Regulog SaeR - Staphylococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	OmpR
Regulation mode:	activator
Biological process:	Virulence
Effector:	SaeS, sensor histidine kinase
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 45 sites [see more]

Member of regulog collections

By taxonomy - Staphylococcaceae
By TF family - OmpR
By effector - SaeS, sensor histidine kinase
By pathway - Virulence

Statistics of regulated genes
Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	32	22
Staphylococcus capitis SK14	6	3
Staphylococcus epidermidis ATCC 12228	6	3
Staphylococcus carnosus subsp. carnosus TM300	7	2
Staphylococcus haemolyticus JCSC1435
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
Macrococcus caseolyticus JCSC5402

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
tst	* Staphylococcus aureus subsp. aureus N315 Site: position = -110 score = 5.19121 sequence = ATTAATATATATTTAA Gene: SA1819: toxic shock syndrome toxin-1	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	toxic shock syndrome toxin-1

CRON 2.
splA	* Staphylococcus aureus subsp. aureus N315 Site: position = -121 score = 5.58116 sequence = TTTAATAAAATGTTAA Site: position = -99 score = 5.63725 sequence = GTTAATTAATATTTAA Gene: SA1631: serine protease SplA	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	serine protease SplA

CRON 3.
set15	* Staphylococcus aureus subsp. aureus N315 Site: position = -123 score = 5.31469 sequence = ATTAATTTTTAGTTAA Gene: SA0393: superantigen-like protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	superantigen-like protein
SA0394	Staphylococcus aureus subsp. aureus N315 Gene: SA0394: hypothetical protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein

CRON 4.
set13	* Staphylococcus aureus subsp. aureus N315 Site: position = -175 score = 5.24488 sequence = ATTAAAAATCAGTTAA Gene: SA0389: superantigen-like protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	superantigen-like protein

CRON 5.
set11	* Staphylococcus aureus subsp. aureus N315 Site: position = -145 score = 5.16731 sequence = GTTCAAAAATAGTTAA Site: position = -134 score = 4.88005 sequence = GTTAAAAAGAGGTTAA Gene: SA0387: superantigen-like protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	superantigen-like protein

CRON 6.
SE2396	Staphylococcus aureus subsp. aureus N315	* Staphylococcus capitis SK14 Site: position = -65 score = 4.95339 sequence = GTTAATTGTTACTTAA Site: position = -87 score = 5.3838 sequence = GTTAATAAAATTTTAA Gene: STACA0001_1401: major facilitator family transporter	* Staphylococcus epidermidis ATCC 12228 Site: position = -288 score = 5.13475 sequence = TTTAATAATAAATTAA Site: position = -65 score = 5.26697 sequence = ATTAATAATTTTTTAA Gene: SE2396: transporter	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	major facilitator family transporter

CRON 7.
Sca_1510	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -50 score = 4.94834 sequence = ATTAATATTCTGTTAA Gene: Sca_1510: hypothetical protein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein
sbi	* Staphylococcus aureus subsp. aureus N315 Site: position = -92 score = 6.05334 sequence = GTTAATAATTAGTTAA Gene: SA2206: IgG-binding protein SBI	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1511: IgG-binding protein SBI	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	IgG-binding protein SBI

CRON 8.
sak	* Staphylococcus aureus subsp. aureus N315 Site: position = -175 score = 5.45869 sequence = GTTAAATATTTGTTAA Site: position = -164 score = 5.3996 sequence = GTTAATTATTTTTTAA Gene: SA1758: staphylokinase	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	staphylokinase

CRON 9.
saeP	* Staphylococcus aureus subsp. aureus N315 Site: position = -99 score = 5.02694 sequence = GTTAAGCGATATTTAA Site: position = -78 score = 5.86932 sequence = GTTAAGAATTAGTTAA Gene: SA0663: hypothetical protein SaeP	* Staphylococcus capitis SK14 Site: position = -79 score = 5.89123 sequence = GTTAATAAAAAGTTAA Site: position = -100 score = 4.99187 sequence = TTTAATTCTTTTTTAA Gene: STACA0001_0321: hypothetical protein SaeP	* Staphylococcus epidermidis ATCC 12228 Site: position = -79 score = 5.89123 sequence = GTTAAGAAATAGTTAA Site: position = -100 score = 4.99187 sequence = TTTAATTCTTTTTTAA Gene: SE0481: hypothetical protein SaeP	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -88 score = 5.79631 sequence = ATTAATAAATAGTTAA Gene: Sca_0350: hypothetical protein SaeP	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein SaeP
saeQ	Staphylococcus aureus subsp. aureus N315 Gene: SA0662: hypothetical protein SaeQ	Staphylococcus capitis SK14 Gene: STACA0001_0322: hypothetical protein SaeQ	Staphylococcus epidermidis ATCC 12228 Gene: SE0480: hypothetical protein SaeQ	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0351: hypothetical protein SaeQ	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein SaeQ
saeR	Staphylococcus aureus subsp. aureus N315 Gene: SA0661: response regulator SaeR	Staphylococcus capitis SK14 Gene: STACA0001_0323: response regulator SaeR	Staphylococcus epidermidis ATCC 12228	2 Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0352a: response regulator SaeR Gene: Sca_0352: response regulator SaeR	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	response regulator SaeR
saeS	Staphylococcus aureus subsp. aureus N315 Gene: SA0660: histidine protein kinase SaeS	Staphylococcus capitis SK14 Gene: STACA0001_0324: histidine protein kinase SaeS	Staphylococcus epidermidis ATCC 12228 Gene: SE0478: histidine protein kinase SaeS	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0353: histidine protein kinase SaeS	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	histidine protein kinase SaeS
saeR	Staphylococcus aureus subsp. aureus N315	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228 Gene: SE0479: response regulator SaeR	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	response regulator SaeR

CRON 10.
SA1818	* Staphylococcus aureus subsp. aureus N315 Site: position = -98 score = 4.7376 sequence = TTTATGTATTTGTTAA Site: position = -87 score = 5.76165 sequence = GTTAATAATTATTTAA Gene: SA1818: lipoprotein involved in pathogenicity	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	lipoprotein involved in pathogenicity

CRON 11.
SA1754	* Staphylococcus aureus subsp. aureus N315 Site: position = -77 score = 5.24012 sequence = GTTAATGAATAATTAA Gene: SA1754: hypothetical protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein

CRON 12.
SA1633	* Staphylococcus aureus subsp. aureus N315 Site: position = -86 score = 4.97027 sequence = TTTGATATTTAGTTAA Site: position = -97 score = 4.57908 sequence = GTTAATACATTTTTGA Site: position = -108 score = 5.76185 sequence = GTTAATAGATAGTTAA Gene: SA1633: beta-lactamase	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	beta-lactamase

CRON 13.
SA1000	* Staphylococcus aureus subsp. aureus N315 Site: position = -99 score = 5.2661 sequence = ATTAATGTTTAGTTAA Site: position = -88 score = 6.07525 sequence = GTTAATAAATAGTTAA Gene: SA1000: similar to fibrinogen binding protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	similar to fibrinogen binding protein

CRON 14.
SA0357	* Staphylococcus aureus subsp. aureus N315 Site: position = -95 score = 5.42376 sequence = GTTAATCAAGAGTTAA Gene: SA0357: hypothetical protein similar to exotoxin 2	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	hypothetical protein similar to exotoxin 2

CRON 15.
SA0213	* Staphylococcus aureus subsp. aureus N315 Site: position = -100 score = 5.79631 sequence = ATTAATAAATAGTTAA Gene: SA0213: putative membrane protein	* Staphylococcus capitis SK14 Site: position = -99 score = 5.79631 sequence = ATTAATAAATAGTTAA Gene: STACA0001_0021: putative membrane protein	* Staphylococcus epidermidis ATCC 12228 Site: position = -99 score = 6.07525 sequence = GTTAATAAATAGTTAA Gene: SE0163: putative membrane protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0082: putative membrane protein	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	putative membrane protein

CRON 16.
map	* Staphylococcus aureus subsp. aureus N315 Site: position = -88 score = 5.16408 sequence = ATTAATATTCAGTTAA Gene: SA1751: MHC class II analog protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	MHC class II analog protein
map	Staphylococcus aureus subsp. aureus N315 Gene: SA1750: MHC class II analog protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	MHC class II analog protein

CRON 17.
lukS	* Staphylococcus aureus subsp. aureus N315 Site: position = -99 score = 5.98092 sequence = TTTAATAAATAGTTAA Gene: SA1813: leukocidin lukS	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	leukocidin lukS
lukF	Staphylococcus aureus subsp. aureus N315 Gene: SA1812: leukocidin lukF	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	leukocidin lukF

CRON 18.
lukE	* Staphylococcus aureus subsp. aureus N315 Site: position = -86 score = 5.48911 sequence = TTTAATGAACAGTTAA Site: position = -335 score = 5.75643 sequence = GTTAATAATCAGTTAA Gene: SA1638: leukotoxin LukE	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	leukotoxin LukE
lukD	Staphylococcus aureus subsp. aureus N315 Gene: SA1637: leukotoxin, LukD	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	leukotoxin, LukD

CRON 19.
lpl2	2 Staphylococcus aureus subsp. aureus N315* Gene: SA0397: lipoprotein involved in pathogenicity Site: position = -253 score = 5.98092 sequence = TTTAATAAATAGTTAA Gene: SA0396: lipoprotein involved in pathogenicity	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	lipoprotein involved in pathogenicity
lpl3	Staphylococcus aureus subsp. aureus N315 Gene: SA0398: lipoprotein involved in pathogenicity	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	lipoprotein involved in pathogenicity

CRON 20.
hlgC	* Staphylococcus aureus subsp. aureus N315 Site: position = -86 score = 5.58345 sequence = GTTAATGAACAGTTAA Gene: SA2208: gamma-hemolysin component C	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	gamma-hemolysin component C
hlgB	Staphylococcus aureus subsp. aureus N315 Gene: SA2209: gamma-hemolysin component B	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	gamma-hemolysin component B

CRON 21.
hla	* Staphylococcus aureus subsp. aureus N315 Site: position = -190 score = 5.41799 sequence = TTTAAATAAAAGTTAA Gene: SA1007: alpha-hemolysin	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	alpha-hemolysin

CRON 22.
SA1003	* Staphylococcus aureus subsp. aureus N315 Site: position = -81 score = 5.7744 sequence = ATTAATAATTAGTTAA Site: position = -85 score = 4.61336 sequence = GTTAATTAATAATTAG Gene: efb: similar to fibrinogen binding protein	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	similar to fibrinogen binding protein

CRON 23.
coa	* Staphylococcus aureus subsp. aureus N315 Site: position = -82 score = 5.76185 sequence = GTTAATATATAGTTAA Site: position = -103 score = 4.65397 sequence = GTTAATGCTTTGTTTA Gene: SA0222: staphylocoagulase precursor	Staphylococcus capitis SK14	Staphylococcus epidermidis ATCC 12228	Staphylococcus carnosus subsp. carnosus TM300	Staphylococcus haemolyticus JCSC1435	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	Macrococcus caseolyticus JCSC5402	staphylocoagulase precursor

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog SaeR - Staphylococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --