Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog BirA - Bacillales

Properties
Regulator type: Transcription factor
Regulator family: BirA
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 36 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Bacillus subtilis subsp. subtilis str. 168 10 3
Bacillus amyloliquefaciens FZB42 10 3
Bacillus pumilus SAFR-032 5 3
Bacillus licheniformis DSM 13 7 2
Anoxybacillus flavithermus WK1 7 4
Geobacillus kaustophilus HTA426 7 5
Bacillus cereus ATCC 14579 10 3
Bacillus halodurans C-125 7 4
Bacillus clausii KSM-K16 3 2
Oceanobacillus iheyensis HTE831 2 2
Paenibacillus sp. JDR-2 7 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
bioY2
*
Bacillus subtilis subsp. subtilis str. 168

Site:
position = -88
score = 8.45358
sequence = ATGTAAAC-(15)-GTTGACAT

Gene: BSU10370: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus amyloliquefaciens FZB42

Site:
position = -87
score = 8.61757
sequence = ATGTTAAC-(15)-GTTGACAT

Gene: RBAM_010550: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus pumilus SAFR-032

Site:
position = -88
score = 8.61757
sequence = ATGTTAAC-(15)-GTTGACAT

Gene: BPUM_2376: Substrate-specific component BioY of biotin ECF transporter
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1
 
Geobacillus kaustophilus HTA426
*
Bacillus cereus ATCC 14579

Site:
position = -46
score = 7.74646
sequence = ATGTTACC-(15)-GTTTACAA

Site:
position = -111
score = 8.57717
sequence = TTGTAAAC-(15)-GTTGACAA

Gene: BC3629: Substrate-specific component BioY of biotin ECF transporter
 
Bacillus halodurans C-125
*
Bacillus clausii KSM-K16

Site:
position = -82
score = 8.74116
sequence = TTGTTAAC-(15)-GTTGACAA

Gene: ABC2607: Substrate-specific component BioY of biotin ECF transporter
*
Oceanobacillus iheyensis HTE831

Site:
position = -81
score = 8.57717
sequence = TTGTAAAC-(15)-GTTGACAA

Gene: OB1717: Substrate-specific component BioY of biotin ECF transporter
*
Paenibacillus sp. JDR-2

Site:
position = -158
score = 8.77913
sequence = TTGTTAAC-(18)-GTTAACAt

Gene: Pjdr2_3366: Substrate-specific component BioY of biotin ECF transporter
Substrate-specific component BioY of biotin ECF transporter
yhfT
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU10360: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_010540: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Bacillus pumilus SAFR-032

Gene: BPUM_2375: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1
 
Geobacillus kaustophilus HTA426
 
Bacillus cereus ATCC 14579

Gene: BC3628: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Bacillus halodurans C-125
*
Bacillus clausii KSM-K16

Site:
position = -87
score = 8.51537
sequence = ATGTAAAC-(15)-GTTGACAA

Gene: ABC0344: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
yhfS
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU10350: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_010530: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Bacillus pumilus SAFR-032

Gene: BPUM_2374: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1
 
Geobacillus kaustophilus HTA426
 
Bacillus cereus ATCC 14579

Gene: BC3627: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Bacillus halodurans C-125
 
Bacillus clausii KSM-K16

Gene: ABC0345: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2
Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
CRON 2.
bioY1
*
Bacillus subtilis subsp. subtilis str. 168

Site:
position = -87
score = 8.74116
sequence = TTGTTAAC-(15)-GTTGACAA

Gene: BSU32030: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus amyloliquefaciens FZB42

Site:
position = -84
score = 7.86636
sequence = TAGTAAAC-(15)-GTTGACAA

Gene: RBAM_029080: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus pumilus SAFR-032

Site:
position = -83
score = 8.74116
sequence = TTGTTAAC-(15)-GTTGACAA

Gene: BPUM_2863: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus licheniformis DSM 13

Site:
position = -89
score = 8.74116
sequence = TTGTTAAC-(15)-GTTGACAA

Gene: BLi03385: Substrate-specific component BioY of biotin ECF transporter
*
Anoxybacillus flavithermus WK1

Site:
position = -31
score = 8.13012
sequence = TCGTTAAC-(15)-GTTAACAA

Gene: Aflv_2398: Substrate-specific component BioY of biotin ECF transporter
*
Geobacillus kaustophilus HTA426

Site:
position = -31
score = 8.61514
sequence = TTGTTAAC-(15)-GTTTACAT

Gene: GK2944: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus cereus ATCC 14579

Site:
position = 107
score = 8.71733
sequence = ATGTTAAC-(16)-GTTAACAT

Gene: BC4917: Substrate-specific component BioY of biotin ECF transporter
*
Bacillus halodurans C-125

Site:
position = -33
score = 7.84865
sequence = ATGTTAAC-(15)-GTAAACAT

Site:
position = -87
score = 8.5796
sequence = ATGTCAAC-(15)-GTTGACAA

Gene: BH3358: Substrate-specific component BioY of biotin ECF transporter
 
Bacillus clausii KSM-K16
*
Oceanobacillus iheyensis HTE831

Site:
position = -81
score = 8.64139
sequence = TTGTCAAC-(15)-GTTGACAA

Gene: OB2346: Substrate-specific component BioY of biotin ECF transporter
 
Paenibacillus sp. JDR-2
Substrate-specific component BioY of biotin ECF transporter
 
CRON 3.
bioW
*
Bacillus subtilis subsp. subtilis str. 168

Site:
position = -85
score = 8.84092
sequence = TTGTTAAC-(15)-GTTAACAA

Gene: BSU30240: Pimeloyl-CoA synthase (EC 6.2.1.14)
*
Bacillus amyloliquefaciens FZB42

Site:
position = -64
score = 8.18574
sequence = GTGTTAAC-(15)-GTTAACAT

Site:
position = -126
score = 7.22626
sequence = CAGTTAAC-(15)-GTTGACAT

Gene: RBAM_018290: Pimeloyl-CoA synthase (EC 6.2.1.14)
 
Bacillus pumilus SAFR-032
*
Bacillus licheniformis DSM 13

Site:
position = -55
score = 8.71733
sequence = ATGTTAAC-(15)-GTTAACAT

Gene: BLi00766: Pimeloyl-CoA synthase (EC 6.2.1.14)
 
Anoxybacillus flavithermus WK1
 
Geobacillus kaustophilus HTA426
 
Bacillus cereus ATCC 14579
 
Bacillus halodurans C-125
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2
Pimeloyl-CoA synthase (EC 6.2.1.14)
bioA
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU30230: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_018280: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13

Gene: BLi00767: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Anoxybacillus flavithermus WK1

Gene: Aflv_1071: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Geobacillus kaustophilus HTA426

Gene: GK3016: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Bacillus cereus ATCC 14579

Site:
position = -45
score = 8.71733
sequence = ATGTTAAC-(15)-GTTAACAT

Gene: BC4119: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Bacillus halodurans C-125

Gene: BH0782: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
*
Paenibacillus sp. JDR-2

Site:
position = 40
score = 8.84092
sequence = TTGTTAAC-(18)-GTTAACAA

Gene: Pjdr2_1461: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
bioF
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU30220: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_018270: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13

Gene: BLi00768: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Anoxybacillus flavithermus WK1

Site:
position = -45
score = 8.45115
sequence = ATGTAAAC-(15)-GTTTACAA

Gene: Aflv_1163: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Geobacillus kaustophilus HTA426

Site:
position = -46
score = 8.38936
sequence = ATGTAAAC-(15)-GTTTACAT

Gene: GK2128: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Bacillus cereus ATCC 14579

Gene: BC4117: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Bacillus halodurans C-125

Site:
position = -66
score = 8.77913
sequence = ATGTTAAC-(15)-GTTAACAA

Gene: BH3907: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2

Gene: Pjdr2_1464: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU30210: Dethiobiotin synthetase (EC 6.3.3.3)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_018260: Dethiobiotin synthetase (EC 6.3.3.3)
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13

Gene: BLi00769: Dethiobiotin synthetase (EC 6.3.3.3)
*
Anoxybacillus flavithermus WK1

Site:
position = -52
score = 8.74116
sequence = TTGTTAAC-(15)-GTTGACAA

Gene: Aflv_1070: Dethiobiotin synthetase (EC 6.3.3.3)
 
Geobacillus kaustophilus HTA426

Gene: GK3017: Dethiobiotin synthetase (EC 6.3.3.3)
 
Bacillus cereus ATCC 14579

Gene: BC4118: Dethiobiotin synthetase (EC 6.3.3.3)
*
Bacillus halodurans C-125

Site:
position = -42
score = 8.71733
sequence = ATGTTAAC-(15)-GTTAACAT

Gene: BH0783: Dethiobiotin synthetase (EC 6.3.3.3)
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2

Gene: Pjdr2_1462: Dethiobiotin synthetase (EC 6.3.3.3)
Dethiobiotin synthetase (EC 6.3.3.3)
bioB
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU30200: Biotin synthase (EC 2.8.1.6)
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_018250: Biotin synthase (EC 2.8.1.6)
*
Bacillus pumilus SAFR-032

Site:
position = -48
score = 8.71733
sequence = ATGTTAAC-(15)-GTTAACAT

Gene: BPUM_2779: Biotin synthase (EC 2.8.1.6)
 
Bacillus licheniformis DSM 13

Gene: BLi00770: Biotin synthase (EC 2.8.1.6)
*
Anoxybacillus flavithermus WK1

Site:
position = -55
score = 8.67936
sequence = TTGTTAAC-(15)-GTTGACAT

Gene: Aflv_1376: Biotin synthase (EC 2.8.1.6)
*
Geobacillus kaustophilus HTA426

Site:
position = -86
score = 7.80457
sequence = AAGTAAAC-(15)-GTTGACAA

Gene: GK1570: Biotin synthase (EC 2.8.1.6)
 
Bacillus cereus ATCC 14579

Gene: BC4114: Biotin synthase (EC 2.8.1.6)
*
Bacillus halodurans C-125

Site:
position = -56
score = 8.67693
sequence = TTGTTAAC-(15)-GTTTACAA

Gene: BH1748: Biotin synthase (EC 2.8.1.6)
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2

Gene: Pjdr2_1463: Biotin synthase (EC 2.8.1.6)
Biotin synthase (EC 2.8.1.6)
bioI
 
Bacillus subtilis subsp. subtilis str. 168

Gene: BSU30190: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing
 
Bacillus amyloliquefaciens FZB42

Gene: RBAM_018240: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13

Gene: BLi00771: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing
 
Anoxybacillus flavithermus WK1
 
Geobacillus kaustophilus HTA426
 
Bacillus cereus ATCC 14579
 
Bacillus halodurans C-125
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2
Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing
bioH
 
Bacillus subtilis subsp. subtilis str. 168
 
Bacillus amyloliquefaciens FZB42
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1

Gene: Aflv_1164: Biotin synthesis protein bioH
*
Geobacillus kaustophilus HTA426

Site:
position = -330
score = 8.45115
sequence = ATGTAAAC-(15)-GTTTACAA

Gene: GK3098: Biotin synthesis protein bioH
 
Bacillus cereus ATCC 14579

Gene: BC4116: Biotin synthesis protein bioH
 
Bacillus halodurans C-125

Gene: BH3908: Biotin synthesis protein bioH
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2

Gene: Pjdr2_1465: Biotin synthesis protein bioH
Biotin synthesis protein bioH
bioC
 
Bacillus subtilis subsp. subtilis str. 168
 
Bacillus amyloliquefaciens FZB42
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1

Gene: Aflv_1165: SAM-dependent methyltransferase
 
Geobacillus kaustophilus HTA426
 
Bacillus cereus ATCC 14579

Gene: BC4115: SAM-dependent methyltransferase
 
Bacillus halodurans C-125

Gene: BH3909: SAM-dependent methyltransferase
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2

Gene: Pjdr2_1466: SAM-dependent methyltransferase
SAM-dependent methyltransferase
bioY
 
Bacillus subtilis subsp. subtilis str. 168
 
Bacillus amyloliquefaciens FZB42
 
Bacillus pumilus SAFR-032
 
Bacillus licheniformis DSM 13
 
Anoxybacillus flavithermus WK1
*
Geobacillus kaustophilus HTA426

Site:
position = -84
score = 8.51537
sequence = ATGTAAAC-(15)-GTTGACAA

Gene: GK3018: Substrate-specific component BioY of biotin ECF transporter
 
Bacillus cereus ATCC 14579
 
Bacillus halodurans C-125
 
Bacillus clausii KSM-K16
 
Oceanobacillus iheyensis HTE831
 
Paenibacillus sp. JDR-2
Substrate-specific component BioY of biotin ECF transporter
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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