Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CodY regulog to Lactococcus lactis subsp. cremoris SK11

Reference regulog properties
Source regulog: CodY - Streptococcaceae
Regulator type: Transcription factor
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Phylum: Firmicutes
Propagated regulon:
Target genome Lactococcus lactis subsp. cremoris SK11
Orthologous TF(s) LACR_0168, LACR_1982
Regulated genes 12
Built upon 273 sites [see more]
Predicted regulatory interactions in Lactococcus lactis subsp. cremoris SK11
Locus tag Position Score Sequence
Position: -101
Score: 5.4
Sequence: AATTTTCTGACAATT
Locus tag: LACR_0168
LACR_0168 -101 5.4 AATTTTCTGACAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: codY
Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family
Lactococcus lactis subsp. cremoris SK11 LACR_0168 -101 5.4 AATTTTCTGACAATT
Lactococcus lactis subsp. lactis Il1403 L0243 -101 5.4 AATTTTCTGACAATT
Streptococcus agalactiae 2603V/R SAG1675 -46 5 AATTTTGAGAATATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1848 -80 5.6 AATTTTCTGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0387 -78 5.6 AATTTTCTGATAATT
Streptococcus gallolyticus UCN34 GALLO_1876 -77 5.6 AATTTTCAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0431 -71 5.6 AATTTTCAGATAATT
Streptococcus mitis B6 smi_0687 -71 5.6 AATTTTCAGATAATT
Streptococcus mutans UA159 SMU.1824c -75 5.4 AATTTTCTGACAATT
Streptococcus pneumoniae TIGR4 SP_1584 -71 5.6 AATTTTCAGATAATT
Streptococcus pyogenes M1 GAS SPy1777 -80 5.6 AATTTTCTGATAATT
Streptococcus sanguinis SK36 SSA_0566 -71 5.6 AATTTTCAGATAATT
Streptococcus suis 05ZYH33 SSU05_0350 -74 5.3 AATATTCTGATAATT
Streptococcus thermophilus CNRZ1066 str1635 -132 5.4 AATTTTCAGACAATT
Streptococcus uberis 0140J SUB1528 -82 5.6 AATTTTCTGATAATT
Position: -123
Score: 5.1
Sequence: AATTGTCAGAAAAAT
Position: -55
Score: 5.2
Sequence: AATTTTCAGAATAAT
Position: -46
Score: 5
Sequence: AATAATTAGAAAATT
Locus tag: LACR_0389
LACR_0389 -123 5.1 AATTGTCAGAAAAAT
-55 5.2 AATTTTCAGAATAAT
-46 5 AATAATTAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA1
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Lactococcus lactis subsp. cremoris SK11 LACR_0389 -123 5.1 AATTGTCAGAAAAAT
-55 5.2 AATTTTCAGAATAAT
Lactococcus lactis subsp. cremoris SK11 LACR_0390 -129 4.7 AATTTTCAGAAAACA
-61 5 AATTTTCTGACAATA
Lactococcus lactis subsp. lactis Il1403 L143312 -123 5.2 AATTATCAGAAAAAT
-55 5.2 AATTTTCAGAATAAT
Lactococcus lactis subsp. lactis Il1403 L145267 -129 4.7 AATTTTCAGAAAACA
-61 5 AATTTTCTGACAATA
Position: -293
Score: 5.8
Sequence: AATTTTCTGAAAATT
Position: -61
Score: 5
Sequence: AATTTTCTGACAATA
Locus tag: LACR_0390
LACR_0390 -293 5.8 AATTTTCTGAAAATT
-61 5 AATTTTCTGACAATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA1
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Lactococcus lactis subsp. cremoris SK11 LACR_0389 -123 5.1 AATTGTCAGAAAAAT
-55 5.2 AATTTTCAGAATAAT
Lactococcus lactis subsp. cremoris SK11 LACR_0390 -129 4.7 AATTTTCAGAAAACA
-61 5 AATTTTCTGACAATA
Lactococcus lactis subsp. lactis Il1403 L143312 -123 5.2 AATTATCAGAAAAAT
-55 5.2 AATTTTCAGAATAAT
Lactococcus lactis subsp. lactis Il1403 L145267 -129 4.7 AATTTTCAGAAAACA
-61 5 AATTTTCTGACAATA
Position: -59
Score: 5.6
Sequence: AATTATCAGAAAATT
Locus tag: LACR_0619
LACR_0619 -59 5.6 AATTATCAGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: serC
Ortholog function: Phosphoserine aminotransferase (EC 2.6.1.52)
Lactococcus lactis subsp. cremoris SK11 LACR_0619 -59 5.6 AATTATCAGAAAATT
Lactococcus lactis subsp. lactis Il1403 L0083 -59 5.6 AATTATCAGAAAATT
Streptococcus gallolyticus UCN34 GALLO_1746 -51 5.3 AAAATTCAGAAAATT
Streptococcus mutans UA159 SMU.1656 -50 5.3 AAAATTCTGAAAATT
Streptococcus suis 05ZYH33 SSU05_0665 -54 5.2 AATTGTCTGAATATT
Streptococcus uberis 0140J SUB0445 -53 5.3 AAAATTCTGAAAATT
Position: -71
Score: 5.6
Sequence: AATTATCTGAAAATT
Locus tag: LACR_0783
LACR_0783 -71 5.6 AATTATCTGAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: thrA
Ortholog function: Aspartokinase (EC 2.7.2.4)
Lactococcus lactis subsp. cremoris SK11 LACR_0783 -71 5.6 AATTATCTGAAAATT
Lactococcus lactis subsp. lactis Il1403 L0097 -70 5.6 AATTATCTGAAAATT
Streptococcus agalactiae 2603V/R SAG0339 -52 4.9 AATTTTCTGACTTTT
Streptococcus gallolyticus UCN34 GALLO_0331 -52 5.3 AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1 SGO_1701 -38 4.5 AATTGTTTGAATAAT
Streptococcus mutans UA159 SMU.1748 -53 5.3 AATTTTCTGAATTTT
Streptococcus sanguinis SK36 SSA_1943 -47 5.3 AATTTTCAGAATTTT
Streptococcus suis 05ZYH33 SSU05_1811 -123 4.6 GTTTTTCTGAAATTT
Streptococcus thermophilus CNRZ1066 str0378 -56 5.1 AATTATCAGAATTTT
Streptococcus uberis 0140J SUB0316 -26 5 AATATTCATAAAATT
Position: -86
Score: 4.9
Sequence: AATATTCTGACAAAT
Locus tag: LACR_1312
LACR_1312 -86 4.9 AATATTCTGACAAAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvD
Ortholog function: Dihydroxy-acid dehydratase (EC 4.2.1.9)
Lactococcus lactis subsp. cremoris SK11 LACR_1312 -86 4.9 AATATTCTGACAAAT
Lactococcus lactis subsp. lactis Il1403 L0077 -86 4.9 AATATTCTGACAAAT
Position: -309
Score: 4.7
Sequence: ATAATTCAGATAATT
Locus tag: LACR_1336
LACR_1336 -309 4.7 ATAATTCAGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: hisC
Ortholog function: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
Lactococcus lactis subsp. cremoris SK11 LACR_1336 -309 4.7 ATAATTCAGATAATT
Lactococcus lactis subsp. lactis Il1403 L0065 -299 4.7 ATAATTCAGATAATT
Streptococcus mutans UA159 SMU.1273 -310 5.1 AATATTCAGAATTTT
Position: -80
Score: 4.9
Sequence: AATTATCAGAATATA
Locus tag: LACR_1407
LACR_1407 -80 4.9 AATTATCAGAATATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gltB
Ortholog function: Glutamate synthase [NADPH] large chain (EC 1.4.1.13)
Lactococcus lactis subsp. cremoris SK11 LACR_1407 -80 4.9 AATTATCAGAATATA
Lactococcus lactis subsp. lactis Il1403 L0119 -80 4.7 AATTGTCAGAATATA
Streptococcus gallolyticus UCN34 GALLO_1991 -59 5 AATATTCTGAATAAT
Streptococcus mutans UA159 SMU.365 -108 5.3 AATTTTCAGAATTTT
Position: -97
Score: 4.8
Sequence: AATTGTTTGAAATTT
Locus tag: LACR_1409
LACR_1409 -97 4.8 AATTGTTTGAAATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ilvE
Ortholog function: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Lactococcus lactis subsp. cremoris SK11 LACR_1409 -97 4.8 AATTGTTTGAAATTT
Streptococcus agalactiae 2603V/R SAG1152 -83 4.7 ATTTATCTGAATTTT
Streptococcus gallolyticus UCN34 GALLO_0979 -84 5.3 AATTTTCAGAATTTT
Streptococcus gordonii str. Challis substr. CH1 SGO_1238 -99 5.8 AATTTTCTGAAAATT
Streptococcus mitis B6 smi_0906 -88 5.8 AATTTTCTGAAAATT
Streptococcus mutans UA159 SMU.1203 -83 5.3 AATTTTCAGAATTTT
Streptococcus pneumoniae TIGR4 SP_0856 -88 5.8 AATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0911 -102 4.6 AATTTTATGATAAAT
Streptococcus sanguinis SK36 SSA_1225 -98 5.8 AATTTTCTGAAAATT
Streptococcus thermophilus CNRZ1066 str0590 -90 4.9 AATTGTCAGAATTTT
Streptococcus uberis 0140J SUB1010 -88 4.8 AATATTCCGAATATT
Position: -61
Score: 5.1
Sequence: AATATTCAGAAAATA
Locus tag: LACR_1699
LACR_1699 -61 5.1 AATATTCAGAAAATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: nrgA
Ortholog function: Ammonium transporter
Lactococcus lactis subsp. cremoris SK11 LACR_1699 -61 5.1 AATATTCAGAAAATA
Lactococcus lactis subsp. lactis Il1403 L0236 -62 5 AATTGTCAGAAAATA
Streptococcus gallolyticus UCN34 GALLO_1749 -148 5 AAAATTTAGAAAATT
Streptococcus mitis B6 smi_0683 -93 5.2 AATTATCAAAAAATT
Streptococcus mutans UA159 SMU.1658 -85 5.5 AATTTTTAGAAAATT
Streptococcus thermophilus CNRZ1066 str0494 -45 5.2 AATTATCAAAAAATT
Position: -125
Score: 4.8
Sequence: ATTTTTTTGATAATT
Locus tag: LACR_2073
LACR_2073 -125 4.8 ATTTTTTTGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: pepC
Ortholog function: Aminopeptidase C (EC 3.4.22.40)
Lactococcus lactis subsp. cremoris SK11 LACR_2073 -125 4.8 ATTTTTTTGATAATT
Lactococcus lactis subsp. lactis Il1403 L130687 -125 4.8 ATTTTTTTGATAATT
Streptococcus agalactiae 2603V/R SAG0297 -48 4.8 AATATTCAGAATGTT
Streptococcus gallolyticus UCN34 GALLO_0478 -125 4.7 AAATGTCAGAATTTT
Streptococcus thermophilus CNRZ1066 str0229 -57 5.1 AATTTTCAGAAATTA
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