Propagation of McbR regulog to Corynebacterium diphtheriae NCTC 13129
| Source regulog: | McbR - Corynebacteriaceae |
| Regulator type: | Transcription factor |
| Regulator family: | TetR |
| Regulation mode: | repressor |
| Biological process: | Methionine biosynthesis |
| Effector: | S-adenosylmethionine; S-adenosylhomocysteine |
| Phylum: | Actinobacteria |
| Propagated regulon: | |
| Target genome | Corynebacterium diphtheriae NCTC 13129 |
| Orthologous TF(s) | DIP2274 |
| Regulated genes | 10 |
| Locus tag | Position | Score | Sequence | |
|---|---|---|---|---|
|
Position: -126
Score: 4.6 Sequence: CGTACCGATCGGTCTA
Locus tag: DIP0123
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| DIP0123 | -126 | 4.6 | CGTACCGATCGGTCTA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: cysR | ||||
| Ortholog function: Sulphur metabolism transcriptional regulator CysR, ROK family | ||||
| Corynebacterium aurimucosum ATCC 700975 | cauri_0079 | -40 | 4.5 | TAGACCATGATGTCTA |
| -6 | 4.7 | TAGACAATGCGGTCTG | ||
| Corynebacterium diphtheriae NCTC 13129 | DIP0123 | -126 | 4.6 | CGTACCGATCGGTCTA |
| -37 | 4.4 | TAGACAAGCTGGTCTA | ||
| Corynebacterium glutamicum ATCC 13032 | cg0156 | -69 | 4.8 | CAGACAATGCGGTCTA |
| -36 | 5.4 | TAGACAGCGTTGTCTA | ||
|
Position: -76
Score: 4.7 Sequence: TAGACCGAGCTGTACA
Locus tag: DIP0610
|
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| DIP0610 | -76 | 4.7 | TAGACCGAGCTGTACA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metQ | ||||
| Ortholog function: Methionine ABC transporter substrate-binding protein | ||||
| Corynebacterium diphtheriae NCTC 13129 | DIP0610 | -76 | 4.7 | TAGACCGAGCTGTACA |
|
Position: -166
Score: 4.7 Sequence: TAGACAAAGCTGTACA
Locus tag: DIP0611
|
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| DIP0611 | -166 | 4.7 | TAGACAAAGCTGTACA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metQ | ||||
| Ortholog function: Methionine ABC transporter substrate-binding protein | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_0284 | -70 | 5 | AAGACAGCTTGGTCTA |
| Corynebacterium diphtheriae NCTC 13129 | DIP0611 | -166 | 4.7 | TAGACAAAGCTGTACA |
| Corynebacterium efficiens YS-314 | CE0631 | -94 | 4.7 | TAGACCGAGCTGTACA |
| Corynebacterium glutamicum ATCC 13032 | cg0737 | -109 | 4.6 | TAGACCAAGCTGTACA |
|
Position: -60
Score: 5.2 Sequence: TAGACAGAGCTGTCCA
Locus tag: DIP0623
|
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| DIP0623 | -60 | 5.2 | TAGACAGAGCTGTCCA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metX | ||||
| Ortholog function: Homoserine O-acetyltransferase (EC 2.3.1.31) | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_0290 | -22 | 4.3 | CGGACTAAGTAGTCTA |
| Corynebacterium aurimucosum ATCC 700975 | cauri_0512 | -92 | 4.2 | CCAACCGCTCGGTCTA |
| -27 | 4.8 | TGAACCGCTTGGTCTA | ||
| Corynebacterium diphtheriae NCTC 13129 | DIP0623 | -60 | 5.2 | TAGACAGAGCTGTCCA |
| Corynebacterium efficiens YS-314 | CE0678 | -139 | 4.6 | CGAACCGCTCGGTCTA |
| -117 | 4.9 | TAGACCGAGCGGTTCA | ||
| Corynebacterium glutamicum ATCC 13032 | cg0754 | -69 | 5.2 | TAGACAGAGCTGTCCA |
| Corynebacterium jeikeium K411 | jk1695 | -171 | 4.5 | TAGACCAAGCGGTATG |
| -93 | 5.2 | TAGACAGAGCGGTTTA | ||
| Corynebacterium kroppenstedtii DSM 44385 | ckrop_1569 | -300 | 4.6 | CATACCGCTTAGTCTA |
| -244 | 4.4 | TAGACAGGGCGGTTTG | ||
| -225 | 4.8 | TAGACCGAGCGGTACA | ||
| Corynebacterium urealyticum DSM 7109 | cur_0422 | -212 | 4.9 | TAGACCAAGTGGTATA |
| -145 | 5.2 | TAGACAGAGCGGTTTA | ||
|
Position: -82
Score: 4.6 Sequence: TAGACCGATCGGTTTC
Locus tag: DIP0630
|
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| DIP0630 | -82 | 4.6 | TAGACCGATCGGTTTC | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metY | ||||
| Ortholog function: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_0291 | -73 | 5 | TAGACAGCTTGGTTCA |
| Corynebacterium aurimucosum ATCC 700975 | cauri_0513 | -92 | 4.2 | CCAACCGCTCGGTCTA |
| -27 | 4.8 | TGAACCGCTTGGTCTA | ||
| Corynebacterium diphtheriae NCTC 13129 | DIP0630 | -138 | 4.1 | CGCACCACTTTGTCTA |
| -82 | 4.6 | TAGACCGATCGGTTTC | ||
| Corynebacterium efficiens YS-314 | CE0679 | -139 | 4.6 | CGAACCGCTCGGTCTA |
| -117 | 4.9 | TAGACCGAGCGGTTCA | ||
| Corynebacterium glutamicum ATCC 13032 | cg0755 | -90 | 4.5 | TATACCACACAGTCTA |
| -68 | 4.7 | TAGACCAAGCTGTTCA | ||
| Corynebacterium jeikeium K411 | jk1694 | -171 | 4.5 | TAGACCAAGCGGTATG |
| -93 | 5.2 | TAGACAGAGCGGTTTA | ||
| Corynebacterium kroppenstedtii DSM 44385 | ckrop_1568 | -300 | 4.6 | CATACCGCTTAGTCTA |
| -244 | 4.4 | TAGACAGGGCGGTTTG | ||
| -225 | 4.8 | TAGACCGAGCGGTACA | ||
| Corynebacterium urealyticum DSM 7109 | cur_0423 | -212 | 4.9 | TAGACCAAGTGGTATA |
| -145 | 5.2 | TAGACAGAGCGGTTTA | ||
|
Position: -17
Score: 4.5 Sequence: CATACTAAGCTGTCTA
Locus tag: DIP1259
|
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| DIP1259 | -17 | 4.5 | CATACTAAGCTGTCTA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metH | ||||
| Ortholog function: 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13) | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_0986 | -19 | 4.6 | TAGACTAAGGTGTCTA |
| Corynebacterium diphtheriae NCTC 13129 | DIP1259 | -17 | 4.5 | CATACTAAGCTGTCTA |
| Corynebacterium efficiens YS-314 | CE1637 | -20 | 4.2 | CGTACTAAGCTGTCTA |
| Corynebacterium glutamicum ATCC 13032 | cg1701 | -95 | 4.2 | CGTACTAAGCTGTCTA |
| Corynebacterium kroppenstedtii DSM 44385 | ckrop_0919 | 20 | 5.1 | TAGACTAAGCTGTCTA |
|
Position: -116
Score: 5.5 Sequence: TAGACAGCTTGGTCTA
Locus tag: DIP1325
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| DIP1325 | -116 | 5.5 | TAGACAGCTTGGTCTA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: metK | ||||
| Ortholog function: S-adenosylmethionine synthetase (EC 2.5.1.6) | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_0910 | -98 | 4.8 | TGAACCGCTTGGTCTA |
| Corynebacterium aurimucosum ATCC 700975 | cauri_1185 | -97 | 5.4 | TAGACCGCTTGGTCTA |
| Corynebacterium diphtheriae NCTC 13129 | DIP1325 | -116 | 5.5 | TAGACAGCTTGGTCTA |
| Corynebacterium efficiens YS-314 | CE1723 | -73 | 5.5 | TAGACAGCTTGGTCTA |
| Corynebacterium glutamicum ATCC 13032 | cg1806 | -74 | 5.5 | TAGACAGCTTGGTCTA |
| Corynebacterium jeikeium K411 | jk1016 | -75 | 5.2 | CAGACAGCTTGGTCTA |
| Corynebacterium kroppenstedtii DSM 44385 | ckrop_0984 | -98 | 5.5 | TAGACAGCTTGGTCTA |
| Corynebacterium urealyticum DSM 7109 | cur_0975 | -110 | 5.4 | TAGACCGCTTGGTCTA |
|
Position: -152
Score: 4.5 Sequence: TAGACCGATCGGTACG
Position: -130
Score: 4.6 Sequence: AAGACAATTCTGTCTA
Locus tag: DIP1890
|
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| DIP1890 | -152 | 4.5 | TAGACCGATCGGTACG | |
| -130 | 4.6 | AAGACAATTCTGTCTA | ||
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: cysK | ||||
| Ortholog function: Cysteine synthase (EC 2.5.1.47) | ||||
| Corynebacterium amycolatum SK46 | CORAM0001_2226 | -103 | 3.9 | TAGACGAACTGGTCTG |
| Corynebacterium aurimucosum ATCC 700975 | cauri_2144 | -74 | 4.8 | TATACCACTCAGTCTA |
| Corynebacterium diphtheriae NCTC 13129 | DIP1890 | -152 | 4.5 | TAGACCGATCGGTACG |
| -130 | 4.6 | AAGACAATTCTGTCTA | ||
| Corynebacterium efficiens YS-314 | CE2446 | -148 | 4.7 | TAGACCGATCCGTCTG |
| Corynebacterium glutamicum ATCC 13032 | cg2833 | -150 | 4.6 | TGAACAGAACTGTCTA |
| Corynebacterium jeikeium K411 | jk0394 | -35 | 5.2 | TAGACCGATCAGTCTA |
| Corynebacterium kroppenstedtii DSM 44385 | ckrop_0419 | -152 | 4.8 | CAGACCGATCTGTCTG |
| Corynebacterium urealyticum DSM 7109 | cur_1592 | -60 | 5.3 | TAGACAGATCAGTCTA |
|
Position: -74
Score: 4.7 Sequence: TAGACTGATCTGTTCA
Locus tag: DIP2274
|
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| DIP2274 | -74 | 4.7 | TAGACTGATCTGTTCA | |
| Supported by regulated orthologs from reference regulons | ||||
| Ortholog gene name: mcbR | ||||
| Ortholog function: Methionine biosynthesis transcriptional regulator McbR, TetR family | ||||
| Corynebacterium aurimucosum ATCC 700975 | cauri_2422 | -57 | 4.4 | CATACCGGTTTGTCTA |
| Corynebacterium diphtheriae NCTC 13129 | DIP2274 | -74 | 4.7 | TAGACTGATCTGTTCA |
| Corynebacterium efficiens YS-314 | CE2788 | -154 | 4.1 | CGAACCGGTTTGTCTA |
| Corynebacterium glutamicum ATCC 13032 | cg3253 | -78 | 4.1 | CGAACCGGTTTGTCTA |