Propagation of PerR regulog to Streptococcus pyogenes MGAS10394

Reference regulog properties
Source regulog:	PerR - Streptococcaceae
Regulator type:	Transcription factor
Regulator family:	FUR
Regulation mode:	repressor
Biological process:	Iron homeostasis; Manganese homeostasis; Oxidative stress response
Effector:	Iron ion, (Fe2+); Manganese ion, (Mn2+); Hydrogen peroxide
Phylum:	Firmicutes
Propagated regulon:
Target genome	Streptococcus pyogenes MGAS10394
Orthologous TF(s)	M6_Spy0207
Regulated genes	6

Built upon 75 sites [see more]

Predicted regulatory interactions in *Streptococcus pyogenes MGAS10394*
	Locus tag	Position	Score	Sequence
Position: -227 Score: 4.5 Sequence: TTAGAATGATTCTCG Position: -205 Score: 5.2 Sequence: TTTTAATCATTCTAA Locus tag: M6_Spy0350
	M6_Spy0350	-227	4.5	TTAGAATGATTCTCG
		-205	5.2	TTTTAATCATTCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: fhuA
Ortholog function: Ferrichrome ABC transporter, ATP-binding protein
Streptococcus agalactiae 2603V/R	SAG1392	-122	4.5	TTTGAATCATTCCAA
		-37	4.6	TTATAATGAACTTAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0434	-229	4.6	CAAGAATGATTATTA
		-207	4.5	TTTTAACCATTCTAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1618	-218	5.4	TGATAATGATTCTAA
Streptococcus gallolyticus UCN34	GALLO_1771	-180	4.8	TTAGAACAATTTTAA
		-158	5.2	TTTGAATGATTCTAA
Streptococcus pyogenes M1 GAS	SPy0386	-228	4.6	TTAGAATGATTATCG
		-206	5.2	TTTTAATCATTCTAA
Streptococcus sanguinis SK36	SSA_1741	-68	4.7	TTAGAAAAATTTTTA
Streptococcus uberis 0140J	SUB0424	-133	4.5	TTTTAACCATTCTAA

Position: -36 Score: 5.6 Sequence: TAATAATCATTATAA Locus tag: M6_Spy0391
	M6_Spy0391	-36	5.6	TAATAATCATTATAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: mntR
Ortholog function: Manganese homeostasis transcriptional regulator MntR, DtxR family
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0487	-36	5.6	TAATAATGATTATAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1470	-36	5.6	TAATAATCATTATAA
Streptococcus pyogenes M1 GAS	SPy0450	-36	5.6	TAATAATCATTATAA
Streptococcus uberis 0140J	SUBp03	-37	5.6	TAATAATGATTATAA

Position: -121 Score: 5.6 Sequence: TTATAATGATTATTA Locus tag: M6_Spy0392
	M6_Spy0392	-121	5.6	TTATAATGATTATTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: mntA
Ortholog function: Manganese ABC transporter, substrate binding protein
Streptococcus agalactiae 2603V/R	SAG1533	-28	5.1	TTATATTAATTTTAA
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_0488	-124	5.6	TTATAATCATTATTA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_1469	-124	5.6	TTATAATGATTATTA
Streptococcus gallolyticus UCN34	GALLO_2047	-66	4.8	TTATATTAAATATAA
Streptococcus mutans UA159	SMU.184	-26	4.8	TTATATTACTTATAA
Streptococcus pyogenes M1 GAS	SPy0453	-124	5.6	TTATAATGATTATTA
Streptococcus sanguinis SK36	SSA_0260	-54	4.4	TTATATTAATTTTAG
Streptococcus uberis 0140J	SUB0473	-123	5.6	TTATAATCATTATTA

Position: -64 Score: 5.8 Sequence: TTAGAATTATTATAA Locus tag: M6_Spy1193
	M6_Spy1193	-64	5.8	TTAGAATTATTATAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: pmtA
Ortholog function: Predicted cation transporting ATPase
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1473	-98	5.5	TTAGAATCGTTCTAA
		-65	5.8	TTAGAATTATTATAA
Streptococcus pyogenes M1 GAS	SPy1434	-97	5.4	TTAGAATGTTTCTAA
		-64	5.8	TTAGAATTATTATAA
Streptococcus suis 05ZYH33	SSU05_0309	-146	5.8	TTAGAATTATTATAA
		-114	5.6	TTATAATCGTTATAA
		-85	5.2	TGATAATAATTCTAA
Streptococcus uberis 0140J	SUB1266	-98	5.8	TTAGAATTATTCTAA
		-65	5.4	TTAGAATAGTTATAA

Position: -157 Score: 4.7 Sequence: CGATAATGATTCTAA Locus tag: M6_Spy1280
	M6_Spy1280	-157	4.7	CGATAATGATTCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: mgrA
Ortholog function: Non-specific DNA-binding protein / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_1517	-148	4.7	CGAGAATGATTCTAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0585	-136	4.7	CGAGAATGATTCTAA
Streptococcus gallolyticus UCN34	GALLO_0592	-76	5.8	TTAGAATTATTCTAA
Streptococcus gordonii str. Challis substr. CH1	SGO_0665	-73	5.3	TTAGAAGCATTATAA
		-37	5.9	TTAGAATGATTATAA
Streptococcus mutans UA159	SMU.540	-57	5.5	TTAGAATCGTTCTAA
Streptococcus pyogenes M1 GAS	SPy1531	-157	4.7	CGATAATGATTCTAA
Streptococcus sanguinis SK36	SSA_0644	-71	5.3	TTAGAAGCATTATAA
		-35	5.9	TTAGAATCATTATAA
Streptococcus suis 05ZYH33	SSU05_1689	-34	5.9	TTATAATTATTATAA
Streptococcus thermophilus CNRZ1066	str0723	-59	5.2	TTATAAATATTTTAA

Position: -154 Score: 5.7 Sequence: TTAGAATCATTTTAA Locus tag: M6_Spy1765
	M6_Spy1765	-154	5.7	TTAGAATCATTTTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ahpC
Ortholog function: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)
Streptococcus dysgalactiae subsp. equisimilis GGS_124	SDEG_2053	-159	5.7	TTAGAATGATTTTAA
Streptococcus equi subsp. zooepidemicus MGCS10565	Sez_0137	-152	5.4	TTAGAATGGTTTTAA
Streptococcus pyogenes M1 GAS	SPy2079	-154	5.7	TTAGAATCATTTTAA
Streptococcus uberis 0140J	SUB1752	-142	5.8	TTAGAATTATTCTAA

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Propagation of PerR regulog to Streptococcus pyogenes MGAS10394

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --