Propagation of CodY regulog to Streptococcus pyogenes MGAS10750
| Source regulog: | CodY - Streptococcaceae |
| Regulator type: | Transcription factor |
| Regulator family: | CodY |
| Regulation mode: | repressor (activator) |
| Biological process: | Amino acid metabolism |
| Effector: | Guanosine triphosphate; Branched-chain amino acids |
| Phylum: | Firmicutes |
| Propagated regulon: | |
| Target genome | Streptococcus pyogenes MGAS10750 |
| Orthologous TF(s) | MGAS10750_Spy1572 |
| Regulated genes | 8 |
| Locus tag | Position | Score | Sequence | |
|---|---|---|---|---|
|
Position: -91
Score: 5.2 Sequence: AATATTCTAAAAATT
Locus tag: MGAS10750_Spy0090
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| MGAS10750_Spy0090 | -91 | 5.2 | AATATTCTAAAAATT | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: rpoB | ||||
| Ortholog function: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) | ||||
| Streptococcus agalactiae 2603V/R | SAG0160 | -128 | 5.2 | AACTTTCTGAAAATT |
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0131 | -91 | 4.6 | AAGATTCTAAAAATT |
| Streptococcus gallolyticus UCN34 | GALLO_0084 | -165 | 4.6 | AAGATTCTAAAAATT |
| Streptococcus gordonii str. Challis substr. CH1 | SGO_1927 | -222 | 5.4 | ATTTTTCTGAAAATT |
| Streptococcus mitis B6 | smi_1847 | -113 | 5 | AAGATTCTGAAAATT |
| Streptococcus mutans UA159 | SMU.1990 | -84 | 5.3 | AAAATTCTGAAAATT |
| Streptococcus pneumoniae TIGR4 | SP_1961 | -112 | 5 | AAGATTCTGAAAATT |
| Streptococcus pyogenes M1 GAS | SPy0098 | -91 | 5.2 | AATATTCTAAAAATT |
| Streptococcus suis 05ZYH33 | SSU05_0121 | -276 | 4.6 | AAGATTCTAAAAATT |
| Streptococcus thermophilus CNRZ1066 | str1868 | -171 | 4.6 | AAAGTTCTAAAAATT |
| Streptococcus uberis 0140J | SUB0115 | -90 | 4.6 | AAGATTCTAAAAATT |
|
Position: -116
Score: 5.3 Sequence: AATATTCAGATAATT
Locus tag: MGAS10750_Spy0246
|
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| MGAS10750_Spy0246 | -116 | 5.3 | AATATTCAGATAATT | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: oppA2 | ||||
| Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1) | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0356 | -115 | 5.3 | AATATTCAGATAATT |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1697 | -119 | 5.3 | AATATTCAGATAATT |
|
Position: -131
Score: 4.8 Sequence: AATTTTCAGTCAATT
Position: -47
Score: 4.9 Sequence: AATTGTTAGAATATT
Locus tag: MGAS10750_Spy0269
|
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| MGAS10750_Spy0269 | -131 | 4.8 | AATTTTCAGTCAATT | |
| -47 | 4.9 | AATTGTTAGAATATT | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: braB | ||||
| Ortholog function: Branched-chain amino acid transport system carrier protein | ||||
| Streptococcus pyogenes M1 GAS | SPy0323 | -131 | 4.8 | AATTTTCAGTCAATT |
| Streptococcus uberis 0140J | SUB0370 | -43 | 5.1 | AATTGTTAGAAAATT |
|
Position: -96
Score: 5.1 Sequence: AATTATCAGAATTTT
Position: -87
Score: 5.3 Sequence: AATTTTCAGATATTT
Locus tag: MGAS10750_Spy1221
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| MGAS10750_Spy1221 | -96 | 5.1 | AATTATCAGAATTTT | |
| -87 | 5.3 | AATTTTCAGATATTT | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: gapN | ||||
| Ortholog function: Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9) | ||||
| Streptococcus agalactiae 2603V/R | SAG0823 | -72 | 4.6 | ATATGTCAGATAATT |
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_1419 | -87 | 4.9 | AATTTTCTGATACTT |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_0766 | -87 | 4.6 | AATTTTCAGACTCTT |
| Streptococcus gallolyticus UCN34 | GALLO_0746 | -87 | 5.3 | AATTTTCTGAATTTT |
| Streptococcus mutans UA159 | SMU.676 | -89 | 5.3 | AATTTTCTGAATTTT |
| Streptococcus pneumoniae TIGR4 | SP_1119 | -55 | 5.2 | GATTTTCTGAAAATT |
| Streptococcus pyogenes M1 GAS | SPy1371 | -87 | 5.3 | AATTTTCAGATATTT |
| Streptococcus sanguinis SK36 | SSA_0774 | -53 | 5.8 | AATTTTCAGAAAATT |
| Streptococcus thermophilus CNRZ1066 | str1263 | -89 | 5 | AATTTTCTGAATACT |
| Streptococcus uberis 0140J | SUB1220 | -87 | 5.4 | AATTTTCAGACAATT |
|
Position: -107
Score: 4.9 Sequence: ATTTTTCAAAATATT
Locus tag: MGAS10750_Spy1376
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| MGAS10750_Spy1376 | -107 | 4.9 | ATTTTTCAAAATATT | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: asnA | ||||
| Ortholog function: Aspartate--ammonia ligase (EC 6.3.1.1) | ||||
| Streptococcus gallolyticus UCN34 | GALLO_0534 | -144 | 4.8 | AATTTTCAAAAAAGT |
| Streptococcus pyogenes M1 GAS | SPy1539 | -107 | 4.9 | ATTTTTCAAAATATT |
| Streptococcus suis 05ZYH33 | SSU05_0467 | -124 | 5.3 | AATTATCAGAATATT |
| Streptococcus uberis 0140J | SUB1323 | -123 | 4.6 | AATATACTGAAAAAT |
|
Position: -41
Score: 5 Sequence: AATTTTCTGAAAAAA
Locus tag: MGAS10750_Spy1468
|
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| MGAS10750_Spy1468 | -41 | 5 | AATTTTCTGAAAAAA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: aapA | ||||
| Ortholog function: Amino acid permease | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_1715 | -41 | 5 | AATTTTCTGAAAAAA |
| Streptococcus pyogenes M1 GAS | SPy1654 | -53 | 5 | AATTTTCTGAAAAAA |
| Streptococcus thermophilus CNRZ1066 | str0509 | -108 | 4.7 | AATATTCTGAATTAT |
| Streptococcus uberis 0140J | SUB1411 | -54 | 4.8 | AATATTCTGAAAAAA |
|
Position: -79
Score: 5.6 Sequence: AATTTTCTGATAATT
Locus tag: MGAS10750_Spy1572
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| MGAS10750_Spy1572 | -79 | 5.6 | AATTTTCTGATAATT | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: codY | ||||
| Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family | ||||
| Lactococcus lactis subsp. cremoris SK11 | LACR_0168 | -101 | 5.4 | AATTTTCTGACAATT |
| Lactococcus lactis subsp. lactis Il1403 | L0243 | -101 | 5.4 | AATTTTCTGACAATT |
| Streptococcus agalactiae 2603V/R | SAG1675 | -46 | 5 | AATTTTGAGAATATT |
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_1848 | -80 | 5.6 | AATTTTCTGATAATT |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_0387 | -78 | 5.6 | AATTTTCTGATAATT |
| Streptococcus gallolyticus UCN34 | GALLO_1876 | -77 | 5.6 | AATTTTCAGATAATT |
| Streptococcus gordonii str. Challis substr. CH1 | SGO_0431 | -71 | 5.6 | AATTTTCAGATAATT |
| Streptococcus mitis B6 | smi_0687 | -71 | 5.6 | AATTTTCAGATAATT |
| Streptococcus mutans UA159 | SMU.1824c | -75 | 5.4 | AATTTTCTGACAATT |
| Streptococcus pneumoniae TIGR4 | SP_1584 | -71 | 5.6 | AATTTTCAGATAATT |
| Streptococcus pyogenes M1 GAS | SPy1777 | -80 | 5.6 | AATTTTCTGATAATT |
| Streptococcus sanguinis SK36 | SSA_0566 | -71 | 5.6 | AATTTTCAGATAATT |
| Streptococcus suis 05ZYH33 | SSU05_0350 | -74 | 5.3 | AATATTCTGATAATT |
| Streptococcus thermophilus CNRZ1066 | str1635 | -132 | 5.4 | AATTTTCAGACAATT |
| Streptococcus uberis 0140J | SUB1528 | -82 | 5.6 | AATTTTCTGATAATT |