Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of CodY regulog to Streptococcus pyogenes MGAS10750

Reference regulog properties
Source regulog: CodY - Streptococcaceae
Regulator type: Transcription factor
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Phylum: Firmicutes
Propagated regulon:
Target genome Streptococcus pyogenes MGAS10750
Orthologous TF(s) MGAS10750_Spy1572
Regulated genes 8
Built upon 273 sites [see more]
Predicted regulatory interactions in Streptococcus pyogenes MGAS10750
Locus tag Position Score Sequence
Position: -91
Score: 5.2
Sequence: AATATTCTAAAAATT
Locus tag: MGAS10750_Spy0090
MGAS10750_Spy0090 -91 5.2 AATATTCTAAAAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: rpoB
Ortholog function: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Streptococcus agalactiae 2603V/R SAG0160 -128 5.2 AACTTTCTGAAAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0131 -91 4.6 AAGATTCTAAAAATT
Streptococcus gallolyticus UCN34 GALLO_0084 -165 4.6 AAGATTCTAAAAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_1927 -222 5.4 ATTTTTCTGAAAATT
Streptococcus mitis B6 smi_1847 -113 5 AAGATTCTGAAAATT
Streptococcus mutans UA159 SMU.1990 -84 5.3 AAAATTCTGAAAATT
Streptococcus pneumoniae TIGR4 SP_1961 -112 5 AAGATTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy0098 -91 5.2 AATATTCTAAAAATT
Streptococcus suis 05ZYH33 SSU05_0121 -276 4.6 AAGATTCTAAAAATT
Streptococcus thermophilus CNRZ1066 str1868 -171 4.6 AAAGTTCTAAAAATT
Streptococcus uberis 0140J SUB0115 -90 4.6 AAGATTCTAAAAATT
Position: -116
Score: 5.3
Sequence: AATATTCAGATAATT
Locus tag: MGAS10750_Spy0246
MGAS10750_Spy0246 -116 5.3 AATATTCAGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: oppA2
Ortholog function: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_0356 -115 5.3 AATATTCAGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_1697 -119 5.3 AATATTCAGATAATT
Position: -131
Score: 4.8
Sequence: AATTTTCAGTCAATT
Position: -47
Score: 4.9
Sequence: AATTGTTAGAATATT
Locus tag: MGAS10750_Spy0269
MGAS10750_Spy0269 -131 4.8 AATTTTCAGTCAATT
-47 4.9 AATTGTTAGAATATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: braB
Ortholog function: Branched-chain amino acid transport system carrier protein
Streptococcus pyogenes M1 GAS SPy0323 -131 4.8 AATTTTCAGTCAATT
Streptococcus uberis 0140J SUB0370 -43 5.1 AATTGTTAGAAAATT
Position: -96
Score: 5.1
Sequence: AATTATCAGAATTTT
Position: -87
Score: 5.3
Sequence: AATTTTCAGATATTT
Locus tag: MGAS10750_Spy1221
MGAS10750_Spy1221 -96 5.1 AATTATCAGAATTTT
-87 5.3 AATTTTCAGATATTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: gapN
Ortholog function: Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9)
Streptococcus agalactiae 2603V/R SAG0823 -72 4.6 ATATGTCAGATAATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1419 -87 4.9 AATTTTCTGATACTT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0766 -87 4.6 AATTTTCAGACTCTT
Streptococcus gallolyticus UCN34 GALLO_0746 -87 5.3 AATTTTCTGAATTTT
Streptococcus mutans UA159 SMU.676 -89 5.3 AATTTTCTGAATTTT
Streptococcus pneumoniae TIGR4 SP_1119 -55 5.2 GATTTTCTGAAAATT
Streptococcus pyogenes M1 GAS SPy1371 -87 5.3 AATTTTCAGATATTT
Streptococcus sanguinis SK36 SSA_0774 -53 5.8 AATTTTCAGAAAATT
Streptococcus thermophilus CNRZ1066 str1263 -89 5 AATTTTCTGAATACT
Streptococcus uberis 0140J SUB1220 -87 5.4 AATTTTCAGACAATT
Position: -107
Score: 4.9
Sequence: ATTTTTCAAAATATT
Locus tag: MGAS10750_Spy1376
MGAS10750_Spy1376 -107 4.9 ATTTTTCAAAATATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: asnA
Ortholog function: Aspartate--ammonia ligase (EC 6.3.1.1)
Streptococcus gallolyticus UCN34 GALLO_0534 -144 4.8 AATTTTCAAAAAAGT
Streptococcus pyogenes M1 GAS SPy1539 -107 4.9 ATTTTTCAAAATATT
Streptococcus suis 05ZYH33 SSU05_0467 -124 5.3 AATTATCAGAATATT
Streptococcus uberis 0140J SUB1323 -123 4.6 AATATACTGAAAAAT
Position: -41
Score: 5
Sequence: AATTTTCTGAAAAAA
Locus tag: MGAS10750_Spy1468
MGAS10750_Spy1468 -41 5 AATTTTCTGAAAAAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: aapA
Ortholog function: Amino acid permease
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1715 -41 5 AATTTTCTGAAAAAA
Streptococcus pyogenes M1 GAS SPy1654 -53 5 AATTTTCTGAAAAAA
Streptococcus thermophilus CNRZ1066 str0509 -108 4.7 AATATTCTGAATTAT
Streptococcus uberis 0140J SUB1411 -54 4.8 AATATTCTGAAAAAA
Position: -79
Score: 5.6
Sequence: AATTTTCTGATAATT
Locus tag: MGAS10750_Spy1572
MGAS10750_Spy1572 -79 5.6 AATTTTCTGATAATT
Supported by regulated orthologs from reference regulons
Ortholog gene name: codY
Ortholog function: Nutrient limitation global transcriptional regulator CodY, CodY family
Lactococcus lactis subsp. cremoris SK11 LACR_0168 -101 5.4 AATTTTCTGACAATT
Lactococcus lactis subsp. lactis Il1403 L0243 -101 5.4 AATTTTCTGACAATT
Streptococcus agalactiae 2603V/R SAG1675 -46 5 AATTTTGAGAATATT
Streptococcus dysgalactiae subsp. equisimilis GGS_124 SDEG_1848 -80 5.6 AATTTTCTGATAATT
Streptococcus equi subsp. zooepidemicus MGCS10565 Sez_0387 -78 5.6 AATTTTCTGATAATT
Streptococcus gallolyticus UCN34 GALLO_1876 -77 5.6 AATTTTCAGATAATT
Streptococcus gordonii str. Challis substr. CH1 SGO_0431 -71 5.6 AATTTTCAGATAATT
Streptococcus mitis B6 smi_0687 -71 5.6 AATTTTCAGATAATT
Streptococcus mutans UA159 SMU.1824c -75 5.4 AATTTTCTGACAATT
Streptococcus pneumoniae TIGR4 SP_1584 -71 5.6 AATTTTCAGATAATT
Streptococcus pyogenes M1 GAS SPy1777 -80 5.6 AATTTTCTGATAATT
Streptococcus sanguinis SK36 SSA_0566 -71 5.6 AATTTTCAGATAATT
Streptococcus suis 05ZYH33 SSU05_0350 -74 5.3 AATATTCTGATAATT
Streptococcus thermophilus CNRZ1066 str1635 -132 5.4 AATTTTCAGACAATT
Streptococcus uberis 0140J SUB1528 -82 5.6 AATTTTCTGATAATT
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