Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of CcpA in Lactococcus lactis subsp. cremoris SK11

Properties
Regulator type: Transcription factor
TF locus tag: LACR_1812
Regulator family: LacI
Regulation mode:
Biological process: Global catabolite repression
Effector: Fructose-1,6-bisphosphate; HPr, phosphocarrier protein
Regulog: CcpA - Streptococcaceae
Statistics of regulated genes:
- Genes 59
- Operons 32
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 968 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -68
Score: 4.1
Sequence: TTTAATACGCTTACAG
Locus tag: LACR_1533
Name: coaA
Funciton: Pantothenate kinase (EC 2.7.1.33)
coaA
Pantothenate kinase (EC 2.7.1.33)

Position: -136
Score: 4.4
Sequence: CTGTAAACCTTTTCAA
Locus tag: LACR_1813
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -167
Score: 3.8
Sequence: TATTTAGCGATTTTAT
Position: -71
Score: 4
Sequence: TTGTAAACGTGTGCAT
Locus tag: LACR_2298
Name: typA
Funciton: GTP-binding protein TypA/BipA
typA
GTP-binding protein TypA/BipA

Position: -184
Score: 4.2
Sequence: TAGAAAACCCTTGCAA
Position: -143
Score: 4.4
Sequence: ATGAAAACGTTTCATA
Locus tag: LACR_1457
Name: pfk
Funciton: 6-phosphofructokinase (EC 2.7.1.11)
Locus tag: LACR_1456
Name: pyk
Funciton: Pyruvate kinase (EC 2.7.1.40)
pfk
6-phosphofructokinase (EC 2.7.1.11)
pyk
Pyruvate kinase (EC 2.7.1.40)

Position: -62
Score: 4
Sequence: ATGAAAACCGTTTTTA
Locus tag: LACR_1734
Name: tkt
Funciton: Transketolase (EC 2.2.1.1)
tkt
Transketolase (EC 2.2.1.1)

Position: -87
Score: 4.3
Sequence: ATGAAAACATTTGCAA
Locus tag: LACR_1863
Name: manL
Funciton: PTS system, mannose-specific IIAB components
Locus tag: LACR_1864
Name: manM
Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69)
Locus tag: LACR_1865
Name: manN
Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
Locus tag: LACR_1866
Name: manO
Funciton: Putative regulator of the mannose operon, ManO
manL
PTS system, mannose-specific IIAB components
manM
PTS system, mannose-specific IIC component (EC 2.7.1.69)
manN
PTS system, mannose-specific IID component (EC 2.7.1.69)
manO
Putative regulator of the mannose operon, ManO

Position: -89
Score: 4.4
Sequence: ATGTAAAAGCTTACAA
Locus tag: LACR_0030
Name: mtlD
Funciton: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)
mtlD
Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)

Position: -52
Score: 4.1
Sequence: TTGGTAGCGGTTACAA
Locus tag: LACR_0027
Name: mtlA
Funciton: Mannitol-specific PTS system, IIBC component (EC 2.7.1.69)
Locus tag: LACR_0028
Name: mtlR
Funciton: Mannitol operon antiterminator, BglG family
Locus tag: LACR_0029
Name: mtlF
Funciton: Mannitol-specific PTS system, mannitol-specific IIA component (EC 2.7.1.69)
mtlA
Mannitol-specific PTS system, IIBC component (EC 2.7.1.69)
mtlR
Mannitol operon antiterminator, BglG family
mtlF
Mannitol-specific PTS system, mannitol-specific IIA component (EC 2.7.1.69)

Position: -30
Score: 4.3
Sequence: AATAAAACGCATACAT
Locus tag: LACR_2294
Name: ackA
Funciton: Acetate kinase (EC 2.7.2.1)
ackA
Acetate kinase (EC 2.7.2.1)

Position: -129
Score: 4.4
Sequence: ATGCAAACGCTTTTTA
Locus tag: LACR_2295
Name: ackA
Funciton: Acetate kinase (EC 2.7.2.1)
ackA
Acetate kinase (EC 2.7.2.1)

Position: -109
Score: 4.2
Sequence: TATGAAGCGATTTCAT
Locus tag: LACR_2247
Name: fruR2
Funciton: Predicted fructose utilization transcriptional regulator FruR2, RpiR family
fruR2
Predicted fructose utilization transcriptional regulator FruR2, RpiR family

Position: -118
Score: 4.1
Sequence: ATAAAAGGGCTTACAG
Locus tag: LACR_0382
Name: gpmA
Funciton: 2,3-bisphosphoglycerate-dependent phosphoglycerate (EC 5.4.2.1)
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate (EC 5.4.2.1)

Position: -186
Score: 4.1
Sequence: TTAAAAACGCAATCAA
Position: -95
Score: 4.5
Sequence: AATAAAACGGTTACAA
Locus tag: LACR_1546
Name: licT
Funciton: Beta-glucoside bgl operon transcriptional antiterminator, BglG family
Locus tag: LACR_1544
Name: bglH
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
licT
Beta-glucoside bgl operon transcriptional antiterminator, BglG family
bglH
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -94
Score: 4.2
Sequence: ATGTGAACGCTTAAAA
Locus tag: LACR_1825
Name: udk
Funciton: Uridine kinase (EC 2.7.1.48) [C1]
udk
Uridine kinase (EC 2.7.1.48) [C1]

Position: -100
Score: 4.4
Sequence: AATAAAGCGGTTACTT
Locus tag: LACR_2168
Name: fbaA
Funciton: Fructose-bisphosphate aldolase class II (EC 4.1.2.13)
fbaA
Fructose-bisphosphate aldolase class II (EC 4.1.2.13)

Position: -50
Score: 4.6
Sequence: CAGAAAACGTTTTAAT
Locus tag: LACR_0408
Name: yjbM
Funciton: GTP pyrophosphokinase (EC 2.7.6.5)
Locus tag: LACR_0409
Name: ppnK
Funciton: Predicted inorganic polyphosphate/ATP-NAD kinase
Locus tag: LACR_0410
Name: yjbO
Funciton: Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type
yjbM
GTP pyrophosphokinase (EC 2.7.6.5)
ppnK
Predicted inorganic polyphosphate/ATP-NAD kinase
yjbO
Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type

Position: -28
Score: 4.3
Sequence: ATAAATACGCTTTCAG
Locus tag: LACR_1054
Name: fdhC
Funciton: Predicted formate transporter
fdhC
Predicted formate transporter

Position: -163
Score: 4.1
Sequence: TTTAAAGGGCTTTATT
Position: -32
Score: 4.7
Sequence: AATAAACCGTTTTCAT
Locus tag: LACR_1853
Name: malE
Funciton: Maltose/maltodextrin ABC transporter, substrate-binding protein
Locus tag: LACR_1854
Name: malF
Funciton: Maltose/maltodextrin ABC transporter, permease protein 1
Locus tag: LACR_1855
Name: malG
Funciton: Maltose/maltodextrin ABC transporter, permease protein 2
malE
Maltose/maltodextrin ABC transporter, substrate-binding protein
malF
Maltose/maltodextrin ABC transporter, permease protein 1
malG
Maltose/maltodextrin ABC transporter, permease protein 2

Position: -93
Score: 4.4
Sequence: TTGAAAAGGTTTACAG
Locus tag: LACR_1812
Name: ccpA
Funciton: Carbon catabolism global transcriptional regulator CcpA, LacI family
ccpA
Carbon catabolism global transcriptional regulator CcpA, LacI family

Position: -133
Score: 4.4
Sequence: ATGAAAGCTGTTTCAT
Locus tag: LACR_0667
Name: raiA
Funciton: Ribosome-associated protein Y
raiA
Ribosome-associated protein Y

Position: -64
Score: 4.6
Sequence: CTGAAAACGCTTTTTT
Locus tag: LACR_2456
Name: ywcC
Funciton: 6-phosphogluconolactonase (EC 3.1.1.31)
ywcC
6-phosphogluconolactonase (EC 3.1.1.31)

Position: -64
Score: 4.5
Sequence: ATGAAAACGGATACAA
Locus tag: LACR_1803
Name: rbsR
Funciton: Ribose utilization transcriptional regulator, LacI family
Locus tag: LACR_1802
Name: rbsK
Funciton: Ribokinase (EC 2.7.1.15)
Locus tag: LACR_1801
Name: rbsD
Funciton: Ribose ABC transport system, high affinity permease RbsD (TC 3.A.1.2.1)
Locus tag: LACR_1800
Name: rbsA
Funciton: Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1)
rbsR
Ribose utilization transcriptional regulator, LacI family
rbsK
Ribokinase (EC 2.7.1.15)
rbsD
Ribose ABC transport system, high affinity permease RbsD (TC 3.A.1.2.1)
rbsA
Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1)

Position: -44
Score: 4.6
Sequence: AAGAATGCGTTTACAA
Locus tag: LACR_1990
Name: adhB1
Funciton: Alcohol dehydrogenase (EC 1.1.1.1)
adhB1
Alcohol dehydrogenase (EC 1.1.1.1)

Position: -156
Score: 5.1
Sequence: ATGAAAACGTTTTAAA
Locus tag: LACR_0691
Name: pfl
Funciton: Pyruvate formate-lyase (EC 2.3.1.54)
pfl
Pyruvate formate-lyase (EC 2.3.1.54)

Position: -148
Score: 4
Sequence: AAATAAGTGCTTACAT
Locus tag: LACR_2470
Name: pgi
Funciton: Glucose-6-phosphate isomerase (EC 5.3.1.9)
pgi
Glucose-6-phosphate isomerase (EC 5.3.1.9)

Position: 0
Score: 4.2
Sequence: ATGAAATTGCTTTTAA
Locus tag: LACR_C06
Name: null
Funciton: Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) # PabAb
Locus tag: LACR_C07
Name: pabB
Funciton: Para-aminobenzoate synthase component I (EC 4.1.3.-); Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) # PabAb
pabB
Para-aminobenzoate synthase component I (EC 4.1.3.-); Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative

Position: -61
Score: 5.1
Sequence: AAGAAAACGTTTTCTT
Locus tag: LACR_0723
Name: malQ
Funciton: 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25)
Locus tag: LACR_0724
Name: glgC
Funciton: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
Locus tag: LACR_0726
Name: glgA
Funciton: Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)
malQ
4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25)
glgC
Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27)
glgA
Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21)

Position: -162
Score: 4.5
Sequence: ATGTAAACGATTTATA
Locus tag: LACR_2317
Name: aat
Funciton: Aspartate aminotransferase (EC 2.6.1.1)
aat
Aspartate aminotransferase (EC 2.6.1.1)

Position: -25
Score: 4.2
Sequence: TTGTAAACGAATTCAG
Locus tag: LACR_1031
Name: fruR
Funciton: Fructose utilization transcriptional regulator FruR, DeoR family
Locus tag: LACR_1032
Name: fruB
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: LACR_1033
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruR
Fructose utilization transcriptional regulator FruR, DeoR family
fruB
1-phosphofructokinase (EC 2.7.1.56)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -115
Score: 4.1
Sequence: TGTTAAACGGTTTCAT
Locus tag: LACR_0133
Name: yscN
Funciton: Predicted oxidoreductase, aldo/keto reductase family
yscN
Predicted oxidoreductase, aldo/keto reductase family

Position: -135
Score: 4.3
Sequence: TATCAAACGCTTACAA
Locus tag: LACR_1939
Name: atpE
Funciton: ATP synthase C chain (EC 3.6.3.14)
Locus tag: LACR_1938
Name: atpB
Funciton: ATP synthase A chain (EC 3.6.3.14)
Locus tag: LACR_1937
Name: atpF
Funciton: ATP synthase B chain (EC 3.6.3.14)
Locus tag: LACR_1936
Name: atpH
Funciton: ATP synthase delta chain (EC 3.6.3.14)
Locus tag: LACR_1935
Name: atpA
Funciton: ATP synthase alpha chain (EC 3.6.3.14)
Locus tag: LACR_1934
Name: atpG
Funciton: ATP synthase gamma chain (EC 3.6.3.14)
Locus tag: LACR_1933
Name: atpD
Funciton: ATP synthase beta chain (EC 3.6.3.14)
Locus tag: LACR_1932
Name: atpC
Funciton: ATP synthase epsilon chain (EC 3.6.3.14)
atpE
ATP synthase C chain (EC 3.6.3.14)
atpB
ATP synthase A chain (EC 3.6.3.14)
atpF
ATP synthase B chain (EC 3.6.3.14)
atpH
ATP synthase delta chain (EC 3.6.3.14)
atpA
ATP synthase alpha chain (EC 3.6.3.14)
atpG
ATP synthase gamma chain (EC 3.6.3.14)
atpD
ATP synthase beta chain (EC 3.6.3.14)
atpC
ATP synthase epsilon chain (EC 3.6.3.14)

Position: -123
Score: 4.3
Sequence: ATGAAAACGGTAAAAT
Locus tag: LACR_1946
Name: natA
Funciton: Na+ export ABC transporter, ATP-binding protein
Locus tag: LACR_1945
Name: natB
Funciton: Na+ export ABC transporter, permease protein
natA
Na+ export ABC transporter, ATP-binding protein
natB
Na+ export ABC transporter, permease protein
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