Regulog PurR - Staphylococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	PurR
Regulation mode:	repressor
Biological process:	Purine metabolism
Effector:	5-phosphoribosyl 1-pyrophosphate
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 26 sites [see more]

Member of regulog collections

By taxonomy - Staphylococcaceae
By TF family - PurR
By effector - 5-phosphoribosyl 1-pyrophosphate
By pathway - Purine metabolism

Statistics of regulated genes
Genome	Genes	Operons
Staphylococcus aureus subsp. aureus N315	14	4
Staphylococcus capitis SK14	13	3
Staphylococcus epidermidis ATCC 12228	13	3
Staphylococcus carnosus subsp. carnosus TM300	13	3
Staphylococcus haemolyticus JCSC1435	14	4
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305	14	4
Macrococcus caseolyticus JCSC5402	14	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
purE	* Staphylococcus aureus subsp. aureus N315 Site: position = -136 score = 9.27833 sequence = AAAAGACGTAAATT-(18)-AAAGTTCGATTTTT Gene: SA0916: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Staphylococcus capitis SK14 Site: position = -136 score = 9.27833 sequence = AAAAGACGTAAATT-(18)-AAAGTTCGATTTTT Gene: STACA0001_2300: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Staphylococcus epidermidis ATCC 12228 Site: position = -137 score = 9.27833 sequence = AAAAGACGTAAATT-(18)-AAAGTTCGATTTTT Gene: SE0762: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -143 score = 9.28832 sequence = TAATTACGTAATTT-(18)-AAAGTTCGATTTTT Gene: Sca_0686: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Staphylococcus haemolyticus JCSC1435 Site: position = -136 score = 9.27833 sequence = AAAAGACGTAAATT-(18)-AAAGTTCGATTTTT Gene: SH1893: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -136 score = 8.9688 sequence = AAAAGACGTAGATT-(18)-AAAGTTCGATTTTT Gene: SSP1726: phosphoribosylaminoimidazole carboxylase catalytic subunit	* Macrococcus caseolyticus JCSC5402 Site: position = -193 score = 7.35057 sequence = AAAATACGAACGAA-(18)-AAAATACGTAATTG Gene: MCCL_0687: phosphoribosylaminoimidazole carboxylase catalytic subunit	phosphoribosylaminoimidazole carboxylase catalytic subunit
purK	Staphylococcus aureus subsp. aureus N315 Gene: SA0917: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Staphylococcus capitis SK14 Gene: STACA0001_2299: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Staphylococcus epidermidis ATCC 12228 Gene: SE0763: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0687: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Staphylococcus haemolyticus JCSC1435 Gene: SH1892: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1725: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0688: phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)	phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)
purC	Staphylococcus aureus subsp. aureus N315 Gene: SA0918: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Staphylococcus capitis SK14 Gene: STACA0001_2298: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Staphylococcus epidermidis ATCC 12228 Gene: SE0764: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0688: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Staphylococcus haemolyticus JCSC1435 Gene: SH1891: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1724: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0689: phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)	phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
purS	Staphylococcus aureus subsp. aureus N315 Gene: SA0919: phosphoribosylformylglycinamidine synthase, PurS protein	Staphylococcus capitis SK14 Gene: STACA0001_2297: phosphoribosylformylglycinamidine synthase, PurS protein	Staphylococcus epidermidis ATCC 12228 Gene: SE0765: phosphoribosylformylglycinamidine synthase, PurS protein	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0689: phosphoribosylformylglycinamidine synthase, PurS protein	Staphylococcus haemolyticus JCSC1435 Gene: SH1890: phosphoribosylformylglycinamidine synthase, PurS protein	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1723: phosphoribosylformylglycinamidine synthase, PurS protein	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0690: phosphoribosylformylglycinamidine synthase, PurS protein	phosphoribosylformylglycinamidine synthase, PurS protein
purQ	Staphylococcus aureus subsp. aureus N315 Gene: SA0920: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Staphylococcus capitis SK14 Gene: STACA0001_2296: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Staphylococcus epidermidis ATCC 12228 Gene: SE0766: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0690: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Staphylococcus haemolyticus JCSC1435 Gene: SH1889: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1722: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0691: phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)	phosphoribosylformylglycinamidine synthase I (EC:6.3.5.3)
purL	Staphylococcus aureus subsp. aureus N315 Gene: SA0921: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Staphylococcus capitis SK14 Gene: STACA0001_2295: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Staphylococcus epidermidis ATCC 12228 Gene: SE0767: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0691: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Staphylococcus haemolyticus JCSC1435 Gene: SH1888: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1721: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0692: phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)	phosphoribosylformylglycinamidine synthase II (EC:6.3.5.3)
purF	Staphylococcus aureus subsp. aureus N315 Gene: SA0922: amidophosphoribosyltransferase (EC:2.4.2.14)	Staphylococcus capitis SK14 Gene: STACA0001_2294: amidophosphoribosyltransferase (EC:2.4.2.14)	Staphylococcus epidermidis ATCC 12228 Gene: SE0768: amidophosphoribosyltransferase (EC:2.4.2.14)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0692: amidophosphoribosyltransferase (EC:2.4.2.14)	Staphylococcus haemolyticus JCSC1435 Gene: SH1887: amidophosphoribosyltransferase (EC:2.4.2.14)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1720: amidophosphoribosyltransferase (EC:2.4.2.14)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0693: amidophosphoribosyltransferase (EC:2.4.2.14)	amidophosphoribosyltransferase (EC:2.4.2.14)
purM	Staphylococcus aureus subsp. aureus N315 Gene: SA0923: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Staphylococcus capitis SK14 Gene: STACA0001_2293: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Staphylococcus epidermidis ATCC 12228 Gene: SE0769: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0693: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Staphylococcus haemolyticus JCSC1435 Gene: SH1886: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1719: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0694: phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)	phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
purN	Staphylococcus aureus subsp. aureus N315 Gene: SA0924: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Staphylococcus capitis SK14 Gene: STACA0001_2292: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Staphylococcus epidermidis ATCC 12228 Gene: SE0770: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0694: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Staphylococcus haemolyticus JCSC1435 Gene: SH1885: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1718: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0695: phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)	phosphoribosylglycinamide formyltransferase (EC:2.1.2.2)
purH	Staphylococcus aureus subsp. aureus N315 Gene: SA0925: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Staphylococcus capitis SK14 Gene: STACA0001_2291: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Staphylococcus epidermidis ATCC 12228 Gene: SE0771: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0695: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Staphylococcus haemolyticus JCSC1435 Gene: SH1884: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1717: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0696: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)	phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3), IMP cyclohydrolase (EC:3.5.4.10)
purD	Staphylococcus aureus subsp. aureus N315 Gene: SA0926: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Staphylococcus capitis SK14 Gene: STACA0001_2290: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Staphylococcus epidermidis ATCC 12228 Gene: SE0772: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_0696: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Staphylococcus haemolyticus JCSC1435 Gene: SH1883: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Gene: SSP1716: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	Macrococcus caseolyticus JCSC5402 Gene: MCCL_0697: phosphoribosylamine--glycine ligase (EC:6.3.4.13)	phosphoribosylamine--glycine ligase (EC:6.3.4.13)

CRON 2.
purB	* Staphylococcus aureus subsp. aureus N315 Site: position = -82 score = 8.39827 sequence = TAAAAACGAACTTT-(18)-AATGTTCTGTTTTT Gene: SA1724: adenylosuccinate lyase (EC:4.3.2.2)	* Staphylococcus capitis SK14 Site: position = -85 score = 8.75799 sequence = TAAATACGAACTTT-(18)-AATGTACAGTTTTT Gene: STACA0001_1961: adenylosuccinate lyase (EC:4.3.2.2)	* Staphylococcus epidermidis ATCC 12228 Site: position = -84 score = 7.86933 sequence = TAGAAACGAACTTT-(18)-AATGTACAGTTTTT Gene: SE1593: adenylosuccinate lyase (EC:4.3.2.2)	Staphylococcus carnosus subsp. carnosus TM300 Gene: Sca_1482: adenylosuccinate lyase (EC:4.3.2.2)	* Staphylococcus haemolyticus JCSC1435 Site: position = -81 score = 8.00828 sequence = TAAAAACGAACTTT-(18)-AATGTACAGTTTTG Gene: SH1043: adenylosuccinate lyase (EC:4.3.2.2)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -89 score = 8.23857 sequence = TAAACACGAACTTT-(18)-AATGTACATGTTTT Gene: SSP0882: adenylosuccinate lyase (EC:4.3.2.2)	* Macrococcus caseolyticus JCSC5402 Site: position = -97 score = 9.04824 sequence = AATACACGAACTTT-(18)-AATGTACGGAATTT Gene: MCCL_1646: adenylosuccinate lyase (EC:4.3.2.2)	adenylosuccinate lyase (EC:4.3.2.2)

CRON 3.
purA	* Staphylococcus aureus subsp. aureus N315 Site: position = -114 score = 7.83032 sequence = AATGATTTTTCTTT-(17)-AATGTTCGATTTTT Gene: SA0016: adenylosuccinate synthase (EC:6.3.4.4)	Staphylococcus capitis SK14 Gene: STACA0001_1358: adenylosuccinate synthase (EC:6.3.4.4)	Staphylococcus epidermidis ATCC 12228 Gene: SE0016: adenylosuccinate synthase (EC:6.3.4.4)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -272 score = 6.74087 sequence = TTTTTACGTACAAT-(18)-ATTGTACGGTTTTT Gene: Sca_2459: adenylosuccinate synthase (EC:6.3.4.4)	* Staphylococcus haemolyticus JCSC1435 Site: position = -272 score = 6.8006 sequence = TTTTACCGTATATT-(18)-AATGTGCGGTTTTT Gene: SH0016: adenylosuccinate synthase (EC:6.3.4.4)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -115 score = 7.28115 sequence = CACCATCAAAATTT-(18)-AATGTTCGATTTTT Site: position = -272 score = 7.17023 sequence = AATTTCCGTACAAT-(18)-ATTGTACGGTTTTT Gene: SSP0017: adenylosuccinate synthase (EC:6.3.4.4)	* Macrococcus caseolyticus JCSC5402 Site: position = -299 score = 8.04891 sequence = AAAAACCGTACATT-(18)-ATTGTACGGTTTTT Gene: MCCL_0019: adenylosuccinate synthase (EC:6.3.4.4)	adenylosuccinate synthase (EC:6.3.4.4)

CRON 4.
folD	* Staphylococcus aureus subsp. aureus N315 Site: position = -110 score = 9.24787 sequence = AAAAATCGAACTTT-(18)-AATTTACGTCTTTT Gene: SA0915: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Staphylococcus capitis SK14 Site: position = -113 score = 9.24787 sequence = AAAAATCGAACTTT-(18)-AATTTACGTCTTTT Gene: STACA0001_2301: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Staphylococcus epidermidis ATCC 12228 Site: position = -113 score = 9.24787 sequence = AAAAATCGAACTTT-(18)-AATTTACGTCTTTT Gene: SE0761: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Staphylococcus carnosus subsp. carnosus TM300 Site: position = -117 score = 8.97787 sequence = AAAAATCGAACTTT-(18)-AAATTACGTAATTA Gene: Sca_0685: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Staphylococcus haemolyticus JCSC1435 Site: position = -121 score = 9.24787 sequence = AAAAATCGAACTTT-(18)-AATTTACGTCTTTT Gene: SH1894: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Site: position = -114 score = 8.98787 sequence = AAAAATCGAACTTT-(18)-AATCTACGTCTTTT Gene: SSP1727: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	* Macrococcus caseolyticus JCSC5402 Site: position = -101 score = 7.35057 sequence = CAATTACGTATTTT-(18)-TTCGTTCGTATTTT Gene: MCCL_0686: methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)	methylenetetrahydrofolate dehydrogenase (EC:1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog PurR - Staphylococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --