Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Collection of regulogs for THF (RF01831) RNA regulatory element

The THF riboswitch, is a highly conserved RNA structure that was identified upstream of the folate transport and biosynthesis genes in Gram-positive bacteria from the Lactobacillales and Clostridiales orders [20659680]. Folates are composed of three moieties: pterin, p-aminobenzoate, and glutamate. An active form of folate, tetrahydrofolate (THF), is an essential cofactor in one-carbon transfer reactions of central metabolism. De novo THF biosynthesis starts from GTP and proceeds in seven consecutive steps [17645794]. Alternatively, Gram-positive bacteria salvage folate from the environment utilizing a unique ECF-type transport system composed of a folate-binding protein (FolT) and a common ECF module [20497229]. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Firmicutes THF - Clostridiaceae 10 (20) 11
Firmicutes THF - Lactobacillaceae 8 (15) 8
Firmicutes THF - Streptococcaceae 4 (15) 4