Regulog IolR - Bacillales

Properties
Regulator type:	Transcription factor
Regulator family:	DeoR
Regulation mode:	repressor
Biological process:	Inositol utilization
Effector:	2-deoxy-5-keto-D-gluconate 6-phosphate
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 9 sites [see more]

Member of regulog collections

By taxonomy - Bacillales
By TF family - DeoR
By effector - 2-deoxy-5-keto-D-gluconate 6-phosphate
By pathway - Inositol utilization

Statistics of regulated genes
Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168	12	2
Bacillus amyloliquefaciens FZB42	12	2
Bacillus pumilus SAFR-032
Bacillus licheniformis DSM 13	12	2
Anoxybacillus flavithermus WK1
Geobacillus kaustophilus HTA426
Bacillus cereus ATCC 14579
Bacillus halodurans C-125
Bacillus clausii KSM-K16	10	2
Oceanobacillus iheyensis HTE831
Paenibacillus sp. JDR-2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
iolR	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -69 score = -1.47248 sequence = ACTATTGATTAACTTTTGGTTT Gene: BSU39770: Transcriptional regulator of myo-inositol utilization, DeoR family	* Bacillus amyloliquefaciens FZB42 Site: position = -69 score = -0.587287 sequence = ACTATTGATTAACTTCTGGTGT Gene: RBAM_036790: Transcriptional regulator of myo-inositol utilization, DeoR family	Bacillus pumilus SAFR-032	* Bacillus licheniformis DSM 13 Site: position = -66 score = -1.71918 sequence = ATTATTGGTTAACTTTTGGGTT Gene: BLi04252: Transcriptional regulator of myo-inositol utilization, DeoR family	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	* Bacillus clausii KSM-K16 Site: position = -160 score = -2.01547 sequence = CTTTTTGATCATTTGTTGGTTA Gene: ABC0421: Transcriptional regulator of myo-inositol utilization, DeoR family	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Transcriptional regulator of myo-inositol utilization, DeoR family
iolS	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39780: Oxidoreductase	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036800: Oxidoreductase	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04253: Oxidoreductase	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16 Gene: ABC1667: Oxidoreductase	Oceanobacillus iheyensis HTE831 Gene: OB0446: Oxidoreductase	Paenibacillus sp. JDR-2	Oxidoreductase

CRON 2.
iolA	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -196 score = 6.44205 sequence = TAACCAAGAAATGACCAAAAAG Gene: BSU39760: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	* Bacillus amyloliquefaciens FZB42 Site: position = -224 score = 6.54509 sequence = TAACCAAGAAATGACCAAAACA Site: position = -213 score = 4.5549 sequence = TGACCAAAACATAACCTGTAAA Gene: RBAM_036780: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Bacillus pumilus SAFR-032	* Bacillus licheniformis DSM 13 Site: position = -242 score = 6.44205 sequence = TAACCAAGAAGTGACCAAAACA Gene: BLi04251: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1887: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	* Bacillus clausii KSM-K16 Site: position = -66 score = 5.91122 sequence = TAACCAACAAATGATCAAAAAG Gene: ABC0422: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1951: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)	Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
iolB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39750: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036770: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04250: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1889: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2320: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus clausii KSM-K16 Gene: ABC0423: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1953: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolC	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39740: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036760: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04249: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1888: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2319: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus clausii KSM-K16 Gene: ABC0424: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1950: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolD	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39730: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036750: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04248: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1891: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2318: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus clausii KSM-K16 Gene: ABC0425: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1948: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase
iolE	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39720: Inosose dehydratase (EC 4.2.1.44)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036740: Inosose dehydratase (EC 4.2.1.44)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04247: Inosose dehydratase (EC 4.2.1.44)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1890: Inosose dehydratase (EC 4.2.1.44)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2317: Inosose dehydratase (EC 4.2.1.44)	Bacillus clausii KSM-K16 Gene: ABC0426: Inosose dehydratase (EC 4.2.1.44)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1949: Inosose dehydratase (EC 4.2.1.44)	Inosose dehydratase (EC 4.2.1.44)
iolF	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39710: Minor myo-inositol transporter IolF	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036730: Minor myo-inositol transporter IolF	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04246: Minor myo-inositol transporter IolF	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Minor myo-inositol transporter IolF
iolG	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39700: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036720: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04245: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2316: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus clausii KSM-K16 Gene: ABC0427: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
iolH	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39690: putative sugar-phosphate epimerase/isomerase IolH	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036710: putative sugar-phosphate epimerase/isomerase IolH	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04244: putative sugar-phosphate epimerase/isomerase IolH	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	putative sugar-phosphate epimerase/isomerase IolH
iolI	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39680: Inosose isomerase (EC 5.3.99.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036700: Inosose isomerase (EC 5.3.99.-)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04243: Inosose isomerase (EC 5.3.99.-)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1892: Inosose isomerase (EC 5.3.99.-)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2315: Inosose isomerase (EC 5.3.99.-)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Inosose isomerase (EC 5.3.99.-)
iolJ	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39670: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036690: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04242: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1886: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2314: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus clausii KSM-K16 Gene: ABC0428: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
iolX	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU10850: Scyllo-inositol dehydrogenase (EC 1.1.1.-)	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16 Gene: ABC0429: Scyllo-inositol dehydrogenase (EC 1.1.1.-)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Scyllo-inositol dehydrogenase (EC 1.1.1.-)
BH2222	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2222: Na+:myo-inositol cotransporter	Bacillus clausii KSM-K16 Gene: ABC0430: Na+:myo-inositol cotransporter	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Na+:myo-inositol cotransporter

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IolR - Bacillales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --