Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CodY in Streptococcus mutans UA159

Properties
Regulator type: Transcription factor
TF locus tag: SMU.1824c
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Regulog: CodY - Streptococcaceae
Statistics of regulated genes:
- Genes 58
- Operons 24
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 273 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -84
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: SMU.1990
Name: rpoB
Funciton: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Locus tag: SMU.1989
Name: rpoC
Funciton: DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
rpoB
DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
rpoC
DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)

Position: -59
Score: 5.2
Sequence: AATTGTCTGATAATT
Locus tag: SMU.70
Name: thrC
Funciton: Threonine synthase (EC 4.2.3.1)
thrC
Threonine synthase (EC 4.2.3.1)

Position: -68
Score: 5.6
Sequence: AATATTCAGAAAATT
Locus tag: SMU.913
Name: gdhA
Funciton: NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
gdhA
NADP-specific glutamate dehydrogenase (EC 1.4.1.4)

Position: -89
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.676
Name: gapN
Funciton: Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9)
gapN
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9)

Position: -75
Score: 5.4
Sequence: AATTTTCTGACAATT
Locus tag: SMU.1824c
Name: codY
Funciton: Nutrient limitation global transcriptional regulator CodY, CodY family
Locus tag: SMU.1823
Name: pncA
Funciton: Nicotinamidase (EC 3.5.1.19)
codY
Nutrient limitation global transcriptional regulator CodY, CodY family
pncA
Nicotinamidase (EC 3.5.1.19)

Position: -105
Score: 5.3
Sequence: AATTTTCTGAAAATA
Locus tag: SMU.1109c
Name: SMU.1109
Funciton: Predicted Mn2+/Fe2+ transporter, NRAMP family
SMU.1109
Predicted Mn2+/Fe2+ transporter, NRAMP family

Position: -36
Score: 5.3
Sequence: AATTTTCAGATTATT
Locus tag: SMU.255
Name: oppA1
Funciton: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Locus tag: SMU.256
Name: oppB1
Funciton: Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1)
Locus tag: SMU.257
Name: oppC1
Funciton: Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1)
Locus tag: SMU.258
Name: oppD1
Funciton: Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1)
Locus tag: SMU.259
Name: oppF1
Funciton: Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)
oppA1
Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
oppB1
Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1)
oppC1
Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1)
oppD1
Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1)
oppF1
Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)

Position: -50
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: SMU.1656
Name: serC
Funciton: Phosphoserine aminotransferase (EC 2.6.1.52)
Locus tag: SMU.1655c
Name: SMU.1655c
Funciton: Hypothetical protein
Locus tag: SMU.1654c
Name: yesJ
Funciton: Acetyltransferase (EC 2.3.1.-), GNAT family
Locus tag: SMU.1653
Name: serA
Funciton: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)
serC
Phosphoserine aminotransferase (EC 2.6.1.52)
SMU.1655c
Hypothetical protein
yesJ
Acetyltransferase (EC 2.3.1.-), GNAT family
serA
D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)

Position: -310
Score: 5.1
Sequence: AATATTCAGAATTTT
Locus tag: SMU.1273
Name: hisC
Funciton: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
Locus tag: SMU.1272
Name: hisZ
Funciton: ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)
Locus tag: SMU.1271
Name: hisG
Funciton: ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)
Locus tag: SMU.1270
Name: hisD
Funciton: Histidinol dehydrogenase (EC 1.1.1.23)
Locus tag: SMU.1269
Name: serB
Funciton: Phosphoserine phosphatase (EC 3.1.3.3)
Locus tag: SMU.1268
Name: hisB
Funciton: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
Locus tag: SMU.1267c
Name: null
Funciton: hypothetical protein
Locus tag: SMU.1266
Name: hisH
Funciton: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisC
Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisZ
ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)
hisG
ATP phosphoribosyltransferase catalytic subunit (EC 2.4.2.17)
hisD
Histidinol dehydrogenase (EC 1.1.1.23)
serB
Phosphoserine phosphatase (EC 3.1.3.3)
hisB
Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hypothetical protein
hisH
Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)

Position: -85
Score: 5.5
Sequence: AATTTTTAGAAAATT
Locus tag: SMU.1658
Name: nrgA
Funciton: Ammonium transporter
Locus tag: SMU.1657c
Name: nrgB
Funciton: Nitrogen regulatory protein P-II
nrgA
Ammonium transporter
nrgB
Nitrogen regulatory protein P-II

Position: -108
Score: 5.3
Sequence: AATTTTCAGAATTTT
Locus tag: SMU.365
Name: gltB
Funciton: Glutamate synthase [NADPH] large chain (EC 1.4.1.13)
Locus tag: SMU.366
Name: gltD
Funciton: Glutamate synthase [NADPH] small chain (EC 1.4.1.13)
gltB
Glutamate synthase [NADPH] large chain (EC 1.4.1.13)
gltD
Glutamate synthase [NADPH] small chain (EC 1.4.1.13)

Position: -83
Score: 5.3
Sequence: AATTTTCAGAATTTT
Locus tag: SMU.1203
Name: ilvE
Funciton: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
ilvE
Branched-chain amino acid aminotransferase (EC 2.6.1.42)

Position: -246
Score: 5.4
Sequence: ATTTTTCAGAAAATT
Locus tag: SMU.1384
Name: leuA
Funciton: 2-isopropylmalate synthase (EC 2.3.3.13)
Locus tag: SMU.1383
Name: leuB
Funciton: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
Locus tag: SMU.1382
Name: leuC
Funciton: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
Locus tag: SMU.1381
Name: leuD
Funciton: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
leuA
2-isopropylmalate synthase (EC 2.3.3.13)
leuB
3-isopropylmalate dehydrogenase (EC 1.1.1.85)
leuC
3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
leuD
3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)

Position: -65
Score: 5.1
Sequence: TATTTTCAGAATATT
Locus tag: SMU.1301c
Name: ubiE
Funciton: SAM-dependent methyltransferase
ubiE
SAM-dependent methyltransferase

Position: -42
Score: 5.5
Sequence: AATTTTTTGAAAATT
Locus tag: SMU.231
Name: ilvB
Funciton: Acetolactate synthase large subunit (EC 2.2.1.6)
Locus tag: SMU.232
Name: ilvN
Funciton: Acetolactate synthase small subunit (EC 2.2.1.6)
Locus tag: SMU.233
Name: ilvC
Funciton: Ketol-acid reductoisomerase (EC 1.1.1.86)
Locus tag: SMU.234
Name: ilvA
Funciton: Threonine dehydratase (EC 4.3.1.19)
ilvB
Acetolactate synthase large subunit (EC 2.2.1.6)
ilvN
Acetolactate synthase small subunit (EC 2.2.1.6)
ilvC
Ketol-acid reductoisomerase (EC 1.1.1.86)
ilvA
Threonine dehydratase (EC 4.3.1.19)

Position: -136
Score: 5.1
Sequence: AAAATTCTGAATATT
Locus tag: SMU.1595
Name: cah
Funciton: Carbonic anhydrase precursor (EC 4.2.1.1)
cah
Carbonic anhydrase precursor (EC 4.2.1.1)

Position: -139
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.63c
Name: SMU.63c
Funciton: Conserved hypothetical secreted protein
SMU.63c
Conserved hypothetical secreted protein

Position: -291
Score: 4.7
Sequence: AATTTTCAGAAAAGA
Locus tag: SMU.1175
Name: dagA
Funciton: Sodium/glycine symporter
dagA
Sodium/glycine symporter

Position: -101
Score: 5.1
Sequence: AATTTTCTGATAATA
Locus tag: SMU.1519
Name: gluQ
Funciton: Glutamate ABC transporter, ATP-binding protein
Locus tag: SMU.1520
Name: gluH
Funciton: Glutamate ABC transporter, substrate-binding protein
Locus tag: SMU.1521
Name: gluM
Funciton: Glutamate ABC transporter, permease protein 1
Locus tag: SMU.1522
Name: gluP
Funciton: Glutamate ABC transporter, permease protein 2
gluQ
Glutamate ABC transporter, ATP-binding protein
gluH
Glutamate ABC transporter, substrate-binding protein
gluM
Glutamate ABC transporter, permease protein 1
gluP
Glutamate ABC transporter, permease protein 2

Position: -39
Score: 5.1
Sequence: AATTTTCAGAATATA
Locus tag: SMU.363
Name: glnR
Funciton: Nitrogen metabolism transcriptional regulator GlnR, MerR family
Locus tag: SMU.364
Name: glnA
Funciton: Glutamine synthetase type I (EC 6.3.1.2)
glnR
Nitrogen metabolism transcriptional regulator GlnR, MerR family
glnA
Glutamine synthetase type I (EC 6.3.1.2)

Position: -53
Score: 5.3
Sequence: AATTTTCTGAATTTT
Locus tag: SMU.1748
Name: thrA
Funciton: Aspartokinase (EC 2.7.2.4)
thrA
Aspartokinase (EC 2.7.2.4)

Position: -154
Score: 5
Sequence: AATCTTCTGAATATT
Locus tag: SMU.1309c
Name: gldA2
Funciton: Glycerol dehydrogenase (EC 1.1.1.6)
gldA2
Glycerol dehydrogenase (EC 1.1.1.6)

Position: -61
Score: 5.2
Sequence: AATTTTCTAAAATTT
Locus tag: SMU.784
Name: aroA
Funciton: 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
Locus tag: SMU.785
Name: aroK
Funciton: Shikimate kinase I (EC 2.7.1.71)
Locus tag: SMU.786
Name: pheA
Funciton: Prephenate dehydratase (EC 4.2.1.51)
aroA
5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19)
aroK
Shikimate kinase I (EC 2.7.1.71)
pheA
Prephenate dehydratase (EC 4.2.1.51)

Position: -66
Score: 5.3
Sequence: AATATTCAGATAATT
Locus tag: SMU.1669
Name: livK
Funciton: Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
Locus tag: SMU.1668
Name: livH
Funciton: Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1)
Locus tag: SMU.1667
Name: livM
Funciton: Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1)
Locus tag: SMU.1666
Name: livG
Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1)
Locus tag: SMU.1665
Name: livF
Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)
livK
Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
livH
Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1)
livM
Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1)
livG
Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1)
livF
Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)
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