Statistics of regulated genes

Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	8	5
Lactococcus lactis subsp. lactis Il1403	8	5
Streptococcus agalactiae 2603V/R	7	5
Streptococcus dysgalactiae subsp. equisimilis GGS_124	5	4
Streptococcus equi subsp. zooepidemicus MGCS10565	7	5
Streptococcus gallolyticus UCN34	7	5
Streptococcus gordonii str. Challis substr. CH1	6	4
Streptococcus mitis B6	7	5
Streptococcus mutans UA159	4	3
Streptococcus pneumoniae TIGR4	7	5
Streptococcus pyogenes M1 GAS	7	5
Streptococcus sanguinis SK36	6	4
Streptococcus suis 05ZYH33	10	4
Streptococcus thermophilus CNRZ1066	7	5
Streptococcus uberis 0140J	5	4

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes																Function
CRON 1.
clpB	* Lactococcus lactis subsp. cremoris SK11 Site: position = -98 score = 6.25715 sequence = AAAAGCTTGACCATTACTGACTAA Gene: LACR_1612: ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones	* Lactococcus lactis subsp. lactis Il1403 Site: position = -98 score = 6.52833 sequence = AAAAGTTTGACCATTACTGACCAA Gene: L166407: ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones
CRON 2.
groS	* Lactococcus lactis subsp. cremoris SK11 Site: position = -95 score = 5.92574 sequence = TTTCTCTTGACTAAATCTGACCAT Gene: LACR_0439: Heat shock protein 60 family co-chaperone GroES	* Lactococcus lactis subsp. lactis Il1403 Site: position = -96 score = 5.92574 sequence = TTTCTCTTGACTAAATCTGACCAT Gene: L198515: Heat shock protein 60 family co-chaperone GroES	* Streptococcus agalactiae 2603V/R Site: position = -109 score = 6.34428 sequence = TTTCTCTTGACTAATTCTGACCAA Gene: SAG2075: Heat shock protein 60 family co-chaperone GroES	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -106 score = 6.86088 sequence = TTTTTCTTGACTATTTTTGACCAA Gene: SDEG_2041: Heat shock protein 60 family co-chaperone GroES	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -110 score = 6.86088 sequence = TTTTTCTTGACTATTTTTGACCAA Gene: Sez_0145: Heat shock protein 60 family co-chaperone GroES	* Streptococcus gallolyticus UCN34 Site: position = -134 score = 6.76219 sequence = TTTTTCTTGACTATTTCTGACCAA Gene: GALLO_0124: Heat shock protein 60 family co-chaperone GroES	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -96 score = 6.86088 sequence = TTTTTCTTGACTATTTTTGACCAA Gene: SGO_1886: Heat shock protein 60 family co-chaperone GroES	* Streptococcus mitis B6 Site: position = -102 score = 6.76219 sequence = TTTTTCTTGACTATTTCTGACCAA Gene: smi_0481: Heat shock protein 60 family co-chaperone GroES	* Streptococcus mutans UA159 Site: position = -91 score = 6.86088 sequence = TTTTTCTTGACTATTTTTGACCAA Gene: SMU.1955: Heat shock protein 60 family co-chaperone GroES	* Streptococcus pneumoniae TIGR4 Site: position = -102 score = 6.23751 sequence = TTTTTCTTGATTATTTCTGACCAA Gene: SP_1907: Heat shock protein 60 family co-chaperone GroES	* Streptococcus pyogenes M1 GAS Site: position = -107 score = 6.86088 sequence = TTTTTCTTGACTATTTTTGACCAA Gene: SPy2072: Heat shock protein 60 family co-chaperone GroES	* Streptococcus sanguinis SK36 Site: position = -97 score = 6.76219 sequence = TTTTTCTTGACTATTTCTGACCAA Gene: SSA_0225: Heat shock protein 60 family co-chaperone GroES	* Streptococcus suis 05ZYH33 Site: position = -66 score = 6.48664 sequence = ATGTTCTTGACTATTTTTGACCAA Gene: SSU05_0147: Heat shock protein 60 family co-chaperone GroES	* Streptococcus thermophilus CNRZ1066 Site: position = -124 score = 6.6754 sequence = TTTTTCTTGACTATTTTTGACTAA Gene: str0203: Heat shock protein 60 family co-chaperone GroES	* Streptococcus uberis 0140J Site: position = -108 score = 6.59261 sequence = TTTTTCTTGACTAATTTTGACCAA Gene: SUB1742: Heat shock protein 60 family co-chaperone GroES	Heat shock protein 60 family co-chaperone GroES
groL	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0440: Heat shock protein 60 family chaperone GroEL	Lactococcus lactis subsp. lactis Il1403 Gene: L198893: Heat shock protein 60 family chaperone GroEL	Streptococcus agalactiae 2603V/R Gene: SAG2074: Heat shock protein 60 family chaperone GroEL	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_2040: Heat shock protein 60 family chaperone GroEL	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0146: Heat shock protein 60 family chaperone GroEL	Streptococcus gallolyticus UCN34 Gene: GALLO_0125: Heat shock protein 60 family chaperone GroEL	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1885: Heat shock protein 60 family chaperone GroEL	Streptococcus mitis B6 Gene: smi_0482: Heat shock protein 60 family chaperone GroEL	Streptococcus mutans UA159 Gene: SMU.1954: Heat shock protein 60 family chaperone GroEL	Streptococcus pneumoniae TIGR4 Gene: SP_1906: Heat shock protein 60 family chaperone GroEL	Streptococcus pyogenes M1 GAS Gene: SPy2070: Heat shock protein 60 family chaperone GroEL	Streptococcus sanguinis SK36 Gene: SSA_0226: Heat shock protein 60 family chaperone GroEL	2 Streptococcus suis 05ZYH33 Gene: SSU05_0148: Heat shock protein 60 family chaperone GroEL Gene: SSU05_0149: Heat shock protein 60 family chaperone GroEL	Streptococcus thermophilus CNRZ1066 Gene: str0204: Heat shock protein 60 family chaperone GroEL	Streptococcus uberis 0140J Gene: SUB1741: Heat shock protein 60 family chaperone GroEL	Heat shock protein 60 family chaperone GroEL
CRON 3.
ctsR	* Lactococcus lactis subsp. cremoris SK11 Site: position = -56 score = 0.423713 sequence = ATAGTCAGTAATAGTCAAAGATTA Gene: LACR_0665: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Lactococcus lactis subsp. lactis Il1403 Site: position = -56 score = 0.423713 sequence = ATAGTCAGTAATAGTCAAAGATTA Gene: L0223: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus agalactiae 2603V/R Site: position = -36 score = -0.674182 sequence = ATAGTCAGTTATAGTCAAAGAGGA Gene: SAG1829: Stress and heat shock response transcriptional regulator CtsR, CtsR family	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_2043: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -69 score = 0.792732 sequence = TTAGTCAGTTTTAGTCAAAAATAA Gene: Sez_0139: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus gallolyticus UCN34 Site: position = -66 score = -0.346024 sequence = ATAGTCAGTTATAGTCAAAGATAG Gene: GALLO_2164: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -110 score = 0.453539 sequence = TTAGTCAAAGATAGTCAATGTCAA Gene: SGO_1999: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus mitis B6 Site: position = -44 score = 0.423713 sequence = ATAGTCAAAGATAGTCAAGGTTTA Gene: smi_2046: Stress and heat shock response transcriptional regulator CtsR, CtsR family	Streptococcus mutans UA159 Gene: SMU.2030: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus pneumoniae TIGR4 Site: position = -44 score = -0.429284 sequence = ATAGTCAAACAAGGTCAAGGTTTA Gene: SP_2195: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus pyogenes M1 GAS Site: position = -78 score = 0.112844 sequence = ATAGTCAGTTTTAGTCAAAATGTA Gene: SPy2074: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus sanguinis SK36 Site: position = -77 score = -0.221117 sequence = TTAGTCAAAGATAGTCAATGTTAG Gene: SSA_2200: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus suis 05ZYH33 Site: position = -34 score = -0.875808 sequence = ATGGTCAAAGATAGTCAAAGAAAG Gene: SSU05_1976: Stress and heat shock response transcriptional regulator CtsR, CtsR family	* Streptococcus thermophilus CNRZ1066 Site: position = -38 score = -0.674182 sequence = ATAGTCAGTTATAGTCAAATTAGA Gene: str0076: Stress and heat shock response transcriptional regulator CtsR, CtsR family	Streptococcus uberis 0140J Gene: SUB1744: Stress and heat shock response transcriptional regulator CtsR, CtsR family	Stress and heat shock response transcriptional regulator CtsR, CtsR family
clpC	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0666: ATP-dependent Clp protease ATP-binding subunit ClpC	Lactococcus lactis subsp. lactis Il1403 Gene: L0222: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus agalactiae 2603V/R Gene: SAG1828: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_2042: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0140: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus gallolyticus UCN34 Gene: GALLO_2163: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1998: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus mitis B6 Gene: smi_2045: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus mutans UA159 Gene: SMU.2029: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus pneumoniae TIGR4 Gene: SP_2194: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus pyogenes M1 GAS Gene: SPy2073: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus sanguinis SK36 Gene: SSA_2199: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus suis 05ZYH33 Gene: SSU05_1975: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus thermophilus CNRZ1066 Gene: str0077: ATP-dependent Clp protease ATP-binding subunit ClpC	Streptococcus uberis 0140J Gene: SUB1743: ATP-dependent Clp protease ATP-binding subunit ClpC	ATP-dependent Clp protease ATP-binding subunit ClpC
CRON 4.
clpL	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -144 score = 6.29907 sequence = TATTTATTGACCTTTACTGACTAA Gene: SAG1303: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -180 score = 6.42288 sequence = TTTTGTTTGACCTTAACTGACCAA Gene: SDEG_0851: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -181 score = 6.29035 sequence = TTTTGTTTGACCTTTACTGACCTT Gene: Sez_1072: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus gallolyticus UCN34 Site: position = -190 score = 6.55594 sequence = AAATATTTGACTTTTACTGACCAA Gene: GALLO_1249: ATP-dependent Clp protease, ATP-binding subunit	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1856: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus mitis B6 Site: position = -276 score = 6.31165 sequence = AAATCCTTGACCTTTTCTGACTAA Gene: smi_1765: ATP-dependent Clp protease, ATP-binding subunit	Streptococcus mutans UA159 Gene: SMU.956: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus pneumoniae TIGR4 Site: position = -275 score = 6.514 sequence = AAACTCTTGACCTTTTCTGACCAA Gene: SP_0338: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus pyogenes M1 GAS Site: position = -172 score = 6.29035 sequence = TTTTGTTTGACCTTTACTGACCTT Gene: SPy0888: ATP-dependent Clp protease, ATP-binding subunit	Streptococcus sanguinis SK36 Gene: SSA_2096: ATP-dependent Clp protease, ATP-binding subunit	*3 Streptococcus suis 05ZYH33 Site: position = -254 score = 6.14037 sequence = AAACTATTGACTTTTACTGACCAA Gene: SSU05_0389: ATP-dependent Clp protease, ATP-binding subunit Gene: SSU05_0390: ATP-dependent Clp protease, ATP-binding subunit Gene: SSU05_0391: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus thermophilus CNRZ1066 Site: position = -84 score = -0.0822352 sequence = TTGGTCAGTAAAAGTCAATTTTTA Gene: str1614: ATP-dependent Clp protease, ATP-binding subunit	* Streptococcus uberis 0140J Site: position = -152 score = 6.88339 sequence = TTTTTCTTGACCTTTTTTGACCAA Gene: SUB0776: ATP-dependent Clp protease, ATP-binding subunit	ATP-dependent Clp protease, ATP-binding subunit
CRON 5.
yffA	* Lactococcus lactis subsp. cremoris SK11 Site: position = -119 score = -0.38974 sequence = ATGGTCAAATATGGTCAAGCTTTT Gene: LACR_0577: Hypothetical protein	* Lactococcus lactis subsp. lactis Il1403 Site: position = -117 score = -0.914416 sequence = ATGGTCAAATATGGTCAAACTTTT Gene: L150017: Hypothetical protein	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
clpE	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0578: ATP-dependent Clp protease, ATP-binding subunit ClpE	Lactococcus lactis subsp. lactis Il1403 Gene: L0221: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus agalactiae 2603V/R Site: position = -65 score = 6.25458 sequence = TAAAGTTTGACTATATTTGACTAT Gene: SAG0488: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -62 score = 6.71234 sequence = TAAAGTTTGACCATTTTTGACTAA Gene: SDEG_1496: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -63 score = 6.71234 sequence = TAAAGTTTGACCATTTTTGACTAA Gene: Sez_0605: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus gallolyticus UCN34 Site: position = -65 score = 5.69378 sequence = TGAAGTTTGACTATCTTTGACCTT Gene: GALLO_0612: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -65 score = 6.8586 sequence = TAAAGTTTGACTATTTTTGACCAA Gene: SGO_0688: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus mitis B6 Site: position = -62 score = 6.27038 sequence = TAGAATTTGACTATTTTTGACCTT Gene: smi_0865: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus mutans UA159 Site: position = -74 score = 6.59844 sequence = TAAAGTTTGACCATTATTGACCAT Gene: SMU.562: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus pneumoniae TIGR4 Site: position = -62 score = 6.27038 sequence = TAGAATTTGACTATTTTTGACCTT Gene: SP_0820: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus pyogenes M1 GAS Site: position = -62 score = 6.71234 sequence = TAAAGTTTGACCATTTTTGACTAA Gene: SPy1509: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus sanguinis SK36 Site: position = -73 score = 6.20615 sequence = AAAACTTTGACTATTTTTGACCTT Gene: SSA_0669: ATP-dependent Clp protease, ATP-binding subunit ClpE	Streptococcus suis 05ZYH33 Gene: SSU05_0492: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus thermophilus CNRZ1066 Site: position = -75 score = 6.52277 sequence = ATAGATTTGACCTTTTTTGACCAA Gene: str0602: ATP-dependent Clp protease, ATP-binding subunit ClpE	* Streptococcus uberis 0140J Site: position = -61 score = 6.71234 sequence = TAAAGTTTGACCATTTTTGACTAA Gene: SUB1281: ATP-dependent Clp protease, ATP-binding subunit ClpE	ATP-dependent Clp protease, ATP-binding subunit ClpE
CRON 6.
clpP	* Lactococcus lactis subsp. cremoris SK11 Site: position = -110 score = 6.80258 sequence = TTTTCTTTGACCTTTTTTGACCAA Gene: LACR_0700: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -110 score = 6.83684 sequence = TATTCTTTGACCTTTTTTGACCAA Gene: L72391: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus agalactiae 2603V/R Site: position = -67 score = 6.6062 sequence = TATTATTTGACCTTTGTTGACCAA Gene: SAG1585: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -125 score = 6.45657 sequence = TATCATTTGACCTTTCTTGACCAA Gene: SDEG_0439: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -93 score = 6.84544 sequence = TATCATTTGACCTTTTTTGACCAA Gene: Sez_1614: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus gallolyticus UCN34 Site: position = -127 score = 6.96082 sequence = TTTTATTTGACCTTTTTTGACCAA Gene: GALLO_1763: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -103 score = 6.63859 sequence = AAAAATTTGACCTTTATTGACCAA Gene: SGO_1632: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus mitis B6 Site: position = -89 score = 6.78449 sequence = AAAAATTTGACCTTTTTTGACCAA Gene: smi_1417: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus mutans UA159 Site: position = -68 score = 6.83975 sequence = AAATATTTGACCTTTTTTGACCAA Gene: SMU.1672: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus pneumoniae TIGR4 Site: position = -89 score = 6.78449 sequence = AAAAATTTGACCTTTTTTGACCAA Gene: SP_0746: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus pyogenes M1 GAS Site: position = -125 score = 6.56646 sequence = TATGATTTGACCTTTATTGACCAA Gene: SPy0395: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus sanguinis SK36 Site: position = -103 score = 6.61783 sequence = TTCTATTTGACCTTTTTTGACCAA Gene: SSA_1731: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	*2 Streptococcus suis 05ZYH33 Site: position = -67 score = 6.10436 sequence = TTTTTATTGACCAATTTTGACTAT Gene: SSU05_1551: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Gene: SSU05_1550: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus thermophilus CNRZ1066 Site: position = -67 score = 6.242 sequence = TTTTATTTGACCTAATTTGACTAA Gene: str0356: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	* Streptococcus uberis 0140J Site: position = -98 score = 6.73002 sequence = TATTATTTGACCTTATTTGACCAA Gene: SUB0429: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)	ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)

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