 -82 5.2 TTGTGATATTCTTAACAA
Position: -52
Score: 4.7
Sequence: AAGTTAATCTTTTCACAA
Locus tag: M6_Spy0265
M6_Spy0265 -52 4.7 AAGTTAATCTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gap
Ortholog function: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
Streptococcus agalactiae 2603V/R SAG1768 -76 4.4 AAGTTAATCTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1936 -78 4.7 AAGTTAATCTTTTCACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0207 -158 4 ATTTGAAAGAATGAACAA
Streptococcus mutans UA159 SMU.360 -81 4.7 AAGTTAATCTTTTCACAA
Streptococcus pyogenes M1 GAS SPy0274 -79 4.7 AAGTTAATCTTTTCACAA
Streptococcus sanguinis SK36 SSA_2108 -157 4.8 TAGTGAAAGAATTCATAA
Streptococcus thermophilus CNRZ1066 str1788 -50 4.7 AAGTTAATCTTTTCACAA
Streptococcus uberis 0140J SUB1630 -78 4.7 AAGTTAATCTTTTCACAA
Position: -96
Score: 5.1
Sequence: TTGTGAAAATATTCCTAA
Locus tag: M6_Spy0530
M6_Spy0530 -96 5.1 TTGTGAAAATATTCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: tpi
Ortholog function: Triosephosphate isomerase (EC 5.3.1.1)
Streptococcus agalactiae 2603V/R SAG0763 -72 4 TCGTGAAACTTTTAATTA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0629 -97 5.1 TTGTGAAAATATTCCTAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1321 -97 5 TTGTGAAAATATTACTAA
Streptococcus gordonii str. Challis substr. CH1 SGO_0762 -89 4.5 TTGATAAAAACTTAGCAA
Streptococcus pyogenes M1 GAS SPy0613 -97 5.1 TTGTGAAAATATTCCTAA
Streptococcus thermophilus CNRZ1066 str0488 -46 4.7 TTGTGATAAAATAAACGA
Streptococcus uberis 0140J SUB0605 -98 5.2 TTGTGAAAATTATCCCAA
Position: -52
Score: 4.3
Sequence: TTGTGGTATTATGAACAT
Locus tag: M6_Spy0576
M6_Spy0576 -52 4.3 TTGTGGTATTATGAACAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: eno
Ortholog function: Enolase (EC 4.2.1.11)
Lactococcus lactis subsp. cremoris SK11 LACR_0668 -80 4.4 TTGAAAAATCTTTCAAAA
Lactococcus lactis subsp. lactis Il1403 L0007 -80 4.4 TTGAAAAATCTTTCAAAA
Streptococcus agalactiae 2603V/R SAG0628 -123 4.4 TAGTGATTTTTTTATCAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0704 -52 4.8 TTGTGGTATTATTAACAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0774 -52 4.8 TTGTGGTATTATTAACAT
Streptococcus gallolyticus UCN34 GALLO_1458 -38 4.4 GTGTAAAAATATTAAAAA
Streptococcus mutans UA159 SMU.1247 -49 4.6 TTGTGGTATGATTAACAT
Streptococcus pyogenes M1 GAS SPy0731 -52 4.3 TTGTGGTATTATGAACAT
Streptococcus sanguinis SK36 SSA_0886 -111 4.7 TTGTGCAAAATTTCTCAA
-35 4.2 TAGTAAATAATTTTAAAT
Streptococcus uberis 0140J SUB0655 -101 4.3 AAGTGAAATTTTTCATTA
-52 4.2 TTGTGATATTATGGACAT
Position: -76
Score: 4.5
Sequence: ATGTTGCATTTTTCACAA
Locus tag: M6_Spy0840
M6_Spy0840 -76 4.5 ATGTTGCATTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: rex
Ortholog function: Redox-sensitive transcriptional regulator Rex, Rex family
Lactococcus lactis subsp. cremoris SK11 LACR_1156 -74 5.3 TTGATAAAATTATCACAA
Lactococcus lactis subsp. lactis Il1403 L71932 -75 5.3 TTGATAAAATTATCACAA
Streptococcus agalactiae 2603V/R SAG1100 -36 4.5 TAATAAAATTTTTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1050 -31 4.4 TAGTTGCATATTTCACAA
Streptococcus gordonii str. Challis substr. CH1 SGO_1228 -54 4.7 TAGTTGATTTTTTCACAA
Streptococcus mitis B6 smi_1188 -57 5 TTGTTGATTTTTTCACAA
Streptococcus mutans UA159 SMU.1053 -117 4.4 TTGTTATAAAAAAAACTA
-58 4.5 ATGTTGCATTTTTCACAA
Streptococcus pneumoniae TIGR4 SP_1090 -57 5 TTGTTGATTTTTTCACAA
Streptococcus pyogenes M1 GAS SPy1120 -76 4.5 ATGTTGCATTTTTCACAA
Streptococcus sanguinis SK36 SSA_1216 -55 4.7 TAGTTGATTTTTTCACAA
Streptococcus suis 05ZYH33 SSU05_1069 -100 4.5 CTGTTGATTTTTTCACAA
Streptococcus thermophilus CNRZ1066 str1463 -39 4.6 TTGTTGCAATCTTCACAA
Streptococcus uberis 0140J SUB0845 -52 4.4 TTGTTACAATAGTAACAT
Position: -23
Score: 4.6
Sequence: TTGTGAAATGAGGAACAA
Locus tag: M6_Spy0868
M6_Spy0868 -23 4.6 TTGTGAAATGAGGAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: noxE
Ortholog function: NADH oxidase (EC 1.6.99.3)
Streptococcus agalactiae 2603V/R SAG0958 -165 4.3 TTGTGAATTTGTGAAAAA
-59 4.7 TTGTGAATAATGTTATAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0909 -23 4.6 TTGTGAAATGAGGAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1023 -81 4.3 TTGTGAAATGAGGAACAT
Streptococcus pyogenes M1 GAS SPy1150 -23 4.6 TTGTGAAATGAGGAACAA
Streptococcus thermophilus CNRZ1066 str1281 -91 4.6 TTGTTCAAAAAGTAACAA
Streptococcus uberis 0140J SUB0877 -170 4.6 TTGTGAATTTATGAACTA
-24 4.7 TTGTGAAAAGAGGAACAA
Position: -88
Score: 3.8
Sequence: TTCTGAATTCAATGACAA
Position: -77
Score: 4.1
Sequence: ATGACAAACAATTATCAA
Locus tag: M6_Spy0869
M6_Spy0869 -88 3.8 TTCTGAATTCAATGACAA
-77 4.1 ATGACAAACAATTATCAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ldh
Ortholog function: L-lactate dehydrogenase (EC 1.1.1.27)
Lactococcus lactis subsp. cremoris SK11 LACR_1455 -63 4.1 TTGTTGAAAAGATTATAT
Lactococcus lactis subsp. lactis Il1403 L0017 -63 4.1 TTGTTGAAAAGATTATAT
Streptococcus agalactiae 2603V/R SAG0959 -102 4.4 TTGCAAATTTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0911 -77 4.2 ATGACAAACAATTCTCAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1022 -79 3.9 ATGACAAAGACATTACAA
Streptococcus gallolyticus UCN34 GALLO_1129 -106 4 TTTTCAAAGTTTTTACAA
Streptococcus gallolyticus UCN34 GALLO_2034 -85 3.8 TTATTATACAATTCCAAA
Streptococcus gordonii str. Challis substr. CH1 SGO_1232 -118 3.8 TTCTAAAAACGTTTACAT
Streptococcus mitis B6 smi_1006 -62 4.2 AAGTGATAAAATTAAAAT
Streptococcus mutans UA159 SMU.1115 -81 4.4 TAGTGACTTTCTTAACAA
Streptococcus pyogenes M1 GAS SPy1151 -77 4.1 ATGACAAACAATTATCAA
Streptococcus sanguinis SK36 SSA_1221 -116 4.5 TTGTAAAAACGTTTACAT
Streptococcus uberis 0140J SUB0879 -77 4.3 GTGACAAACTATTCACAA
Position: -48
Score: 3.8
Sequence: TTTTAAAATATGTTATAA
Position: -39
Score: 4.7
Sequence: ATGTTATAATAGTAACAA
Locus tag: M6_Spy1404
M6_Spy1404 -48 3.8 TTTTAAAATATGTTATAA
-39 4.7 ATGTTATAATAGTAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: pncB
Ortholog function: Nicotinate phosphoribosyltransferase (EC 2.4.2.11)
Lactococcus lactis subsp. cremoris SK11 LACR_1202 -218 4 TTGTAGTATAAAAAACAT
Lactococcus lactis subsp. lactis Il1403 L107468 -181 3.9 TTGTAGTACAAAAAACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1714 -39 4.7 ATGTTATAATAGTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1574 -39 4.3 ATGGTATAATAATAACAA
Streptococcus mitis B6 smi_1492 -114 4.3 TTGTTACTCTTTTCTCAA
Streptococcus mutans UA159 SMU.464 -265 4.3 GTGTTATAATAGTAACAA
Streptococcus pneumoniae TIGR4 SP_1421 -114 4.3 TTGTTACTCTTTTCTCAA
Streptococcus pyogenes M1 GAS SPy1653 -39 4.7 ATGTTATAATAGTAACAA
Position: -136
Score: 4.8
Sequence: ATGTGATTTGTTTCACAA
Locus tag: M6_Spy1765
M6_Spy1765 -136 4.8 ATGTGATTTGTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ahpC
Ortholog function: Alkyl hydroperoxide reductase protein C (EC 1.11.1.15)
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_2053 -141 4.5 ATGTGATGCTATTCACAT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0137 -134 5 TTGTGACTAAATTCACAT
Streptococcus pyogenes M1 GAS SPy2079 -136 5.1 ATGTGATTTATTTCACAA