Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of PurR in Lactococcus lactis subsp. cremoris SK11

Properties
Regulator type: Transcription factor
TF locus tag: LACR_2590
Regulator family: PurR
Regulation mode: repressor
Biological process: Purine metabolism
Effector: 5-phosphoribosyl 1-pyrophosphate
Regulog: PurR - Streptococcaceae
Statistics of regulated genes:
- Genes 21
- Operons 13
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 100 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -134
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1007
Name: fhs
Funciton: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
fhs
Formate--tetrahydrofolate ligase (EC 6.3.4.3)

Position: -53
Score: 4.9
Sequence: AATTACGAACAAT
Locus tag: LACR_0921
Name: folD
Funciton: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
folD
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)

Position: -205
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_0617
Name: glyA
Funciton: Serine hydroxymethyltransferase (EC 2.1.2.1)
glyA
Serine hydroxymethyltransferase (EC 2.1.2.1)

Position: -124
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1527
Name: bmpA
Funciton: Predicted nucleoside ABC transporter, substrate-binding protein
bmpA
Predicted nucleoside ABC transporter, substrate-binding protein

Position: -232
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1256
Name: guaC
Funciton: GMP reductase (EC 1.7.1.7)
guaC
GMP reductase (EC 1.7.1.7)

Position: -266
Score: 4.9
Sequence: AATTCCGAACAAT
Locus tag: LACR_1601
Name: purD
Funciton: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Locus tag: LACR_1600
Name: null
Funciton: Hypothetical hydrolase
Locus tag: LACR_1599
Name: purE
Funciton: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
Locus tag: LACR_1598
Name: purK
Funciton: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
purD
Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
Hypothetical hydrolase
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)

Position: -171
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1605
Name: purH
Funciton: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
purH
IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)

Position: -157
Score: 4.5
Sequence: ATAACCGAACAAA
Locus tag: LACR_1998
Name: ppa
Funciton: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)
ppa
Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)

Position: -184
Score: 4.7
Sequence: ATTACCGAACGAT
Locus tag: LACR_1894
Name: pbuO
Funciton: Guanine/hypoxanthine permease
pbuO
Guanine/hypoxanthine permease

Position: -115
Score: 4.8
Sequence: ATTTCCGAACAAT
Locus tag: LACR_1611
Name: purM
Funciton: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
Locus tag: LACR_1610
Name: purN
Funciton: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
purM
Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
purN
Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)

Position: -109
Score: 4.7
Sequence: ATTTCCGAACGTT
Locus tag: LACR_1606
Name: hprT
Funciton: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)
hprT
Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)

Position: -132
Score: 4.8
Sequence: ATTTCCGAACATT
Position: -115
Score: 5.1
Sequence: AAAACCGAACAAT
Locus tag: LACR_1622
Name: purC
Funciton: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
Locus tag: LACR_1621
Name: purS
Funciton: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
Locus tag: LACR_1620
Name: null
Funciton: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
Locus tag: LACR_1619
Name: purL
Funciton: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
Locus tag: LACR_1618
Name: purF
Funciton: Amidophosphoribosyltransferase (EC 2.4.2.14)
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
purS
Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
purL
Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
purF
Amidophosphoribosyltransferase (EC 2.4.2.14)

Position: 6
Score: 4.4
Sequence: AGAAACGAACGTT
Locus tag: LACR_2590
Name: purR
Funciton: Purine metabolism transcriptional regulator PurR, PurR family
purR
Purine metabolism transcriptional regulator PurR, PurR family
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