Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CodY in Streptococcus mitis B6

Properties
Regulator type: Transcription factor
TF locus tag: smi_0687
Regulator family: CodY
Regulation mode: repressor (activator)
Biological process: Amino acid metabolism
Effector: Guanosine triphosphate; Branched-chain amino acids
Regulog: CodY - Streptococcaceae
Statistics of regulated genes:
- Genes 50
- Operons 22
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 273 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -95
Score: 5.5
Sequence: AATTTTTAGAAAATT
Locus tag: smi_0814
Name: gdhA
Funciton: NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
gdhA
NADP-specific glutamate dehydrogenase (EC 1.4.1.4)

Position: -93
Score: 5.2
Sequence: AATTATCAAAAAATT
Locus tag: smi_0683
Name: nrgA
Funciton: Ammonium transporter
Locus tag: smi_0684
Name: nrgB
Funciton: Nitrogen regulatory protein P-II
nrgA
Ammonium transporter
nrgB
Nitrogen regulatory protein P-II

Position: -71
Score: 5.6
Sequence: AATTTTCAGATAATT
Locus tag: smi_0687
Name: codY
Funciton: Nutrient limitation global transcriptional regulator CodY, CodY family
Locus tag: smi_0688
Name: pncA
Funciton: Nicotinamidase (EC 3.5.1.19)
codY
Nutrient limitation global transcriptional regulator CodY, CodY family
pncA
Nicotinamidase (EC 3.5.1.19)

Position: -56
Score: 4.7
Sequence: AATTGTCAGATAATA
Locus tag: smi_1568
Name: ubiE
Funciton: SAM-dependent methyltransferase
ubiE
SAM-dependent methyltransferase

Position: -259
Score: 5.3
Sequence: AATTTTCAGAAAATA
Locus tag: smi_1218
Name: leuA
Funciton: 2-isopropylmalate synthase (EC 2.3.3.13)
Locus tag: smi_1217
Name: leuB
Funciton: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
Locus tag: smi_1216
Name: ygaE
Funciton: Predicted transmembrane protein
Locus tag: smi_1215
Name: leuC
Funciton: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
Locus tag: smi_1214
Name: leuD
Funciton: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
Locus tag: smi_1213
Name: yfjA
Funciton: Conserved hypothetical protein
leuA
2-isopropylmalate synthase (EC 2.3.3.13)
leuB
3-isopropylmalate dehydrogenase (EC 1.1.1.85)
ygaE
Predicted transmembrane protein
leuC
3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
leuD
3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
yfjA
Conserved hypothetical protein

Position: -83
Score: 5.6
Sequence: AATATTCTGAAAATT
Locus tag: smi_0322
Name: oppA2
Funciton: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Locus tag: smi_0323
Name: oppB2
Funciton: Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1)
Locus tag: smi_0324
Name: oppC2
Funciton: Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1)
Locus tag: smi_0325
Name: oppD2
Funciton: Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1)
Locus tag: smi_0326
Name: oppF2
Funciton: Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)
oppA2
Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
oppB2
Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1)
oppC2
Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1)
oppD2
Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1)
oppF2
Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)

Position: -71
Score: 5.3
Sequence: AAAATTCAGAAAATT
Locus tag: smi_1758
Name: oppA2
Funciton: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
oppA2
Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)

Position: -57
Score: 5.4
Sequence: AATTTTCTGAAAAAT
Locus tag: smi_0193
Name: thrC
Funciton: Threonine synthase (EC 4.2.3.1)
thrC
Threonine synthase (EC 4.2.3.1)

Position: -88
Score: 5.8
Sequence: AATTTTCTGAAAATT
Locus tag: smi_0906
Name: ilvE
Funciton: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
ilvE
Branched-chain amino acid aminotransferase (EC 2.6.1.42)

Position: -93
Score: 5.3
Sequence: AAAATTCAGAAAATT
Locus tag: smi_1825
Name: ilvB
Funciton: Acetolactate synthase large subunit (EC 2.2.1.6)
Locus tag: smi_1824
Name: ilvN
Funciton: Acetolactate synthase small subunit (EC 2.2.1.6)
Locus tag: smi_1823
Name: ilvC
Funciton: Ketol-acid reductoisomerase (EC 1.1.1.86)
Locus tag: smi_1822
Name: ilvA
Funciton: Threonine dehydratase (EC 4.3.1.19)
ilvB
Acetolactate synthase large subunit (EC 2.2.1.6)
ilvN
Acetolactate synthase small subunit (EC 2.2.1.6)
ilvC
Ketol-acid reductoisomerase (EC 1.1.1.86)
ilvA
Threonine dehydratase (EC 4.3.1.19)

Position: -85
Score: 5.8
Sequence: AATTTTCTGAAAATT
Locus tag: smi_0113
Name: ilvD
Funciton: Dihydroxy-acid dehydratase (EC 4.2.1.9)
ilvD
Dihydroxy-acid dehydratase (EC 4.2.1.9)

Position: -92
Score: 4.7
Sequence: ACTTTTCTGAATTTT
Locus tag: smi_1410
Name: acuB
Funciton: Acetoin utilization protein AcuB
acuB
Acetoin utilization protein AcuB

Position: -69
Score: 4.6
Sequence: AAGTGTCAGAATATT
Locus tag: smi_1950
Name: mutR
Funciton: Predicted transcriptional regulator, Xre family
mutR
Predicted transcriptional regulator, Xre family

Position: -56
Score: 5.2
Sequence: AATTTTCACAAAATT
Locus tag: smi_0773
Name: hom
Funciton: Homoserine dehydrogenase (EC 1.1.1.3)
Locus tag: smi_0774
Name: thrB
Funciton: Homoserine kinase (EC 2.7.1.39)
hom
Homoserine dehydrogenase (EC 1.1.1.3)
thrB
Homoserine kinase (EC 2.7.1.39)

Position: -92
Score: 5.4
Sequence: AATTTTCTGACAATT
Locus tag: smi_1278
Name: efeO
Funciton: Ferrous iron transport periplasmic protein EfeO, contains peptidase-M75 domain and (frequently) cupredoxin-like domain
Locus tag: smi_1277
Name: efeB
Funciton: Ferrous iron transport peroxidase EfeB
Locus tag: smi_1276
Name: efeU
Funciton: Ferrous iron transport permease EfeU
Locus tag: smi_1275
Name: tatC
Funciton: Twin-arginine translocation protein TatC
Locus tag: smi_1274
Name: tatA
Funciton: Twin-arginine translocation protein TatA
efeO
Ferrous iron transport periplasmic protein EfeO, contains peptidase-M75 domain and (frequently) cupredoxin-like domain
efeB
Ferrous iron transport peroxidase EfeB
efeU
Ferrous iron transport permease EfeU
tatC
Twin-arginine translocation protein TatC
tatA
Twin-arginine translocation protein TatA

Position: -57
Score: 5.6
Sequence: AATTTTCAGATAATT
Locus tag: smi_1398
Name: scpC
Funciton: Serine endopeptidase ScpC (EC 3.4.21.-)
scpC
Serine endopeptidase ScpC (EC 3.4.21.-)

Position: 4
Score: 5.3
Sequence: AAAATTCTGAAAATT
Locus tag: smi_1990
Name: ymdE
Funciton: Conserved hypothetical protein
ymdE
Conserved hypothetical protein

Position: -64
Score: 5.4
Sequence: ATTTTTCAGAAAATT
Locus tag: smi_1779
Name: dtpT
Funciton: Di- and tripeptide permease DtpT
dtpT
Di- and tripeptide permease DtpT

Position: -124
Score: 5.3
Sequence: AAATTTCAGAAATTT
Locus tag: smi_1436
Name: str1582
Funciton: Predicted amino acid ABC transporter, permease protein 1
Locus tag: smi_1437
Name: str1581
Funciton: Predicted amino acid ABC transporter, permease protein 2
Locus tag: smi_1438
Name: str1580
Funciton: Predicted amino acid ABC transporter, ATP-binding protein
Locus tag: smi_1439
Name: str1579
Funciton: Predicted amino acid ABC transporter, substrate-binding protein
str1582
Predicted amino acid ABC transporter, permease protein 1
str1581
Predicted amino acid ABC transporter, permease protein 2
str1580
Predicted amino acid ABC transporter, ATP-binding protein
str1579
Predicted amino acid ABC transporter, substrate-binding protein

Position: -61
Score: 5.6
Sequence: AATTTTCTGATAATT
Locus tag: smi_1415
Name: livK
Funciton: Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
Locus tag: smi_1414
Name: livH
Funciton: Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1)
Locus tag: smi_1413
Name: livM
Funciton: Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1)
Locus tag: smi_1412
Name: livG
Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1)
Locus tag: smi_1411
Name: livF
Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)
livK
Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
livH
Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1)
livM
Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1)
livG
Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1)
livF
Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)

Position: -113
Score: 5
Sequence: AAGATTCTGAAAATT
Locus tag: smi_1847
Name: rpoB
Funciton: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
Locus tag: smi_1846
Name: rpoC
Funciton: DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
rpoB
DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
rpoC
DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)

Position: -31
Score: 5.5
Sequence: AATTTTTAGAAAATT
Locus tag: smi_1133
Name: asd
Funciton: Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
Locus tag: smi_1132
Name: dapA
Funciton: Dihydrodipicolinate synthase (EC 4.2.1.52)
asd
Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
dapA
Dihydrodipicolinate synthase (EC 4.2.1.52)
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Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD