Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Propagation of McbR regulog to Corynebacterium urealyticum DSM 7109

Reference regulog properties
Source regulog: McbR - Corynebacteriaceae
Regulator type: Transcription factor
Regulator family: TetR
Regulation mode: repressor
Biological process: Methionine biosynthesis
Effector: S-adenosylmethionine; S-adenosylhomocysteine
Phylum: Actinobacteria
Propagated regulon:
Target genome Corynebacterium urealyticum DSM 7109
Orthologous TF(s) cur_0113
Regulated genes 13
Built upon 162 sites [see more]
Predicted regulatory interactions in Corynebacterium urealyticum DSM 7109
Locus tag Position Score Sequence
Position: -183
Score: 4.8
Sequence: TAGACCGCATGGTCTG
Position: -105
Score: 4.6
Sequence: TAGACAGTTCGGTATG
Position: -39
Score: 5
Sequence: TAGACAGATCGGTTCA
Locus tag: cur_0176
cur_0176 -183 4.8 TAGACCGCATGGTCTG
-105 4.6 TAGACAGTTCGGTATG
-39 5 TAGACAGATCGGTTCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: CE2728
Ortholog function: Predicted permease protein
Corynebacterium amycolatum SK46 CORAM0001_2013 -163 4 TATACGGTTCGGTCTG
-65 4.6 TAGACAGGTCTGTTCA
Corynebacterium efficiens YS-314 CE2728 -99 4.9 TAGACCTCTCTGTCTA
Corynebacterium jeikeium K411 jk0156 -41 4.7 CAGACAGATCGGTTCA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0159 -153 5.6 TAGACAGATCGGTCTA
Corynebacterium urealyticum DSM 7109 cur_0176 -183 4.8 TAGACCGCATGGTCTG
-105 4.6 TAGACAGTTCGGTATG
-39 5 TAGACAGATCGGTTCA
Position: -41
Score: 5
Sequence: TAGACAGATCTGTTCA
Locus tag: cur_0251
cur_0251 -41 5 TAGACAGATCTGTTCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg2678
Ortholog function: Predicted ABC transporter, substrate-binding protein
Corynebacterium aurimucosum ATCC 700975 cauri_2043 -36 5 TAGACTGTGCTGTCTA
Corynebacterium efficiens YS-314 CE2334 -71 5.5 TAGACAGATTGGTCTA
-48 4.2 AGTACCGATCAGTCTA
Corynebacterium glutamicum ATCC 13032 cg2678 -112 4.8 TAGACAGGTTGGTCTG
-90 4.9 TATACCGATCAGTCTA
Corynebacterium urealyticum DSM 7109 cur_0251 -41 5 TAGACAGATCTGTTCA
Position: -61
Score: 4.9
Sequence: TGAACAGATCTGTCTA
Locus tag: cur_0252
cur_0252 -61 4.9 TGAACAGATCTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cg2679
Ortholog function: Conserved hypothetical protein
Corynebacterium aurimucosum ATCC 700975 cauri_2044 -36 5 TAGACAGCACAGTCTA
Corynebacterium efficiens YS-314 CE2335 -75 4.1 TAGACTGATCGGTACT
-52 5.3 TAGACCAATCTGTCTA
Corynebacterium glutamicum ATCC 13032 cg2679 -72 5 TAGACTGATCGGTATA
-50 4.4 CAGACCAACCTGTCTA
Corynebacterium urealyticum DSM 7109 cur_0252 -61 4.9 TGAACAGATCTGTCTA
Position: -127
Score: 4.9
Sequence: TAGACCAAGTTGTCCA
Locus tag: cur_0411
cur_0411 -127 4.9 TAGACCAAGTTGTCCA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metQ
Ortholog function: Methionine ABC transporter substrate-binding protein
Corynebacterium jeikeium K411 jk1710 -103 4.5 TAGACTAAGTTGTTCA
Corynebacterium urealyticum DSM 7109 cur_0411 -127 4.9 TAGACCAAGTTGTCCA
Position: -212
Score: 4.9
Sequence: TAGACCAAGTGGTATA
Position: -145
Score: 5.2
Sequence: TAGACAGAGCGGTTTA
Locus tag: cur_0423
cur_0423 -212 4.9 TAGACCAAGTGGTATA
-145 5.2 TAGACAGAGCGGTTTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metY
Ortholog function: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48)
Corynebacterium amycolatum SK46 CORAM0001_0291 -73 5 TAGACAGCTTGGTTCA
Corynebacterium aurimucosum ATCC 700975 cauri_0513 -92 4.2 CCAACCGCTCGGTCTA
-27 4.8 TGAACCGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP0630 -138 4.1 CGCACCACTTTGTCTA
-82 4.6 TAGACCGATCGGTTTC
Corynebacterium efficiens YS-314 CE0679 -139 4.6 CGAACCGCTCGGTCTA
-117 4.9 TAGACCGAGCGGTTCA
Corynebacterium glutamicum ATCC 13032 cg0755 -90 4.5 TATACCACACAGTCTA
-68 4.7 TAGACCAAGCTGTTCA
Corynebacterium jeikeium K411 jk1694 -171 4.5 TAGACCAAGCGGTATG
-93 5.2 TAGACAGAGCGGTTTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1568 -300 4.6 CATACCGCTTAGTCTA
-244 4.4 TAGACAGGGCGGTTTG
-225 4.8 TAGACCGAGCGGTACA
Corynebacterium urealyticum DSM 7109 cur_0423 -212 4.9 TAGACCAAGTGGTATA
-145 5.2 TAGACAGAGCGGTTTA
Position: -134
Score: 5.5
Sequence: TAGACAGCTTGGTCTA
Locus tag: cur_0694
cur_0694 -134 5.5 TAGACAGCTTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: hom
Ortholog function: Homoserine dehydrogenase (EC 1.1.1.3)
Corynebacterium aurimucosum ATCC 700975 cauri_1049 -70 4.6 TAGACAGCTCGTTCTG
Corynebacterium efficiens YS-314 CE1289 -110 4.9 TGAACAGCTTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1337 -113 4.9 TGAACAGCTTGGTCTA
Corynebacterium jeikeium K411 jk1352 -105 5.2 TGGACAGCTTTGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1290 -100 4.5 CATACAGCTTTGTCTG
Corynebacterium urealyticum DSM 7109 cur_0694 -134 5.5 TAGACAGCTTGGTCTA
Position: -110
Score: 5.4
Sequence: TAGACCGCTTGGTCTA
Locus tag: cur_0975
cur_0975 -110 5.4 TAGACCGCTTGGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metK
Ortholog function: S-adenosylmethionine synthetase (EC 2.5.1.6)
Corynebacterium amycolatum SK46 CORAM0001_0910 -98 4.8 TGAACCGCTTGGTCTA
Corynebacterium aurimucosum ATCC 700975 cauri_1185 -97 5.4 TAGACCGCTTGGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP1325 -116 5.5 TAGACAGCTTGGTCTA
Corynebacterium efficiens YS-314 CE1723 -73 5.5 TAGACAGCTTGGTCTA
Corynebacterium glutamicum ATCC 13032 cg1806 -74 5.5 TAGACAGCTTGGTCTA
Corynebacterium jeikeium K411 jk1016 -75 5.2 CAGACAGCTTGGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0984 -98 5.5 TAGACAGCTTGGTCTA
Corynebacterium urealyticum DSM 7109 cur_0975 -110 5.4 TAGACCGCTTGGTCTA
Position: -9
Score: 5
Sequence: TAGACAGAGATGTCTA
Locus tag: cur_1218
cur_1218 -9 5 TAGACAGAGATGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metF
Ortholog function: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Corynebacterium aurimucosum ATCC 700975 cauri_0019 -182 4.5 TAGACAGCTTTGTACG
-70 4.3 TGGACAGCTTGGTACG
Corynebacterium jeikeium K411 jk0737 -30 5.3 TGGACAGCTCTGTCTA
Corynebacterium urealyticum DSM 7109 cur_1218 -9 5 TAGACAGAGATGTCTA
Position: -60
Score: 5.3
Sequence: TAGACAGATCAGTCTA
Locus tag: cur_1592
cur_1592 -60 5.3 TAGACAGATCAGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysK
Ortholog function: Cysteine synthase (EC 2.5.1.47)
Corynebacterium amycolatum SK46 CORAM0001_2226 -103 3.9 TAGACGAACTGGTCTG
Corynebacterium aurimucosum ATCC 700975 cauri_2144 -74 4.8 TATACCACTCAGTCTA
Corynebacterium diphtheriae NCTC 13129 DIP1890 -152 4.5 TAGACCGATCGGTACG
-130 4.6 AAGACAATTCTGTCTA
Corynebacterium efficiens YS-314 CE2446 -148 4.7 TAGACCGATCCGTCTG
Corynebacterium glutamicum ATCC 13032 cg2833 -150 4.6 TGAACAGAACTGTCTA
Corynebacterium jeikeium K411 jk0394 -35 5.2 TAGACCGATCAGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_0419 -152 4.8 CAGACCGATCTGTCTG
Corynebacterium urealyticum DSM 7109 cur_1592 -60 5.3 TAGACAGATCAGTCTA
Position: -219
Score: 4.9
Sequence: TAGACCAGGCGGTCTA
Position: -111
Score: 5.1
Sequence: TAGACCGAGCGGTCTG
Locus tag: cur_1744
cur_1744 -219 4.9 TAGACCAGGCGGTCTA
-111 5.1 TAGACCGAGCGGTCTG
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysH
Ortholog function: Adenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.10)
Corynebacterium aurimucosum ATCC 700975 cauri_2335 -115 4.2 TAGTCCGCTCGGTTCA
Corynebacterium efficiens YS-314 CE2642 -281 4.4 CCGACCACTCTGTCTA
-247 5.1 TAGACCGCTTGGTCTG
-163 4.4 TAGACCGTCCAGTCTA
-46 4.6 TAGACAGATCGGTACG
Corynebacterium glutamicum ATCC 13032 cg3116 -286 5.1 TAGACCGCTTGGTCTG
-201 5.6 TAGACAGATCGGTCTA
-83 4.5 TAGACAGAGCGGTACG
Corynebacterium jeikeium K411 jk0245 -134 5.3 TGGACAGATTGGTCTA
-100 4.9 CAGACCGATCGGTCTG
Corynebacterium urealyticum DSM 7109 cur_1744 -219 4.9 TAGACCAGGCGGTCTA
-111 5.1 TAGACCGAGCGGTCTG
Position: -181
Score: 5.2
Sequence: TAGACAGCATTGTCTA
Position: -97
Score: 4.9
Sequence: TAGACCGCACGGTCTG
Locus tag: cur_1757
cur_1757 -181 5.2 TAGACAGCATTGTCTA
-97 4.9 TAGACCGCACGGTCTG
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysI
Ortholog function: Ferredoxin--sulfite reductase, actinobacterial type (EC 1.8.7.1)
Corynebacterium amycolatum SK46 CORAM0001_1359 -113 4.7 CAGACTGGTCGGTCTA
-77 5.1 TAGACCAAACGGTCTA
Corynebacterium aurimucosum ATCC 700975 cauri_0665 -65 4.4 AAGACTGCTTTGTCTG
Corynebacterium efficiens YS-314 CE2644 -281 4.4 CCGACCACTCTGTCTA
-247 5.1 TAGACCGCTTGGTCTG
-163 4.4 TAGACCGTCCAGTCTA
-46 4.6 TAGACAGATCGGTACG
Corynebacterium glutamicum ATCC 13032 cg3118 -286 5.1 TAGACCGCTTGGTCTG
-201 5.6 TAGACAGATCGGTCTA
-83 4.5 TAGACAGAGCGGTACG
Corynebacterium jeikeium K411 jk0243 -114 5.4 TAGACAACTCTGTCTA
-34 5 CAGACAGATCAGTCTA
Corynebacterium urealyticum DSM 7109 cur_1757 -181 5.2 TAGACAGCATTGTCTA
-97 4.9 TAGACCGCACGGTCTG
Position: -124
Score: 5
Sequence: TAGACAATGCTGTCTA
Locus tag: cur_1758
cur_1758 -124 5 TAGACAATGCTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: cysJ
Ortholog function: Ferredoxin--NADP reductase (EC 1.18.1.2)
Corynebacterium amycolatum SK46 CORAM0001_1361 -98 4.9 TAGACCAGTTTGTCTA
-63 5.4 TAGACCGATTGGTCTA
Corynebacterium jeikeium K411 jk0242 -297 4.9 TAGACTGATCTGTCTG
-217 5.4 TAGACAGAGTTGTCTA
Corynebacterium kroppenstedtii DSM 44385 ckrop_1688 -198 5.1 TAGACAGAGTGGTATA
Corynebacterium urealyticum DSM 7109 cur_1758 -208 4.9 CAGACCGTGCGGTCTA
-124 5 TAGACAATGCTGTCTA
Position: -256
Score: 5
Sequence: CAGACCAAGCTGTCTA
Locus tag: cur_1766
cur_1766 -256 5 CAGACCAAGCTGTCTA
Supported by regulated orthologs from reference regulons
Ortholog gene name: metE
Ortholog function: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)
Corynebacterium efficiens YS-314 CE1209 -290 4.3 CAGACCATGCTGTCTG
Corynebacterium glutamicum ATCC 13032 cg1290 -272 4.9 CAGACCGAGCAGTCTA
Corynebacterium jeikeium K411 jk0234 -205 4.8 CAGACTAAGCTGTCTA
Corynebacterium urealyticum DSM 7109 cur_1766 -256 5 CAGACCAAGCTGTCTA