Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Collection of regulogs for SMK_box_riboswitch (RF01767) RNA regulatory element

The SMK box riboswitch, also known as SAM-III, is an RNA regulatory element that was found upstream of the methionine synthase metK genes in lactic acid bacteria from the Lactobacillales order of Firmicutes [16491091]. This riboswitch is one of several riboswitches that recognize S-adenosylmethionine (SAM) as a ligand, and regulates the SAM synthase MetK [16491091]. SAM is a common co-substrate involved in methyl group transfers and is synthesized from the methionine amino acid by MetK synthase. SAM binding to Smk box RNA causes a structural rearrangement that se-questers the ribosomal binding site, thus the S mk box riboswitch inhibits translation of the metK gene [17360376]. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Firmicutes SMK_box_riboswitch - Lactobacillaceae 13 (15) 13