Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Orthologous regulated operons containing hemL gene

Properties
Regulator type: RNA regulatory element
Name: Cobalamin
RFAM: RF00174
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector: Adenosylcobalamin
Phylum: Firmicutes
Orthologous operons
Operon Position Score Sequence Locus Tag of the First Gene
Clostridium cellulolyticum H10
Position: -380
Score: 95.57
Sequence: TAATAATTAACGATA...
Locus tag: Ccel_1266
Name: cbiM
Funciton: Substrate-specific component CbiM of cobalt ECF transporter
Locus tag: Ccel_1267
Name: cbiN
Funciton: Additional substrate-specific component CbiN of cobalt ECF transporter
Locus tag: Ccel_1268
Name: cbiQ
Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter
Locus tag: Ccel_1269
Name: cbiO
Funciton: ATPase component CbiO of energizing module of cobalt ECF transporter
Locus tag: Ccel_1270
Name: cbiD
Funciton: Cobalt-precorrin-6 synthase, anaerobic
Locus tag: Ccel_1271
Name: cbiL
Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Locus tag: Ccel_1272
Name: cbiF
Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Locus tag: Ccel_1273
Name: cbiG
Funciton: Cobalamin biosynthesis protein CbiG
Locus tag: Ccel_1274
Name: hemA
Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70)
Locus tag: Ccel_1275
Name: cbiH
Funciton: Cobalt-precorrin-3b C17-methyltransferase
Locus tag: Ccel_1276
Name: cbiJ
Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54)
Locus tag: Ccel_1277
Name: hemC
Funciton: Porphobilinogen deaminase (EC 2.5.1.61)
Locus tag: Ccel_1278
Name: cobA-hemD
Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75)
Locus tag: Ccel_1279
Name: hemB
Funciton: Porphobilinogen synthase (EC 4.2.1.24)
Locus tag: Ccel_1280
Name: hemL
Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
Locus tag: Ccel_1281
Name: cbiX
Funciton: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
Locus tag: Ccel_1282
Name: cbiET
Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Locus tag: Ccel_1283
Name: cbiA
Funciton: Cobyrinic acid A,C-diamide synthase
Locus tag: Ccel_1284
Name: cbiP
Funciton: Cobyric acid synthase
Locus tag: Ccel_1285
Name: cbiC
Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Locus tag: Ccel_1286
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: Ccel_1287
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiM-cbiN-cbiQ-cbiO-cbiD-cbiL-cbiF-cbiG-hemA-cbiH-cbiJ-hemC-cobA-hemD-hemB-hemL-cbiX-cbiET-cbiA-cbiP-cbiC-cbiB-cobD -380 95.6 TAATAATTAACGATA... Ccel_1266
Clostridium phytofermentans ISDg
Position: -362
Score: 109.4
Sequence: ACAATTTAGATCTTT...
Locus tag: null
Name: hemA
Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70)
Locus tag: null
Name: cysG3
Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76)
Locus tag: null
Name: hemC
Funciton: Porphobilinogen deaminase (EC 2.5.1.61)
Locus tag: null
Name: cobA-hemD
Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75)
Locus tag: null
Name: hemB
Funciton: Porphobilinogen synthase (EC 4.2.1.24)
Locus tag: null
Name: hemL
Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
Locus tag: null
Name: cbiD
Funciton: Cobalt-precorrin-6 synthase, anaerobic
Locus tag: null
Name: cbiL
Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Locus tag: null
Name: cbiF
Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Locus tag: null
Name: cbiG
Funciton: Cobalamin biosynthesis protein CbiG
Locus tag: null
Name: cbiH
Funciton: Cobalt-precorrin-3b C17-methyltransferase
Locus tag: null
Name: cbiJ
Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54)
Locus tag: null
Name: cbiA
Funciton: Cobyrinic acid A,C-diamide synthase
Locus tag: null
Name: btuR
Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Locus tag: null
Name: cbiC
Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
hemA-cysG3-hemC-cobA-hemD-hemB-hemL-cbiD-cbiL-cbiF-cbiG-cbiH-cbiJ-cbiA-btuR-cbiC -362 109.4 ACAATTTAGATCTTT... null
Clostridium tetani E88
Position: -400
Score: 126.42
Sequence: GAATATGAAAATATT...
Locus tag: CTC00720
Name: cbiP
Funciton: Cobyric acid synthase
Locus tag: CTC00721
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: CTC00722
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Locus tag: CTC00723
Name: cbiM
Funciton: Substrate-specific component CbiM of cobalt ECF transporter
Locus tag: CTC00724
Name: cbiQ
Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter
Locus tag: CTC00725
Name: hemA
Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70)
Locus tag: CTC00726
Name: cysG1
Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4)
Locus tag: CTC00727
Name: hemC
Funciton: Porphobilinogen deaminase (EC 2.5.1.61)
Locus tag: CTC00728
Name: cobA-hemD
Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75)
Locus tag: CTC00729
Name: hemB
Funciton: Porphobilinogen synthase (EC 4.2.1.24)
Locus tag: CTC00730
Name: hemL
Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
Locus tag: CTC00731
Name: cbiA
Funciton: Cobyrinic acid A,C-diamide synthase
Locus tag: CTC00732
Name: cbiC
Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Locus tag: CTC00733
Name: cbiD
Funciton: Cobalt-precorrin-6 synthase, anaerobic
Locus tag: CTC00734
Name: cbiET
Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Locus tag: CTC00735
Name: cbiL
Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Locus tag: CTC00736
Name: cbiF
Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Locus tag: CTC00737
Name: cbiG
Funciton: Cobalamin biosynthesis protein CbiG
Locus tag: CTC00739
Name: cbiH
Funciton: Cobalt-precorrin-3b C17-methyltransferase
Locus tag: CTC00740
Name: cbiJ
Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54)
Locus tag: CTC00741
Name: cblT
Funciton: Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole
Locus tag: CTC00742
Name: cblS
Funciton: Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis
Locus tag: CTC00743
Name: cbiK
Funciton: Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3)
Locus tag: CTC00744
Name: btuR
Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiP-cbiB-cobD-cbiM-cbiQ-hemA-cysG1-hemC-cobA-hemD-hemB-hemL-cbiA-cbiC-cbiD-cbiET-cbiL-cbiF-cbiG-cbiH-cbiJ-cblT-cblS-cbiK-btuR -400 126.4 GAATATGAAAATATT... CTC00720