Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of McbR regulog to Corynebacterium glutamicum ATCC 13032

Reference regulog properties
Source regulog: McbR - Corynebacteriaceae
Regulator type: Transcription factor
Regulator family: TetR
Regulation mode: repressor
Biological process: Methionine biosynthesis
Effector: S-adenosylmethionine; S-adenosylhomocysteine
Phylum: Actinobacteria
Propagated regulon:
Target genome Corynebacterium glutamicum ATCC 13032
Orthologous TF(s) cg3253
Regulated genes 24
Built upon 162 sites [see more]
Predicted regulatory interactions in Corynebacterium glutamicum ATCC 13032
Locus tag Position Score Sequence
Position: -69
Score: 4.8
Sequence: CAGACAATGCGGTCTA
Position: -36
Score: 5.4
Sequence: TAGACAGCGTTGTCTA
Locus tag: cg0156
cg0156 -69 4.8 CAGACAATGCGGTCTA
-36 5.4 TAGACAGCGTTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysR
Ortholog function: Sulphur metabolism transcriptional regulator CysR, ROK family
Corynebacterium aurimucosum ATCC 700975 cauri_0079 -40 4.5 TAGACCATGATGTCTA
-6 4.7 TAGACAATGCGGTCTG
Corynebacterium diphtheriae NCTC 13129 DIP0123 -126 4.6 CGTACCGATCGGTCTA
-37 4.4 TAGACAAGCTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg0156 -69 4.8 CAGACAATGCGGTCTA
-36 5.4 TAGACAGCGTTGTCTA
Position: -109
Score: 4.6
Sequence: TAGACCAAGCTGTACA
Locus tag: cg0737
cg0737 -109 4.6 TAGACCAAGCTGTACA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metQ
Ortholog function: Methionine ABC transporter substrate-binding protein
Corynebacterium amycolatum SK46 CORAM0001_0284 -70 5 AAGACAGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP0611 -166 4.7 TAGACAAAGCTGTACA
Corynebacterium efficiens YS-314 CE0631 -94 4.7 TAGACCGAGCTGTACA
Corynebacterium glutamicum ATCC 13032 cg0737 -109 4.6 TAGACCAAGCTGTACA
Position: -69
Score: 5.2
Sequence: TAGACAGAGCTGTCCA
Locus tag: cg0754
cg0754 -69 5.2 TAGACAGAGCTGTCCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metX
Ortholog function: Homoserine O-acetyltransferase (EC 2.3.1.31)
Corynebacterium amycolatum SK46 CORAM0001_0290 -22 4.3 CGGACTAAGTAGTCTA
Corynebacterium aurimucosum ATCC 700975 cauri_0512 -92 4.2 CCAACCGCTCGGTCTA
-27 4.8 TGAACCGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP0623 -60 5.2 TAGACAGAGCTGTCCA
Corynebacterium efficiens YS-314 CE0678 -139 4.6 CGAACCGCTCGGTCTA
-117 4.9 TAGACCGAGCGGTTCA
Corynebacterium glutamicum ATCC 13032 cg0754 -69 5.2 TAGACAGAGCTGTCCA
Corynebacterium jeikeium K411 jk1695 -171 4.5 TAGACCAAGCGGTATG
-93 5.2 TAGACAGAGCGGTTTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1569 -300 4.6 CATACCGCTTAGTCTA
-244 4.4 TAGACAGGGCGGTTTG
-225 4.8 TAGACCGAGCGGTACA
Corynebacterium urealyticum DSM 7109 cur_0422 -212 4.9 TAGACCAAGTGGTATA
-145 5.2 TAGACAGAGCGGTTTA
Position: -68
Score: 4.7
Sequence: TAGACCAAGCTGTTCA
Locus tag: cg0755
cg0755 -68 4.7 TAGACCAAGCTGTTCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metY
Ortholog function: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
Corynebacterium amycolatum SK46 CORAM0001_0291 -73 5 TAGACAGCTTGGTTCA
Corynebacterium aurimucosum ATCC 700975 cauri_0513 -92 4.2 CCAACCGCTCGGTCTA
-27 4.8 TGAACCGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP0630 -138 4.1 CGCACCACTTTGTCTA
-82 4.6 TAGACCGATCGGTTTC
Corynebacterium efficiens YS-314 CE0679 -139 4.6 CGAACCGCTCGGTCTA
-117 4.9 TAGACCGAGCGGTTCA
Corynebacterium glutamicum ATCC 13032 cg0755 -90 4.5 TATACCACACAGTCTA
-68 4.7 TAGACCAAGCTGTTCA
Corynebacterium jeikeium K411 jk1694 -171 4.5 TAGACCAAGCGGTATG
-93 5.2 TAGACAGAGCGGTTTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1568 -300 4.6 CATACCGCTTAGTCTA
-244 4.4 TAGACAGGGCGGTTTG
-225 4.8 TAGACCGAGCGGTACA
Corynebacterium urealyticum DSM 7109 cur_0423 -212 4.9 TAGACCAAGTGGTATA
-145 5.2 TAGACAGAGCGGTTTA
Position: -79
Score: 5
Sequence: TAGACTGAATTGTCTA
Locus tag: cg1147
cg1147 -79 5 TAGACTGAATTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ssuI
Ortholog function: Predicted flavin reductase
Corynebacterium amycolatum SK46 CORAM0001_0383 -134 4.8 TAGACAATACTGTCTA
-113 4.8 TGTACCGAGTTGTCTA
-25 5.2 TAGACCACGTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1147 -79 5 TAGACTGAATTGTCTA
-24 4.3 TAGACTGAATGGCCTA
Position: -36
Score: 4.9
Sequence: TAGACAAAGATGTCTA
Locus tag: cg1151
cg1151 -36 4.9 TAGACAAAGATGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: seuA
Ortholog function: coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase
Corynebacterium amycolatum SK46 CORAM0001_0382 -134 4.8 TAGACAATACTGTCTA
-113 4.8 TGTACCGAGTTGTCTA
-25 5.2 TAGACCACGTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1151 -36 4.9 TAGACAAAGATGTCTA
Position: -24
Score: 5.1
Sequence: TAGACCGTGTGGTCTA
Locus tag: cg1156
cg1156 -24 5.1 TAGACCGTGTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ssuD
Ortholog function: Alkanesulfonate monooxygenase
Corynebacterium amycolatum SK46 CORAM0001_0384 -134 4.8 TAGACAATACTGTCTA
-113 4.8 TGTACCGAGTTGTCTA
-25 5.2 TAGACCACGTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1376 -182 4.6 TAGACCGCTTAGTCTT
-117 5 TAGACATCTCGGTCTA
-30 4.4 TAGACGAAGCGGTCTG
Corynebacterium glutamicum ATCC 13032 cg1156 -24 5.1 TAGACCGTGTGGTCTA
Position: -272
Score: 4.9
Sequence: CAGACCGAGCAGTCTA
Locus tag: cg1290
cg1290 -272 4.9 CAGACCGAGCAGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)
Corynebacterium efficiens YS-314 CE1209 -290 4.3 CAGACCATGCTGTCTG
Corynebacterium glutamicum ATCC 13032 cg1290 -272 4.9 CAGACCGAGCAGTCTA
Corynebacterium jeikeium K411 jk0234 -205 4.8 CAGACTAAGCTGTCTA
Corynebacterium urealyticum DSM 7109 cur_1766 -256 5 CAGACCAAGCTGTCTA
Position: -113
Score: 4.9
Sequence: TGAACAGCTTGGTCTA
Locus tag: cg1337
cg1337 -113 4.9 TGAACAGCTTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: hom
Ortholog function: Homoserine dehydrogenase (EC 1.1.1.3)
Corynebacterium aurimucosum ATCC 700975 cauri_1049 -70 4.6 TAGACAGCTCGTTCTG
Corynebacterium efficiens YS-314 CE1289 -110 4.9 TGAACAGCTTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1337 -113 4.9 TGAACAGCTTGGTCTA
Corynebacterium jeikeium K411 jk1352 -105 5.2 TGGACAGCTTTGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1290 -100 4.5 CATACAGCTTTGTCTG
Corynebacterium urealyticum DSM 7109 cur_0694 -134 5.5 TAGACAGCTTGGTCTA
Position: -117
Score: 5
Sequence: TAGACATCTCGGTCTA
Locus tag: cg1376
cg1376 -117 5 TAGACATCTCGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ssuD
Ortholog function: Alkanesulfonate monooxygenase
Corynebacterium amycolatum SK46 CORAM0001_0384 -134 4.8 TAGACAATACTGTCTA
-113 4.8 TGTACCGAGTTGTCTA
-25 5.2 TAGACCACGTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1376 -182 4.6 TAGACCGCTTAGTCTT
-117 5 TAGACATCTCGGTCTA
-30 4.4 TAGACGAAGCGGTCTG
Corynebacterium glutamicum ATCC 13032 cg1156 -24 5.1 TAGACCGTGTGGTCTA
Position: -158
Score: 4.5
Sequence: TAGACTGGTTTGTCTG
Locus tag: cg1386
cg1386 -158 4.5 TAGACTGGTTTGTCTG
Supported by regulated orthologs from reference regulons
Ortholog gene name: fixB
Ortholog function: Electron transfer flavoprotein, beta subunit
Corynebacterium efficiens YS-314 CE1328 -119 5 TAGACTGTTCTGTCTA
Corynebacterium glutamicum ATCC 13032 cg1386 -158 4.5 TAGACTGGTTTGTCTG
Position: -95
Score: 4.2
Sequence: CGTACTAAGCTGTCTA
Locus tag: cg1701
cg1701 -95 4.2 CGTACTAAGCTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metH
Ortholog function: 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13)
Corynebacterium amycolatum SK46 CORAM0001_0986 -19 4.6 TAGACTAAGGTGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP1259 -17 4.5 CATACTAAGCTGTCTA
Corynebacterium efficiens YS-314 CE1637 -20 4.2 CGTACTAAGCTGTCTA
Corynebacterium glutamicum ATCC 13032 cg1701 -95 4.2 CGTACTAAGCTGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0919 20 5.1 TAGACTAAGCTGTCTA
Position: -13
Score: 4.4
Sequence: TAGACTAAGCGGTATG
Locus tag: cg1739
cg1739 -13 4.4 TAGACTAAGCGGTATG
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg1739
Ortholog function: GMP synthase-Glutamine amidotransferase domain (EC 6.3.5.2)
Corynebacterium amycolatum SK46 CORAM0001_0958 -19 4.8 TGGACTAAGCTGTCTA
Corynebacterium amycolatum SK46 CORAM0001_0957 -19 4.8 TGGACTAAGCTGTCTA
Corynebacterium glutamicum ATCC 13032 cg1739 -13 4.4 TAGACTAAGCGGTATG
Corynebacterium jeikeium K411 jk0976 -30 4.9 TAGACCAAGCGGTCTG
Position: -74
Score: 5.5
Sequence: TAGACAGCTTGGTCTA
Locus tag: cg1806
cg1806 -74 5.5 TAGACAGCTTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metK
Ortholog function: S-adenosylmethionine synthetase (EC 2.5.1.6)
Corynebacterium amycolatum SK46 CORAM0001_0910 -98 4.8 TGAACCGCTTGGTCTA
Corynebacterium aurimucosum ATCC 700975 cauri_1185 -97 5.4 TAGACCGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP1325 -116 5.5 TAGACAGCTTGGTCTA
Corynebacterium efficiens YS-314 CE1723 -73 5.5 TAGACAGCTTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1806 -74 5.5 TAGACAGCTTGGTCTA
Corynebacterium jeikeium K411 jk1016 -75 5.2 CAGACAGCTTGGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0984 -98 5.5 TAGACAGCTTGGTCTA
Corynebacterium urealyticum DSM 7109 cur_0975 -110 5.4 TAGACCGCTTGGTCTA
Position: -90
Score: 4.9
Sequence: TATACCGATCAGTCTA
Locus tag: cg2678
cg2678 -90 4.9 TATACCGATCAGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg2678
Ortholog function: Predicted ABC transporter, substrate-binding protein
Corynebacterium aurimucosum ATCC 700975 cauri_2043 -36 5 TAGACTGTGCTGTCTA
Corynebacterium efficiens YS-314 CE2334 -71 5.5 TAGACAGATTGGTCTA
-48 4.2 AGTACCGATCAGTCTA
Corynebacterium glutamicum ATCC 13032 cg2678 -112 4.8 TAGACAGGTTGGTCTG
-90 4.9 TATACCGATCAGTCTA
Corynebacterium urealyticum DSM 7109 cur_0251 -41 5 TAGACAGATCTGTTCA
Position: -72
Score: 5
Sequence: TAGACTGATCGGTATA
Locus tag: cg2679
cg2679 -72 5 TAGACTGATCGGTATA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg2679
Ortholog function: Conserved hypothetical protein
Corynebacterium aurimucosum ATCC 700975 cauri_2044 -36 5 TAGACAGCACAGTCTA
Corynebacterium efficiens YS-314 CE2335 -75 4.1 TAGACTGATCGGTACT
-52 5.3 TAGACCAATCTGTCTA
Corynebacterium glutamicum ATCC 13032 cg2679 -72 5 TAGACTGATCGGTATA
-50 4.4 CAGACCAACCTGTCTA
Corynebacterium urealyticum DSM 7109 cur_0252 -61 4.9 TGAACAGATCTGTCTA
Position: -78
Score: 5.3
Sequence: TGGACAGCTTGGTCTA
Locus tag: cg2687
cg2687 -78 5.3 TGGACAGCTTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metB
Ortholog function: Cystathionine gamma-synthase (EC 2.5.1.48)
Corynebacterium aurimucosum ATCC 700975 cauri_2045 -28 4.9 TGAACAGCTTGGTCTA
Corynebacterium efficiens YS-314 CE2343 1 5.3 TGGACAGCTTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg2687 -78 5.3 TGGACAGCTTGGTCTA
Corynebacterium jeikeium K411 jk0055 -108 5.3 TAGACTGCTTGGTCTA
Position: -175
Score: 4.3
Sequence: TAGACTTATGGGTCTA
Position: -118
Score: 5.2
Sequence: TAGACAGATCTGTTTA
Locus tag: cg2810
cg2810 -175 4.3 TAGACTTATGGGTCTA
-118 5.2 TAGACAGATCTGTTTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: gltT
Ortholog function: Predicted sodium:dicarboxylate symporter
Corynebacterium aurimucosum ATCC 700975 cauri_0959 -72 4.5 TGAACCGATCGGTATA
-29 4.8 TATACAACACTGTCTA
Corynebacterium glutamicum ATCC 13032 cg2810 -175 4.3 TAGACTTATGGGTCTA
-118 5.2 TAGACAGATCTGTTTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1960 -88 4.4 TAGACAGACCAGTCTG
Position: -150
Score: 4.6
Sequence: TGAACAGAACTGTCTA
Locus tag: cg2833
cg2833 -150 4.6 TGAACAGAACTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Corynebacterium amycolatum SK46 CORAM0001_2226 -103 3.9 TAGACGAACTGGTCTG
Corynebacterium aurimucosum ATCC 700975 cauri_2144 -74 4.8 TATACCACTCAGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP1890 -152 4.5 TAGACCGATCGGTACG
-130 4.6 AAGACAATTCTGTCTA
Corynebacterium efficiens YS-314 CE2446 -148 4.7 TAGACCGATCCGTCTG
Corynebacterium glutamicum ATCC 13032 cg2833 -150 4.6 TGAACAGAACTGTCTA
Corynebacterium jeikeium K411 jk0394 -35 5.2 TAGACCGATCAGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0419 -152 4.8 CAGACCGATCTGTCTG
Corynebacterium urealyticum DSM 7109 cur_1592 -60 5.3 TAGACAGATCAGTCTA
Position: -286
Score: 5.1
Sequence: TAGACCGCTTGGTCTG
Position: -201
Score: 5.6
Sequence: TAGACAGATCGGTCTA
Position: -83
Score: 4.5
Sequence: TAGACAGAGCGGTACG
Locus tag: cg3118
cg3118 -286 5.1 TAGACCGCTTGGTCTG
-201 5.6 TAGACAGATCGGTCTA
-83 4.5 TAGACAGAGCGGTACG
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysI
Ortholog function: Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
Corynebacterium amycolatum SK46 CORAM0001_1359 -113 4.7 CAGACTGGTCGGTCTA
-77 5.1 TAGACCAAACGGTCTA
Corynebacterium aurimucosum ATCC 700975 cauri_0665 -65 4.4 AAGACTGCTTTGTCTG
Corynebacterium efficiens YS-314 CE2644 -281 4.4 CCGACCACTCTGTCTA
-247 5.1 TAGACCGCTTGGTCTG
-163 4.4 TAGACCGTCCAGTCTA
-46 4.6 TAGACAGATCGGTACG
Corynebacterium glutamicum ATCC 13032 cg3118 -286 5.1 TAGACCGCTTGGTCTG
-201 5.6 TAGACAGATCGGTCTA
-83 4.5 TAGACAGAGCGGTACG
Corynebacterium jeikeium K411 jk0243 -114 5.4 TAGACAACTCTGTCTA
-34 5 CAGACAGATCAGTCTA
Corynebacterium urealyticum DSM 7109 cur_1757 -181 5.2 TAGACAGCATTGTCTA
-97 4.9 TAGACCGCACGGTCTG
Position: -315
Score: 4.6
Sequence: CGTACCGCTCTGTCTA
Position: -197
Score: 5.4
Sequence: TAGACCGATCTGTCTA
Position: -112
Score: 5
Sequence: CAGACCAAGCGGTCTA
Locus tag: cg3119
cg3119 -315 4.6 CGTACCGCTCTGTCTA
-197 5.4 TAGACCGATCTGTCTA
-112 5 CAGACCAAGCGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysJ
Ortholog function: Ferredoxin--NADP reductase (EC 1.18.1.2)
Corynebacterium aurimucosum ATCC 700975 cauri_0664 -180 4.3 CAGACAAAGCAGTCTT
Corynebacterium efficiens YS-314 CE2645 -212 4.7 TAGACTGGACGGTCTA
-128 5 CAGACCAAGCGGTCTA
-94 4.4 TAGACAGAGTGGTCGG
Corynebacterium glutamicum ATCC 13032 cg3119 -197 5.4 TAGACCGATCTGTCTA
-112 5 CAGACCAAGCGGTCTA
Position: -78
Score: 4.1
Sequence: CGAACCGGTTTGTCTA
Locus tag: cg3253
cg3253 -78 4.1 CGAACCGGTTTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: mcbR
Ortholog function: Methionine biosynthesis transcriptional regulator McbR, TetR family
Corynebacterium aurimucosum ATCC 700975 cauri_2422 -57 4.4 CATACCGGTTTGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP2274 -74 4.7 TAGACTGATCTGTTCA
Corynebacterium efficiens YS-314 CE2788 -154 4.1 CGAACCGGTTTGTCTA
Corynebacterium glutamicum ATCC 13032 cg3253 -78 4.1 CGAACCGGTTTGTCTA
Position: -69
Score: 5.2
Sequence: TAGACAGCATGGTCTA
Locus tag: cg3372
cg3372 -69 5.2 TAGACAGCATGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg3372
Ortholog function: Hypothetical protein
Corynebacterium glutamicum ATCC 13032 cg3372 -69 5.2 TAGACAGCATGGTCTA
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