Propagation of Rex regulog to Streptococcus pyogenes MGAS10394

Reference regulog properties
Source regulog:	Rex - Streptococcaceae
Regulator type:	Transcription factor
Regulator family:	Rex
Regulation mode:	repressor
Biological process:	Energy metabolism
Effector:	NADH
Phylum:	Firmicutes
Propagated regulon:
Target genome	Streptococcus pyogenes MGAS10394
Orthologous TF(s)	M6_Spy0840
Regulated genes	13

Built upon 161 sites [see more]

Predicted regulatory interactions in *Streptococcus pyogenes MGAS10394*
	Locus tag	Position	Score	Sequence
Position: -112 Score: 5.2 Sequence: TTGAAAAAAACTTCACAA Position: -89 Score: 4.7 Sequence: TCGTGAAATGATTTACAA Position: -34 Score: 5.5 Sequence: TTGTGAAACTTTTAACAA Locus tag: M6_Spy0088
	M6_Spy0088	-112	5.2	TTGAAAAAAACTTCACAA
		-89	4.7	TCGTGAAATGATTTACAA
		-34	5.5	TTGTGAAACTTTTAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: adhE
Ortholog function: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
Streptococcus agalactiae 2603V/R	SAG0053	-113	5.2	TTGAAAAAAAGTTCACAA
		-90	5.5	TTGTGAAACTATTTACAA
		-35	5.6	TTGTGAAACATTTAACAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0061	-112	5.2	TTGAAAAAAACTTCACAA
		-89	5.4	TTGTGAAATGATTTACAA
		-34	5.5	TTGTGAAACTTTTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0043	-112	5	TTGAAAAAAACATCACAA
		-89	5.4	TTGTGAAATGATTTACAA
		-34	5.5	TTGTGAAACTTTTAACAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0113	-140	5.1	TTGAAATATATTTCACAA
		-51	5.8	TTGTGAAAAAATTAACAA
Streptococcus mitis B6	smi_0231	-209	4.5	TTGTGAAATAAAAAATAT
		-191	5.1	TTGAAATAATTTTCACAA
		-141	5.4	ATGAGAAAAATTTCACAA
		-97	4.6	TTATGAAACTGTTTACAA
		-53	5.8	TTGTGAAAAAATTAACAA
Streptococcus pneumoniae TIGR4	SP_2026	-208	4.5	TTGTGAAATAAAAAATAT
		-190	5.1	TTGAAATAAATTTCACAA
		-140	5.1	ATGAGAAAAGTTTCACAA
		-96	4.6	TTATGAAACTGTTTACAA
		-52	5.8	TTGTGAAAAAATTAACAA
Streptococcus sanguinis SK36	SSA_0068	-226	4.3	ATGTGAAATCTTTAAAAT
		-156	5	TTGTTATGTATTTCACAA
		-67	5.7	TTGTGAAATATTTAACAA
Streptococcus suis 05ZYH33	SSU05_0280	-129	4.5	TTGGGGAAAAGTTAACAA
Streptococcus uberis 0140J	SUB0063	-116	5.2	TTGAAAAAAAGTTCACAA
		-93	5.5	TTGTGAAACTATTTACAA
		-38	5.5	TTGTGAAACTTTTAACAA

Position: -67 Score: 5 Sequence: TTGTGAAAAGATGTACAA Locus tag: M6_Spy0090
	M6_Spy0090	-67	5	TTGTGAAAAGATGTACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: adhB1
Ortholog function: Alcohol dehydrogenase (EC 1.1.1.1), Zn-dependent
Streptococcus agalactiae 2603V/R	SAG0054	-118	4.4	TTAAGAATATTTTCAAAA
		-73	4.8	TTGTGAAGAATAATACAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0062	-76	5.1	TTGTGAAAAGATATACAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0046	-80	5.1	TTGTGAAAAAGTATACAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0565	-52	5.2	TTGTGATATAATTAACAT
Streptococcus mitis B6	smi_0275	-114	5.1	TTGTGATATACTTCACAT
Streptococcus pneumoniae TIGR4	SP_0285	-114	5.1	TTGTGATATACTTCACAT
Streptococcus pyogenes M1 GAS	SPy0044	-67	5	TTGTGAAAAGATGTACAA
Streptococcus sanguinis SK36	SSA_1917	-51	5.2	TTGTGATATAATTAACAT
Streptococcus suis 05ZYH33	SSU05_0279	-82	5.2	TTGTGATATTCTTAACAA

Position: -52 Score: 4.7 Sequence: AAGTTAATCTTTTCACAA Locus tag: M6_Spy0265
	M6_Spy0265	-52	4.7	AAGTTAATCTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gap
Ortholog function: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
Streptococcus agalactiae 2603V/R	SAG1768	-76	4.4	AAGTTAATCTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1936	-78	4.7	AAGTTAATCTTTTCACAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0207	-158	4	ATTTGAAAGAATGAACAA
Streptococcus mutans UA159	SMU.360	-81	4.7	AAGTTAATCTTTTCACAA
Streptococcus pyogenes M1 GAS	SPy0274	-79	4.7	AAGTTAATCTTTTCACAA
Streptococcus sanguinis SK36	SSA_2108	-157	4.8	TAGTGAAAGAATTCATAA
Streptococcus thermophilus CNRZ1066	str1788	-50	4.7	AAGTTAATCTTTTCACAA
Streptococcus uberis 0140J	SUB1630	-78	4.7	AAGTTAATCTTTTCACAA

Position: -96 Score: 5.1 Sequence: TTGTGAAAATATTCCTAA Locus tag: M6_Spy0530
	M6_Spy0530	-96	5.1	TTGTGAAAATATTCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: tpi
Ortholog function: Triosephosphate isomerase (EC 5.3.1.1)
Streptococcus agalactiae 2603V/R	SAG0763	-72	4	TCGTGAAACTTTTAATTA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0629	-97	5.1	TTGTGAAAATATTCCTAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1321	-97	5	TTGTGAAAATATTACTAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0762	-89	4.5	TTGATAAAAACTTAGCAA
Streptococcus pyogenes M1 GAS	SPy0613	-97	5.1	TTGTGAAAATATTCCTAA
Streptococcus thermophilus CNRZ1066	str0488	-46	4.7	TTGTGATAAAATAAACGA
Streptococcus uberis 0140J	SUB0605	-98	5.2	TTGTGAAAATTATCCCAA

Position: -52 Score: 4.3 Sequence: TTGTGGTATTATGAACAT Locus tag: M6_Spy0576
	M6_Spy0576	-52	4.3	TTGTGGTATTATGAACAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: eno
Ortholog function: Enolase (EC 4.2.1.11)
Lactococcus lactis subsp. cremoris SK11	LACR_0668	-80	4.4	TTGAAAAATCTTTCAAAA
Lactococcus lactis subsp. lactis Il1403	L0007	-80	4.4	TTGAAAAATCTTTCAAAA
Streptococcus agalactiae 2603V/R	SAG0628	-123	4.4	TAGTGATTTTTTTATCAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0704	-52	4.8	TTGTGGTATTATTAACAT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0774	-52	4.8	TTGTGGTATTATTAACAT
Streptococcus gallolyticus UCN34	GALLO_1458	-38	4.4	GTGTAAAAATATTAAAAA
Streptococcus mutans UA159	SMU.1247	-49	4.6	TTGTGGTATGATTAACAT
Streptococcus pyogenes M1 GAS	SPy0731	-52	4.3	TTGTGGTATTATGAACAT
Streptococcus sanguinis SK36	SSA_0886	-111	4.7	TTGTGCAAAATTTCTCAA
		-35	4.2	TAGTAAATAATTTTAAAT
Streptococcus uberis 0140J	SUB0655	-101	4.3	AAGTGAAATTTTTCATTA
		-52	4.2	TTGTGATATTATGGACAT

Position: -76 Score: 4.5 Sequence: ATGTTGCATTTTTCACAA Locus tag: M6_Spy0840
	M6_Spy0840	-76	4.5	ATGTTGCATTTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: rex
Ortholog function: Redox-sensitive transcriptional regulator Rex, Rex family
Lactococcus lactis subsp. cremoris SK11	LACR_1156	-74	5.3	TTGATAAAATTATCACAA
Lactococcus lactis subsp. lactis Il1403	L71932	-75	5.3	TTGATAAAATTATCACAA
Streptococcus agalactiae 2603V/R	SAG1100	-36	4.5	TAATAAAATTTTTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1050	-31	4.4	TAGTTGCATATTTCACAA
Streptococcus gordonii str. Challis substr. CH1	SGO_1228	-54	4.7	TAGTTGATTTTTTCACAA
Streptococcus mitis B6	smi_1188	-57	5	TTGTTGATTTTTTCACAA
Streptococcus mutans UA159	SMU.1053	-117	4.4	TTGTTATAAAAAAAACTA
		-58	4.5	ATGTTGCATTTTTCACAA
Streptococcus pneumoniae TIGR4	SP_1090	-57	5	TTGTTGATTTTTTCACAA
Streptococcus pyogenes M1 GAS	SPy1120	-76	4.5	ATGTTGCATTTTTCACAA
Streptococcus sanguinis SK36	SSA_1216	-55	4.7	TAGTTGATTTTTTCACAA
Streptococcus suis 05ZYH33	SSU05_1069	-100	4.5	CTGTTGATTTTTTCACAA
Streptococcus thermophilus CNRZ1066	str1463	-39	4.6	TTGTTGCAATCTTCACAA
Streptococcus uberis 0140J	SUB0845	-52	4.4	TTGTTACAATAGTAACAT

Position: -23 Score: 4.6 Sequence: TTGTGAAATGAGGAACAA Locus tag: M6_Spy0868
	M6_Spy0868	-23	4.6	TTGTGAAATGAGGAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: noxE
Ortholog function: NADH oxidase (EC 1.6.99.3)
Streptococcus agalactiae 2603V/R	SAG0958	-165	4.3	TTGTGAATTTGTGAAAAA
		-59	4.7	TTGTGAATAATGTTATAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0909	-23	4.6	TTGTGAAATGAGGAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1023	-81	4.3	TTGTGAAATGAGGAACAT
Streptococcus pyogenes M1 GAS	SPy1150	-23	4.6	TTGTGAAATGAGGAACAA
Streptococcus thermophilus CNRZ1066	str1281	-91	4.6	TTGTTCAAAAAGTAACAA
Streptococcus uberis 0140J	SUB0877	-170	4.6	TTGTGAATTTATGAACTA
		-24	4.7	TTGTGAAAAGAGGAACAA

Position: -88 Score: 3.8 Sequence: TTCTGAATTCAATGACAA Position: -77 Score: 4.1 Sequence: ATGACAAACAATTATCAA Locus tag: M6_Spy0869
	M6_Spy0869	-88	3.8	TTCTGAATTCAATGACAA
		-77	4.1	ATGACAAACAATTATCAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ldh
Ortholog function: L-lactate dehydrogenase (EC 1.1.1.27)
Lactococcus lactis subsp. cremoris SK11	LACR_1455	-63	4.1	TTGTTGAAAAGATTATAT
Lactococcus lactis subsp. lactis Il1403	L0017	-63	4.1	TTGTTGAAAAGATTATAT
Streptococcus agalactiae 2603V/R	SAG0959	-102	4.4	TTGCAAATTTTTTCACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0911	-77	4.2	ATGACAAACAATTCTCAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1022	-79	3.9	ATGACAAAGACATTACAA
Streptococcus gallolyticus UCN34	GALLO_1129	-106	4	TTTTCAAAGTTTTTACAA
Streptococcus gallolyticus UCN34	GALLO_2034	-85	3.8	TTATTATACAATTCCAAA
Streptococcus gordonii str. Challis substr. CH1	SGO_1232	-118	3.8	TTCTAAAAACGTTTACAT
Streptococcus mitis B6	smi_1006	-62	4.2	AAGTGATAAAATTAAAAT
Streptococcus mutans UA159	SMU.1115	-81	4.4	TAGTGACTTTCTTAACAA
Streptococcus pyogenes M1 GAS	SPy1151	-77	4.1	ATGACAAACAATTATCAA
Streptococcus sanguinis SK36	SSA_1221	-116	4.5	TTGTAAAAACGTTTACAT
Streptococcus uberis 0140J	SUB0879	-77	4.3	GTGACAAACTATTCACAA

Position: -48 Score: 3.8 Sequence: TTTTAAAATATGTTATAA Position: -39 Score: 4.7 Sequence: ATGTTATAATAGTAACAA Locus tag: M6_Spy1404
	M6_Spy1404	-48	3.8	TTTTAAAATATGTTATAA
		-39	4.7	ATGTTATAATAGTAACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: pncB
Ortholog function: Nicotinate phosphoribosyltransferase (EC 2.4.2.11)
Lactococcus lactis subsp. cremoris SK11	LACR_1202	-218	4	TTGTAGTATAAAAAACAT
Lactococcus lactis subsp. lactis Il1403	L107468	-181	3.9	TTGTAGTACAAAAAACAT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1714	-39	4.7	ATGTTATAATAGTAACAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1574	-39	4.3	ATGGTATAATAATAACAA
Streptococcus mitis B6	smi_1492	-114	4.3	TTGTTACTCTTTTCTCAA
Streptococcus mutans UA159	SMU.464	-265	4.3	GTGTTATAATAGTAACAA
Streptococcus pneumoniae TIGR4	SP_1421	-114	4.3	TTGTTACTCTTTTCTCAA
Streptococcus pyogenes M1 GAS	SPy1653	-39	4.7	ATGTTATAATAGTAACAA

Position: -136 Score: 4.8 Sequence: ATGTGATTTGTTTCACAA Locus tag: M6_Spy1765
	M6_Spy1765	-136	4.8	ATGTGATTTGTTTCACAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ahpC
Ortholog function: Alkyl hydroperoxide reductase protein C (EC 1.11.1.15)
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_2053	-141	4.5	ATGTGATGCTATTCACAT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0137	-134	5	TTGTGACTAAATTCACAT
Streptococcus pyogenes M1 GAS	SPy2079	-136	5.1	ATGTGATTTATTTCACAA

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Propagation of Rex regulog to Streptococcus pyogenes MGAS10394

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --