Orthologous regulated operons containing cobA-hemD gene

Properties
Regulator type:	RNA regulatory element
Name:	Cobalamin
RFAM:	RF00174
Regulation mode:
Biological process:	Cobalamin biosynthesis
Effector:	Adenosylcobalamin
Phylum:	Firmicutes

Orthologous operons
Operon	Position	Score	Sequence	Locus Tag of the First Gene
Clostridium bartlettii DSM 16795
Position: -274 Score: 71.78 Sequence: AGGGAAAAAGGTACA... Locus tag: CLOBAR_01422 Name: cbiP Funciton: Cobyric acid synthase Locus tag: CLOBAR_01421 Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: CLOBAR_01420 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: CLOBAR_01419 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Locus tag: CLOBAR_01418 Name: pduX Funciton: Threonine kinase in B12 biosynthesis Locus tag: CLOBAR_01417 Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Locus tag: CLOBAR_01416 Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: CLOBAR_01415 Name: cbiE Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) Locus tag: CLOBAR_01414 Name: cbiT Funciton: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) Locus tag: CLOBAR_01413 Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: CLOBAR_01412 Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: CLOBAR_01411 Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: CLOBAR_01410 Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: CLOBAR_01409 Name: cbiK Funciton: Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Locus tag: CLOBAR_01408 Name: cbiL Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: CLOBAR_01407 Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: CLOBAR_01406 Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: CLOBAR_01405 Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: CLOBAR_01404 Name: sstT Funciton: hypothetical protein Locus tag: CLOBAR_01403 Name: sstT Funciton: hypothetical protein Locus tag: CLOBAR_01402 Name: cysG3 Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76)
cbiP-cbiA-cbiB-cobD-pduX-cbiC-cbiD-cbiE-cbiT-cbiF-cbiG-cbiH-cbiJ-cbiK-cbiL-hemC-cobA-hemD-hemB-sstT-sstT-cysG3	-274	71.8	AGGGAAAAAGGTACA...	CLOBAR_01422
Clostridium botulinum A str. ATCC 3502
Position: -323 Score: 122.69 Sequence: TTTAATAAAAAGATT... Locus tag: CBO0914 Name: cbiP Funciton: Cobyric acid synthase Locus tag: CBO0915 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: CBO0916 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Locus tag: CBO0917 Name: cbiM Funciton: Substrate-specific component CbiM of cobalt ECF transporter Locus tag: CBO0917A Name: cbiN Funciton: Additional substrate-specific component CbiN of cobalt ECF transporter Locus tag: CBO0918 Name: cbiQ Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter Locus tag: CBO0919 Name: cysG1 Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) Locus tag: CBO0920 Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: CBO0921 Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: CBO0922 Name: null Funciton: hypothetical protein Locus tag: CBO0923 Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: CBO0924 Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: CBO0925 Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Locus tag: CBO0926 Name: null Funciton: CAAX amino terminal protease family Locus tag: CBO0927 Name: wrbA Funciton: Iron-sulfur flavoprotein Locus tag: CBO0928 Name: Cbei_2684 Funciton: HD domain protein Locus tag: CBO0929 Name: null Funciton: hypothetical protein Locus tag: CBO0930 Name: null Funciton: Transcriptional regulator, MerR family Locus tag: CBO0931 Name: CBO0931 Funciton: Acetyltransferase (EC 2.3.1.-) Locus tag: CBO0933 Name: CD0837 Funciton: Nitroreductase family protein Locus tag: CBO0934 Name: null Funciton: membrane protein Locus tag: CBO0935 Name: null Funciton: Glutamate-rich protein grpB Locus tag: CBO0936 Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: CBO0937 Name: cbiE Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) Locus tag: CBO0938 Name: CBO0938 Funciton: CAAX amino terminal protease family protein Locus tag: CBO0939 Name: cbiT Funciton: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) Locus tag: CBO0940 Name: null Funciton: hypothetical protein Locus tag: CBO0941 Name: null Funciton: hypothetical protein Locus tag: CBO0941A Name: null Funciton: membrane protein Locus tag: CBO0942 Name: null Funciton: membrane protein Locus tag: CBO0943 Name: null Funciton: hypothetical protein Locus tag: CBO0944 Name: null Funciton: Predicted secreted nucleic acid binding protein Locus tag: CBO0945 Name: Cbei_3085 Funciton: Isochorismatase (EC 3.3.2.1) Locus tag: CBO0946 Name: cbiL Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: CBO0947 Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: CBO0948 Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: CBO0949 Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: CBO0950 Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: CBO0951 Name: cblT Funciton: Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole Locus tag: CBO0952 Name: cbiK Funciton: Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Locus tag: CBO0953 Name: pduX Funciton: Threonine kinase in B12 biosynthesis Locus tag: CBO0954 Name: btuR Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiP-cbiB-cobD-cbiM-cbiN-cbiQ-cysG1-hemC-cobA-hemD-CBO0922-hemB-cbiA-cbiC-CBO0926-wrbA-Cbei_2684-CBO0929-CBO0930-CBO0931-CD0837-CBO0934-CBO0935-cbiD-cbiE-CBO0938-cbiT-CBO0940-CBO0941-CBO0941A-CBO0942-CBO0943-CBO0944-Cbei_3085-cbiL-cbiF-cbiG-cbiH-cbiJ-cblT-cbiK-pduX-btuR	-323	122.7	TTTAATAAAAAGATT...	CBO0914
Clostridium cellulolyticum H10
Position: -380 Score: 95.57 Sequence: TAATAATTAACGATA... Locus tag: Ccel_1266 Name: cbiM Funciton: Substrate-specific component CbiM of cobalt ECF transporter Locus tag: Ccel_1267 Name: cbiN Funciton: Additional substrate-specific component CbiN of cobalt ECF transporter Locus tag: Ccel_1268 Name: cbiQ Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter Locus tag: Ccel_1269 Name: cbiO Funciton: ATPase component CbiO of energizing module of cobalt ECF transporter Locus tag: Ccel_1270 Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: Ccel_1271 Name: cbiL Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: Ccel_1272 Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: Ccel_1273 Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: Ccel_1274 Name: hemA Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70) Locus tag: Ccel_1275 Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: Ccel_1276 Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: Ccel_1277 Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: Ccel_1278 Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: Ccel_1279 Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: Ccel_1280 Name: hemL Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) Locus tag: Ccel_1281 Name: cbiX Funciton: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) Locus tag: Ccel_1282 Name: cbiET Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) Locus tag: Ccel_1283 Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: Ccel_1284 Name: cbiP Funciton: Cobyric acid synthase Locus tag: Ccel_1285 Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Locus tag: Ccel_1286 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: Ccel_1287 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiM-cbiN-cbiQ-cbiO-cbiD-cbiL-cbiF-cbiG-hemA-cbiH-cbiJ-hemC-cobA-hemD-hemB-hemL-cbiX-cbiET-cbiA-cbiP-cbiC-cbiB-cobD	-380	95.6	TAATAATTAACGATA...	Ccel_1266
Clostridium difficile 630
Position: -295 Score: 102.08 Sequence: GAATATTAGATTAAA... Locus tag: CD3435 Name: cbiP Funciton: Cobyric acid synthase Locus tag: CD3434 Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: CD3433 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: CD3432 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Locus tag: CD3431 Name: pduX Funciton: Threonine kinase in B12 biosynthesis Locus tag: CD3430 Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Locus tag: CD3429 Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: CD3428 Name: cbiE Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) Locus tag: CD3427 Name: cbiT Funciton: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) Locus tag: CD3426 Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: CD3425 Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: CD3424 Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: CD3423 Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: CD3422 Name: cbiKL Funciton: Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) / Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: CD3421 Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: CD3420 Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: CD3419 Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: CD3418 Name: cysG3 Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76)
cbiP-cbiA-cbiB-cobD-pduX-cbiC-cbiD-cbiE-cbiT-cbiF-cbiG-cbiH-cbiJ-cbiKL-hemC-cobA-hemD-hemB-cysG3	-295	102.1	GAATATTAGATTAAA...	CD3435
Clostridium phytofermentans ISDg
Position: -362 Score: 109.4 Sequence: ACAATTTAGATCTTT... Locus tag: null Name: hemA Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70) Locus tag: null Name: cysG3 Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) Locus tag: null Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: null Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: null Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: null Name: hemL Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) Locus tag: null Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: null Name: cbiL Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: null Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: null Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: null Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: null Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: null Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: null Name: btuR Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Locus tag: null Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
hemA-cysG3-hemC-cobA-hemD-hemB-hemL-cbiD-cbiL-cbiF-cbiG-cbiH-cbiJ-cbiA-btuR-cbiC	-362	109.4	ACAATTTAGATCTTT...	null
Clostridium tetani E88
Position: -400 Score: 126.42 Sequence: GAATATGAAAATATT... Locus tag: CTC00720 Name: cbiP Funciton: Cobyric acid synthase Locus tag: CTC00721 Name: cbiB Funciton: Adenosylcobinamide-phosphate synthase Locus tag: CTC00722 Name: cobD Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Locus tag: CTC00723 Name: cbiM Funciton: Substrate-specific component CbiM of cobalt ECF transporter Locus tag: CTC00724 Name: cbiQ Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter Locus tag: CTC00725 Name: hemA Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70) Locus tag: CTC00726 Name: cysG1 Funciton: Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) Locus tag: CTC00727 Name: hemC Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: CTC00728 Name: cobA-hemD Funciton: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) / Uroporphyrinogen-III synthase (EC 4.2.1.75) Locus tag: CTC00729 Name: hemB Funciton: Porphobilinogen synthase (EC 4.2.1.24) Locus tag: CTC00730 Name: hemL Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) Locus tag: CTC00731 Name: cbiA Funciton: Cobyrinic acid A,C-diamide synthase Locus tag: CTC00732 Name: cbiC Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Locus tag: CTC00733 Name: cbiD Funciton: Cobalt-precorrin-6 synthase, anaerobic Locus tag: CTC00734 Name: cbiET Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) Locus tag: CTC00735 Name: cbiL Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Locus tag: CTC00736 Name: cbiF Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Locus tag: CTC00737 Name: cbiG Funciton: Cobalamin biosynthesis protein CbiG Locus tag: CTC00739 Name: cbiH Funciton: Cobalt-precorrin-3b C17-methyltransferase Locus tag: CTC00740 Name: cbiJ Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54) Locus tag: CTC00741 Name: cblT Funciton: Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole Locus tag: CTC00742 Name: cblS Funciton: Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis Locus tag: CTC00743 Name: cbiK Funciton: Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Locus tag: CTC00744 Name: btuR Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiP-cbiB-cobD-cbiM-cbiQ-hemA-cysG1-hemC-cobA-hemD-hemB-hemL-cbiA-cbiC-cbiD-cbiET-cbiL-cbiF-cbiG-cbiH-cbiJ-cblT-cblS-cbiK-btuR	-400	126.4	GAATATGAAAATATT...	CTC00720