Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CodY regulog to Streptococcus pneumoniae SP23-BS72

Reference regulog properties
Source regulog: CodY - Streptococcaceae
Regulator type: Transcription factor
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pneumoniae SP23-BS72
Orthologous TF(s) CGSSp23BS72_07756
Regulated genes 19
Built upon 273 sites [see more]
Predicted regulatory interactions in Streptococcus pneumoniae SP23-BS72
Locus tag Position Score Sequence
Position: -41
Score: 5
Sequence: AAAATTTAGAAAATT
Locus tag: CGSSp23BS72_10525
CGSSp23BS72_10525 -41 5 AAAATTTAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ymdE
Ortholog function: Conserved hypothetical protein
Streptococcus gordonii str. Challis substr. CH1 SGO_0476 -42 5.3 AAAATTCAGAAAATT
Streptococcus mitis B6 smi_1990 4 5.3 AAAATTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_0095 -41 5 AAAATTTAGAAAATT
Streptococcus sanguinis SK36 SSA_0593 -42 5.3 AAAATTCAGAAAATT
Position: -33
Score: 5.2
Sequence: ATTATTCTGAAAATT
Locus tag: CGSSp23BS72_10910
CGSSp23BS72_10910 -33 5.2 ATTATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: SMU.1109
Ortholog function: Predicted Mn2+/Fe2+ transporter, NRAMP family
Streptococcus gallolyticus UCN34 GALLO_1124 -45 5.3 AATTATCTGAATATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1506 -102 4.8 TATTTTCCGAAAATT
-42 5.6 AATTATCTGAAAATT
Streptococcus mutans UA159 SMU.1109c -105 5.3 AATTTTCTGAAAATA
Streptococcus pneumoniae TIGR4 SP_0159 -33 5.2 ATTATTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str0745 -106 5 ATTTTTCAGAAAATA
-33 5.2 ATTATTCTGAAAATT
Position: -74
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: CGSSp23BS72_12000
CGSSp23BS72_12000 -74 5.3 AAAATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA2
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Streptococcus gordonii str. Challis substr. CH1 SGO_1712 -90 5.2 AATATTCTGACAATT
Streptococcus mitis B6 smi_1758 -71 5.3 AAAATTCAGAAAATT
Streptococcus pneumoniae TIGR4 SP_0366 -71 5.3 AAAATTCTGAAAATT
Streptococcus sanguinis SK36 SSA_2165 -78 5.6 AATTATCAGAAAATT
Streptococcus sanguinis SK36 SSA_1948 -87 5.6 AATATTCTGAAAATT
Position: -56
Score: 5.2
Sequence: AATTTTCACAAAATT
Locus tag: CGSSp23BS72_05155
CGSSp23BS72_05155 -56 5.2 AATTTTCACAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: hom
Ortholog function: Homoserine dehydrogenase (EC 1.1.1.3)
Lactococcus lactis subsp. lactis Il1403 L0090 -41 4.9 AATTATCTTAAAATT
Streptococcus gallolyticus UCN34 GALLO_1241 -118 4.8 ATTTTTCTGTAAATT
Streptococcus mitis B6 smi_0773 -56 5.2 AATTTTCACAAAATT
Streptococcus pneumoniae TIGR4 SP_1361 -56 5.2 AATTTTCACAAAATT
Streptococcus suis 05ZYH33 SSU05_0801 -52 5 AATAGTCAGAATATT
Streptococcus thermophilus CNRZ1066 str0469 -70 4.6 AATATTCTGTCAATT
Position: -31
Score: 5.5
Sequence: AATTTTTAGAAAATT
Locus tag: CGSSp23BS72_03388
CGSSp23BS72_03388 -31 5.5 AATTTTTAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: asd
Ortholog function: Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1025 -60 5.5 AATTTTTAGAAAATT
Streptococcus gallolyticus UCN34 GALLO_1113 -52 5.1 ATTTTTTAGAAAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1206 -29 5.5 AATTTTTAGAAAATT
Streptococcus mitis B6 smi_1133 -31 5.5 AATTTTTAGAAAATT
Streptococcus pneumoniae TIGR4 SP_1013 -31 5.5 AATTTTTAGAAAATT
Streptococcus sanguinis SK36 SSA_1194 -30 5.5 AATTTTTTGAAAATT
Streptococcus uberis 0140J SUB0939 -54 5.5 AATTTTTAGAAAATT
Position: 10
Score: 4.7
Sequence: AAAAATTAGAAAATT
Locus tag: CGSSp23BS72_03683
CGSSp23BS72_03683 10 4.7 AAAAATTAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ppc
Ortholog function: Phosphoenolpyruvate carboxylase (EC 4.1.1.31)
Streptococcus agalactiae 2603V/R SAG0759 -96 5.1 AAAAATCTGAAAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0621 -167 4.5 CATTTTCAGGAAATT
Streptococcus gallolyticus UCN34 GALLO_1515 -132 5.1 AAAAATCAGAAAATT
Streptococcus thermophilus CNRZ1066 str0718 -108 4.9 AAAAGTCAGAAAATT
Streptococcus uberis 0140J SUB0602 -55 4.8 AATTTTCAGAAAAAG
Position: -85
Score: 5.8
Sequence: AATTTTCTGAAAATT
Locus tag: CGSSp23BS72_08379
CGSSp23BS72_08379 -85 5.8 AATTTTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvD
Ortholog function: Dihydroxy-acid dehydratase (EC 4.2.1.9)
Streptococcus gordonii str. Challis substr. CH1 SGO_2064 -95 5.3 AAAATTCTGAAAATT
Streptococcus mitis B6 smi_0113 -85 5.8 AATTTTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_2126 -85 5.8 AATTTTCTGAAAATT
Streptococcus sanguinis SK36 SSA_2286 -78 5.3 AATCTTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str1604 -61 4.7 ATTTTTTAGACAATT
Position: -124
Score: 5.3
Sequence: AAATTTCAGAAATTT
Locus tag: CGSSp23BS72_06249
CGSSp23BS72_06249 -124 5.3 AAATTTCAGAAATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: str1582
Ortholog function: Predicted amino acid ABC transporter, permease protein 1
Streptococcus gordonii str. Challis substr. CH1 SGO_0985 -248 4.8 TATTTTCAGAATAAT
Streptococcus mitis B6 smi_1436 -124 5.3 AAATTTCAGAAATTT
Streptococcus pneumoniae TIGR4 SP_0711 -183 5.3 AAATTTCAGAAATTT
Position: -183
Score: 4.4
Sequence: TAATTTCTAATAATT
Locus tag: CGSSp23BS72_06469
CGSSp23BS72_06469 -183 4.4 TAATTTCTAATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: acuB
Ortholog function: Acetoin utilization protein AcuB
Streptococcus gordonii str. Challis substr. CH1 SGO_1625 -173 4.8 AATTTTTAGAAACTT
Streptococcus mitis B6 smi_1410 -92 4.7 ACTTTTCTGAATTTT
Streptococcus pneumoniae TIGR4 SP_0754 -183 4.4 TAATTTCTAATAATT
Streptococcus sanguinis SK36 SSA_1724 -112 4.6 ATTTTTCTAAATTTT
Position: -88
Score: 5.8
Sequence: AATTTTCTGAAAATT
Locus tag: CGSSp23BS72_08290
CGSSp23BS72_08290 -88 5.8 AATTTTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvE
Ortholog function: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Lactococcus lactis subsp. cremoris SK11 LACR_1409 -97 4.8 AATTGTTTGAAATTT
Streptococcus agalactiae 2603V/R SAG1152 -83 4.7 ATTTATCTGAATTTT
Streptococcus gallolyticus UCN34 GALLO_0979 -84 5.3 AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1 SGO_1238 -99 5.8 AATTTTCTGAAAATT
Streptococcus mitis B6 smi_0906 -88 5.8 AATTTTCTGAAAATT
Streptococcus mutans UA159 SMU.1203 -83 5.3 AATTTTCAGAATTTT
Streptococcus pneumoniae TIGR4 SP_0856 -88 5.8 AATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0911 -102 4.6 AATTTTATGATAAAT
Streptococcus sanguinis SK36 SSA_1225 -98 5.8 AATTTTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str0590 -90 4.9 AATTGTCAGAATTTT
Streptococcus uberis 0140J SUB1010 -88 4.8 AATATTCCGAATATT
Position: -112
Score: 5
Sequence: AAGATTCTGAAAATT
Locus tag: CGSSp23BS72_00935
CGSSp23BS72_00935 -112 5 AAGATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: rpoB
Ortholog function: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Streptococcus agalactiae 2603V/R SAG0160 -128 5.2 AACTTTCTGAAAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0131 -91 4.6 AAGATTCTAAAAATT
Streptococcus gallolyticus UCN34 GALLO_0084 -165 4.6 AAGATTCTAAAAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1927 -222 5.4 ATTTTTCTGAAAATT
Streptococcus mitis B6 smi_1847 -113 5 AAGATTCTGAAAATT
Streptococcus mutans UA159 SMU.1990 -84 5.3 AAAATTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_1961 -112 5 AAGATTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0098 -91 5.2 AATATTCTAAAAATT
Streptococcus suis 05ZYH33 SSU05_0121 -276 4.6 AAGATTCTAAAAATT
Streptococcus thermophilus CNRZ1066 str1868 -171 4.6 AAAGTTCTAAAAATT
Streptococcus uberis 0140J SUB0115 -90 4.6 AAGATTCTAAAAATT
Position: -71
Score: 5.6
Sequence: AATTTTCAGATAATT
Locus tag: CGSSp23BS72_07756
CGSSp23BS72_07756 -71 5.6 AATTTTCAGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: codY
Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family
Lactococcus lactis subsp. cremoris SK11 LACR_0168 -101 5.4 AATTTTCTGACAATT
Lactococcus lactis subsp. lactis Il1403 L0243 -101 5.4 AATTTTCTGACAATT
Streptococcus agalactiae 2603V/R SAG1675 -46 5 AATTTTGAGAATATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1848 -80 5.6 AATTTTCTGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0387 -78 5.6 AATTTTCTGATAATT
Streptococcus gallolyticus UCN34 GALLO_1876 -77 5.6 AATTTTCAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0431 -71 5.6 AATTTTCAGATAATT
Streptococcus mitis B6 smi_0687 -71 5.6 AATTTTCAGATAATT
Streptococcus mutans UA159 SMU.1824c -75 5.4 AATTTTCTGACAATT
Streptococcus pneumoniae TIGR4 SP_1584 -71 5.6 AATTTTCAGATAATT
Streptococcus pyogenes M1 GAS SPy1777 -80 5.6 AATTTTCTGATAATT
Streptococcus sanguinis SK36 SSA_0566 -71 5.6 AATTTTCAGATAATT
Streptococcus suis 05ZYH33 SSU05_0350 -74 5.3 AATATTCTGATAATT
Streptococcus thermophilus CNRZ1066 str1635 -132 5.4 AATTTTCAGACAATT
Streptococcus uberis 0140J SUB1528 -82 5.6 AATTTTCTGATAATT
Position: -57
Score: 5.4
Sequence: AATTTTCTGAAAAAT
Locus tag: CGSSp23BS72_04395
CGSSp23BS72_04395 -57 5.4 AATTTTCTGAAAAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: thrC
Ortholog function: Threonine synthase (EC 4.2.3.1)
Streptococcus agalactiae 2603V/R SAG0055 -100 5.2 AATTTTCTGAAAATC
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0063 -113 5.2 AATTTTCAGAAAACT
Streptococcus gallolyticus UCN34 GALLO_0042 -61 5.6 AATTTTCTGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0139 -57 5.2 AATTTTCTGATAAAT
Streptococcus mitis B6 smi_0193 -57 5.4 AATTTTCTGAAAAAT
Streptococcus mutans UA159 SMU.70 -59 5.2 AATTGTCTGATAATT
Streptococcus pneumoniae TIGR4 SP_2066 -57 5.4 AATTTTCTGAAAAAT
Streptococcus sanguinis SK36 SSA_0095 -57 5.2 AATTTTCTGATAAAT
Streptococcus suis 05ZYH33 SSU05_0281 -56 4.8 AATTTTCTGTCAATT
Streptococcus thermophilus CNRZ1066 str1878 -59 5.4 AATTTTCTGACAATT
Position: -93
Score: 5.3
Sequence: AAAATTCAGAAAATT
Locus tag: CGSSp23BS72_07286
CGSSp23BS72_07286 -93 5.3 AAAATTCAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvB
Ortholog function: Acetolactate synthase large subunit (EC 2.2.1.6)
Lactococcus lactis subsp. cremoris SK11 LACR_1311 -86 4.9 AATATTCTGACAAAT
Lactococcus lactis subsp. lactis Il1403 L0078 -86 4.9 AATATTCTGACAAAT
Streptococcus gallolyticus UCN34 GALLO_0305 -42 5.2 AATTTTTAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0526 -249 5.8 AATTTTCTGAAAATT
-27 5.1 AATTTTTTGACAATT
Streptococcus mitis B6 smi_1825 -93 5.3 AAAATTCAGAAAATT
Streptococcus mutans UA159 SMU.231 -42 5.5 AATTTTTTGAAAATT
Streptococcus pneumoniae TIGR4 SP_0445 -93 5.3 AAAATTCAGAAAATT
Streptococcus sanguinis SK36 SSA_1970 -37 5.5 AATTTTTAGAAAATT
Streptococcus suis 05ZYH33 SSU05_1888 -296 5.8 AATTTTCAGAAAATT
Streptococcus thermophilus CNRZ1066 str1873 -27 5.2 AATTTTTAGATAATT
Position: -95
Score: 5.2
Sequence: AATTGTCAGAAATTT
Locus tag: CGSSp23BS72_09993
CGSSp23BS72_09993 -95 5.2 AATTGTCAGAAATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: fatD
Ortholog function: Iron-siderophore ABC transporter, permease protein 1
Streptococcus agalactiae 2603V/R SAG1010 -177 4.7 AATATTCTGCTAATT
Streptococcus gallolyticus UCN34 GALLO_0871 -109 5.8 AATTTTCAGAAAATT
Streptococcus pneumoniae TIGR4 SP_1869 -80 5.2 AATTGTCAGAAATTT
Position: -87
Score: 5.6
Sequence: AATATTCTGAAAATT
Locus tag: CGSSp23BS72_04055
CGSSp23BS72_04055 -87 5.6 AATATTCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA2
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Streptococcus mitis B6 smi_0322 -83 5.6 AATATTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_1891 -87 5.6 AATATTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str1445 -76 4.7 AATTTTCTGATAAAA
Streptococcus thermophilus CNRZ1066 str1443 -194 4.6 ATTTTTTAGAAAATA
-121 4.9 ATTATTCTGAAAAAT
Streptococcus thermophilus CNRZ1066 str1442 -194 4.6 ATTTTTTAGAAAATA
-121 4.9 ATTATTCTGAAAAAT
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