Propagation of PerR regulog to Streptococcus pyogenes MGAS6180
| Source regulog: | PerR - Streptococcaceae |
| Regulator type: | Transcription factor |
| Regulator family: | FUR |
| Regulation mode: | repressor |
| Biological process: | Iron homeostasis; Manganese homeostasis; Oxidative stress response |
| Effector: | Iron ion, (Fe2+); Manganese ion, (Mn2+); Hydrogen peroxide |
| Phylum: | Firmicutes |
| Propagated regulon: | |
| Target genome | Streptococcus pyogenes MGAS6180 |
| Orthologous TF(s) | M28_Spy0159 |
| Regulated genes | 6 |
| Locus tag | Position | Score | Sequence | |
|---|---|---|---|---|
|
Position: -228
Score: 4.6 Sequence: TTAGAATGATTATCG
Position: -206
Score: 5.2 Sequence: TTTTAATCATTCTAA
Locus tag: M28_Spy0313
|
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| M28_Spy0313 | -228 | 4.6 | TTAGAATGATTATCG | |
| -206 | 5.2 | TTTTAATCATTCTAA | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: fhuA | ||||
| Ortholog function: Ferrichrome ABC transporter, ATP-binding protein | ||||
| Streptococcus agalactiae 2603V/R | SAG1392 | -122 | 4.5 | TTTGAATCATTCCAA |
| -37 | 4.6 | TTATAATGAACTTAA | ||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0434 | -229 | 4.6 | CAAGAATGATTATTA |
| -207 | 4.5 | TTTTAACCATTCTAA | ||
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1618 | -218 | 5.4 | TGATAATGATTCTAA |
| Streptococcus gallolyticus UCN34 | GALLO_1771 | -180 | 4.8 | TTAGAACAATTTTAA |
| -158 | 5.2 | TTTGAATGATTCTAA | ||
| Streptococcus pyogenes M1 GAS | SPy0386 | -228 | 4.6 | TTAGAATGATTATCG |
| -206 | 5.2 | TTTTAATCATTCTAA | ||
| Streptococcus sanguinis SK36 | SSA_1741 | -68 | 4.7 | TTAGAAAAATTTTTA |
| Streptococcus uberis 0140J | SUB0424 | -133 | 4.5 | TTTTAACCATTCTAA |
|
Position: -35
Score: 5.6 Sequence: TAATAATCATTATAA
Locus tag: M28_Spy0356
|
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| M28_Spy0356 | -35 | 5.6 | TAATAATCATTATAA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: mntR | ||||
| Ortholog function: Manganese homeostasis transcriptional regulator MntR, DtxR family | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0487 | -36 | 5.6 | TAATAATGATTATAA |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1470 | -36 | 5.6 | TAATAATCATTATAA |
| Streptococcus pyogenes M1 GAS | SPy0450 | -36 | 5.6 | TAATAATCATTATAA |
| Streptococcus uberis 0140J | SUBp03 | -37 | 5.6 | TAATAATGATTATAA |
|
Position: -121
Score: 5.6 Sequence: TTATAATGATTATTA
Locus tag: M28_Spy0357
|
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| M28_Spy0357 | -121 | 5.6 | TTATAATGATTATTA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: mntA | ||||
| Ortholog function: Manganese ABC transporter, substrate binding protein | ||||
| Streptococcus agalactiae 2603V/R | SAG1533 | -28 | 5.1 | TTATATTAATTTTAA |
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_0488 | -124 | 5.6 | TTATAATCATTATTA |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_1469 | -124 | 5.6 | TTATAATGATTATTA |
| Streptococcus gallolyticus UCN34 | GALLO_2047 | -66 | 4.8 | TTATATTAAATATAA |
| Streptococcus mutans UA159 | SMU.184 | -26 | 4.8 | TTATATTACTTATAA |
| Streptococcus pyogenes M1 GAS | SPy0453 | -124 | 5.6 | TTATAATGATTATTA |
| Streptococcus sanguinis SK36 | SSA_0260 | -54 | 4.4 | TTATATTAATTTTAG |
| Streptococcus uberis 0140J | SUB0473 | -123 | 5.6 | TTATAATCATTATTA |
|
Position: -64
Score: 5.8 Sequence: TTAGAATTATTATAA
Locus tag: M28_Spy1161
|
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| M28_Spy1161 | -64 | 5.8 | TTAGAATTATTATAA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: pmtA | ||||
| Ortholog function: Predicted cation transporting ATPase | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_1473 | -98 | 5.5 | TTAGAATCGTTCTAA |
| -65 | 5.8 | TTAGAATTATTATAA | ||
| Streptococcus pyogenes M1 GAS | SPy1434 | -97 | 5.4 | TTAGAATGTTTCTAA |
| -64 | 5.8 | TTAGAATTATTATAA | ||
| Streptococcus suis 05ZYH33 | SSU05_0309 | -146 | 5.8 | TTAGAATTATTATAA |
| -114 | 5.6 | TTATAATCGTTATAA | ||
| -85 | 5.2 | TGATAATAATTCTAA | ||
| Streptococcus uberis 0140J | SUB1266 | -98 | 5.8 | TTAGAATTATTCTAA |
| -65 | 5.4 | TTAGAATAGTTATAA | ||
|
Position: -157
Score: 4.7 Sequence: CGATAATGATTCTAA
Locus tag: M28_Spy1198
|
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| M28_Spy1198 | -157 | 4.7 | CGATAATGATTCTAA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: mgrA | ||||
| Ortholog function: Non-specific DNA-binding protein / Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1) | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_1517 | -148 | 4.7 | CGAGAATGATTCTAA |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_0585 | -136 | 4.7 | CGAGAATGATTCTAA |
| Streptococcus gallolyticus UCN34 | GALLO_0592 | -76 | 5.8 | TTAGAATTATTCTAA |
| Streptococcus gordonii str. Challis substr. CH1 | SGO_0665 | -73 | 5.3 | TTAGAAGCATTATAA |
| -37 | 5.9 | TTAGAATGATTATAA | ||
| Streptococcus mutans UA159 | SMU.540 | -57 | 5.5 | TTAGAATCGTTCTAA |
| Streptococcus pyogenes M1 GAS | SPy1531 | -157 | 4.7 | CGATAATGATTCTAA |
| Streptococcus sanguinis SK36 | SSA_0644 | -71 | 5.3 | TTAGAAGCATTATAA |
| -35 | 5.9 | TTAGAATCATTATAA | ||
| Streptococcus suis 05ZYH33 | SSU05_1689 | -34 | 5.9 | TTATAATTATTATAA |
| Streptococcus thermophilus CNRZ1066 | str0723 | -59 | 5.2 | TTATAAATATTTTAA |
|
Position: -154
Score: 5.7 Sequence: TTAGAATCATTTTAA
Locus tag: M28_Spy1752
|
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| M28_Spy1752 | -154 | 5.7 | TTAGAATCATTTTAA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: ahpC | ||||
| Ortholog function: Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) | ||||
| Streptococcus dysgalactiae subsp. equisimilis GGS_124 | SDEG_2053 | -159 | 5.7 | TTAGAATGATTTTAA |
| Streptococcus equi subsp. zooepidemicus MGCS10565 | Sez_0137 | -152 | 5.4 | TTAGAATGGTTTTAA |
| Streptococcus pyogenes M1 GAS | SPy2079 | -154 | 5.7 | TTAGAATCATTTTAA |
| Streptococcus uberis 0140J | SUB1752 | -142 | 5.8 | TTAGAATTATTCTAA |