Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CcpA in Streptococcus thermophilus CNRZ1066

Properties
Regulator type: Transcription factor
TF locus tag: str0630
Regulator family: LacI
Regulation mode:
Biological process: Global catabolite repression
Effector: Fructose-1,6-bisphosphate; HPr, phosphocarrier protein
Regulog: CcpA - Streptococcaceae
Statistics of regulated genes:
- Genes 76
- Operons 35
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 968 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -134
Score: 3.8
Sequence: TATTCATCGCTTACAA
Locus tag: str0629
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -96
Score: 4.2
Sequence: ATGTAAGGCTTTTCAT
Locus tag: str1051
Name: acoA
Funciton: Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
Locus tag: str1050
Name: acoB
Funciton: Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)
acoA
Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
acoB
Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)

Position: -89
Score: 4.3
Sequence: TGAAAAACGTTTACAA
Locus tag: str0729
Name: typA
Funciton: GTP-binding protein TypA/BipA
typA
GTP-binding protein TypA/BipA

Position: -67
Score: 4.1
Sequence: TTGAAAACGGTTTTAC
Locus tag: str1197
Name: pfk
Funciton: 6-phosphofructokinase (EC 2.7.1.11)
Locus tag: str1196
Name: pyk
Funciton: Pyruvate kinase (EC 2.7.1.40)
pfk
6-phosphofructokinase (EC 2.7.1.11)
pyk
Pyruvate kinase (EC 2.7.1.40)

Position: -139
Score: 4.5
Sequence: ATGATAACGCTTTATA
Locus tag: str0333
Name: manL
Funciton: PTS system, mannose-specific IIAB components
Locus tag: str0332
Name: manM
Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69)
Locus tag: str0331
Name: manN
Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
Locus tag: str0330
Name: manO
Funciton: Putative regulator of the mannose operon, ManO
manL
PTS system, mannose-specific IIAB components
manM
PTS system, mannose-specific IIC component (EC 2.7.1.69)
manN
PTS system, mannose-specific IID component (EC 2.7.1.69)
manO
Putative regulator of the mannose operon, ManO

Position: 0
Score: 4.9
Sequence: TTGAAAGCGTTTTATA
Locus tag: str1857
Name: ackA
Funciton: Acetate kinase (EC 2.7.2.1)
ackA
Acetate kinase (EC 2.7.2.1)

Position: -45
Score: 4.3
Sequence: TTGATAAGGCTTACAT
Locus tag: str0799
Name: coaA
Funciton: Pantothenate kinase (EC 2.7.1.33)
coaA
Pantothenate kinase (EC 2.7.1.33)

Position: -181
Score: 4
Sequence: GTGTAATCGATTTCTA
Locus tag: str1067
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
Locus tag: str1066
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
Locus tag: str1065
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
Locus tag: str1064
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -58
Score: 4
Sequence: CTATAAAGGTTTTCAA
Locus tag: str0727
Name: yvaA
Funciton: Bacterial conserved protein of unknown function (DUF910) family
Locus tag: str0728
Name: glcK
Funciton: Glucokinase (EC 2.7.1.2)
yvaA
Bacterial conserved protein of unknown function (DUF910) family
glcK
Glucokinase (EC 2.7.1.2)

Position: -115
Score: 4.5
Sequence: TTTAAAACGCTTTCAC
Locus tag: str1280
Name: ldh
Funciton: L-lactate dehydrogenase (EC 1.1.1.27)
ldh
L-lactate dehydrogenase (EC 1.1.1.27)

Position: -180
Score: 4.5
Sequence: AAGAAAACGATTACAG
Locus tag: str1631
Name: ascB
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
Locus tag: str1630
Name: ascB
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
ascB
6-phospho-beta-glucosidase (EC 3.2.1.86)
ascB
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -82
Score: 3.9
Sequence: ATACAATCGGTTACAA
Locus tag: str0364
Name: acuB
Funciton: Acetoin utilization protein AcuB
Locus tag: str0365
Name: acuB
Funciton: Acetoin utilization protein AcuB
acuB
Acetoin utilization protein AcuB
acuB
Acetoin utilization protein AcuB

Position: -62
Score: 4.1
Sequence: AAAATAGCGTTTTTAA
Locus tag: str0112
Name: SP_0238
Funciton: Predicted transcriptional regulator, ACT family
Locus tag: str0113
Name: SP_0238
Funciton: Glycerol-3-phosphate dehydrogenase homolog (EC 1.1.1.94)
SP_0238
Predicted transcriptional regulator, ACT family
SP_0238
Glycerol-3-phosphate dehydrogenase homolog (EC 1.1.1.94)

Position: -106
Score: 4.6
Sequence: ATCAAAACGCTTACAA
Position: -44
Score: 4.2
Sequence: ATGTAAACGGGTTCAA
Locus tag: str1899
Name: fbaA
Funciton: Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
fbaA
Fructose-bisphosphate aldolase class II (EC 4.1.2.13)

Position: -72
Score: 4.4
Sequence: AAGAAAACGCTTTACA
Position: -21
Score: 3.9
Sequence: ATGCAAACGCTCGCAT
Locus tag: str0189
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: str0190
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: str0191
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: str0192
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: str0193
Name: rgfB
Funciton: Exodeoxyribonuclease III (EC 3.1.11.2)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
rgfB
Exodeoxyribonuclease III (EC 3.1.11.2)

Position: -41
Score: 4.8
Sequence: TTGAAAGTGTTTTCAA
Locus tag: str0630
Name: ccpA
Funciton: Carbon catabolism global transcriptional regulator CcpA, LacI family
ccpA
Carbon catabolism global transcriptional regulator CcpA, LacI family

Position: -57
Score: 3.9
Sequence: ATGAAAAGGATATAAT
Position: -34
Score: 4.7
Sequence: AAGAAAACGCTAACAA
Locus tag: str0370
Name: raiA
Funciton: Ribosome-associated protein Y
raiA
Ribosome-associated protein Y

Position: -33
Score: 4.8
Sequence: ATGTAAGCGTTTAAAA
Locus tag: str0787
Name: pgm
Funciton: Phosphoglucomutase (EC 5.4.2.2)
pgm
Phosphoglucomutase (EC 5.4.2.2)

Position: -50
Score: 4.3
Sequence: ATGTAAGCGTTGATAT
Locus tag: str0880
Name: adhB1
Funciton: Alcohol dehydrogenase (EC 1.1.1.1)
Locus tag: str0881
Name: adhB1
Funciton: Alcohol dehydrogenase (EC 1.1.1.1)
Locus tag: str0882
Name: adhB1
Funciton: Alcohol dehydrogenase (EC 1.1.1.1)
adhB1
Alcohol dehydrogenase (EC 1.1.1.1)
adhB1
Alcohol dehydrogenase (EC 1.1.1.1)
adhB1
Alcohol dehydrogenase (EC 1.1.1.1)

Position: -93
Score: 4.4
Sequence: ATGTAAGCGGTTACTG
Locus tag: str1657
Name: pfl
Funciton: Pyruvate formate-lyase (EC 2.3.1.54)
pfl
Pyruvate formate-lyase (EC 2.3.1.54)

Position: -110
Score: 4.1
Sequence: ATGTAATCGATTACCA
Locus tag: str0359
Name: livJ
Funciton: Branched-chain amino acid ABC transporter, substrate-binding protein
Locus tag: str0360
Name: livH
Funciton: Branched-chain amino acid ABC transporter, permease protein 1
Locus tag: str0361
Name: livM
Funciton: Branched-chain amino acid ABC transporter, permease protein 2
Locus tag: str0362
Name: livG
Funciton: Branched-chain amino acid ABC transporter, ATP-binding protein 1
Locus tag: str0363
Name: livF
Funciton: Branched-chain amino acid ABC transporter, ATP-binding protein 2
livJ
Branched-chain amino acid ABC transporter, substrate-binding protein
livH
Branched-chain amino acid ABC transporter, permease protein 1
livM
Branched-chain amino acid ABC transporter, permease protein 2
livG
Branched-chain amino acid ABC transporter, ATP-binding protein 1
livF
Branched-chain amino acid ABC transporter, ATP-binding protein 2

Position: -186
Score: 4.5
Sequence: TAGTAAGGGTTTTCAA
Locus tag: str1128
Name: xylH
Funciton: 4-oxalocrotonate tautomerase (EC 5.3.2.-); Xylose transport system permease protein xylH
xylH
4-oxalocrotonate tautomerase (EC 5.3.2.-); Xylose transport system permease protein xylH

Position: -35
Score: 4.8
Sequence: ATGTAAACGTATTCAA
Locus tag: str1398
Name: lacS
Funciton: Lactose and galactose permease, GPH translocator family
Locus tag: str1397
Name: lacLM
Funciton: Beta-galactosidase (EC 3.2.1.23)
lacS
Lactose and galactose permease, GPH translocator family
lacLM
Beta-galactosidase (EC 3.2.1.23)

Position: -56
Score: 4.3
Sequence: TTGTAAGGGTTATCAT
Locus tag: str1265
Name: ptsH
Funciton: Phosphotransferase system, HPr-related protein
Locus tag: str1264
Name: ptsI
Funciton: Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)
ptsH
Phosphotransferase system, HPr-related protein
ptsI
Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)

Position: -57
Score: 4.2
Sequence: GTGTAACCGTTTTCTA
Locus tag: str1281
Name: naoX
Funciton: Predicted NADH oxidase
naoX
Predicted NADH oxidase

Position: -107
Score: 4.8
Sequence: ATGAAACCGTTATCAT
Locus tag: str1014
Name: malR
Funciton: Maltose utilization transcriptional regulator MalR, LacI family
malR
Maltose utilization transcriptional regulator MalR, LacI family

Position: -109
Score: 3.8
Sequence: AGGTTAGCGTTTTATA
Position: -27
Score: 4.5
Sequence: TTGTAAACGATTACAG
Locus tag: str0399
Name: fruR
Funciton: Fructose utilization transcriptional regulator FruR, DeoR family
Locus tag: str0400
Name: fruB
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: str0401
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str0402
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str0403
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str0404
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str0405
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str0407
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruR
Fructose utilization transcriptional regulator FruR, DeoR family
fruB
1-phosphofructokinase (EC 2.7.1.56)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -124
Score: 4.9
Sequence: TTGACAACGTTTTCAT
Locus tag: str0909
Name: butA
Funciton: 2,3-butanediol dehydrogenase, S-alcohol forming, (R)-acetoin-specific (EC 1.1.1.4) / Acetoin (diacetyl) reductase (EC 1.1.1.5)
Locus tag: str0910
Name: butA
Funciton: 2,3-butanediol dehydrogenase, S-alcohol forming, (R)-acetoin-specific (EC 1.1.1.4) / Acetoin (diacetyl) reductase (EC 1.1.1.5)
butA
2,3-butanediol dehydrogenase, S-alcohol forming, (R)-acetoin-specific (EC 1.1.1.4) / Acetoin (diacetyl) reductase (EC 1.1.1.5)
butA
2,3-butanediol dehydrogenase, S-alcohol forming, (R)-acetoin-specific (EC 1.1.1.4) / Acetoin (diacetyl) reductase (EC 1.1.1.5)

Position: -165
Score: 4.1
Sequence: TTGAATTCCTTTTCAT
Locus tag: str0635
Name: eno
Funciton: Enolase (EC 4.2.1.11)
eno
Enolase (EC 4.2.1.11)

Position: -59
Score: 4.1
Sequence: ATGAAAAGGAATTCAA
Locus tag: str0634
Name: yuel
Funciton: Conserved hypothetical protein
yuel
Conserved hypothetical protein

Position: -106
Score: 4.4
Sequence: ATGAAATCGGTTATAT
Locus tag: str0557
Name: merA
Funciton: Mercuric ion reductase (EC 1.16.1.1)
merA
Mercuric ion reductase (EC 1.16.1.1)

Position: -100
Score: 4
Sequence: AGTGAAACGTTTTCAA
Locus tag: str1734
Name: scrA
Funciton: Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: str1733
Name: scrK
Funciton: Fructokinase (EC 2.7.1.4)
scrA
Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
scrK
Fructokinase (EC 2.7.1.4)

Position: -158
Score: 4
Sequence: TTGAAAACGTTTCACT
Locus tag: str1735
Name: scrB
Funciton: Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
Locus tag: str1736
Name: scrR
Funciton: Sucrose operon repressor ScrR, LacI family
Locus tag: str1737
Name: scrR
Funciton: Sucrose operon repressor ScrR, LacI family
scrB
Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
scrR
Sucrose operon repressor ScrR, LacI family
scrR
Sucrose operon repressor ScrR, LacI family

Position: -80
Score: 4.6
Sequence: ATTATAGCGTTTACAA
Locus tag: str0657
Name: cas5-2
Funciton: CRISPR/Cas system-associated protein Cas9
Locus tag: str0658
Name: cas1
Funciton: CRISPR/Cas system-associated protein Cas1
Locus tag: str0659
Name: cas2
Funciton: CRISPR/Cas system-associated protein Cas2
Locus tag: str0660
Name: str0660
Funciton: hypothetical protein
cas5-2
CRISPR/Cas system-associated protein Cas9
cas1
CRISPR/Cas system-associated protein Cas1
cas2
CRISPR/Cas system-associated protein Cas2
str0660
hypothetical protein

Position: -94
Score: 4.5
Sequence: TTGATAGCCTTTTCAT
Locus tag: str1121
Name: rpiA
Funciton: Ribose 5-phosphate isomerase A (EC 5.3.1.6)
Locus tag: str1120
Name: deoB
Funciton: Phosphopentomutase (EC 5.4.2.7)
Locus tag: str1118
Name: arsC
Funciton: Arsenate reductase (EC 1.20.4.1)
Locus tag: str1117
Name: punA
Funciton: Purine nucleoside phosphorylase (EC 2.4.2.1)
rpiA
Ribose 5-phosphate isomerase A (EC 5.3.1.6)
deoB
Phosphopentomutase (EC 5.4.2.7)
arsC
Arsenate reductase (EC 1.20.4.1)
punA
Purine nucleoside phosphorylase (EC 2.4.2.1)
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Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD