Propagation of CodY regulog to Streptococcus pyogenes MGAS5005

Reference regulog properties
Source regulog:	CodY - Streptococcaceae
Regulator type:	Transcription factor
Regulator family:	CodY
Regulation mode:	repressor (activator)
Biological process:	Amino acid metabolism
Effector:	Guanosine triphosphate; Branched-chain amino acids
Phylum:	Firmicutes
Propagated regulon:
Target genome	Streptococcus pyogenes MGAS5005
Orthologous TF(s)	M5005_Spy_1512
Regulated genes	10

Built upon 273 sites [see more]

Predicted regulatory interactions in *Streptococcus pyogenes MGAS5005*
	Locus tag	Position	Score	Sequence
Position: -91 Score: 5.2 Sequence: AATATTCTAAAAATT Locus tag: M5005_Spy_0083
	M5005_Spy_0083	-91	5.2	AATATTCTAAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: rpoB
Ortholog function: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Streptococcus agalactiae 2603V/R	SAG0160	-128	5.2	AACTTTCTGAAAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0131	-91	4.6	AAGATTCTAAAAATT
Streptococcus gallolyticus UCN34	GALLO_0084	-165	4.6	AAGATTCTAAAAATT
Streptococcus gordonii str. Challis substr. CH1	SGO_1927	-222	5.4	ATTTTTCTGAAAATT
Streptococcus mitis B6	smi_1847	-113	5	AAGATTCTGAAAATT
Streptococcus mutans UA159	SMU.1990	-84	5.3	AAAATTCTGAAAATT
Streptococcus pneumoniae TIGR4	SP_1961	-112	5	AAGATTCTGAAAATT
Streptococcus pyogenes M1 GAS	SPy0098	-91	5.2	AATATTCTAAAAATT
Streptococcus suis 05ZYH33	SSU05_0121	-276	4.6	AAGATTCTAAAAATT
Streptococcus thermophilus CNRZ1066	str1868	-171	4.6	AAAGTTCTAAAAATT
Streptococcus uberis 0140J	SUB0115	-90	4.6	AAGATTCTAAAAATT

Position: -125 Score: 5.3 Sequence: AATATTCAGATAATT Locus tag: M5005_Spy_0249
	M5005_Spy_0249	-125	5.3	AATATTCAGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA2
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0356	-115	5.3	AATATTCAGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1697	-119	5.3	AATATTCAGATAATT

Position: -131 Score: 4.8 Sequence: AATTTTCAGTCAATT Locus tag: M5005_Spy_0274
	M5005_Spy_0274	-131	4.8	AATTTTCAGTCAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: braB
Ortholog function: Branched-chain amino acid transport system carrier protein
Streptococcus pyogenes M1 GAS	SPy0323	-131	4.8	AATTTTCAGTCAATT
Streptococcus uberis 0140J	SUB0370	-43	5.1	AATTGTTAGAAAATT

Position: -102 Score: 4.6 Sequence: AATTTTATGATAAAT Locus tag: M5005_Spy_0713
	M5005_Spy_0713	-102	4.6	AATTTTATGATAAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvE
Ortholog function: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Lactococcus lactis subsp. cremoris SK11	LACR_1409	-97	4.8	AATTGTTTGAAATTT
Streptococcus agalactiae 2603V/R	SAG1152	-83	4.7	ATTTATCTGAATTTT
Streptococcus gallolyticus UCN34	GALLO_0979	-84	5.3	AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1	SGO_1238	-99	5.8	AATTTTCTGAAAATT
Streptococcus mitis B6	smi_0906	-88	5.8	AATTTTCTGAAAATT
Streptococcus mutans UA159	SMU.1203	-83	5.3	AATTTTCAGAATTTT
Streptococcus pneumoniae TIGR4	SP_0856	-88	5.8	AATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS	SPy0911	-102	4.6	AATTTTATGATAAAT
Streptococcus sanguinis SK36	SSA_1225	-98	5.8	AATTTTCTGAAAATT
Streptococcus thermophilus CNRZ1066	str0590	-90	4.9	AATTGTCAGAATTTT
Streptococcus uberis 0140J	SUB1010	-88	4.8	AATATTCCGAATATT

Position: -96 Score: 5.1 Sequence: AATTATCAGAATTTT Position: -87 Score: 5.3 Sequence: AATTTTCAGATATTT Locus tag: M5005_Spy_1119
	M5005_Spy_1119	-96	5.1	AATTATCAGAATTTT
		-87	5.3	AATTTTCAGATATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gapN
Ortholog function: Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9)
Streptococcus agalactiae 2603V/R	SAG0823	-72	4.6	ATATGTCAGATAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1419	-87	4.9	AATTTTCTGATACTT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0766	-87	4.6	AATTTTCAGACTCTT
Streptococcus gallolyticus UCN34	GALLO_0746	-87	5.3	AATTTTCTGAATTTT
Streptococcus mutans UA159	SMU.676	-89	5.3	AATTTTCTGAATTTT
Streptococcus pneumoniae TIGR4	SP_1119	-55	5.2	GATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS	SPy1371	-87	5.3	AATTTTCAGATATTT
Streptococcus sanguinis SK36	SSA_0774	-53	5.8	AATTTTCAGAAAATT
Streptococcus thermophilus CNRZ1066	str1263	-89	5	AATTTTCTGAATACT
Streptococcus uberis 0140J	SUB1220	-87	5.4	AATTTTCAGACAATT

Position: -29 Score: 5.1 Sequence: AATTTTTAAAAAATT Locus tag: M5005_Spy_1153
	M5005_Spy_1153	-29	5.1	AATTTTTAAAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: kup
Ortholog function: Kup system potassium uptake protein
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1454	-93	4.8	AATTTTCTGAAAAAG
		-29	5.1	AATTTTTAAAAAATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0647	-89	5.3	AATTTTCTGAAAATA
Streptococcus pyogenes M1 GAS	SPy1414	-93	4.8	AATTTTCTGAAAAAG
		-29	5.1	AATTTTTAAAAAATT

Position: -107 Score: 4.9 Sequence: ATTTTTCAAAATATT Locus tag: M5005_Spy_1269
	M5005_Spy_1269	-107	4.9	ATTTTTCAAAATATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: asnA
Ortholog function: Aspartate--ammonia ligase (EC 6.3.1.1)
Streptococcus gallolyticus UCN34	GALLO_0534	-144	4.8	AATTTTCAAAAAAGT
Streptococcus pyogenes M1 GAS	SPy1539	-107	4.9	ATTTTTCAAAATATT
Streptococcus suis 05ZYH33	SSU05_0467	-124	5.3	AATTATCAGAATATT
Streptococcus uberis 0140J	SUB1323	-123	4.6	AATATACTGAAAAAT

Position: -53 Score: 5 Sequence: AATTTTCTGAAAAAA Locus tag: M5005_Spy_1359
	M5005_Spy_1359	-53	5	AATTTTCTGAAAAAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: aapA
Ortholog function: Amino acid permease
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1715	-41	5	AATTTTCTGAAAAAA
Streptococcus pyogenes M1 GAS	SPy1654	-53	5	AATTTTCTGAAAAAA
Streptococcus thermophilus CNRZ1066	str0509	-108	4.7	AATATTCTGAATTAT
Streptococcus uberis 0140J	SUB1411	-54	4.8	AATATTCTGAAAAAA

Position: -80 Score: 5.6 Sequence: AATTTTCTGATAATT Locus tag: M5005_Spy_1512
	M5005_Spy_1512	-80	5.6	AATTTTCTGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: codY
Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family
Lactococcus lactis subsp. cremoris SK11	LACR_0168	-101	5.4	AATTTTCTGACAATT
Lactococcus lactis subsp. lactis Il1403	L0243	-101	5.4	AATTTTCTGACAATT
Streptococcus agalactiae 2603V/R	SAG1675	-46	5	AATTTTGAGAATATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1848	-80	5.6	AATTTTCTGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0387	-78	5.6	AATTTTCTGATAATT
Streptococcus gallolyticus UCN34	GALLO_1876	-77	5.6	AATTTTCAGATAATT
Streptococcus gordonii str. Challis substr. CH1	SGO_0431	-71	5.6	AATTTTCAGATAATT
Streptococcus mitis B6	smi_0687	-71	5.6	AATTTTCAGATAATT
Streptococcus mutans UA159	SMU.1824c	-75	5.4	AATTTTCTGACAATT
Streptococcus pneumoniae TIGR4	SP_1584	-71	5.6	AATTTTCAGATAATT
Streptococcus pyogenes M1 GAS	SPy1777	-80	5.6	AATTTTCTGATAATT
Streptococcus sanguinis SK36	SSA_0566	-71	5.6	AATTTTCAGATAATT
Streptococcus suis 05ZYH33	SSU05_0350	-74	5.3	AATATTCTGATAATT
Streptococcus thermophilus CNRZ1066	str1635	-132	5.4	AATTTTCAGACAATT
Streptococcus uberis 0140J	SUB1528	-82	5.6	AATTTTCTGATAATT

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Propagation of CodY regulog to Streptococcus pyogenes MGAS5005

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --