Regulog LexA - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type:	Transcription factor
Regulator family:	LexA
Regulation mode:	repressor
Biological process:	SOS response
Effector:	DNA damage
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 68 sites [see more]

Member of regulog collections

By trascription factor - LexA
By taxonomy - Frankineae/Propionibacterineae/Pseudonocardiaceae
By TF family - LexA
By effector - DNA damage
By pathway - SOS response

Statistics of regulated genes
Genome	Genes	Operons
Frankia sp. CcI3	12	8
Frankia sp. EAN1pec	13	9
Nakamurella multipartita DSM 44233	9	6
Acidothermus cellulolyticus 11B	8	5
Nocardioides sp. JS614	8	5
Propionibacterium acnes KPA171202	2	1
Actinosynnema mirum DSM 43827	12	8
Saccharomonospora viridis DSM 43017	9	5
Saccharopolyspora erythraea NRRL 2338	6	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
ruvC	* Frankia sp. CcI3 Site: position = -40 score = 4.52504 sequence = TCGAACGAATGTTCTT Gene: Francci3_1369: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Frankia sp. EAN1pec Site: position = -37 score = 5.3571 sequence = TCGAACGGATGTTCGT Gene: Franean1_5146: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Nakamurella multipartita DSM 44233 Site: position = -85 score = 4.04182 sequence = CTGGACAGGTGTTCGC Gene: Namu_3396: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Acidothermus cellulolyticus 11B Site: position = 15 score = 5.52401 sequence = CCGAACATGCGTTCGA Gene: Acel_1345: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Nocardioides sp. JS614 Site: position = -31 score = 5.42347 sequence = CCGAACACCTGTTCGG Gene: Noca_2385: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	Propionibacterium acnes KPA171202 Gene: PPA1158: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Actinosynnema mirum DSM 43827 Site: position = -58 score = 5.00898 sequence = TCGAACTGGTGTTCGC Gene: Amir_1692: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Saccharomonospora viridis DSM 43017 Site: position = -33 score = 5.00898 sequence = TCGAACTGGTGTTCGC Gene: Svir_15060: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	* Saccharopolyspora erythraea NRRL 2338 Site: position = -37 score = 5.05181 sequence = TCGAACGCGTGTTCAG Gene: SACE_2021: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)	Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
ruvA	Frankia sp. CcI3 Gene: Francci3_1370: Holliday junction DNA helicase RuvA	Frankia sp. EAN1pec Gene: Franean1_5145: Holliday junction DNA helicase RuvA	Nakamurella multipartita DSM 44233 Gene: Namu_3395: Holliday junction DNA helicase RuvA	Acidothermus cellulolyticus 11B Gene: Acel_1344: Holliday junction DNA helicase RuvA	Nocardioides sp. JS614 Gene: Noca_2386: Holliday junction DNA helicase RuvA	Propionibacterium acnes KPA171202 Gene: PPA1159: Holliday junction DNA helicase RuvA	Actinosynnema mirum DSM 43827 Gene: Amir_1691: Holliday junction DNA helicase RuvA	Saccharomonospora viridis DSM 43017 Gene: Svir_15070: Holliday junction DNA helicase RuvA	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_2022: Holliday junction DNA helicase RuvA	Holliday junction DNA helicase RuvA
ruvB	Frankia sp. CcI3 Gene: Francci3_1371: Holliday junction DNA helicase RuvB	Frankia sp. EAN1pec Gene: Franean1_5144: Holliday junction DNA helicase RuvB	Nakamurella multipartita DSM 44233 Gene: Namu_3394: Holliday junction DNA helicase RuvB	Acidothermus cellulolyticus 11B Gene: Acel_1343: Holliday junction DNA helicase RuvB	Nocardioides sp. JS614 Gene: Noca_2387: Holliday junction DNA helicase RuvB	Propionibacterium acnes KPA171202 Gene: PPA1160: Holliday junction DNA helicase RuvB	Actinosynnema mirum DSM 43827 Gene: Amir_1690: Holliday junction DNA helicase RuvB	Saccharomonospora viridis DSM 43017 Gene: Svir_15080: Holliday junction DNA helicase RuvB	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_2023: Holliday junction DNA helicase RuvB	Holliday junction DNA helicase RuvB

CRON 2.
lexA	* Frankia sp. CcI3 Site: position = -198 score = 5.38324 sequence = TCGAACAGACGTTTGA Site: position = -251 score = 5.25263 sequence = TCGAACGCGTGGTCGA Site: position = -267 score = 5.00596 sequence = TCGAACCTTCGTTCGA Gene: Francci3_3510: SOS-response repressor and protease LexA (EC 3.4.21.88)	* Frankia sp. EAN1pec Site: position = -298 score = 4.90907 sequence = TCGAACGCCTGAGCGA Site: position = -244 score = 5.38324 sequence = TCGAACAGACGTTTGA Gene: Franean1_1232: SOS-response repressor and protease LexA (EC 3.4.21.88)	* Nakamurella multipartita DSM 44233 Site: position = -202 score = 5.08489 sequence = TCGAACGGACGTTCTA Site: position = -186 score = 4.43881 sequence = TCGAACGTCTGCACGA Site: position = -123 score = 5.49247 sequence = TCGAACGGGTGTTTGA Gene: Namu_3979: SOS-response repressor and protease LexA (EC 3.4.21.88)	* Acidothermus cellulolyticus 11B Site: position = -106 score = 5.12966 sequence = TCGAACTGGTGTTTGA Site: position = -161 score = 5.28686 sequence = TCGAACGGGTGTACGA Site: position = -177 score = 5.89309 sequence = TCGAACACGCGTTCGA Gene: Acel_1479: SOS-response repressor and protease LexA (EC 3.4.21.88)	* Nocardioides sp. JS614 Site: position = -47 score = 5.57628 sequence = TCGAACAGGTGTTTGA Gene: Noca_3817: SOS-response repressor and protease LexA (EC 3.4.21.88)	Propionibacterium acnes KPA171202	2 Actinosynnema mirum DSM 43827* Site: position = -157 score = 3.75798 sequence = ACGACCTCGTGCTCGA Gene: Amir_3974: SOS-response repressor and protease LexA (EC 3.4.21.88) Site: position = -184 score = 5.575 sequence = TCGAACAACCGTTCGA Site: position = -168 score = 5.28722 sequence = TCGAACGCCCGTGCGA Site: position = -103 score = 5.57628 sequence = TCGAACAGGTGTTTGA Gene: Amir_1434: SOS-response repressor and protease LexA (EC 3.4.21.88)	* Saccharomonospora viridis DSM 43017 Site: position = -102 score = 5.13261 sequence = TCGAACAAACGTTTGA Site: position = -165 score = 5.37103 sequence = TCGAACACCCGTGCGA Gene: Svir_27590: SOS-response repressor and protease LexA (EC 3.4.21.88)	2 Saccharopolyspora erythraea NRRL 2338* Site: position = -98 score = 5.57628 sequence = TCGAACAGGTGTTTGA Site: position = -164 score = 4.80198 sequence = TCGAACCTGCGTGCGA Site: position = -180 score = 5.09884 sequence = TCGAATGGATGTTCGA Gene: SACE_1760: SOS-response repressor and protease LexA (EC 3.4.21.88) Gene: SACE_2836: SOS-response repressor and protease LexA (EC 3.4.21.88)	SOS-response repressor and protease LexA (EC 3.4.21.88)

CRON 3.
recA	* Frankia sp. CcI3 Site: position = -139 score = 5.39083 sequence = TCGAACGCATGTTCGT Gene: Francci3_3525: Recombinase A	2 Frankia sp. EAN1pec* Site: position = -138 score = 5.49028 sequence = TCGAACGGATGTTCGG Gene: Franean1_1219: Recombinase A Site: position = -142 score = 5.23965 sequence = TCGAACGAATGTTCGG Gene: Franean1_6708: Recombinase A	* Nakamurella multipartita DSM 44233 Site: position = -132 score = 4.97764 sequence = TCGAACAGGTGTACGT Site: position = -284 score = 3.92661 sequence = TCGATCAGGCGCTGGA Gene: Namu_3994: Recombinase A	* Acidothermus cellulolyticus 11B Site: position = -142 score = 5.57408 sequence = TCGAACATCTGTTCGG Gene: Acel_1492: Recombinase A	* Nocardioides sp. JS614 Site: position = -151 score = 5.68332 sequence = TCGAACAGGTGTTCGG Gene: Noca_2341: Recombinase A	Propionibacterium acnes KPA171202 Gene: PPA1012: Recombinase A	* Actinosynnema mirum DSM 43827 Site: position = -151 score = 5.68332 sequence = TCGAACACCTGTTCGG Site: position = -264 score = 4.22706 sequence = CCGACCAGGCGTTGGA Gene: Amir_1419: Recombinase A	* Saccharomonospora viridis DSM 43017 Site: position = -168 score = 5.68332 sequence = TCGAACAGGTGTTCGG Gene: Svir_27820: Recombinase A	* Saccharopolyspora erythraea NRRL 2338 Site: position = -143 score = 5.46634 sequence = TCGAACACCCGTTCGT Gene: SACE_1736: Recombinase A	Recombinase A
recX	Frankia sp. CcI3 Gene: Francci3_3524: Regulatory protein RecX	Frankia sp. EAN1pec Gene: Franean1_1220: Regulatory protein RecX	Nakamurella multipartita DSM 44233 Gene: Namu_3993: Regulatory protein RecX	Acidothermus cellulolyticus 11B Gene: Acel_1491: Regulatory protein RecX	Nocardioides sp. JS614 Gene: Noca_2342: Regulatory protein RecX	Propionibacterium acnes KPA171202 Gene: PPA1013: Regulatory protein RecX	Actinosynnema mirum DSM 43827 Gene: Amir_1420: Regulatory protein RecX	Saccharomonospora viridis DSM 43017 Gene: Svir_27810: Regulatory protein RecX	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_1737: Regulatory protein RecX	Regulatory protein RecX

CRON 4.
uvrA	Frankia sp. CcI3 Gene: Francci3_1631: Excinuclease ABC, subunit A	* Frankia sp. EAN1pec Site: position = -227 score = 5.44239 sequence = TCGAACGCGCGTTTGA Gene: Franean1_2057: Excinuclease ABC, subunit A	Nakamurella multipartita DSM 44233 Gene: Namu_2992: Excinuclease ABC, subunit A	Acidothermus cellulolyticus 11B Gene: Acel_1109: Excinuclease ABC, subunit A	* Nocardioides sp. JS614 Site: position = -42 score = 5.55014 sequence = ACGAACACCTGTTCGA Gene: Noca_2524: Excinuclease ABC, subunit A	Propionibacterium acnes KPA171202 Gene: PPA0807: Excinuclease ABC, subunit A	* Actinosynnema mirum DSM 43827 Site: position = -38 score = 5.60781 sequence = TCGAACATGTGTTCGG Gene: Amir_5483: Excinuclease ABC, subunit A	Saccharomonospora viridis DSM 43017 Gene: Svir_25750: Excinuclease ABC, subunit A	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_5314: Excinuclease ABC, subunit A	Excinuclease ABC, subunit A

CRON 5.
PF02720	* Frankia sp. CcI3 Site: position = -197 score = 4.96735 sequence = CCGAACACATGGTCGA Site: position = 28 score = 5.60781 sequence = TCGAACACATGTTCGG Gene: Francci3_0067: HNH endonuclease	2 Frankia sp. EAN1pec* Gene: Franean1_4861: HNH endonuclease Site: position = -75 score = 3.72378 sequence = CCGTTCGGGTGTTCTG Gene: Franean1_3452: HNH endonuclease	* Nakamurella multipartita DSM 44233 Site: position = -49 score = 3.95802 sequence = GTGGACACCCGTTCGG Gene: Namu_3157: HNH endonuclease	Acidothermus cellulolyticus 11B	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	HNH endonuclease

CRON 6.
dnaB	* Frankia sp. CcI3 Site: position = -50 score = 5.28159 sequence = ACGAACATACGTTCGA Gene: Francci3_4518: Replicative DNA helicase (EC 3.6.1.-)	* Frankia sp. EAN1pec Site: position = -137 score = 5.75842 sequence = TCGAACATATGTTCGA Gene: Franean1_7308: Replicative DNA helicase (EC 3.6.1.-)	* Nakamurella multipartita DSM 44233 Site: position = -98 score = 4.45388 sequence = CAGAACACATGTCCGA Gene: Namu_5363: Replicative DNA helicase (EC 3.6.1.-)	Acidothermus cellulolyticus 11B Gene: Acel_2083: Replicative DNA helicase (EC 3.6.1.-)	Nocardioides sp. JS614 Gene: Noca_4657: Replicative DNA helicase (EC 3.6.1.-)	Propionibacterium acnes KPA171202 Gene: PPA2244: Replicative DNA helicase (EC 3.6.1.-)	Actinosynnema mirum DSM 43827 Gene: Amir_7043: Replicative DNA helicase (EC 3.6.1.-)	* Saccharomonospora viridis DSM 43017 Site: position = -44 score = 5.85936 sequence = TCGAACAGGCGTTCGA Gene: Svir_39470: Replicative DNA helicase (EC 3.6.1.-)	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_7347: Replicative DNA helicase (EC 3.6.1.-)	Replicative DNA helicase (EC 3.6.1.-)

CRON 7.
dprA	* Frankia sp. CcI3 Site: position = -268 score = 4.12562 sequence = CCGAGCGGGCATTCGA Gene: Francci3_3584: DNA protecting protein DprA	* Frankia sp. EAN1pec Site: position = -154 score = 4.05011 sequence = CCGACCGTGCCTTCGA Gene: Franean1_1158: DNA protecting protein DprA	Nakamurella multipartita DSM 44233 Gene: Namu_3121: DNA protecting protein DprA	* Acidothermus cellulolyticus 11B Site: position = -46 score = 4.27636 sequence = GCGAACACGTGGACGA Site: position = -151 score = 4.32766 sequence = TCGAACGCGCCTTGGA Gene: Acel_1548: DNA protecting protein DprA	Nocardioides sp. JS614 Gene: Noca_3246: DNA protecting protein DprA	Propionibacterium acnes KPA171202 Gene: PPA1429: DNA protecting protein DprA	* Actinosynnema mirum DSM 43827 Site: position = -26 score = 5.75013 sequence = TCGAACAGACGTTCGA Site: position = -87 score = 4.18541 sequence = TCGACCACCCGGTCGT Gene: Amir_5585: DNA protecting protein DprA	Saccharomonospora viridis DSM 43017 Gene: Svir_09850: DNA protecting protein DprA	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_6043: DNA protecting protein DprA	DNA protecting protein DprA
xerC	Frankia sp. CcI3 Gene: Francci3_3583: Site-specific DNA-tyrosine recombinase, XerC	Frankia sp. EAN1pec Gene: Franean1_1159: Site-specific DNA-tyrosine recombinase, XerC	Nakamurella multipartita DSM 44233 Gene: Namu_3115: Site-specific DNA-tyrosine recombinase, XerC	Acidothermus cellulolyticus 11B Gene: Acel_1547: Site-specific DNA-tyrosine recombinase, XerC	Nocardioides sp. JS614 Gene: Noca_3245: Site-specific DNA-tyrosine recombinase, XerC	Propionibacterium acnes KPA171202 Gene: PPA1522: Site-specific DNA-tyrosine recombinase, XerC	Actinosynnema mirum DSM 43827 Gene: Amir_5914: Site-specific DNA-tyrosine recombinase, XerC	Saccharomonospora viridis DSM 43017 Gene: Svir_09860: Site-specific DNA-tyrosine recombinase, XerC	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_6041: Site-specific DNA-tyrosine recombinase, XerC	Site-specific DNA-tyrosine recombinase, XerC

CRON 8.
PPA1757	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Acidothermus cellulolyticus 11B	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -83 score = 3.97338 sequence = TCGATCGTGGGATCGT Gene: PPA1757: Hypothetical protein	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Hypothetical protein
uvrD	* Frankia sp. CcI3 Site: position = -22 score = 4.86901 sequence = TCGAACGTACGATCGG Gene: Francci3_0647: ATP-dependent DNA helicase II	* Frankia sp. EAN1pec Site: position = -22 score = 5.12886 sequence = TCGAACGTACGATCGA Gene: Franean1_5987: ATP-dependent DNA helicase II	* Nakamurella multipartita DSM 44233 Site: position = -77 score = 5.22136 sequence = CCGAACAGGTGATCGA Gene: Namu_1258: ATP-dependent DNA helicase II	* Acidothermus cellulolyticus 11B Site: position = 29 score = 3.6491 sequence = CCGGCCACGTGATCGT Gene: Acel_0375: ATP-dependent DNA helicase II	* Nocardioides sp. JS614 Site: position = -289 score = 4.29323 sequence = CCGACAACCTGTTCGA Gene: Noca_3593: ATP-dependent DNA helicase II	Propionibacterium acnes KPA171202 Gene: PPA1756: ATP-dependent DNA helicase II	Actinosynnema mirum DSM 43827 Gene: Amir_6513: ATP-dependent DNA helicase II	Saccharomonospora viridis DSM 43017 Gene: Svir_04890: ATP-dependent DNA helicase II	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_6681: ATP-dependent DNA helicase II	ATP-dependent DNA helicase II

CRON 9.
gyrB	Frankia sp. CcI3 Gene: Francci3_1761: Topoisomerase IV, subunit B (EC 5.99.1.-)	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Acidothermus cellulolyticus 11B Gene: Acel_1427: Topoisomerase IV, subunit B (EC 5.99.1.-)	Nocardioides sp. JS614 Gene: Noca_2958: Topoisomerase IV, subunit B (EC 5.99.1.-)	Propionibacterium acnes KPA171202 Gene: PPA1042: Topoisomerase IV, subunit B (EC 5.99.1.-)	* Actinosynnema mirum DSM 43827 Site: position = -100 score = 5.5262 sequence = TCGAACGCGTGTTTGA Gene: Amir_2280: Topoisomerase IV, subunit B (EC 5.99.1.-)	* Saccharomonospora viridis DSM 43017 Site: position = -24 score = 4.62435 sequence = TCGAACAGTTGACCGA Gene: Svir_08220: Topoisomerase IV, subunit B (EC 5.99.1.-)	Saccharopolyspora erythraea NRRL 2338	Topoisomerase IV, subunit B (EC 5.99.1.-)
gyrA	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Acidothermus cellulolyticus 11B Gene: Acel_1422: Topoisomerase IV, subunit A (EC 5.99.1.-)	Nocardioides sp. JS614 Gene: Noca_2949: Topoisomerase IV, subunit A (EC 5.99.1.-)	Propionibacterium acnes KPA171202 Gene: PPA1045: Topoisomerase IV, subunit A (EC 5.99.1.-)	Actinosynnema mirum DSM 43827 Gene: Amir_2281: Topoisomerase IV, subunit A (EC 5.99.1.-)	Saccharomonospora viridis DSM 43017 Gene: Svir_08230: Topoisomerase IV, subunit A (EC 5.99.1.-)	Saccharopolyspora erythraea NRRL 2338	Topoisomerase IV, subunit A (EC 5.99.1.-)

CRON 10.
hsdR	* Frankia sp. CcI3 Site: position = -233 score = 3.73751 sequence = GAGAACGGCAGTACGA Gene: Francci3_0194: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Acidothermus cellulolyticus 11B	Nocardioides sp. JS614	Propionibacterium acnes KPA171202	* Actinosynnema mirum DSM 43827 Site: position = 16 score = 4.09539 sequence = ACGAATCCGCGTTCGG Gene: Amir_0958: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)	Saccharomonospora viridis DSM 43017	* Saccharopolyspora erythraea NRRL 2338 Site: position = -177 score = 4.08266 sequence = AGGAACAGGCGGTCGA Gene: SACE_0868: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)	Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog LexA - Frankineae/Propionibacterineae/Pseudonocardiaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --