Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of IscR in Roseobacter sp. MED193

Properties
Regulator type: Transcription factor
TF locus tag: MED193_04321
Regulator family: Rrf2
Regulation mode: repressor (activator)
Biological process: Iron-sulfur cluster biogenesis; Iron homeostasis
Effector: Iron-sulfur cluster redox state; Iron ion, (Fe2+)
Regulog: IscR - Rhodobacterales
Statistics of regulated genes:
- Genes 39
- Operons 8
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 125 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -355
Score: 4
Sequence: CTTGACAAAACCTGTAAGG
Locus tag: MED193_22076
Name: fecB
Funciton: ABC-type Fe3+-hydroxamate transport system, periplasmic component
Locus tag: MED193_22071
Name: fecC
Funciton: ABC-type Fe3+-siderophore transport system, permease component
Locus tag: MED193_22066
Name: fecD
Funciton: ABC-type Fe3+-siderophore transport system, permease component
Locus tag: MED193_22061
Name: fecE
Funciton: ABC Fe+3-siderophore transporter, ATPase subunit
Locus tag: MED193_22056
Name: mxcB
Funciton: Siderophore-interacting protein
Locus tag: MED193_22051
Name: exbB
Funciton: Ferric siderophore transport system, biopolymer transport protein ExbB
Locus tag: MED193_22046
Name: exbD1
Funciton: Biopolymer transport protein ExbD/TolR
Locus tag: MED193_22041
Name: exbD2
Funciton: Biopolymer transport protein ExbD/TolR
Locus tag: MED193_22036
Name: tonB
Funciton: Ferric siderophore transport system, periplasmic binding protein TonB
fecB
ABC-type Fe3+-hydroxamate transport system, periplasmic component
fecC
ABC-type Fe3+-siderophore transport system, permease component
fecD
ABC-type Fe3+-siderophore transport system, permease component
fecE
ABC Fe+3-siderophore transporter, ATPase subunit
mxcB
Siderophore-interacting protein
exbB
Ferric siderophore transport system, biopolymer transport protein ExbB
exbD1
Biopolymer transport protein ExbD/TolR
exbD2
Biopolymer transport protein ExbD/TolR
tonB
Ferric siderophore transport system, periplasmic binding protein TonB

Position: 69
Score: 4
Sequence: GTTGACTGTTTTTATCACC
Locus tag: MED193_17504
Name: hmuR
Funciton: TonB-dependent hemin , ferrichrome receptor
Locus tag: MED193_17509
Name: Mlr1156
Funciton: Mlr1156 protein
Locus tag: MED193_17514
Name: exbB
Funciton: Ferric siderophore transport system, biopolymer transport protein ExbB
Locus tag: MED193_17519
Name: exbD1
Funciton: Ferric siderophore transport system, periplasmic binding protein ExbD
Locus tag: MED193_17524
Name: exbD2
Funciton: Ferric siderophore transport system, periplasmic binding protein ExbD
Locus tag: MED193_17529
Name: tonB
Funciton: Ferric siderophore transport system, periplasmic binding protein TonB
hmuR
TonB-dependent hemin , ferrichrome receptor
Mlr1156
Mlr1156 protein
exbB
Ferric siderophore transport system, biopolymer transport protein ExbB
exbD1
Ferric siderophore transport system, periplasmic binding protein ExbD
exbD2
Ferric siderophore transport system, periplasmic binding protein ExbD
tonB
Ferric siderophore transport system, periplasmic binding protein TonB

Position: -58
Score: 3.8
Sequence: TCCGACCAAAATGATCGCA
Locus tag: MED193_12813
Name: fbpB
Funciton: Ferric iron ABC transporter, permease protein
fbpB
Ferric iron ABC transporter, permease protein

Position: -139
Score: 5.3
Sequence: TCTGACTATTTTTGTCAGA
Locus tag: MED193_15812
Name: TM1040_2633
Funciton: hypothetical protein
TM1040_2633
hypothetical protein

Position: -103
Score: 4.4
Sequence: CCTGACAAAAACAATAAGC
Position: -72
Score: 4.5
Sequence: CCTTATTGTTTTTGTCAGA
Locus tag: MED193_19654
Name: bfd
Funciton: Bacterioferritin-associated ferredoxin
Locus tag: MED193_19649
Name: bfr
Funciton: Bacterioferritin (cytochrome b1)
Locus tag: MED193_19644
Name: COG3488
Funciton: Probable thiol oxidoreductase with 2 cytochrome c heme-binding sites
Locus tag: MED193_19639
Name: COG3489
Funciton: Predicted periplasmic lipoprotein
Locus tag: MED193_19634
Name: COG3490
Funciton: Uncharacterised conserved protein UCP028101
bfd
Bacterioferritin-associated ferredoxin
bfr
Bacterioferritin (cytochrome b1)
COG3488
Probable thiol oxidoreductase with 2 cytochrome c heme-binding sites
COG3489
Predicted periplasmic lipoprotein
COG3490
Uncharacterised conserved protein UCP028101

Position: -118
Score: 5.3
Sequence: TCTGACAAAAATAGTCAGA
Position: -91
Score: 4.7
Sequence: CTTGATTGTTTTAATCAGG
Locus tag: MED193_19679
Name: MED193_19679
Funciton: hypothetical protein
Locus tag: MED193_19674
Name: hemP
Funciton: Hemin uptake protein HemP
Locus tag: MED193_19669
Name: null
Funciton: hypothetical protein
Locus tag: MED193_19664
Name: irpA
Funciton: Iron-regulated protein A precursor
Locus tag: MED193_19659
Name: hmuX
Funciton: hypothetical porin
MED193_19679
hypothetical protein
hemP
Hemin uptake protein HemP
hypothetical protein
irpA
Iron-regulated protein A precursor
hmuX
hypothetical porin

Position: -144
Score: 4
Sequence: CTTGACGAATTCCATCAGC
Locus tag: MED193_04321
Name: iscR
Funciton: Iron-sulfur cluster regulator IscR, Rrf2 family
Locus tag: MED193_04316
Name: iscS
Funciton: Cysteine desulfurase (EC 2.8.1.7)
Locus tag: MED193_04311
Name: sufB
Funciton: Iron-sulfur cluster assembly protein SufB
Locus tag: MED193_04306
Name: null
Funciton: hypothetical protein
Locus tag: MED193_04301
Name: RSP_0439
Funciton: protein of unknown function DUF74
Locus tag: MED193_04296
Name: Jann_2361
Funciton: ExoV domain protein
Locus tag: MED193_04291
Name: sufC
Funciton: Iron-sulfur cluster assembly ATPase protein SufC
Locus tag: MED193_04286
Name: sufD
Funciton: Iron-sulfur cluster assembly protein SufD
Locus tag: MED193_04281
Name: RSP_0433
Funciton: hypothetical protein
Locus tag: MED193_04276
Name: null
Funciton: hypothetical protein
Locus tag: MED193_04271
Name: sufS
Funciton: Cysteine desulfurase (EC 2.8.1.7), SufS subfamily
iscR
Iron-sulfur cluster regulator IscR, Rrf2 family
iscS
Cysteine desulfurase (EC 2.8.1.7)
sufB
Iron-sulfur cluster assembly protein SufB
hypothetical protein
RSP_0439
protein of unknown function DUF74
Jann_2361
ExoV domain protein
sufC
Iron-sulfur cluster assembly ATPase protein SufC
sufD
Iron-sulfur cluster assembly protein SufD
RSP_0433
hypothetical protein
hypothetical protein
sufS
Cysteine desulfurase (EC 2.8.1.7), SufS subfamily

Position: -65
Score: 4.2
Sequence: ACTGACAAAAGAAGTCGGA
Locus tag: MED193_12793
Name: fbpA
Funciton: Ferric iron ABC transporter, iron-binding protein
fbpA
Ferric iron ABC transporter, iron-binding protein
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