Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes

-- version 3.2 --

This section of the database represents the results of manually curated reconstrutions of transcriptional regulons using the comparative genomics approach.

Browse collections that organize the reconstructed regulons by phylogenetic, structural or functional properties of regulators.

Taxonomy
Transcription factor
TF family
RNA family
Effector
Pathway

This section of the database represents the results of accurate automatic propagation of the manually curated regulons to novel closely related genomes.

For each regulog, the propagation procedure checks for the presence of orthologs for both a transcription factor gene and target genes (regulog members), and then performs search for candidate TF-binding sites in upstream regions of orthologous target genes

This procedure is considered to be accurate and conservative since it relies on the manually curated regulons and does not make an attempt for automatic prediction of new members of regulon.