Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CcpA in Streptococcus pyogenes M1 GAS

Properties
Regulator type: Transcription factor
TF locus tag: SPy0514
Regulator family: LacI
Regulation mode:
Biological process: Global catabolite repression
Effector: Fructose-1,6-bisphosphate; HPr, phosphocarrier protein
Regulog: CcpA - Streptococcaceae
Statistics of regulated genes:
- Genes 157
- Operons 69
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 968 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -90
Score: 4.9
Sequence: ATGTAAACGATTACAA
Locus tag: SPy2052
Name: celX
Funciton: Cellobiose-specific PTS system, IIA component (EC 2.7.1.69)
Locus tag: SPy2051
Name: celY
Funciton: Cellobiose-specific PTS system, cellobiose-specific IIB component (EC 2.7.1.69)
Locus tag: SPy2050
Name: celZ
Funciton: Cellobiose-specific PTS system, IIC component (EC 2.7.1.69)
celX
Cellobiose-specific PTS system, IIA component (EC 2.7.1.69)
celY
Cellobiose-specific PTS system, cellobiose-specific IIB component (EC 2.7.1.69)
celZ
Cellobiose-specific PTS system, IIC component (EC 2.7.1.69)

Position: -122
Score: 4
Sequence: TAAAAATGGTTTTCAA
Position: -52
Score: 4.9
Sequence: TTATAAGCGCTTTCAT
Locus tag: SPy1180
Name: citN
Funciton: Mg2+/citrate complex secondary transporter
citN
Mg2+/citrate complex secondary transporter

Position: -65
Score: 4.2
Sequence: AATAAAACGTTTACCA
Locus tag: SPy1879
Name: SPy1879
Funciton: Predicted membrane protein
SPy1879
Predicted membrane protein

Position: -168
Score: 4.7
Sequence: AAGAAAGGGTTTTCAA
Position: -60
Score: 4.3
Sequence: TTGAAACCGCTTTACT
Locus tag: SPy1113
Name: aphA
Funciton: Class B acid phosphatase precursor (EC 3.1.3.2)
aphA
Class B acid phosphatase precursor (EC 3.1.3.2)

Position: -116
Score: 4.9
Sequence: TTTAAATCGCTTTCAT
Locus tag: SPy0872
Name: yhcR
Funciton: 5'-nucleotidase (EC 3.1.3.5)
yhcR
5'-nucleotidase (EC 3.1.3.5)

Position: -190
Score: 4.9
Sequence: ATGAAAACGCTGTCAT
Locus tag: SPy0137
Name: atoE
Funciton: Short chain fatty acids transporter
atoE
Short chain fatty acids transporter

Position: -117
Score: 4.3
Sequence: TTGTAACCACTTTCAA
Position: -84
Score: 4.6
Sequence: TTGAAAAAGTTTTCAA
Locus tag: SPy0513
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -111
Score: 4.3
Sequence: TTGCAATCGATTACAA
Locus tag: SPy2097
Name: treP
Funciton: Trehalose-specific PTS system, IIABC components (EC 2.7.1.69)
Locus tag: SPy2096
Name: treA
Funciton: Trehalose-6-phosphate hydrolase (EC 3.2.1.93)
treP
Trehalose-specific PTS system, IIABC components (EC 2.7.1.69)
treA
Trehalose-6-phosphate hydrolase (EC 3.2.1.93)

Position: -79
Score: 4.7
Sequence: TAGAAAGCGATTTAAT
Locus tag: SPy1026
Name: acoA
Funciton: Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
Locus tag: SPy1028
Name: acoB
Funciton: Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)
acoA
Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
acoB
Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)

Position: -77
Score: 4.3
Sequence: ATGAGAACGTATTCAT
Locus tag: SPy1277
Name: phnA
Funciton: Zn-ribbon-containing protein involved in phosphonate metabolism
phnA
Zn-ribbon-containing protein involved in phosphonate metabolism

Position: -199
Score: 3.7
Sequence: CAAAAAACGATATCTT
Position: -53
Score: 4
Sequence: ATTAAAAGGTTTATAA
Locus tag: SPy1415
Name: rheA
Funciton: Cold-shock DEAD-box protein A
rheA
Cold-shock DEAD-box protein A

Position: -76
Score: 4.2
Sequence: TTGTAAACGGTTACCA
Locus tag: SPy1711
Name: gatA
Funciton: PTS system, galactose-specific IIA component (EC 2.7.1.69)
Locus tag: SPy1710
Name: gatB
Funciton: PTS system, galactose-specific IIB component (EC 2.7.1.69)
Locus tag: SPy1709
Name: gatC
Funciton: PTS system, galactose-specific IIC component (EC 2.7.1.69)
gatA
PTS system, galactose-specific IIA component (EC 2.7.1.69)
gatB
PTS system, galactose-specific IIB component (EC 2.7.1.69)
gatC
PTS system, galactose-specific IIC component (EC 2.7.1.69)

Position: -55
Score: 4.7
Sequence: TTGAAAAGGTTTACAA
Locus tag: SPy1602
Name: araR
Funciton: Arabinoside utilization transcriptional regulator AraR, GntR family
Locus tag: SPy1600
Name: hylZ
Funciton: Hyaluronoglucosaminidase (EC 3.2.1.35)
Locus tag: SPy1599
Name: bglB
Funciton: Beta-glucosidase (EC 3.2.1.21)
araR
Arabinoside utilization transcriptional regulator AraR, GntR family
hylZ
Hyaluronoglucosaminidase (EC 3.2.1.35)
bglB
Beta-glucosidase (EC 3.2.1.21)

Position: -81
Score: 5
Sequence: TTGAAAGCGCTTTATT
Locus tag: SPy0251
Name: nanE
Funciton: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)
Locus tag: SPy0252
Name: nanU
Funciton: N-acetylneuraminate ABC transporter, substrate-binding protein
Locus tag: SPy0254
Name: nanV
Funciton: N-acetylneuraminate ABC transporter, permease protein 1
Locus tag: SPy0255
Name: nanW
Funciton: N-acetylneuraminate ABC transporter, permease protein 2
Locus tag: SPy0256
Name: SPy0256
Funciton: Conserved hypothetical protein
Locus tag: SPy0257
Name: nanA
Funciton: N-acetylneuraminate lyase (EC 4.1.3.3)
Locus tag: SPy0258
Name: nanK
Funciton: N-acetylmannosamine kinase (EC 2.7.1.60)
nanE
N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)
nanU
N-acetylneuraminate ABC transporter, substrate-binding protein
nanV
N-acetylneuraminate ABC transporter, permease protein 1
nanW
N-acetylneuraminate ABC transporter, permease protein 2
SPy0256
Conserved hypothetical protein
nanA
N-acetylneuraminate lyase (EC 4.1.3.3)
nanK
N-acetylmannosamine kinase (EC 2.7.1.60)

Position: -171
Score: 4
Sequence: AAGTAAGTGCTTATAT
Locus tag: SPy0889
Name: rpiA
Funciton: Ribose 5-phosphate isomerase A (EC 5.3.1.6)
Locus tag: SPy0890
Name: deoB
Funciton: Phosphopentomutase (EC 5.4.2.7)
Locus tag: SPy0891
Name: arsC
Funciton: Arsenate reductase (EC 1.20.4.1)
Locus tag: SPy0892
Name: punA
Funciton: Purine nucleoside phosphorylase (EC 2.4.2.1)
rpiA
Ribose 5-phosphate isomerase A (EC 5.3.1.6)
deoB
Phosphopentomutase (EC 5.4.2.7)
arsC
Arsenate reductase (EC 1.20.4.1)
punA
Purine nucleoside phosphorylase (EC 2.4.2.1)

Position: -131
Score: 4.4
Sequence: GTGAAAACGTTTTAAA
Locus tag: SPy1738
Name: manL
Funciton: PTS system, mannose-specific IIAB components
Locus tag: SPy1739
Name: manM
Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69)
Locus tag: SPy1740
Name: manN
Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
Locus tag: SPy1741
Name: manO
Funciton: Putative regulator of the mannose operon, ManO
manL
PTS system, mannose-specific IIAB components
manM
PTS system, mannose-specific IIC component (EC 2.7.1.69)
manN
PTS system, mannose-specific IID component (EC 2.7.1.69)
manO
Putative regulator of the mannose operon, ManO

Position: -28
Score: 4.6
Sequence: CAGAAAACGATTTCAA
Locus tag: SPy0109
Name: ackA
Funciton: Acetate kinase (EC 2.7.2.1)
ackA
Acetate kinase (EC 2.7.2.1)

Position: -176
Score: 4.2
Sequence: TGGTAACCGTTTACAA
Locus tag: SPy1712
Name: lacR2
Funciton: Lactose phosphotransferase system transcriptional regulator LacR, DeoR family
lacR2
Lactose phosphotransferase system transcriptional regulator LacR, DeoR family

Position: -82
Score: 4.3
Sequence: AGAAAAACGCTTTCTT
Locus tag: SPy1567
Name: null
Funciton: CRISPR-associated helicase Cas3
Locus tag: SPy1566
Name: cas5
Funciton: CRISPR/Cas system-associated RAMP superfamily protein Cas5
Locus tag: SPy1565
Name: cas8c
Funciton: CRISPR/Cas system-associated protein Cas8c
Locus tag: SPy1564
Name: cas7
Funciton: CRISPR/Cas system-associated RAMP superfamily protein Cas7
Locus tag: SPy1563
Name: null
Funciton: CRISPR-associated RecB family exonuclease Cas4
Locus tag: SPy1562
Name: cas1
Funciton: CRISPR/Cas system-associated protein Cas1
Locus tag: SPy1561
Name: cas2
Funciton: CRISPR/Cas system-associated protein Cas2
CRISPR-associated helicase Cas3
cas5
CRISPR/Cas system-associated RAMP superfamily protein Cas5
cas8c
CRISPR/Cas system-associated protein Cas8c
cas7
CRISPR/Cas system-associated RAMP superfamily protein Cas7
CRISPR-associated RecB family exonuclease Cas4
cas1
CRISPR/Cas system-associated protein Cas1
cas2
CRISPR/Cas system-associated protein Cas2

Position: -31
Score: 4.6
Sequence: AGGAAAACGCTTACTT
Locus tag: SPy1684
Name: glpK
Funciton: Glycerol kinase (EC 2.7.1.30)
Locus tag: SPy1683
Name: glpD
Funciton: Alpha-glycerophosphate oxidase (EC 1.1.3.21)
Locus tag: SPy1682
Name: glpF
Funciton: Glycerol uptake facilitator protein
glpK
Glycerol kinase (EC 2.7.1.30)
glpD
Alpha-glycerophosphate oxidase (EC 1.1.3.21)
glpF
Glycerol uptake facilitator protein

Position: -78
Score: 4.4
Sequence: TTGAAAGGGCTTGCAT
Locus tag: SPy1424
Name: fdhC
Funciton: Predicted formate transporter
fdhC
Predicted formate transporter

Position: -123
Score: 4.2
Sequence: TTGGAAGCGTTATCAG
Locus tag: SPy1151
Name: ldh
Funciton: L-lactate dehydrogenase (EC 1.1.1.27)
ldh
L-lactate dehydrogenase (EC 1.1.1.27)

Position: -99
Score: 4.3
Sequence: TTTGAACCGTTTTCAT
Locus tag: SPy0636
Name: kduD
Funciton: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127)
Locus tag: SPy0637
Name: kduI
Funciton: 5-keto-4-deoxyuronate isomerase (EC 5.3.1.17)
Locus tag: SPy0638
Name: kdgK
Funciton: 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)
Locus tag: SPy0639
Name: kdgA
Funciton: 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
kduD
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127)
kduI
5-keto-4-deoxyuronate isomerase (EC 5.3.1.17)
kdgK
2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45)
kdgA
2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

Position: -54
Score: 4.3
Sequence: TTGAAAGCGCTACAAT
Locus tag: SPy0634
Name: hylD
Funciton: PTS system, hyaluronate-oligosaccharide-specific IIA component (EC 2.7.1.69)
Locus tag: SPy0632
Name: ugl
Funciton: Unsaturated glucuronyl hydrolase (EC 3.2.1.-)
Locus tag: SPy0631
Name: hylE
Funciton: PTS system, hyaluronate-oligosaccharide-specific IIB component (EC 2.7.1.69)
Locus tag: SPy0630
Name: hylF
Funciton: PTS system, hyaluronate-oligosaccharide-specific IIC component (EC 2.7.1.69)
Locus tag: SPy0629
Name: hylG
Funciton: PTS system, hyaluronate-oligosaccharide-specific IID component (EC 2.7.1.69)
Locus tag: SPy0628
Name: ohl
Funciton: Oligohyaluronate lyase (EC 4.2.2.-)
Locus tag: SPy0627
Name: regR
Funciton: Transcriptional regulator of hyaluronate and KDG utilization, LacI family
hylD
PTS system, hyaluronate-oligosaccharide-specific IIA component (EC 2.7.1.69)
ugl
Unsaturated glucuronyl hydrolase (EC 3.2.1.-)
hylE
PTS system, hyaluronate-oligosaccharide-specific IIB component (EC 2.7.1.69)
hylF
PTS system, hyaluronate-oligosaccharide-specific IIC component (EC 2.7.1.69)
hylG
PTS system, hyaluronate-oligosaccharide-specific IID component (EC 2.7.1.69)
ohl
Oligohyaluronate lyase (EC 4.2.2.-)
regR
Transcriptional regulator of hyaluronate and KDG utilization, LacI family

Position: -97
Score: 4.2
Sequence: ATGTAAGGGTTTATAA
Locus tag: SPy1032
Name: hyl
Funciton: Hyaluronate lyase precursor (EC 4.2.2.1)
hyl
Hyaluronate lyase precursor (EC 4.2.2.1)

Position: -163
Score: 4.3
Sequence: ATGAAAGCGATTACGA
Locus tag: SPy1306
Name: malX
Funciton: Maltose/maltodextrin ABC transporter, substrate-binding protein
Locus tag: SPy1304
Name: dexC
Funciton: Neopullulanase (EC 3.2.1.135)
Locus tag: SPy1302
Name: amyA
Funciton: Cyclodextrin glucanotransferase( EC:2.4.1.19 )
Locus tag: SPy1301
Name: malC
Funciton: Maltose/maltodextrin ABC transporter, permease protein 1
Locus tag: SPy1299
Name: malD
Funciton: Maltose/maltodextrin ABC transporter, permease protein 2
Locus tag: SPy1298
Name: malA
Funciton: Maltodextrose utilization protein MalA
malX
Maltose/maltodextrin ABC transporter, substrate-binding protein
dexC
Neopullulanase (EC 3.2.1.135)
amyA
Cyclodextrin glucanotransferase( EC:2.4.1.19 )
malC
Maltose/maltodextrin ABC transporter, permease protein 1
malD
Maltose/maltodextrin ABC transporter, permease protein 2
malA
Maltodextrose utilization protein MalA

Position: -155
Score: 4.4
Sequence: AAGAAAACGCTTTACA
Position: -101
Score: 4.3
Sequence: ATGCAAGCGATTGCAT
Locus tag: SPy1986
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: SPy1985
Name: rgfB
Funciton: Exodeoxyribonuclease III (EC 3.1.11.2)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
rgfB
Exodeoxyribonuclease III (EC 3.1.11.2)

Position: -34
Score: 5.1
Sequence: TAGAAAGCGTTTTCTA
Locus tag: SPy1325
Name: celR
Funciton: Cellobiose utilization transcriptional regulator CelR, BglG family
Locus tag: SPy1324
Name: celB2
Funciton: Cellobiose-specific PTS, component EIIB
Locus tag: SPy1323
Name: celA2
Funciton: Cellobiose-specific PTS, component EIIA
Locus tag: SPy1322
Name: SPy1322
Funciton: Conserved hypothetical protein
celR
Cellobiose utilization transcriptional regulator CelR, BglG family
celB2
Cellobiose-specific PTS, component EIIB
celA2
Cellobiose-specific PTS, component EIIA
SPy1322
Conserved hypothetical protein

Position: -107
Score: 4.2
Sequence: TGGAAAACGCTTTAAG
Locus tag: SPy1889
Name: fbaA
Funciton: Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
fbaA
Fructose-bisphosphate aldolase class II (EC 4.1.2.13)

Position: -115
Score: 4.3
Sequence: TTGTAATCGATTGCAA
Locus tag: SPy2099
Name: treR
Funciton: Trehalose utilization transcriptional regulator TreR, GntR family
treR
Trehalose utilization transcriptional regulator TreR, GntR family

Position: -36
Score: 4
Sequence: ATGAAAGCGCAAATAA
Locus tag: SPy1777
Name: codY
Funciton: Amino acid metabolism global transcriptional regulator CodY, CodY family
Locus tag: SPy1776
Name: pncA
Funciton: Nicotinamidase (EC 3.5.1.19)
codY
Amino acid metabolism global transcriptional regulator CodY, CodY family
pncA
Nicotinamidase (EC 3.5.1.19)

Position: -60
Score: 4.5
Sequence: TAGAAAGCGATTCCAT
Locus tag: SPy1530
Name: yvaA
Funciton: Bacterial conserved protein of unknown function (DUF910) family
Locus tag: SPy1529
Name: glcK
Funciton: Glucokinase (EC 2.7.1.2)
Locus tag: SPy1528
Name: yvaB
Funciton: Rhodanese-like domain protein
yvaA
Bacterial conserved protein of unknown function (DUF910) family
glcK
Glucokinase (EC 2.7.1.2)
yvaB
Rhodanese-like domain protein

Position: -105
Score: 4.6
Sequence: TTGAAAACTTTTTCAA
Position: -72
Score: 4.3
Sequence: TTGAAAGTGGTTACAA
Locus tag: SPy0514
Name: ccpA
Funciton: Carbon catabolism global transcriptional regulator CcpA, LacI family
ccpA
Carbon catabolism global transcriptional regulator CcpA, LacI family

Position: -56
Score: 3.9
Sequence: CTGCAAGCGGTTGCAT
Locus tag: SPy1294
Name: malE
Funciton: Maltose/maltodextrin ABC transporter, substrate-binding protein
Locus tag: SPy1295
Name: malF
Funciton: Maltose/maltodextrin ABC transporter, permease protein 1
Locus tag: SPy1296
Name: malG
Funciton: Maltose/maltodextrin ABC transporter, permease protein 2
malE
Maltose/maltodextrin ABC transporter, substrate-binding protein
malF
Maltose/maltodextrin ABC transporter, permease protein 1
malG
Maltose/maltodextrin ABC transporter, permease protein 2

Position: -64
Score: 3.8
Sequence: ATGAAAGCAGTATAAT
Position: -35
Score: 4
Sequence: AAGTAAGCGCTTCAAG
Locus tag: SPy1613
Name: raiA
Funciton: Ribosome-associated protein Y
raiA
Ribosome-associated protein Y

Position: -170
Score: 4.7
Sequence: TTGTAAACGCTTTTTT
Locus tag: SPy1870
Name: SAG2073
Funciton: Predicted deoxynucleoside utilization transcriptional regulator, GntR family
SAG2073
Predicted deoxynucleoside utilization transcriptional regulator, GntR family

Position: -35
Score: 4.9
Sequence: ATGAAAGCGTTTATAA
Locus tag: SPy1224
Name: pgm
Funciton: Phosphoglucomutase (EC 5.4.2.2)
pgm
Phosphoglucomutase (EC 5.4.2.2)

Position: -44
Score: 4.6
Sequence: TTGTAACCGATTACAA
Locus tag: SPy0044
Name: adhB1
Funciton: Alcohol dehydrogenase (EC 1.1.1.1)
adhB1
Alcohol dehydrogenase (EC 1.1.1.1)

Position: -168
Score: 5
Sequence: ATGTAAACGCTTTAAA
Locus tag: SPy1329
Name: pnuC
Funciton: Ribosyl nicotinamide transporter
pnuC
Ribosyl nicotinamide transporter

Position: -70
Score: 4.4
Sequence: TTTTTAGCGTTTTCTT
Position: -39
Score: 3.9
Sequence: TGGAAAGCGCTTTTCT
Locus tag: SPy1637
Name: atoB
Funciton: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) / Acetyl-CoA acetyltransferase (EC 2.3.1.9)
Locus tag: SPy1638
Name: atoD
Funciton: Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)
Locus tag: SPy1639
Name: atoA
Funciton: Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)
Locus tag: SPy1640
Name: bdhA
Funciton: D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)
Locus tag: SPy1641
Name: bdhP
Funciton: D-beta-hydroxybutyrate permease
atoB
3-ketoacyl-CoA thiolase (EC 2.3.1.16) / Acetyl-CoA acetyltransferase (EC 2.3.1.9)
atoD
Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)
atoA
Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)
bdhA
D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)
bdhP
D-beta-hydroxybutyrate permease

Position: -37
Score: 4.5
Sequence: ATGTAAGCGTTTCAAT
Locus tag: SPy0140
Name: atoB
Funciton: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) / Acetyl-CoA acetyltransferase (EC 2.3.1.9)
Locus tag: SPy0141
Name: atoD
Funciton: Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)
Locus tag: SPy0142
Name: atoA
Funciton: Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)
atoB
3-ketoacyl-CoA thiolase (EC 2.3.1.16) / Acetyl-CoA acetyltransferase (EC 2.3.1.9)
atoD
Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)
atoA
Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)

Position: -83
Score: 4.7
Sequence: TTGAAAACCCTTTCTT
Locus tag: SPy1111
Name: adh
Funciton: Alcohol dehydrogenase, Zn-dependent (EC 1.1.1.1)
adh
Alcohol dehydrogenase, Zn-dependent (EC 1.1.1.1)

Position: -59
Score: 4.9
Sequence: TTGAAATCGATTTCAT
Locus tag: SPy1067
Name: gabD
Funciton: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)
gabD
Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)

Position: -30
Score: 4.1
Sequence: TAGCAACCGCTTTTAT
Locus tag: SPy1990
Name: pabB
Funciton: Para-aminobenzoate synthase component I (EC 4.1.3.-); Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative
pabB
Para-aminobenzoate synthase component I (EC 4.1.3.-); Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative

Position: -68
Score: 4.1
Sequence: TTGGAAGCGTTTTTTG
Locus tag: SPy1150
Name: naoX
Funciton: Predicted NADH oxidase
naoX
Predicted NADH oxidase

Position: -58
Score: 4.3
Sequence: TTGTAAGGGTTATCAT
Locus tag: SPy1373
Name: ptsH
Funciton: Phosphotransferase system, HPr-related protein
Locus tag: SPy1372
Name: ptsI
Funciton: Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)
ptsH
Phosphotransferase system, HPr-related protein
ptsI
Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)

Position: -121
Score: 4.2
Sequence: ACGAAAACCTTTTCAA
Position: -52
Score: 4.3
Sequence: TAGAAAAGGTTATCAT
Locus tag: SPy0215
Name: pgi
Funciton: Glucose-6-phosphate isomerase (EC 5.3.1.9)
pgi
Glucose-6-phosphate isomerase (EC 5.3.1.9)

Position: -33
Score: 4.3
Sequence: GTAAAAACGTTTACAA
Locus tag: SPy0379
Name: pflA
Funciton: Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)
pflA
Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)

Position: -173
Score: 4.2
Sequence: ATTAAAGCGTTCTCAG
Locus tag: SPy0571
Name: licT
Funciton: Beta-glucoside bgl operon transcriptional antiterminator, BglG family
Locus tag: SPy0572
Name: bglP
Funciton: Beta-glucoside-specific PTS system, IIBCA component (EC 2.7.1.69)
Locus tag: SPy0574
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
licT
Beta-glucoside bgl operon transcriptional antiterminator, BglG family
bglP
Beta-glucoside-specific PTS system, IIBCA component (EC 2.7.1.69)
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -60
Score: 4.7
Sequence: TTGTAAACGATTTCAG
Locus tag: SPy0853
Name: fruR
Funciton: Fructose utilization transcriptional regulator FruR, DeoR family
Locus tag: SPy0854
Name: fruB
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: SPy0855
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruR
Fructose utilization transcriptional regulator FruR, DeoR family
fruB
1-phosphofructokinase (EC 2.7.1.56)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -38
Score: 4.2
Sequence: ATAATATCGTTTTCTA
Locus tag: SPy1858
Name: pepX
Funciton: Xaa-Pro dipeptidyl-peptidase
pepX
Xaa-Pro dipeptidyl-peptidase

Position: -119
Score: 5.1
Sequence: TTTAAAACGTTTTCAT
Locus tag: SPy1057
Name: ptsA
Funciton: Predicted mannose/fructose-specific PTS system, IIA component
Locus tag: SPy1058
Name: ptsB
Funciton: Predicted mannose/fructose-specific PTS system, IIB component
Locus tag: SPy1059
Name: ptsC
Funciton: Predicted mannose/fructose-specific PTS system, IIC component
Locus tag: SPy1060
Name: ptsD
Funciton: Predicted mannose/fructose-specific PTS system, IID component
ptsA
Predicted mannose/fructose-specific PTS system, IIA component
ptsB
Predicted mannose/fructose-specific PTS system, IIB component
ptsC
Predicted mannose/fructose-specific PTS system, IIC component
ptsD
Predicted mannose/fructose-specific PTS system, IID component

Position: -47
Score: 3.9
Sequence: GGTAAAACGCTTTCAT
Locus tag: SPy1681
Name: hcaD
Funciton: NADH peroxidase (EC 1.11.1.1)
Locus tag: SPy1680
Name: hcaR
Funciton: Predicted NADH peroxidase transcriptional regulator
hcaD
NADH peroxidase (EC 1.11.1.1)
hcaR
Predicted NADH peroxidase transcriptional regulator

Position: -188
Score: 4.6
Sequence: AAGAAAGGGTTTACAT
Locus tag: SPy0738
Name: sagA
Funciton: Streptolysin S precursor
Locus tag: SPy0739
Name: sagB
Funciton: Streptolysin S biosynthesis protein
Locus tag: SPy0740
Name: sagC
Funciton: Streptolysin S biosynthesis protein
Locus tag: SPy0741
Name: sagD
Funciton: Streptolysin S biosynthesis protein
Locus tag: SPy0742
Name: sagE
Funciton: Streptolysin S putative self-immunity protein
Locus tag: SPy0743
Name: sagF
Funciton: Streptolysin S biosynthesis protein
Locus tag: SPy0744
Name: sagG
Funciton: Streptolysin S export ABC trasporter, ATP-binding protein
Locus tag: SPy0745
Name: sagH
Funciton: Streptolysin S export ABC trasporter, permease protein 1
Locus tag: SPy0746
Name: sagI
Funciton: Streptolysin S export ABC trasporter, permease protein 2
sagA
Streptolysin S precursor
sagB
Streptolysin S biosynthesis protein
sagC
Streptolysin S biosynthesis protein
sagD
Streptolysin S biosynthesis protein
sagE
Streptolysin S putative self-immunity protein
sagF
Streptolysin S biosynthesis protein
sagG
Streptolysin S export ABC trasporter, ATP-binding protein
sagH
Streptolysin S export ABC trasporter, permease protein 1
sagI
Streptolysin S export ABC trasporter, permease protein 2

Position: -81
Score: 5.1
Sequence: TTTAAAACGCTTTCAT
Locus tag: SPy0174
Name: sgaT
Funciton: Ascorbate-specific PTS system, IIC component
Locus tag: SPy0175
Name: sgaB
Funciton: Ascorbate-specific PTS system, IIB component (EC 2.7.1.69)
Locus tag: SPy0176
Name: sgaC
Funciton: Ascorbate-specific PTS system, IIA component (EC 2.7.1.-)
Locus tag: SPy0177
Name: sgaH
Funciton: 3-keto-L-gulonate 6-phosphate decarboxylase (EC 4.1.1.85)
Locus tag: SPy0178
Name: sgaU
Funciton: L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-)
Locus tag: SPy0179
Name: sgaE
Funciton: L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4)
sgaT
Ascorbate-specific PTS system, IIC component
sgaB
Ascorbate-specific PTS system, IIB component (EC 2.7.1.69)
sgaC
Ascorbate-specific PTS system, IIA component (EC 2.7.1.-)
sgaH
3-keto-L-gulonate 6-phosphate decarboxylase (EC 4.1.1.85)
sgaU
L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-)
sgaE
L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4)

Position: -65
Score: 4.7
Sequence: TTAAAAACGCTTTAAA
Locus tag: SPy1896
Name: ropA
Funciton: Cell division trigger factor (EC 5.2.1.8)
ropA
Cell division trigger factor (EC 5.2.1.8)

Position: -194
Score: 4
Sequence: ATTATATCGATTTCTA
Locus tag: SPy0731
Name: eno
Funciton: Enolase (EC 4.2.1.11)
eno
Enolase (EC 4.2.1.11)

Position: -48
Score: 4
Sequence: TAGAAATCGATATAAT
Locus tag: SPy0729
Name: yuel
Funciton: Conserved hypothetical protein
yuel
Conserved hypothetical protein

Position: -34
Score: 4.8
Sequence: ATGTAAGCGCTAACAA
Locus tag: SPy0414
Name: lctO
Funciton: Lactate 2-monooxygenase (EC 1.13.12.4)
lctO
Lactate 2-monooxygenase (EC 1.13.12.4)

Position: -46
Score: 4.6
Sequence: TAGAAAACGTTTAATT
Locus tag: SPy_1676
Name: tkt
Funciton: Transketolase (EC 2.2.1.1)
tkt
Transketolase (EC 2.2.1.1)

Position: -223
Score: 4.4
Sequence: TTGAAATGGTTTACAA
Position: -32
Score: 4.2
Sequence: ATGTAAGCACTGTCAA
Locus tag: SPy1233
Name: coaA
Funciton: Pantothenate kinase (EC 2.7.1.33)
coaA
Pantothenate kinase (EC 2.7.1.33)

Position: -145
Score: 4.8
Sequence: TTGTAAACGTTTTATT
Position: -131
Score: 4.3
Sequence: TTTAAAACATTTTCTA
Locus tag: SPy1924
Name: lacR2
Funciton: Lactose phosphotransferase system transcriptional regulator LacR, DeoR family
lacR2
Lactose phosphotransferase system transcriptional regulator LacR, DeoR family

Position: -53
Score: 4.3
Sequence: CTGTAAGCGCTTAATA
Locus tag: SPy1339
Name: SPy1339
Funciton: Dihydrolipoamide acyltransferase
SPy1339
Dihydrolipoamide acyltransferase

Position: -16
Score: 4.1
Sequence: ATGAAAGGGATTTTTT
Locus tag: SPy0531
Name: rnc
Funciton: Ribonuclease III (EC 3.1.26.3)
Locus tag: SPy0532
Name: yibB
Funciton: Chromosome segregation ATPase
rnc
Ribonuclease III (EC 3.1.26.3)
yibB
Chromosome segregation ATPase

Position: 23
Score: 4.3
Sequence: ATCAAAGCGCTATCAA
Locus tag: SPy1972
Name: pulA
Funciton: Pullulanase (EC 3.2.1.41)
pulA
Pullulanase (EC 3.2.1.41)

Position: -85
Score: 4.7
Sequence: AAAAAAGCGTTTACAA
Locus tag: SPy1869
Name: udp
Funciton: Uridine phosphorylase (EC 2.4.2.3)
Locus tag: SPy1868
Name: nupC
Funciton: Na+ dependent nucleoside transporter
Locus tag: SPy1867
Name: deoC
Funciton: Deoxyribose-phosphate aldolase (EC 4.1.2.4)
udp
Uridine phosphorylase (EC 2.4.2.3)
nupC
Na+ dependent nucleoside transporter
deoC
Deoxyribose-phosphate aldolase (EC 4.1.2.4)

Position: -182
Score: 4.2
Sequence: AAGTAAACGAATACAA
Locus tag: SPy1547
Name: arcA
Funciton: Arginine deiminase (EC 3.5.3.6)
Locus tag: SPy1546
Name: SPy1546
Funciton: Predicted acetyltransferase (EC 2.3.1.-)
Locus tag: SPy1544
Name: arcB
Funciton: Ornithine carbamoyltransferase (EC 2.1.3.3)
arcA
Arginine deiminase (EC 3.5.3.6)
SPy1546
Predicted acetyltransferase (EC 2.3.1.-)
arcB
Ornithine carbamoyltransferase (EC 2.1.3.3)

Position: -125
Score: 4.7
Sequence: ATGAAAAGGCTTTCTA
Position: -58
Score: 4.5
Sequence: ATGAAAGCGCTTGATA
Locus tag: SPy1595
Name: msmX
Funciton: Multiple sugar ABC transporter, membrane-spanning permease protein MsmF
Locus tag: SPy1593
Name: msmY
Funciton: Multiple sugar ABC transporter, membrane-spanning permease protein MsmG
Locus tag: SPy1592
Name: msmZ
Funciton: Multiple sugar ABC transporter, substrate-binding protein
Locus tag: SPy1591
Name: msmZ
Funciton: Multiple sugar ABC transporter, substrate-binding protein
msmX
Multiple sugar ABC transporter, membrane-spanning permease protein MsmF
msmY
Multiple sugar ABC transporter, membrane-spanning permease protein MsmG
msmZ
Multiple sugar ABC transporter, substrate-binding protein
msmZ
Multiple sugar ABC transporter, substrate-binding protein

Position: -66
Score: 4.7
Sequence: TTGTAAACCTTTTCAA
Locus tag: SPy1603
Name: SPy1603
Funciton: Conserved hypothetical protein
Locus tag: SPy1604
Name: mngB
Funciton: 2-O-(6-phospho-mannosyl)-D-glycerate hydrolase (EC 3.2.1.170)
SPy1603
Conserved hypothetical protein
mngB
2-O-(6-phospho-mannosyl)-D-glycerate hydrolase (EC 3.2.1.170)
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