Regulon of MetR in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Properties
Regulator type:	Transcription factor
TF locus tag:	KPN_04324
Regulator family:	LysR
Regulation mode:	repressor (activator)
Biological process:	Methionine biosynthesis
Effector:	Homocysteine
Regulog:	MetR - Enterobacteriales
Statistics of regulated genes:
- Genes	12
- Operons	11
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 140 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - MetR
By TF family - LysR
By effector - Homocysteine
By pathway - Methionine biosynthesis

Regulated operons
	Locus Tag	Name	Function
Position: -217 Score: 4 Sequence: AAGAAAAAATCTCAA Position: -13 Score: 4.9 Sequence: GTGAAGGACTTTCAT Locus tag: KPN_04324 Name: metR Funciton: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
	KPN_04324	metR	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Position: -249 Score: 4.9 Sequence: ATGAAAGTCCTTCAC Locus tag: KPN_04325 Name: metE Funciton: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
	KPN_04325	metE	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
Position: -98 Score: 3.9 Sequence: ATGAAATCCTCTCAA Locus tag: KPN_02168 Name: metQ2 Funciton: Methionine ABC transporter substrate-binding protein
	KPN_02168	metQ2	Methionine ABC transporter substrate-binding protein
Position: -216 Score: 4.7 Sequence: ATGAAGAATTTGCAT Locus tag: KPN_02876 Name: glyA Funciton: Serine hydroxymethyltransferase (EC 2.1.2.1)
	KPN_02876	glyA	Serine hydroxymethyltransferase (EC 2.1.2.1)
Position: -152 Score: 5 Sequence: TTGAAAATTTTTCAT Position: -132 Score: 4.2 Sequence: ATGAAATATTCTCGT Locus tag: KPN_01615 Name: metE2 Funciton: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
	KPN_01615	metE2	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
Position: -83 Score: 4.2 Sequence: ATGCGCGTCTTTCAT Locus tag: KPN_03018 Name: luxS Funciton: S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS
	KPN_03018	luxS	S-ribosylhomocysteine lyase (EC 4.4.1.21) / Autoinducer-2 production protein LuxS
Position: -124 Score: 4.7 Sequence: ATGCAAATTCTTCAT Locus tag: KPN_02877 Name: hmp Funciton: Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)
	KPN_02877	hmp	Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (EC 1.14.12.17)
Position: -106 Score: 4.3 Sequence: CTGAACATGTCTCAT Locus tag: KPN_04399 Name: metH Funciton: 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)
	KPN_04399	metH	5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13)
Position: -155 Score: 4.8 Sequence: ATGAACTTTTTTCAT Position: 0 Score: 4.6 Sequence: ATGAGCTTTTTTCAC Locus tag: KPN_04239 Name: metF Funciton: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
	KPN_04239	metF	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Position: -111 Score: 4.8 Sequence: GTGAAATTTTCTCAC Locus tag: KPN_04394 Name: metA Funciton: Homoserine O-succinyltransferase (EC 2.3.1.46)
	KPN_04394	metA	Homoserine O-succinyltransferase (EC 2.3.1.46)
Position: -192 Score: 4.2 Sequence: ATGAGGATGGCTCAT Locus tag: KPN_02153 Name: PF08908 Funciton: Protein of unknown function DUF1852 Locus tag: KPN_02152 Name: metE2-2 Funciton: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
	KPN_02153	PF08908	Protein of unknown function DUF1852
	KPN_02152	metE2-2	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of MetR in Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --