Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulon of HypR in Pseudomonas aeruginosa PAO1

Properties
Regulator type: Transcription factor
TF locus tag: PA1269
Regulator family: GntR/Others
Regulation mode: activator (repressor)
Biological process: Proline and 4-hydrohyproline utilization
Effector: Proline; 4-hydroxyproline
Regulog: HypR - Pseudomonadaceae
Statistics of regulated genes:
- Genes 11
- Operons 3
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 3 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -61
Score: 4.5
Sequence: TTCGTATACAAT
Locus tag: PA1269
Name: hypR
Funciton: Predicted regulator for proline and hydrohyproline utilization, GntR family
Locus tag: PA1268
Name: hypE
Funciton: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
Locus tag: PA1267
Name: hypO
Funciton: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
hypR
Predicted regulator for proline and hydrohyproline utilization, GntR family
hypE
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypO
D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster

Position: -67
Score: 3.8
Sequence: ATCGTATACGAA
Locus tag: PA1260
Name: hypM
Funciton: Predicted hydroxyproline ABC transporter, substrate-binding protein
Locus tag: PA1259
Name: hypX
Funciton: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
Locus tag: PA1258
Name: hypN
Funciton: Predicted hydroxyproline ABC transporter, permease protein
Locus tag: PA1257
Name: hypP
Funciton: Predicted hydroxyproline ABC transporter, permease protein
Locus tag: PA1256
Name: hypQ
Funciton: Predicted hydroxyproline ABC transporter, ATP-binding protein
Locus tag: PA1255
Name: hypY
Funciton: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypM
Predicted hydroxyproline ABC transporter, substrate-binding protein
hypX
Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
hypN
Predicted hydroxyproline ABC transporter, permease protein
hypP
Predicted hydroxyproline ABC transporter, permease protein
hypQ
Predicted hydroxyproline ABC transporter, ATP-binding protein
hypY
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)

Position: -32
Score: 3.7
Sequence: TTCGTATACGAA
Locus tag: PA1254
Name: hypD
Funciton: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
Locus tag: PA1253
Name: hypH
Funciton: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
hypD
1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
hypH
Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
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