Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Propagation of DtxR regulog to Corynebacterium diphtheriae NCTC 13129

Reference regulog properties
Source regulog: DtxR - Corynebacteriaceae
Regulator type: Transcription factor
Regulator family: DtxR
Regulation mode: repressor, activator
Biological process: Iron homeostasis
Effector: Iron ion, (Fe2+)
Phylum: Actinobacteria
Propagated regulon:
Target genome Corynebacterium diphtheriae NCTC 13129
Orthologous TF(s) DIP1414
Regulated genes 24
Built upon 139 sites [see more]
Predicted regulatory interactions in Corynebacterium diphtheriae NCTC 13129
Locus tag Position Score Sequence
Position: -48
Score: 4.3
Sequence: TATAGTAAGCCTTGCCTCA
Locus tag: DIP0108
DIP0108 -48 4.3 TATAGTAAGCCTTGCCTCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: irp6A
Ortholog function: Ferrichrome ABC transporter, substrate-binding protein (TC 3.A.1.14.3)
Corynebacterium amycolatum SK46 CORAM0001_0629 -105 5 TAAGGTAAGGCGTGCCTAA
Corynebacterium diphtheriae NCTC 13129 DIP0108 -73 4.2 TTTTCTTTGCCTAGCCTAA
-48 4.3 TATAGTAAGCCTTGCCTCA
Corynebacterium jeikeium K411 jk0561 -93 4.1 TATAGTTAGCCTACCCTCG
-72 4.4 ACTGGCAAGGCTAAGCTAA
Position: -74
Score: 4.1
Sequence: TTAGGGAACTCTTGCCTTA
Locus tag: DIP0124
DIP0124 -74 4.1 TTAGGGAACTCTTGCCTTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: piuB
Ortholog function: Predicted iron-uptake protein
Corynebacterium diphtheriae NCTC 13129 DIP0124 -74 4.1 TTAGGGAACTCTTGCCTTA
Position: -129
Score: 4.9
Sequence: TTAGGTCAGGGTACCCTAA
Locus tag: DIP0370
DIP0370 -129 4.9 TTAGGTCAGGGTACCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: sdhC
Ortholog function: Succinate dehydrogenase cytochrome b subunit
Corynebacterium aurimucosum ATCC 700975 cauri_0257 -129 4.6 TAAGGTGATCCTTGCCTTA
Corynebacterium diphtheriae NCTC 13129 DIP0370 -129 4.9 TTAGGTCAGGGTACCCTAA
Corynebacterium efficiens YS-314 CE0386 -130 4.8 CGAGGTGAGGCTAGCCTAA
Corynebacterium glutamicum ATCC 13032 cg0445 -130 5.2 TAAAGTAAGGCTATCCTAA
Position: -30
Score: 4.7
Sequence: TTAGCTTAACCTTGCCTAT
Locus tag: DIP0415
DIP0415 -30 4.7 TTAGCTTAACCTTGCCTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg0527
Ortholog function: Putative ArsR family regulatory protein
Corynebacterium diphtheriae NCTC 13129 DIP0415 -30 4.7 TTAGCTTAACCTTGCCTAT
Corynebacterium efficiens YS-314 CE0466 -73 4.6 ATAGCTTAGGCTTACCTGC
Corynebacterium glutamicum ATCC 13032 cg0527 -30 4.8 TTAGGCTTGCCATACCTAT
Position: -65
Score: 4.7
Sequence: GAAGATAAGGCTTACCTTT
Locus tag: DIP0523
DIP0523 -65 4.7 GAAGATAAGGCTTACCTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: chtA
Ortholog function: Predicted membrane protein
Corynebacterium diphtheriae NCTC 13129 DIP0523 -142 4.3 ATAGGCTGACCTAACTTTT
-65 4.7 GAAGATAAGGCTTACCTTT
Position: -267
Score: 4.2
Sequence: CTAGGTTAGGGGTGCCTAA
Locus tag: DIP0540
DIP0540 -267 4.2 CTAGGTTAGGGGTGCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: secY
Ortholog function: Preprotein translocase secY subunit (TC 3.A.5.1.1)
Corynebacterium diphtheriae NCTC 13129 DIP0540 -267 4.2 CTAGGTTAGGGGTGCCTAA
Position: -20
Score: 4.9
Sequence: TTAGGGTAGCTTCGCCTAA
Locus tag: DIP0586
DIP0586 -20 4.9 TTAGGGTAGCTTCGCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cuiE
Ortholog function: Predicted siderophore biosynthesis related protein
Corynebacterium diphtheriae NCTC 13129 DIP0586 -20 4.9 TTAGGGTAGCTTCGCCTAA
Position: -171
Score: 4.6
Sequence: TTAGGTAAGTGTAGCCTAT
Locus tag: DIP0625
DIP0625 -171 4.6 TTAGGTAAGTGTAGCCTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: htaA
Ortholog function: Predicted membrane protein
Corynebacterium aurimucosum ATCC 700975 cauri_1726 -70 4.2 TTAGGCCAGAATTACCTAA
-50 5.1 CAAGGTAAGCCTAACCTAT
Corynebacterium diphtheriae NCTC 13129 DIP0625 -171 4.6 TTAGGTAAGTGTAGCCTAT
Corynebacterium jeikeium K411 jk0315 -112 4.7 TAAGTCGAGCCTTACCTAA
-92 4.3 TAAGGTAACACTATCCTAA
Position: -47
Score: 4.5
Sequence: TAAGGTACGCCTTGCCTTT
Locus tag: DIP0629
DIP0629 -47 4.5 TAAGGTACGCCTTGCCTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: htaC
Ortholog function: Predicted membrane protein
Corynebacterium diphtheriae NCTC 13129 DIP0629 -67 4 AAAGTTAAAGCAAACCTTT
-47 4.5 TAAGGTACGCCTTGCCTTT
Corynebacterium jeikeium K411 jk0319 -112 4.7 TAAGTCGAGCCTTACCTAA
-92 4.3 TAAGGTAACACTATCCTAA
Position: -31
Score: 4.5
Sequence: TAAGGTATGCCTTAGTTAT
Locus tag: DIP0762
DIP0762 -31 4.5 TAAGGTATGCCTTAGTTAT
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg2311
Ortholog function: Predicted methyltransferase (EC 2.1.1.-)
Corynebacterium diphtheriae NCTC 13129 DIP0762 -31 4.5 TAAGGTATGCCTTAGTTAT
Corynebacterium glutamicum ATCC 13032 cg2311 -18 4.7 TCAAGTAAGGTTTACCTTA
Position: -25
Score: 3.8
Sequence: CTAGGATTGCCTACACTTA
Locus tag: DIP0894
DIP0894 -25 3.8 CTAGGATTGCCTACACTTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg1070
Ortholog function: Conserved hypothetical protein
Corynebacterium diphtheriae NCTC 13129 DIP0894 -25 3.8 CTAGGATTGCCTACACTTA
Corynebacterium efficiens YS-314 CE1009 -42 4.1 TTTTGTTAGGCATCCCTTG
Corynebacterium glutamicum ATCC 13032 cg1070 -37 4.7 ATAGGTTATCCAAGCCTAA
Position: -95
Score: 4.4
Sequence: TAACCTTAGGCTTGCCTTT
Locus tag: DIP0922
DIP0922 -95 4.4 TAACCTTAGGCTTGCCTTT
Supported by regulated orthologs from reference regulons
Ortholog gene name: ripA
Ortholog function: Iron homeostasis transcription regulator RipA, AraC family
Corynebacterium diphtheriae NCTC 13129 DIP0922 -95 4.4 TAACCTTAGGCTTGCCTTT
Corynebacterium glutamicum ATCC 13032 cg1120 -51 5 TGAGGTTAGCGTAACCTAC
Position: -47
Score: 4
Sequence: GTTGGACAGGTTACCCTAA
Locus tag: DIP1061
DIP1061 -47 4 GTTGGACAGGTTACCCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: frgC
Ortholog function: Fe-siderophore ABC transporter, permaease protein 1
Corynebacterium aurimucosum ATCC 700975 cauri_2324 -71 5.1 AAAAGGTAGCCTAACCTAA
Corynebacterium diphtheriae NCTC 13129 DIP1061 -47 4 GTTGGACAGGTTACCCTAA
Position: -24
Score: 4
Sequence: TGAAATTAGGGTAACCTGT
Locus tag: DIP1062
DIP1062 -24 4 TGAAATTAGGGTAACCTGT
Supported by regulated orthologs from reference regulons
Ortholog gene name: frgD
Ortholog function: Fe-siderophore ABC transporter, substrate-binding protein
Corynebacterium aurimucosum ATCC 700975 cauri_2325 -19 5.3 TTAGGTTAGGCTACCTTTT
Corynebacterium diphtheriae NCTC 13129 DIP1062 -24 4 TGAAATTAGGGTAACCTGT
Corynebacterium glutamicum ATCC 13032 cg3404 -18 4.4 TTGCGTTAGGATAGCCTAA
Position: -173
Score: 4.7
Sequence: TTAGGGTGGGCTAACCTGC
Locus tag: DIP1296
DIP1296 -173 4.7 TTAGGGTGGGCTAACCTGC
Supported by regulated orthologs from reference regulons
Ortholog gene name: sufR
Ortholog function: Iron-sulfur cluster biogenesis transcriptional regulator SufR, ArsR family
Corynebacterium diphtheriae NCTC 13129 DIP1296 -173 4.7 TTAGGGTGGGCTAACCTGC
Corynebacterium glutamicum ATCC 13032 cg1765 -146 3.8 TTAGGGTTCGCTTAGTTTT
Corynebacterium jeikeium K411 jk0985 -124 4.2 TTAGGCAGGGTTACCTTAG
Position: -219
Score: 4
Sequence: GTAACAAAGGCAAGCCTAA
Position: -214
Score: 4.1
Sequence: AAAGGCAAGCCTAAGTAAA
Locus tag: DIP1510
DIP1510 -219 4 GTAACAAAGGCAAGCCTAA
-214 4.1 AAAGGCAAGCCTAAGTAAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: xerC
Ortholog function: Tyrosine recombinase
Corynebacterium amycolatum SK46 CORAM0001_0780 -150 5.1 ATAGGCAAGGCAAGCCTAA
Corynebacterium diphtheriae NCTC 13129 DIP1510 -214 4.1 AAAGGCAAGCCTAAGTAAA
Corynebacterium efficiens YS-314 CE1917 -221 4.4 GTGGGTGAGGCAAGCCTAA
Corynebacterium glutamicum ATCC 13032 cg2224 -112 4 GTGTGTGAGGCAAGCCTAA
Position: -19
Score: 5.2
Sequence: TAAGGTTTGGTTTACCTTA
Locus tag: DIP1519
DIP1519 -19 5.2 TAAGGTTTGGTTTACCTTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: htaC
Ortholog function: Predicted membrane protein
Corynebacterium aurimucosum ATCC 700975 cauri_1722 -70 4.2 TTAGGCCAGAATTACCTAA
-50 5.1 CAAGGTAAGCCTAACCTAT
Corynebacterium diphtheriae NCTC 13129 DIP1519 -19 5.2 TAAGGTTTGGTTTACCTTA
Position: -86
Score: 5.3
Sequence: ATAGGTTAGGTTAACCTTG
Position: -81
Score: 5.1
Sequence: TTAGGTTAACCTTGCTTAA
Locus tag: DIP1520
DIP1520 -86 5.3 ATAGGTTAGGTTAACCTTG
-81 5.1 TTAGGTTAACCTTGCTTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: chtB
Ortholog function: Predicted membrane protein
Corynebacterium diphtheriae NCTC 13129 DIP0522 -142 4.3 ATAGGCTGACCTAACTTTT
-65 4.7 GAAGATAAGGCTTACCTTT
Corynebacterium diphtheriae NCTC 13129 DIP1520 -86 5.3 ATAGGTTAGGTTAACCTTG
Position: -80
Score: 4.8
Sequence: TGAGGGGAACCTAACCTAA
Locus tag: DIP1669
DIP1669 -80 4.8 TGAGGGGAACCTAACCTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: hmuO
Ortholog function: Heme oxygenase (EC 1.14.99.3)
Corynebacterium amycolatum SK46 CORAM0001_1802 -165 5.6 TAAGGATAGGCTAACCTAG
Corynebacterium aurimucosum ATCC 700975 cauri_1721 -70 4.2 TTAGGCCAGAATTACCTAA
-50 5.1 CAAGGTAAGCCTAACCTAT
Corynebacterium diphtheriae NCTC 13129 DIP1669 -80 4.8 TGAGGGGAACCTAACCTAA
Corynebacterium glutamicum ATCC 13032 cg2445 -139 4.7 GTAGGTGTGGGTAACCTAA
Corynebacterium jeikeium K411 jk0320 -112 4.7 TAAGTCGAGCCTTACCTAA
-92 4.3 TAAGGTAACACTATCCTAA
Corynebacterium urealyticum DSM 7109 cur_1670 -74 4.6 CTAGGTTATGCTAACCTCA
-54 4.7 CGAGGTTAACCTAACCTAT
Position: -221
Score: 4.2
Sequence: TTTGGTTTGGCTATGTTTA
Position: -56
Score: 4.5
Sequence: TTATGCTGGGCTATCTTAA
Locus tag: DIP1866
DIP1866 -221 4.2 TTTGGTTTGGCTATGTTTA
-56 4.5 TTATGCTGGGCTATCTTAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: ftn
Ortholog function: Ferritin
Corynebacterium amycolatum SK46 CORAM0001_0900 -74 4.1 ATAGGCAAGGCCTGGCTTA
Corynebacterium aurimucosum ATCC 700975 cauri_0076 -121 4.6 TTGGGTTAGGTAAACCTAC
Corynebacterium diphtheriae NCTC 13129 DIP1866 -56 4.5 TTATGCTGGGCTATCTTAA
Corynebacterium efficiens YS-314 CE2420 -56 4.1 TTATGGTGCGCTAACCTTG
Corynebacterium glutamicum ATCC 13032 cg2782 -56 4.4 TTATGCTGCGCTAACCTAT
Position: -239
Score: 4.6
Sequence: TTAGGGTAGGCTAATCCAA
Locus tag: DIP2161
DIP2161 -239 4.6 TTAGGGTAGGCTAATCCAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: sidA
Ortholog function: Nonribosomal peptide synthase
Corynebacterium diphtheriae NCTC 13129 DIP2161 -239 4.6 TTAGGGTAGGCTAATCCAA
Position: -81
Score: 3.9
Sequence: TAAGGATAGGCCACCCCAA
Locus tag: DIP2303
DIP2303 -81 3.9 TAAGGATAGGCCACCCCAA
Supported by regulated orthologs from reference regulons
Ortholog gene name: dps
Ortholog function: Iron-binding ferritin-like antioxidant protein / Ferroxidase (EC 1.16.3.1)
Corynebacterium diphtheriae NCTC 13129 DIP2303 -81 3.9 TAAGGATAGGCCACCCCAA
Corynebacterium glutamicum ATCC 13032 cg3327 -80 4.1 TCAGGATAGGACAACCTAA
-60 3.9 ATAAATAAGCTTAGGCTAA
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