Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Collection of regulogs in Francisellaceae taxonomic group

General statistics
Genomes 3
TF regulogs 2
TF regulons 4
TF binding sites 9
RNA regulogs 3
RNA regulons 6
RNA sites 7

This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.

Studied genomes and reconstructed regulon statistics
TF RNA Total
Genomes Regulons Sites Regulons Sites Regulons Sites
Francisella novicida FTE 1 1 2 2 3 3
Francisella philomiragia subsp. philomiragia ATCC 25017 2 7 2 3 4 10
Francisella tularensis subsp. tularensis SCHU S4 1 1 2 2 3 3
Genomic distribution of regulons
Family Type Regulator Function
ArgR TF ArgR
3 ArgR

Francisella philomiragia subsp. philomiragia ATCC 25017
Arginine biosynthesis
TrpR TF TrpR
1 TrpR

Francisella tularensis subsp. tularensis SCHU S4
1 TrpR

Francisella novicida FTE
1 TrpR

Francisella philomiragia subsp. philomiragia ATCC 25017
Tryptophan biosynthesis
RF00050 RNA FMN
1 FMN

Francisella tularensis subsp. tularensis SCHU S4
1 FMN

Francisella novicida FTE
1 FMN

Francisella philomiragia subsp. philomiragia ATCC 25017
Riboflavin biosynthesis
RF00059 RNA TPP
1 TPP

Francisella tularensis subsp. tularensis SCHU S4
1 TPP

Francisella novicida FTE
2 TPP

Francisella philomiragia subsp. philomiragia ATCC 25017
Thiamine biosynthesis
RF01055 RNA MOCO_RNA_motif